Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study

Oncology Reports

Volumn 33, Issue 2, 2015, Pages 868-874

  Song, Haibin ^a,b   Bao, Junjie ^a   Wei, Yuzhe ^a   Chen, Yang ^b   Mao, Xiaoguang ^b   Li, Jianguo ^b   Yang, Zhiwei ^b   Xue, Yingwei ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b HEILONGJIANG PROVINCIAL HOSPITAL   (China)

Author keywords

Apoptosis; Cell cycle arrest; Gastric cancer; Kaempferol

Indexed keywords

CASPASE 3; CASPASE 9; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLOOXYGENASE 2; KAEMPFEROL; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; ANTINEOPLASTIC AGENT; KAEMPFEROL DERIVATIVE; KI 67 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; G2 PHASE CELL CYCLE CHECKPOINT; GASTRIC CANCER CELL LINE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; STOMACH CANCER; TUMOR XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; DRUG SCREENING; HUMAN; METABOLISM; STOMACH NEOPLASMS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KAEMPFEROLS; KI-67 ANTIGEN; MICE; NEOPLASM TRANSPLANTATION; STOMACH NEOPLASMS;

EID: 84919427485     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3662     Document Type: Article

References (29)

1. Alberts SR, Cervantes A and van de Velde CJ: Gastric cancer: epidemiology, pathology and treatment. Ann Oncol 14 (Suppl 2): ii31-ii36, 2003.
2. Hundahl SA, Menck HR, Mansour EG and Winchester DP: The National Cancer Data Base report on gastric carcinoma. Cancer 80: 2333-2341, 1997.
3. Ajani JA: Evolving chemotherapy for advanced gastric cancer. Oncologist 10 (Suppl 3): S49-S58, 2005.
4. Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71: 1397-1421, 2006.
5. Naithani R, Huma LC, Moriarty RM, McCormick DL and Mehta G: Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinoGenesis models and clinical trials. Curr Med Chem 15: 1044-1071, 2008.
6. Kaefer CM and Milner JA: The role of herbs and spices in cancer prevention. J Nutr Biochem 19: 347-361, 2008.
7. Russo GL: Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem Pharmacol 74: 533-544, 2007.
8. Moiseeva EP and Manson MM: Dietary chemopreventive phyto-chemicals: too little or too much? Cancer Prev Res 2: 611-616, 2009.
9. Seifried HE, Anderson DE, Fisher EI and Milner JA: A review of the interaction among dietary antioxidants and reactive oxygen species. J Nutr Biochem 18: 567-579, 2007.
10. Luo H, Jiang BH, King SM and Chen YC: Inhibition of cell Growth and VEGF expression in ovarian cancer cells by favonoids. Nutr Cancer 60: 800-809, 2008.
11. Somerset SM and Johannot L: Dietary flavonoid sources in Australian adults. Nutr Cancer 60: 442-449, 2008.
12. Zhang Y, Chen AY, Li M, Chen C and Yao Q: Ginkgo biloba extract kaempferol inhibits cell proliferation and induces Apoptosis in pancreatic cancer cells. J Surg Res 148: 17-23, 2008.
13. Choi EJ and Ahn WS: Kaempferol induced the Apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells. Nutr Res Pract 2: 322-325, 2008.
14. Luo H, Rankin GO, Liu L, Daddysman MK, Jiang BH and Chen YC: Kaempferol inhibits angioGenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells. Nutr Cancer 61: 554-563, 2009.
15. Luo H, Daddysman MK, Rankin GO, Jiang BH and Chen YC: Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting Apoptosis caused by down regulation of cMyc. Cancer Cell Int 10: 16, 2010.
16. Luo H, Rankin GO, Li Z, Depriest L and Chen YC: Kaempferol induces Apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem 128: 513-519, 2011.
17. Nguyen TT, Tran E, Ong CK, et al: Kaempferol-induced Growth inhibition and Apoptosis in A549 lung cancer cells is mediated by activation of MEK-MAPK. J Cell Physiol 197: 110-121, 2003.
18. Chen HJ, Lin CM, Lee CY, et al: Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in u-2 OS human osteosarcoma cells. Oncol Rep 30: 925-932, 2013.
19. Song W, Dang Q, Xu D, et al: Kaempferol induces cell cycle arrest and Apoptosis in renal cell carcinoma through EGFR/p38 signaling. Oncol Rep 31: 1350-1356, 2014.
20. Debatin KM: Apoptosis pathways in cancer and cancer therapy. Cancer Immunol Immunother 53: 153-159, 2004.
21. Fisher DE: Pathways of Apoptosis and the modulation of cell death in cancer. Hematol Oncol Clin North Am 15: 931-956, IX, 2001.
22. Fulda S and Debatin KM: Targeting Apoptosis pathways in cancer therapy. Curr Cancer Drug Targets 4: 569-576, 2004.
23. Susnow N, Zeng L, Margineantu D and Hockenbery DM: Bcl-2 family proteins as regulators of oxidative stress. Semin Cancer Biol 19: 42-49, 2009.
24. Daniel P T, Schulze-Osthoff K, Belka C and Güner D: Guardians of cell death: the Bcl-2 family proteins. Essays Biochem 39: 73-88, 2003.
25. Cory S and Adams JM: The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2: 647-656, 2002.
26. Molinari M: Cell cycle checkpoints and their inactivation in human cancer. Cell Prolif 33: 261-274, 2000.
27. Cully M, You H, Levine AJ and Mak TW: Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumoriGenesis. Nat Rev Cancer 6: 184-192, 2006.
28. Chang F, Lee JT, Navolanic PM, et al: Involvement of PI3K/Akt pathway in cell cycle progression, Apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 17: 590-603, 2003.
29. Lee KM, Lee DE, Seo SK, et al: Phosphatidylinositol 3-kinase, a novel target molecule for the inhibitory effects of kaempferol on neoplastic cell transformation. CarcinoGenesis 31: 1338-1343, 2010.