Ten Years with New Delhi Metallo-β-lactamase-1 (NDM-1): From Structural Insights to Inhibitor Design

ACS Infectious Diseases

Volumn 5, Issue 1, 2019, Pages 9-34

  Linciano, Pasquale ^a   Cendron, Laura ^b   Gianquinto, Eleonora ^c   Spyrakis, Francesca ^c   Tondi, Donatella ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

bacterial resistance; biological activity; enzyme inhibitors; NDM 1 metallo lactamase; structural analysis; structure based drug design

Indexed keywords

ALIPHATIC CARBOXYLIC ACID; ANTIBIOTIC AGENT; CARBAPENEM; CEFUROXIME; CEPHALOSPORIN; CHELATING AGENT; IMIPENEM; MEROPENEM; METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE 1; PENICILLIN DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; BETA-LACTAMASE NDM-1; CARBAPENEM DERIVATIVE;

ACINETOBACTER BAUMANNII; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DRUG DESIGN; DRUG DEVELOPMENT; ENZYME ACTIVE SITE; IC50; LD50; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY; BACTERIUM; BINDING SITE; CHEMISTRY; CLINICAL TRIAL (TOPIC); DRUG EFFECT; HUMAN; HYDROLYSIS; MICROBIAL SENSITIVITY TEST; MOLECULAR MODEL; MULTIDRUG RESISTANCE; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BACTERIA; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; BINDING SITES; CARBAPENEMS; CLINICAL TRIALS AS TOPIC; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS; HYDROLYSIS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 85058110423     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.8b00247     Document Type: Article

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