메뉴 건너뛰기




Volumn 543, Issue 1-2, 2018, Pages 214-223

Kaempferol-loaded mucoadhesive nanoemulsion for intranasal administration reduces glioma growth in vitro

Author keywords

Brain delivery; Glioma; Intranasal; Kaempferol; Mucoadhesive nanoemulsion

Indexed keywords

CHITOSAN; KAEMPFEROL; ANTINEOPLASTIC AGENT; KAEMPFEROL DERIVATIVE; NANOPARTICLE;

EID: 85044720636     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2018.03.055     Document Type: Article
Times cited : (121)

References (57)
  • 4
    • 0037107001 scopus 로고    scopus 로고
    • Permeability issues in nasal drug delivery
    • Arora, P., Sharma, S., Garg, S., Permeability issues in nasal drug delivery. Drug Discov. Today 7 (2002), 967–975.
    • (2002) Drug Discov. Today , vol.7 , pp. 967-975
    • Arora, P.1    Sharma, S.2    Garg, S.3
  • 5
    • 84922922606 scopus 로고    scopus 로고
    • Cellular uptake of quercetin and luteolin and their effects on monoamine oxidase-A in human neuroblastoma SH-SY5Y cells
    • Bandaruk, Y., Mukai, R., Terao, J., Cellular uptake of quercetin and luteolin and their effects on monoamine oxidase-A in human neuroblastoma SH-SY5Y cells. Toxicol. Rep. 1 (2014), 639–649.
    • (2014) Toxicol. Rep. , vol.1 , pp. 639-649
    • Bandaruk, Y.1    Mukai, R.2    Terao, J.3
  • 6
    • 70349972154 scopus 로고    scopus 로고
    • Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats
    • Barve, A., Chen, C., Hebbar, V., Desiderio, J., Saw, C.L., Kong, A.N., Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats. Biopharm. Drug Dispos. 30 (2009), 356–365.
    • (2009) Biopharm. Drug Dispos. , vol.30 , pp. 356-365
    • Barve, A.1    Chen, C.2    Hebbar, V.3    Desiderio, J.4    Saw, C.L.5    Kong, A.N.6
  • 9
    • 84883635050 scopus 로고    scopus 로고
    • Chitosan and cyclodextrin in intranasal microemulsion for improved brain buspirone hydrochloride pharmacokinetics in rats
    • Bshara, H., Osman, R., Mansour, S., El-Shamy Ael, H., Chitosan and cyclodextrin in intranasal microemulsion for improved brain buspirone hydrochloride pharmacokinetics in rats. Carbohydr. Polym. 99 (2014), 297–305.
    • (2014) Carbohydr. Polym. , vol.99 , pp. 297-305
    • Bshara, H.1    Osman, R.2    Mansour, S.3    El-Shamy Ael, H.4
  • 10
    • 84880358885 scopus 로고    scopus 로고
    • Nanocarriers for antioxidant resveratrol: formulation approach, vesicle self-assembly and stability evaluation
    • Caddeo, C., Manconi, M., Fadda, A.M., Lai, F., Lampis, S., Diez-Sales, O., Sinico, C., Nanocarriers for antioxidant resveratrol: formulation approach, vesicle self-assembly and stability evaluation. Colloids Surf. B Biointerfaces 111 (2013), 327–332.
    • (2013) Colloids Surf. B Biointerfaces , vol.111 , pp. 327-332
    • Caddeo, C.1    Manconi, M.2    Fadda, A.M.3    Lai, F.4    Lampis, S.5    Diez-Sales, O.6    Sinico, C.7
  • 13
    • 84876937725 scopus 로고    scopus 로고
    • Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy
    • Carvalho, F.C., Campos, M.L., Peccinini, R.G., Gremiao, M.P., Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy. Eur. J. Pharm. Biopharm. 84 (2013), 219–227.
    • (2013) Eur. J. Pharm. Biopharm. , vol.84 , pp. 219-227
    • Carvalho, F.C.1    Campos, M.L.2    Peccinini, R.G.3    Gremiao, M.P.4
  • 14
    • 84906785011 scopus 로고    scopus 로고
    • Chitosan in nasal delivery systems for therapeutic drugs
    • Casettari, L., Illum, L., Chitosan in nasal delivery systems for therapeutic drugs. J. Control. Release 190 (2014), 189–200.
    • (2014) J. Control. Release , vol.190 , pp. 189-200
    • Casettari, L.1    Illum, L.2
  • 15
    • 84865995105 scopus 로고    scopus 로고
    • The effect of submicron emulsion systems on transdermal delivery of kaempferol
    • Chao, Y., Huang, C.T., Fu, L.T., Huang, Y.B., Tsai, Y.H., Wu, P.C., The effect of submicron emulsion systems on transdermal delivery of kaempferol. Chem. Pharm. Bull. 60 (2012), 1171–1175.
    • (2012) Chem. Pharm. Bull. , vol.60 , pp. 1171-1175
    • Chao, Y.1    Huang, C.T.2    Fu, L.T.3    Huang, Y.B.4    Tsai, Y.H.5    Wu, P.C.6
  • 16
    • 84874002570 scopus 로고    scopus 로고
    • A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention
    • Chen, A.Y., Chen, Y.C., A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem. 138 (2013), 2099–2107.
    • (2013) Food Chem. , vol.138 , pp. 2099-2107
    • Chen, A.Y.1    Chen, Y.C.2
  • 17
    • 78549261367 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats
    • Chen, Z.P., Sun, J., Chen, H.X., Xiao, Y.Y., Liu, D., Chen, J., Cai, H., Cai, B.C., Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats. Fitoterapia 81 (2010), 1045–1052.
    • (2010) Fitoterapia , vol.81 , pp. 1045-1052
    • Chen, Z.P.1    Sun, J.2    Chen, H.X.3    Xiao, Y.Y.4    Liu, D.5    Chen, J.6    Cai, H.7    Cai, B.C.8
  • 18
    • 84856538036 scopus 로고    scopus 로고
    • Development of udenafil-loaded microemulsions for intranasal delivery: in vitro and in vivo evaluations
    • Cho, H.J., Ku, W.S., Termsarasab, U., Yoon, I., Chung, C.W., Moon, H.T., Kim, D.D., Development of udenafil-loaded microemulsions for intranasal delivery: in vitro and in vivo evaluations. Int. J. Pharm. 423 (2012), 153–160.
    • (2012) Int. J. Pharm. , vol.423 , pp. 153-160
    • Cho, H.J.1    Ku, W.S.2    Termsarasab, U.3    Yoon, I.4    Chung, C.W.5    Moon, H.T.6    Kim, D.D.7
  • 19
    • 84894055126 scopus 로고    scopus 로고
    • Kaempferol Induces Cell Cycle Arrest in HT-29 Human Colon Cancer Cells
    • Cho, H.J., Park, J.H., Kaempferol Induces Cell Cycle Arrest in HT-29 Human Colon Cancer Cells. J. Cancer Prev. 18 (2013), 257–263.
    • (2013) J. Cancer Prev. , vol.18 , pp. 257-263
    • Cho, H.J.1    Park, J.H.2
  • 20
    • 77952868913 scopus 로고    scopus 로고
    • Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells
    • Choi, E.J., Ahn, W.S., Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells. Nutr. Res. Pract. 2 (2008), 322–325.
    • (2008) Nutr. Res. Pract. , vol.2 , pp. 322-325
    • Choi, E.J.1    Ahn, W.S.2
  • 21
    • 84893420560 scopus 로고    scopus 로고
    • Cellular uptake and anticancer effects of mucoadhesive curcumin-containing chitosan nanoparticles
    • Chuah, L.H., Roberts, C.J., Billa, N., Abdullah, S., Rosli, R., Cellular uptake and anticancer effects of mucoadhesive curcumin-containing chitosan nanoparticles. Colloids Surf. B 116 (2014), 228–236.
    • (2014) Colloids Surf. B , vol.116 , pp. 228-236
    • Chuah, L.H.1    Roberts, C.J.2    Billa, N.3    Abdullah, S.4    Rosli, R.5
  • 22
    • 85027511654 scopus 로고    scopus 로고
    • Validation of an HPLC-UV method for analysis of Kaempferol-loaded nanoemulsion and its application to in vitro and in vivo tests
    • Colombo, M., Melchiades, G.d.L., Figueiró F., Battastini, A.M.O., Teixeira, H.F., Koester, L.S., Validation of an HPLC-UV method for analysis of Kaempferol-loaded nanoemulsion and its application to in vitro and in vivo tests. J. Pharm. Biomed. Anal. 145 (2017), 831–837.
    • (2017) J. Pharm. Biomed. Anal. , vol.145 , pp. 831-837
    • Colombo, M.1    Melchiades, G.D.L.2    Figueiró, F.3    Battastini, A.M.O.4    Teixeira, H.F.5    Koester, L.S.6
  • 23
    • 84946134030 scopus 로고    scopus 로고
    • Opportunities and challenges for the nasal administration of nanoemulsions
    • Comfort, C., Garrastazu, G., Pozzoli, M., Sonvico, F., Opportunities and challenges for the nasal administration of nanoemulsions. Curr. Top. Med. Chem. 15 (2015), 356–368.
    • (2015) Curr. Top. Med. Chem. , vol.15 , pp. 356-368
    • Comfort, C.1    Garrastazu, G.2    Pozzoli, M.3    Sonvico, F.4
  • 24
    • 84938992202 scopus 로고    scopus 로고
    • Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis
    • Dang, Q., Song, W., Xu, D., Ma, Y., Li, F., Zeng, J., Zhu, G., Wang, X., Chang, L.S., He, D., Li, L., Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis. Mol. Carcinog. 54 (2015), 831–840.
    • (2015) Mol. Carcinog. , vol.54 , pp. 831-840
    • Dang, Q.1    Song, W.2    Xu, D.3    Ma, Y.4    Li, F.5    Zeng, J.6    Zhu, G.7    Wang, X.8    Chang, L.S.9    He, D.10    Li, L.11
  • 26
    • 84870383902 scopus 로고    scopus 로고
    • The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles
    • Frohlich, E., The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Int. J. Nanomed. 7 (2012), 5577–5591.
    • (2012) Int. J. Nanomed. , vol.7 , pp. 5577-5591
    • Frohlich, E.1
  • 27
    • 34548533271 scopus 로고    scopus 로고
    • Influence of formulation viscosity on drug absorption following nasal application in rats
    • Furubayashi, T., Inoue, D., Kamaguchi, A., Higashi, Y., Sakane, T., Influence of formulation viscosity on drug absorption following nasal application in rats. Drug Metab. Pharmacokinet. 22 (2007), 206–211.
    • (2007) Drug Metab. Pharmacokinet. , vol.22 , pp. 206-211
    • Furubayashi, T.1    Inoue, D.2    Kamaguchi, A.3    Higashi, Y.4    Sakane, T.5
  • 28
    • 68949208465 scopus 로고    scopus 로고
    • Nanocarriers’ entry into the cell: relevance to drug delivery
    • Hillaireau, H., Couvreur, P., Nanocarriers’ entry into the cell: relevance to drug delivery. Cell. Mol. Life Sci. 66 (2009), 2873–2896.
    • (2009) Cell. Mol. Life Sci. , vol.66 , pp. 2873-2896
    • Hillaireau, H.1    Couvreur, P.2
  • 29
    • 0034095651 scopus 로고    scopus 로고
    • Transport of drugs from the nasal cavity to the central nervous system
    • Illum, L., Transport of drugs from the nasal cavity to the central nervous system. Eur. J. Pharm. Sci. 11 (2000), 1–18.
    • (2000) Eur. J. Pharm. Sci. , vol.11 , pp. 1-18
    • Illum, L.1
  • 30
    • 67349190889 scopus 로고    scopus 로고
    • Kaempferol induces cell death through ERK and Akt-dependent down-regulation of XIAP and survivin in human glioma cells
    • Jeong, J.C., Kim, M.S., Kim, T.H., Kim, Y.K., Kaempferol induces cell death through ERK and Akt-dependent down-regulation of XIAP and survivin in human glioma cells. Neurochem. Res. 34 (2009), 991–1001.
    • (2009) Neurochem. Res. , vol.34 , pp. 991-1001
    • Jeong, J.C.1    Kim, M.S.2    Kim, T.H.3    Kim, Y.K.4
  • 31
    • 44449106460 scopus 로고    scopus 로고
    • Intranasal nanoemulsion based brain targeting drug delivery system of risperidone
    • Kumar, M., Misra, A., Babbar, A.K., Mishra, A.K., Mishra, P., Pathak, K., Intranasal nanoemulsion based brain targeting drug delivery system of risperidone. Int. J. Pharm. 358 (2008), 285–291.
    • (2008) Int. J. Pharm. , vol.358 , pp. 285-291
    • Kumar, M.1    Misra, A.2    Babbar, A.K.3    Mishra, A.K.4    Mishra, P.5    Pathak, K.6
  • 32
    • 65749099862 scopus 로고    scopus 로고
    • Formulation and characterization of nanoemulsion-based drug delivery system of risperidone
    • Kumar, M., Pathak, K., Misra, A., Formulation and characterization of nanoemulsion-based drug delivery system of risperidone. Drug Dev. Ind. Pharm. 35 (2009), 387–395.
    • (2009) Drug Dev. Ind. Pharm. , vol.35 , pp. 387-395
    • Kumar, M.1    Pathak, K.2    Misra, A.3
  • 33
    • 84864125452 scopus 로고    scopus 로고
    • Preparation and characterization of cationic curcumin nanoparticles for improvement of cellular uptake
    • Liu, J., Xu, L., Liu, C., Zhang, D., Wang, S., Deng, Z., Lou, W., Xu, H., Bai, Q., Ma, J., Preparation and characterization of cationic curcumin nanoparticles for improvement of cellular uptake. Carbohydr. Polym. 90 (2012), 16–22.
    • (2012) Carbohydr. Polym. , vol.90 , pp. 16-22
    • Liu, J.1    Xu, L.2    Liu, C.3    Zhang, D.4    Wang, S.5    Deng, Z.6    Lou, W.7    Xu, H.8    Bai, Q.9    Ma, J.10
  • 34
    • 33751076526 scopus 로고    scopus 로고
    • The uptake behaviors of kaempferol and quercetin through rat primary cultured cortical neurons
    • Liu, R., Wang, X., Zhao, Y., Wang, Z., Du, L., The uptake behaviors of kaempferol and quercetin through rat primary cultured cortical neurons. Biomed. Chromatogr. 20 (2006), 1178–1184.
    • (2006) Biomed. Chromatogr. , vol.20 , pp. 1178-1184
    • Liu, R.1    Wang, X.2    Zhao, Y.3    Wang, Z.4    Du, L.5
  • 36
    • 84870352900 scopus 로고    scopus 로고
    • Kaempferol nanoparticles achieve strong and selective inhibition of ovarian cancer cell viability
    • Luo, H., Jiang, B., Li, B., Li, Z., Jiang, B.H., Chen, Y.C., Kaempferol nanoparticles achieve strong and selective inhibition of ovarian cancer cell viability. Int. J. Nanomed. 7 (2012), 3951–3959.
    • (2012) Int. J. Nanomed. , vol.7 , pp. 3951-3959
    • Luo, H.1    Jiang, B.2    Li, B.3    Li, Z.4    Jiang, B.H.5    Chen, Y.C.6
  • 37
    • 68649090916 scopus 로고    scopus 로고
    • Nanoparticles for direct nose-to-brain delivery of drugs
    • Mistry, A., Stolnik, S., Illum, L., Nanoparticles for direct nose-to-brain delivery of drugs. Int. J. Pharm. 379 (2009), 146–157.
    • (2009) Int. J. Pharm. , vol.379 , pp. 146-157
    • Mistry, A.1    Stolnik, S.2    Illum, L.3
  • 38
    • 77953070882 scopus 로고    scopus 로고
    • Effects of kaempferol on the mechanisms of drug resistance in the human glioblastoma cell line T98G
    • Nakatsuma, A., Fukami, T., Suzuki, T., Furuishi, T., Tomono, K., Hidaka, S., Effects of kaempferol on the mechanisms of drug resistance in the human glioblastoma cell line T98G. Pharmazie 65 (2010), 379–383.
    • (2010) Pharmazie , vol.65 , pp. 379-383
    • Nakatsuma, A.1    Fukami, T.2    Suzuki, T.3    Furuishi, T.4    Tomono, K.5    Hidaka, S.6
  • 39
    • 84879401096 scopus 로고    scopus 로고
    • Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood-brain barrier: an excellent platform for brain targeting
    • Pardeshi, C.V., Belgamwar, V.S., Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood-brain barrier: an excellent platform for brain targeting. Expert Opin. Drug Deliv. 10 (2013), 957–972.
    • (2013) Expert Opin. Drug Deliv. , vol.10 , pp. 957-972
    • Pardeshi, C.V.1    Belgamwar, V.S.2
  • 40
    • 20744444385 scopus 로고    scopus 로고
    • Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids
    • Rothwell, J.A., Day, A.J., Morgan, M.R., Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids. J. Agric. Food Chem. 53 (2005), 4355–4360.
    • (2005) J. Agric. Food Chem. , vol.53 , pp. 4355-4360
    • Rothwell, J.A.1    Day, A.J.2    Morgan, M.R.3
  • 41
    • 44749087653 scopus 로고    scopus 로고
    • Inhibition of peroxide-induced radical generation by plant polyphenols in C6 astroglioma cells
    • Ruweler, M., Anker, A., Gulden, M., Maser, E., Seibert, H., Inhibition of peroxide-induced radical generation by plant polyphenols in C6 astroglioma cells. Toxicol. In Vitro 22 (2008), 1377–1381.
    • (2008) Toxicol. In Vitro , vol.22 , pp. 1377-1381
    • Ruweler, M.1    Anker, A.2    Gulden, M.3    Maser, E.4    Seibert, H.5
  • 42
    • 79960894101 scopus 로고    scopus 로고
    • Cytoprotective activity against peroxide-induced oxidative damage and cytotoxicity of flavonoids in C6 rat glioma cells
    • Seibert, H., Maser, E., Schweda, K., Seibert, S., Gulden, M., Cytoprotective activity against peroxide-induced oxidative damage and cytotoxicity of flavonoids in C6 rat glioma cells. Food Chem. Toxicol. 49 (2011), 2398–2407.
    • (2011) Food Chem. Toxicol. , vol.49 , pp. 2398-2407
    • Seibert, H.1    Maser, E.2    Schweda, K.3    Seibert, S.4    Gulden, M.5
  • 43
    • 84969584583 scopus 로고    scopus 로고
    • Non-invasive intranasal delivery of quetiapine fumarate loaded microemulsion for brain targeting: Formulation, physicochemical and pharmacokinetic consideration
    • Shah, B., Khunt, D., Misra, M., Padh, H., Non-invasive intranasal delivery of quetiapine fumarate loaded microemulsion for brain targeting: Formulation, physicochemical and pharmacokinetic consideration. Eur. J. Pharm. Sci. 91 (2016), 196–207.
    • (2016) Eur. J. Pharm. Sci. , vol.91 , pp. 196-207
    • Shah, B.1    Khunt, D.2    Misra, M.3    Padh, H.4
  • 44
    • 84942892337 scopus 로고    scopus 로고
    • Nose to brain microemulsion-based drug delivery system of rivastigmine: formulation and ex-vivo characterization
    • Shah, B.M., Misra, M., Shishoo, C.J., Padh, H., Nose to brain microemulsion-based drug delivery system of rivastigmine: formulation and ex-vivo characterization. Drug Deliv. 22 (2015), 918–930.
    • (2015) Drug Deliv. , vol.22 , pp. 918-930
    • Shah, B.M.1    Misra, M.2    Shishoo, C.J.3    Padh, H.4
  • 45
    • 34748887195 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in glioblastoma cells through oxidative stress
    • Sharma, V., Joseph, C., Ghosh, S., Agarwal, A., Mishra, M.K., Sen, E., Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Mol. Cancer Ther. 6 (2007), 2544–2553.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 2544-2553
    • Sharma, V.1    Joseph, C.2    Ghosh, S.3    Agarwal, A.4    Mishra, M.K.5    Sen, E.6
  • 46
    • 56249131797 scopus 로고    scopus 로고
    • The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin
    • Siegelin, M.D., Reuss, D.E., Habel, A., Herold-Mende, C., von Deimling, A., The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin. Mol. Cancer Ther. 7 (2008), 3566–3574.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3566-3574
    • Siegelin, M.D.1    Reuss, D.E.2    Habel, A.3    Herold-Mende, C.4    von Deimling, A.5
  • 47
    • 84991804311 scopus 로고    scopus 로고
    • The regrowth kinetic of the surviving population is independent of acute and chronic responses to temozolomide in glioblastoma cell lines
    • Silva, A.O., Dalsin, E., Onzi, G.R., Filippi-Chiela, E.C., Lenz, G., The regrowth kinetic of the surviving population is independent of acute and chronic responses to temozolomide in glioblastoma cell lines. Exp. Cell Res. 348 (2016), 177–183.
    • (2016) Exp. Cell Res. , vol.348 , pp. 177-183
    • Silva, A.O.1    Dalsin, E.2    Onzi, G.R.3    Filippi-Chiela, E.C.4    Lenz, G.5
  • 48
    • 84896691526 scopus 로고    scopus 로고
    • Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling
    • Song, W., Dang, Q., Xu, D., Chen, Y., Zhu, G., Wu, K., Zeng, J., Long, Q., Wang, X., He, D., Li, L., Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling. Oncol. Rep. 31 (2014), 1350–1356.
    • (2014) Oncol. Rep. , vol.31 , pp. 1350-1356
    • Song, W.1    Dang, Q.2    Xu, D.3    Chen, Y.4    Zhu, G.5    Wu, K.6    Zeng, J.7    Long, Q.8    Wang, X.9    He, D.10    Li, L.11
  • 49
    • 84885227307 scopus 로고    scopus 로고
    • Optimization of curcumin nanoemulsion for intranasal delivery using design of experiment and its toxicity assessment
    • Sood, S., Jain, K., Gowthamarajan, K., Optimization of curcumin nanoemulsion for intranasal delivery using design of experiment and its toxicity assessment. Colloids Surf. B Biointerfaces 113 (2014), 330–337.
    • (2014) Colloids Surf. B Biointerfaces , vol.113 , pp. 330-337
    • Sood, S.1    Jain, K.2    Gowthamarajan, K.3
  • 51
    • 39049117318 scopus 로고    scopus 로고
    • Flavonols (kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants
    • Sultana, B., Anwar, F., Flavonols (kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants. Food Chem. 108 (2008), 879–884.
    • (2008) Food Chem. , vol.108 , pp. 879-884
    • Sultana, B.1    Anwar, F.2
  • 52
    • 0003948263 scopus 로고    scopus 로고
    • The United States Pharmacopeia
    • 33 ed United States Pharmacopeia Convetional Rockville
    • USP, The United States Pharmacopeia. 33 ed, 2011, United States Pharmacopeia Convetional, Rockville.
    • (2011)
    • USP1
  • 54
    • 84882659385 scopus 로고    scopus 로고
    • Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM?
    • van Woensel, M., Wauthoz, N., Rosiere, R., Amighi, K., Mathieu, V., Lefranc, F., van Gool, S.W., de Vleeschouwer, S., Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM?. Cancers 5 (2013), 1020–1048.
    • (2013) Cancers , vol.5 , pp. 1020-1048
    • van Woensel, M.1    Wauthoz, N.2    Rosiere, R.3    Amighi, K.4    Mathieu, V.5    Lefranc, F.6    van Gool, S.W.7    de Vleeschouwer, S.8
  • 56
    • 84918595285 scopus 로고    scopus 로고
    • Hyaluronic acid/chitosan nanoparticles for delivery of curcuminoid and its in vitro evaluation in glioma cells
    • Yang, L., Gao, S., Asghar, S., Liu, G., Song, J., Wang, X., Ping, Q., Zhang, C., Xiao, Y., Hyaluronic acid/chitosan nanoparticles for delivery of curcuminoid and its in vitro evaluation in glioma cells. Int. J. Biol. Macromol. 72 (2015), 1391–1401.
    • (2015) Int. J. Biol. Macromol. , vol.72 , pp. 1391-1401
    • Yang, L.1    Gao, S.2    Asghar, S.3    Liu, G.4    Song, J.5    Wang, X.6    Ping, Q.7    Zhang, C.8    Xiao, Y.9
  • 57
    • 56549123324 scopus 로고    scopus 로고
    • Chitosan-coated magnetic nanoparticles as carriers of 5-fluorouracil: preparation, characterization and cytotoxicity studies
    • Zhu, L., Ma, J., Jia, N., Zhao, Y., Shen, H., Chitosan-coated magnetic nanoparticles as carriers of 5-fluorouracil: preparation, characterization and cytotoxicity studies. Colloids Surf. B 68 (2009), 1–6.
    • (2009) Colloids Surf. B , vol.68 , pp. 1-6
    • Zhu, L.1    Ma, J.2    Jia, N.3    Zhao, Y.4    Shen, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.