Efficacy of calcium-EDTA as an inhibitor for metallo-β-lactamase in a mouse model of Pseudomonas aeruginosa pneumonia

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 11, 2010, Pages 4582-4588

  Aoki, Nobumasa ^a,b   Ishii, Yoshikazu ^a   Tateda, Kazuhiro ^a   Saga, Tomoo ^a   Kimura, Soichiro ^a   Kikuchi, Yoshiaki ^a   Kobayashi, Tetsuo ^b   Tanabe, Yoshinari ^b   Tsukada, Hiroki ^b   Gejyo, Fumitake ^b   Yamaguchi, Keizo ^a  

^a TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; CEFTAZIDIME; EDETATE CALCIUM; IMIPENEM; METALLO BETA LACTAMASE;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VIABILITY; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HYPEROXIA; IC 50; IN VITRO STUDY; LUNG; LUNG ALVEOLUS EPITHELIUM; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS PNEUMONIA; SURVIVAL; VENTILATOR ASSOCIATED PNEUMONIA;

ANIMALS; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CALCIUM; CELL LINE; CELL SURVIVAL; EDETIC ACID; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; PNEUMONIA; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 78049300941     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00511-10     Document Type: Article

References (47)

1. American Thoracic Society. 2005. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am. J. Respir. Crit. Care Med. 171:388-416.
2. Aoki, N., K. Tateda, Y. Kikuchi, S. Kimura, C. Miyazaki, Y. Ishii, Y. Tanabe, F. Gejyo, and K. Yamaguchi. 2009. Efficacy of colistin combination therapy in a mouse model of pneumonia caused by multidrug-resistant Pseudomonas aeruginosa. J. Antimicrob. Chemother. 63:534-542.
3. Azghani, A. O., J. C. Connelly, B. T. Peterson, L. D. Gray, M. L. Collins, and A. R. Johnson. 1990. Effects of Pseudomonas aeruginosa elastase on alveolar epithelial permeability in guinea pigs. Infect. Immun. 58:433-438.
4. Azghani, A. O., L. D. Gray, and A. R. Johnson. 1993. A bacterial protease perturbs the paracellular barrier function of transporting epithelial monolayers in culture. Infect. Immun. 61:2681-2686.
5. Banin, E., K. M. Brady, and E. P. Greenberg. 2006. Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm. Appl. Environ. Microbiol. 72:2064-2069.
6. Bedenić, B., J. Vranes, M. Sviben, N. Beader, and S. Kalenic. 2008. Postantibiotic and post-β-lactamase inhibitor effect of carbapenems combined with EDTA against Pseudomonas aeruginosa strains producing VIM-metallo β-lactamases. Chemotherapy 54:188-193.
7. Bhattacharya, A., R. Shukla, E. D. Auyang, K. N. Dietrich, and R. Bornschein. 2007. Effect of succimer chelation therapy on postural balance and gait outcomes in children with early exposure to environmental lead. Neurotoxicology 28:686-695.
8. Chastre, J., and J. Y. Fagon. 2002. Ventilator-associated pneumonia. Am. J. Respir. Crit. Care Med. 165:867-903.
9. Chisolm, J. J., Jr. 1990. Evaluation of the potential role of chelation therapy in treatment of low to moderate lead exposures. Environ. Health Perspect. 89:67-74.
10. Clinical and Laboratory Standards Institute. 2009. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard, 8th ed., M07-A8. CLSI, Wayne, PA.
11. Cook, D. J., S. D. Walter, R. J. Cook, L. E. Griffith, G. H. Guyatt, D. Leasa, R. Z. Jaeschke, and C. Brun-Buisson. 1998. Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann. Intern. Med. 129:433-440.
12. Cornaglia, G., A. Mazzariol, L. Lauretti, G. M. Rossolini, and R. Fontana. 2000. Hospital outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-1, a novel transferable metallo-β-lactamase. Clin. Infect. Dis. 31:1119-1125.
13. Goyer, R. A., M. G. Cherian, M. M. Jones, and J. R. Reigart. 1995. Role of chelating agents for prevention, intervention, and treatment of exposures to toxic metals. Environ. Health Perspect. 103:1048-1052.
14. Isnard, N., J. M. Legeais, G. Renard, and L. Robert. 2001. Effect of hyaluronan on MMP expression and activation. Cell Biol. Int. 25:735-739.
15. Jones, R. N., L. M. Deshpande, J. M. Bell, J. D. Turnidge, S. Kohno, Y. Hirakata, Y. Ono, Y. Miyazawa, S. Kawakama, M. Inoue, Y. Hirata, and M. A. Toleman. 2004. Evaluation of the contemporary occurrence rates of metallo-β-lactamases in multidrug-resistant Gram-negative bacilli in Japan: report from the SENTRY Antimicrobial Surveillance Program (1998-2002). Diagn. Microbiol. Infect. Dis. 49:289-294.
16. Kipnis, E., T. Sawa, and J. Wiener-Kronish. 2006. Targeting mechanisms of Pseudomonas aeruginosa pathogenesis. Med. Mal. Infect. 36:78-91.
17. Koh, T. H., K. Yamaguchi, and Y. Ishii. 2008. Characterisation of the metallo-β-lactamase VIM-6 and its genetic support. Int. J. Antimicrob. Agents 32:446-449.
18. Kollef, M. H. 1993. Ventilator-associated pneumonia. A multivariate analysis. JAMA 270:1965-1970.
19. Lambert, R. J., G. W. Hanlon, and S. P. Denyer. 2004. The synergistic effect of EDTA/antimicrobial combinations on Pseudomonas aeruginosa. J. Appl. Microbiol. 96:244-253.
20. Lee, K., W. G. Lee, Y. Uh, G. Y. Ha, J. Cho, and Y. Chong. 2003. VIM- and IMP-type metallo-β-lactamase-producing Pseudomonas spp. and Acinetobacter spp. in Korean hospitals. Emerg. Infect. Dis. 9:868-871.
21. Lee, K., Y. S. Lim, D. Yong, J. H. Yum, and Y. Chong. 2003. Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-β-lactamase-producing isolates of Pseudomonas spp. and Acinetobacter spp. J. Clin. Microbiol. 41:4623-4629.
22. Leidal, K. G., K. L. Munson, M. C. Johnson, and G. M. Denning. 2003. Metalloproteases from Pseudomonas aeruginosa degrade human RANTES, MCP-1, and ENA-78. J. Interferon Cytokine Res. 23:307-318.
23. Lin-Tan, D. T., J. L. Lin, T. H. Yen, K. H. Chen, and Y. L. Huang. 2007. Long-term outcome of repeated lead chelation therapy in progressive nondiabetic chronic kidney diseases. Nephrol. Dial. Transplant. 22:2924-2931.
24. Livermore, D. M. 2002. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare? Clin. Infect. Dis. 34:634-640.
25. Nordmann, P., and L. Poirel. 2002. Emerging carbapenemases in Gramnegative aerobes. Clin. Microbiol. Infect. 8:321-331.
26. Osano, E., Y. Arakawa, R. Wacharotayankun, M. Ohta, T. Horii, H. Ito, F. Yoshimura, and N. Kato. 1994. Molecular characterization of an enterobacterial metallo β-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance. Antimicrob. Agents Chemother. 38:71-78.
27. Osterloh, J., and C. E. Becker. 1986. Pharmacokinetics of CaNa2EDTA and chelation of lead in renal failure. Clin. Pharmacol. Ther. 40:686-693.
28. Pitout, J. D., D. B. Gregson, L. Poirel, J. A. McClure, P. Le, and D. L. Church. 2005. Detection of Pseudomonas aeruginosa producing metallo-β- lactamases in a large centralized laboratory. J. Clin. Microbiol. 43:3129-3135.
29. Poirel, L., T. Naas, D. Nicolas, L. Collet, S. Bellais, J. D. Cavallo, and P. Nordmann. 2000. Characterization of VIM-2, a carbapenem-hydrolyzing metallo-β-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France. Antimicrob. Agents Chemother. 44:891-897.
30. Queenan, A. M., and K. Bush. 2007. Carbapenemases: the versatile β-lactamases. Clin. Microbiol. Rev. 20:440-458.
31. Raad, I., H. Hanna, T. Dvorak, G. Chaiban, and R. Hachem. 2007. Optimal antimicrobial catheter lock solution, using different combinations of minocycline, EDTA, and 25-percent ethanol, rapidly eradicates organisms embedded in biofilm. Antimicrob. Agents Chemother. 51:78-83.
32. Rahal, J. J. 2006. Novel antibiotic combinations against infections with almost completely resistant Pseudomonas aeruginosa and Acinetobacter species. Clin. Infect. Dis. 43(Suppl. 2):S95-S99.
33. Ranes, J. L., S. M. Gordon, P. Chen, C. Fatica, J. Hammel, J. P. Gonzales, and A. C. Arroliga. 2006. Predictors of long-term mortality in patients with ventilator-associated pneumonia. Am. J. Med. 119:897e13-897e19.
34. Rello, J., D. A. Ollendorf, G. Oster, M. Vera-Llonch, L. Bellm, R. Redman, and M. H. Kollef. 2002. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 122:2115-2121.
35. Rello, J., L. Vidaur, A. Sandiumenge, A. Rodriguez, B. Gualis, C. Boque, and E. Diaz. 2004. De-escalation therapy in ventilator-associated pneumonia. Crit. Care Med. 32:2183-2190.
36. Richards, M. J., J. R. Edwards, D. H. Culver, and R. P. Gaynes. 1999. Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance System. Crit. Care Med. 27:887-892.
37. Rosenthal, V. D., S. Guzman, and P. W. Orellano. 2003. Nosocomial infections in medical-surgical intensive care units in Argentina: attributable mortality and length of stay. Am. J. Infect. Control 31:291-295.
38. Sadikot, R. T., T. S. Blackwell, J. W. Christman, and A. S. Prince. 2005. Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am. J. Respir. Crit. Care Med. 171:1209-1223.
39. Sherertz, R. J., M. S. Boger, C. A. Collins, L. Mason, and I. I. Raad. 2006. Comparative in vitro efficacies of various catheter lock solutions. Antimicrob. Agents Chemother. 50:1865-1868.
40. Shigematsu, T., N. Suda, K. Okuda, and J. Fukushima. 2007. Reliable enzyme-linked immunosorbent assay systems for pathogenic factors of Pseudomonas aeruginosa alkaline proteinase, elastase, and exotoxin A: a comparison of methods for labeling detection antibodies with horseradish peroxidase. Microbiol. Immunol. 51:1149-1159.
41. Tan, J., J. D. Pitout, and D. S. Guttman. 2008. New and sensitive assay for determining Pseudomonas aeruginosa metallo-β-lactamase resistance to imipenem. J. Clin. Microbiol. 46:1870-1872.
42. Tateda, K., J. C. Deng, T. A. Moore, M. W. Newstead, R. Paine III, N. Kobayashi, K. Yamaguchi, and T. J. Standiford. 2003. Hyperoxia mediates acute lung injury and increased lethality in murine Legionella pneumonia: the role of apoptosis. J. Immunol. 170:4209-4216.
43. Tateda, K., K. Takashima, H. Miyazaki, T. Matsumoto, T. Hatori, and K. Yamaguchi. 1996. Noncompromised penicillin-resistant pneumococcal pneumonia CBA/J mouse model and comparative efficacies of antibiotics in this model. Antimicrob. Agents Chemother. 40:1520-1525.
44. Vaara, M. 1992. Agents that increase the permeability of the outer membrane. Microbiol. Rev. 56:395-411.
45. Van Eldere, J. 2003. Multicentre surveillance of Pseudomonas aeruginosa susceptibility patterns in nosocomial infections. J. Antimicrob. Chemother. 51:347-352.
46. Walsh, T. R., M. A. Toleman, L. Poirel, and P. Nordmann. 2005. Metallo-β-lactamases: the quiet before the storm? Clin. Microbiol. Rev. 18:306-325.
47. IMP-8 in a university medical center in Taiwan. J. Clin. Microbiol. 39:4433-4439.