The effect of short-term kaempferol exposure on reactive oxygen levels and integrity of human (HL-60) leukaemic cells

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1740, Issue 3, 2005, Pages 340-349

  Bestwick, Charles S ^a   Milne, Lesley ^a   Pirie, Lynn ^a   Duthie, Susan J ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Cell cycle; DNA damage; Flavonoid; HL 60; Kaempferol; Oxidative stress

Indexed keywords

CASPASE 3; KAEMPFEROL; PURINE; REACTIVE OXYGEN METABOLITE; SINGLE STRANDED DNA; THYMIDINE; TRITIUM;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA CONTENT; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMIA CELL LINE; MEMBRANE DAMAGE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CASPASE 3; CASPASES; CELL CYCLE; CELL MEMBRANE; CELL SURVIVAL; DIETARY SUPPLEMENTS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; KAEMPFEROLS; MEMBRANE POTENTIALS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; THYMIDINE; TRITIUM;

EID: 20444371369     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2004.10.005     Document Type: Article

References (55)

1. G. Block, B. Patterson, and A. Subar Fruit, vegetables, and cancer prevention-A review of the epidemiologic evidence Nutr. Cancer 18 1992 1 29
2. K.A. Steinmetz, and J.D. Potter Vegetables, fruit, and cancer I: Epidemiology (review) Cancer Cause Control 5 1991 325 357
3. J.W. Powles Fruit and vegetables, and cardiovascular disease: a review Int. J. Epidemiol. 26 1997 1 13
4. A. Trichopoulou, A. Naska, A. Antoniou, S. Friel, K. Trygg, and A. Turrini Vegetable and fruit: the evidence in their favour and the public health perspective Int. J. Vitam. Nutr. Res. 73 2003 63 69
5. N.J. Temple, and K.K. Gladwin Fruit, vegetables, and the prevention of cancer: research challenges Nutrition 19 2003 467 470
6. P.C.H. Hollman, and M.B. Katan Health effects and bioavailability of dietary flavonols Free Radic. Res. 31 1999 S75 S80
7. L. Bravo Polyphenols: chemistry, dietary sources, metabolism and nutritional significance Nutr. Rev. 56 1998 317 333
8. G.G. Duthie, S.J. Duthie, and J.A.M. Kyle Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants Nutr. Res. Rev. 13 2000 79 106
9. E. Middleton, C. Kandaswami, and T.C. Theoharides The effect of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer Pharmacol. Rev. 52 2000 673 751
10. G. Di Carlo, N. Mascolo, A.A. Izzo, and F. Capasso Flavonoids: old and new aspects of a class of natural therapeutic drugs Life Sci. 65 1999 337 353
11. J.A. Knight Diseases related to oxygen-derived free radicals Ann. Clin. Lab. Sci. 25 1995 111 121
12. D. Dreher, and A.F. Junod Role of oxygen free radicals in cancer development Eur. J. Cancer 32A 1995 30 38
13. H. de Groot, and U. Rauen Tissue injury by reactive oxygen species and the protective effects of flavonoids Fundam. Clin. Pharmacol. 12 1998 249 255
14. Y. Chen, R. Zheng, Z. Jia, and Y. Ju Flavonoids as superoxide scavengers and antioxidants Free Radic. Biol. Med. 9 1990 19 21
15. J. Torel, J. Cillard, and P. Cillard Antioxidant activity of flavonoids and reactivity with peroxy radical Phytochemistry 25 1986 383 385
16. S.R. Husain, J. Cillard, and P. Cillard Hydroxyl radical scavenging activity of flavonoids Phytochemistry 26 1987 2489 2491
17. W.F. Hodnick, S. Ahmad, and R.S. Pardini Induction of oxidative stress by redox active flavonoids J.A. Manthey B.S. Buslig Flavonoids in the Living System 1998 Plenum New York 131 150
18. E. Sergediene, K. Jonsson, H. Szymusiak, B. Tyrakowska, I.M.C.M. Rietjens, and N. Cenas Pro-oxidant toxicity of polyphenolic antioxidants to HL-60 cells description of quantitative structure activity relationships FEBS Lett. 462 1999 392 396
19. N. Yamashita, and S. Kawanishi Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin Free Radic. Res. 33 2000 623 63320
20. I. Duarte Silva, J. Gaspar, A. Rodrigues, G. Gomes da Costa, A. Laires, and J. Rueff Mechanisms of myricetin mutagenicity in V79 cells: Involvement of radicular species Teratog., Carcinog., Mutagen. 16 1996 253 268
21. N. Yamashita, H. Tanemura, and S. Kawanishi Mechanism of oxidative DNA damage induced by quercetin in the presence of Cu(II) Mutat. Res., Fundam. Mol. Mech. 425 1999 107 115
22. I.-K. Wang, S.-Y. Lin-Shiau, and J.-K. Lin Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells Eur. J. Cancer 35 1999 1517 1525
23. M. Marone, G. D'Andrilli, N. Das, C. Ferlini, S. Chatterjee, and G. Scambia Quercetin abrogates taxol-mediated signalling by inhibiting multiple kinases Exp. Cell Res. 270 2001 1 12
24. L.I. Cipak, P. Rauko, E. Miadokova, I. Cipakova, and L. Novotny Effects of flavonoids on cisplatin-induced apoptosis of HL-60 and L1210 leukemia cells Leuk. Res. 27 2003 65 72
25. M. Kitamura, and Y. Ishikawa Oxidant induced apoptosis of glomerular cells: intracellular signalling and its intervention by bioflavonoid Kidney Int. 56 1999 1223 1229
26. R.P. Haugland Handbook of Fluorescent Probes and Research Chemicals 1996 Molecular Probes Leiden, The Netherlands
27. C.S. Bestwick, and L. Milne Quercetin modifies reactive oxygen levels but exerts only partial protection against oxidative stress within HL-60 cells Biochim. Biophys. Acta 1528 2001 49 59
28. M.J. Burkitt, L. Milne, S.Y. Tsang, and S.C. Tam Calcium indicator dye quin2 inhibits hydrogen peroxide-induced DNA strand break formation via chelation of iron Arch. Biochem. Biophys. 311 1994 321 328
29. S.J. Duthie, S. Narayanan, S. Blum, L. Pirie, and G.M. Brand Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalised normal human colon cells Nutr. Cancer 37 2000 245 251
30. S.J. Duthie, G. Grant, and S. Naraynan Increased uracil misincorporation in lymphocytes from folate-deficient rats Br. J. Cancer 83 2000 1532 1537
31. Z. Darzynkiewicz, and X. Li Measurement of cell death by flow cytometry T.G. Cotter S.J. Martin Techniques in Apoptosis 1996 Portland London 71 106
32. C.S. Bestwick, and L. Milne Effects of β-carotene on antioxidant enzyme activity, intracellular reactive oxygen and membrane integrity within post confluent Caco-2 intestinal cells Biochim. Biophys. Acta 1474 2000 47 55
33. S.K. Jonas, P.A. Riley, and R.L. Willson Hydrogen peroxide cytotoxicity: low-temperature enhancement by ascorbate or reduced lipoate Biochem. J. 254 1989 651 655
34. P. Cos, M. Calomme, J.-B. Sindambiwe, T. De Bruyne, K. Cimanga, L. Pieters, A.J. Vlietinck, and D.V. Berghe Cytotoxicity and lipid peroxidation-inhibiting activity of flavonoids Planta Med. 67 2001 515 519
35. S.A. Aherne, and N.M. O'Brien Mechanism of protection by the flavonoids quercetin and rutin against tert-butylhydroperxoide- and menadione induced DNA single strand breaks in Caco-2 cells Free Radic. Biol. Med. 29 2000 507 514
36. S.J. Duthie, and V.L. Dobson Dietary flavonoids protect human colonocyte DNA from oxidative attack in vitro Eur. J. Nutr. 38 1999 28 34
37. M. Noroozi, W.J. Angerson, and E.J. Lean Effect of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes Am. J. Clin. Nutr. 67 1998 1210 1218
38. K. Ishige, D. Schubert, and Y. Sagara Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms Free Radic. Biol. Med. 30 2001 433 446
39. I.-W. Peng, and S.-M. Kuo Flavonoid structure affects the inhibition of lipid peroxidation in Caco-2 intestinal cells at physiological concentrations J. Nutr. 133 2003 2184 2187
40. S.C. Sahu, and G.C. Gray Kaempferol-induced nuclear DNA damage and lipid peroxidation Cancer Lett. 85 1994 159 164
41. N. Sugihara, T. Arakawa, M. Ohnishi, and K. Furuno Anti- and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide- dependent lipid peroxidation in cultured hepatocytes loaded with alpha-linolenic acid Free Radic. Biol. Med. 27 1999 1313 1323
42. H.Y. Kim, O.H. Kim, and M.K. Sung Effects of phenol-depleted and phenol-rich diets on blood markers of oxidative stress, and urinary excretion of quercetin and kaempferol in healthy volunteers J. Am. Coll. Nutr. 22 2003 217 223
43. J.F. Young, L.O. Dragsted, J. Haraldsdottir, B. Daneshvar, M.A. Kall, S. Loft, L. Nilssson, S.E. Nielson, B. Mayer, L.H. Skibsted, T. Huynh-Ba, A. Hermetter, and B. Sandstrom Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet Br. J. Nutr. 87 2002 343 355
44. S.J. Duthie, W. Johnson, and V.L. Dobson The effect of dietary flavonoids on DNA damage (strand breaks and oxidised pyrimidines) and growth in human cells Mutat. Res. 390 1997 141 151
45. A. Puppo Effect of flavonoids on hydroxyl radical formation by Fenton-type reactions; influence of the iron chelator Phytochemistry 31 1992 85 88
46. F. Casagrande, and J.-M. Darbon Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1 Biochem. Pharmacol. 61 2001 1205 1215
47. S. Villamarin, N. Ferrer-Miralles, S. Mansilla, W. Priebe, and J. Portugal Induction of G2/M arrest and inhibition of c-myc and p53 transcription in Jurkat T lymphocytes Biochem. Pharmacol. 63 2002 1251 1258
48. S. Kuntz, U. Wenzel, and H. Daniel Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity and apoptosis in human colon cancer cell lines Eur. J. Nutr. 38 1999 133 142
49. Z. Darzynkiewicz, X. Li, J. Gong, S. Hara, and F. Traganos Analysis of cell death by flow cytometry G.P. Studzinski Cell Growth and Apoptosis 1995 IRL press Oxford 143 167
50. D.R. Green, and J.C. Reed Mitochondria and apoptosis Science 281 1998 1309 1312
51. J.L. Liesveld, C.N. Abboud, C. Lu, C. McNair, A. Menon, A. Smith, K. Rosell, and A.P. Rapoportc Flavonoid effects on normal and leukemic cells Leuk. Res. 27 2003 517 527
52. Z.P. Chen, J.B. Scell, C.-T. Ho, and K.Y. Chen Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counter parts Cancer Lett. 129 1998 173 179
53. S.-M. Kuo Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells Cancer Lett. 110 1996 41 48
54. C.F. Skibola, and M.T. Smith Potential health impacts of excessive flavonoid intake Free Radic. Biol. Med. 29 2000 375 383
55. I.D. Silva, J. Gaspar, G. Gomes da Costa, A.S. Rodrigues, A. Laires, and J. Rueff Chemical features of flavonols affecting their genotoxicity. Potential implications in their use as therapeutic agents Chem.-Biol. Interact. 124 2000 29 51