6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells

Toxicology and Applied Pharmacology

Volumn 336, Issue , 2017, Pages 31-39

  Wonganan, Orawan ^a,e   He, Yu jiao ^a,b   Shen, Xiao fei ^a   Wongkrajang, Kanjana ^a,d   Suksamrarn, Apichart ^c   Zhang, Guo lin ^a   Wang, Fei ^a  

^a CHENGDU INSTITUTE OF BIOLOGY   (China)

^b CHENGDU UNIVERSITY   (China)

^c RAMKHAMHAENG UNIVERSITY   (Thailand)

^d PIBULSONGKRAM RAJABHAT UNIVERSITY   (Thailand)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Interferon; JAK STAT; Kaempferol glucopyranoside; Saussurea stella; SOCS3

Indexed keywords

6 HYDROXY 3 O METHYL KAEMPFEROL 6 O GLUCOPYRANOSIDE; ALPHA INTERFERON; ANTINEOPLASTIC AGENT; BETA INTERFERON; GLUCOPYRANOSIDE; JANUS KINASE; JANUS KINASE 1; KAEMPFEROL DERIVATIVE; MESSENGER RNA; PROTEIN KINASE TYK2; STAT PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG; 6-HYDROXY-3-O-METHYLKAEMPFEROL 6-O-GLUCOPYRANOSIDE; GLUCOSIDE; JAK1 PROTEIN, HUMAN; SOCS3 PROTEIN, HUMAN; STAT1 PROTEIN, HUMAN; STAT2 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; EC50; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HEP-G2 CELL LINE; HEPATOCELLULAR CARCINOMA CELL LINE; HUH-7 CELL LINE; HUMAN; HUMAN CELL; JAK-STAT SIGNALING; LUCIFERASE ASSAY; PLASMID; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; CELL PROLIFERATION; DNA RESPONSIVE ELEMENT; DOSE RESPONSE; DRUG EFFECTS; DRUG POTENTIATION; ENZYMOLOGY; GENETICS; HEK293 CELL LINE; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME FACTOR;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GLUCOSIDES; HEK293 CELLS; HEP G2 CELLS; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; JANUS KINASE 1; KAEMPFEROLS; LIVER NEOPLASMS; PHOSPHORYLATION; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING 3 PROTEIN; TIME FACTORS; TRANSFECTION;

EID: 85031741003     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2017.10.004     Document Type: Article

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