Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1

European Journal of Medicinal Chemistry

Volumn 155, Issue , 2018, Pages 285-302

  Jin, Wen Bin ^a   Xu, Chen ^a   Cheng, Qipeng ^a   Qi, Xiao Lin ^a   Gao, Wei ^a   Zheng, Zhiwei ^a   Chan, Edward W C ^a   Leung, Yun Chung ^a   Chan, Tak Hang ^a,b   Wong, Kwok Yin ^a   Chen, Sheng ^a   Chan, Kin Fai ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Carbapenem adjuvants; Carbapenem resistant Enterobacteriaceae; Drug combination; Ebselen derivatives; NDM 1 inhibitors; Synergistic activity

Indexed keywords

1,2 BENZISOSELENAZOL 3(2H) ONE DERIVATIVE; CARBAPENEM DERIVATIVE; EBSELEN; MEROPENEM; TERT BUTYL[2 (3 OXOBENZO[D][1,2]SELENAZOL 2(3H) YL)ETHYL]CARBAMATE; UNCLASSIFIED DRUG; ZINC ION; ANTIINFECTIVE AGENT; BETA LACTAMASE; BETA-LACTAMASE NDM-1; THIENAMYCIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; CARBAPENEM-RESISTANT ENTEROBACTERIACEAE; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG POTENTIATION; ELECTROSPRAY MASS SPECTROMETRY; EUKARYOTIC CELL; GALLERIA MELLONELLA; MINIMUM INHIBITORY CONCENTRATION; MONOTHERAPY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; HELA CELL LINE; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; TUMOR CELL LINE;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CARBAPENEM-RESISTANT ENTEROBACTERIACEAE; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIENAMYCINS;

EID: 85049528882     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2018.06.007     Document Type: Article

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