Antioxidant rich morus alba leaf extract induces apoptosis in human colon and breast cancer cells by the downregulation of nitric oxide produced by inducible nitric oxide synthase

Nutrition and Cancer

Volumn 65, Issue 2, 2013, Pages 305-310

  Deepa, Mundekkad ^a   Sureshkumar, Thavamani ^a   Satheeshkumar, Padikara Kutty ^a   Priya, Sulochana ^a  

^a VIT UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CASPASE 3; EPICATECHIN; GALLIC ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; KAEMPFEROL; LUTEOLIN; MULBERRY EXTRACT; MYRICETIN; NITRIC OXIDE; PARA COUMARIC ACID; PELARGONIDIN; QUERCETIN HYDRATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DOWN REGULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MORUS ALBA; PLANT LEAF;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; COLONIC NEOPLASMS; FEMALE; FLAVONOIDS; HUMANS; INHIBITORY CONCENTRATION 50; KAEMPFEROLS; MORUS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PLANT LEAVES;

EID: 84874641255     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2013.748924     Document Type: Article

References (21)

1. Gueritte F and Fahy J: The Vinca alkaloids In: Anticancer agents from Natural Products, Cragg GM, Kingston DGI, and Newman DJ (eds.). Boca Raton, FL: CRC Press, 2005, pp. 71-87.
2. Ghose KA, Herbertz T, Salvino MJ, and Mallamo PJ: Knowledge-based chemoinformatic approaches to drug discovery. Drug Discovery Today 11, 1107-1114, 2006.
3. Alcaraz MJ and Guillen MI: The nitric oxide related therapeutic phenomenon: a challenging task. Curr Pharm Des 8, 215-231, 2002.
4. Thomsen LL, Miles DW, Happerfield L, Bobrow LG, Knowledges RG, et al.: Nitric oxide synthase activity in human breast cancer. Br J Cancer 72, 41-45, 1995.
5. AsanoN,Yamashita T,Yasuda K, IkedaK,Kizu H, et al.: Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J Agr Food Chem 49, 4208-4213, 2001.
6. Zhang QJ, Tang YB, Chen RY, and Yu DQ: Three new cytotoxic Diels-Alder-type adducts from Morus australis. Chem Biodivers 4, 1533-1540, 2007.
7. Andallu B and Varadacharyulu N: Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clin Chim Acta 338, 3-10, 2003.
8. Park KT, Kim JK, Hwang D, Yoo Y, and Lim YH: Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation. Food Chem Toxicol 49, 3038-3045, 2011.
9. Dat NT, Binh PT, Quynh le TP, Van Minh C, Huong HT, et al.: Cytotoxic prenylated flavonoids from Morus alba. Fitoterapia 81, 1224-1227, 2010.
10. Scudiero DA, Shoemaker RH, Paull KD, Monks A, Tierney S, et al.: Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res 48, 4827-4833, 1988.
11. Grisham MB, Johnson GG, and Lancaster JR, Jr.: Quantitation of nitrate and nitrite in extracellular fluids. Meth Enzymol 268, 237-246, 1996.
12. Doi K, Kojima T, and Fujimoto Y: Mulberry leaf extract inhibits oxidative modification of rabbit and human low-density lipoprotein. Biol Pharm Bull 23, 1066-1071, 2000.
13. Bharani SE, Asad M, Dhamanigi SS, and Chandrakala GK: Immunomodulatory activity of methanol extract of Morus alba Linn. (mulberry) leaves. Pak J Pharm Sci 23, 63-68, 2010.
14. Oh KS, Ryu SY, Lee S, Seo HW, Oh BK, et al.: Melanin-concentrating hormone-1 receptor antagonism and anti-obesity effects of ethanolic extract fromMorus alba leaves in diet-induced obese mice. J Ethnopharmacol 122, 216-220, 2009.
15. Chang LW, Juang LJ, Wang BS, Wang MY, Tai HM, et al.: Antioxidant and antityrosinase activity of mulberry (Morus alba L.) twigs and root bark. Food Chem Toxicol 49, 785-790, 2011.
16. Kikuchi T, Nihei M, Nagai H, Fukushi H, Tabata K, et al.: Albanol A from the root bark of Morus alba L. induces apoptotic cell death in HL60 human leukemia cell line. Chem Pharm Bull 58, 568-571, 2010.
17. Arends MJ andWyllie AH: Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol 32, 223-354, 1991.
18. Huang TT, Liu FG, Wei CF, Lu CC, Chen CC, et al.: Activation of multiple apoptotic pathways in human nasopharyngeal carcinoma cells by the prenylated isoflavone, osajin. PLoS One 6, e18308-e18309, 2011.
19. Ambs S, Merriam WG, Bennett WP, Felley-Bosco E, Ogunfusika MO, et al.: Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res 58, 334-411, 998.
20. Hamsa TP and Kuttan G: Inhibition of invasion and experimental metastasis of murine melanoma cells by Ipomoea obscura (L.) is mediated through the down-regulation of inflammatory mediators and matrix-metalloproteinases. J Exp Ther Oncol 9, 139-151, 2011.
21. Dat NT, Xuan Binh PT, Phuong Quynh le T, Huong HT, and Van Minh C: Sanggenon C and O inhibit NO production, iNOS expression and NF-κB activation in LPS-induced RAW264.7 cells. Immunopharmacol Immunotoxicol 34, 84-88, 2012.