Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Lin, Chiao Wen ^a,b   Chen, Pei Ni ^a,b   Chen, Mu Kuan ^a,c   Yang, Wei En ^a   Tang, Chih Hsin ^d,e   Yang, Shun Fa ^a,b   Hsieh, Yih Shou ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e ASIA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; KAEMPFEROL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN C JUN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR AP 1; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; DNA; KAEMPFEROL DERIVATIVE; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; NITRILE; PROTEIN BINDING; TIMP2 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL INVASION; CELL MIGRATION; CELL STRAIN SCC4; CELL VIABILITY ASSAY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; TONGUE CARCINOMA; TRANSCRIPTION REGULATION; WESTERN BLOTTING; ZYMOGRAPHY; CELL MOTION; CELL SURVIVAL; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOUTH TUMOR; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; TUMOR INVASION;

BUTADIENES; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DNA, NEOPLASM; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KAEMPFEROLS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE INHIBITORS; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; NITRILES; PHOSPHORYLATION; PROTEIN BINDING; RNA, MESSENGER; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC;

EID: 84896690124     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080883     Document Type: Article

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