Synthesis and biological evaluation of Aspergillomarasmine A derivatives as novel NDM-1 inhibitor to overcome antibiotics resistance

Bioorganic and Medicinal Chemistry

Volumn 25, Issue 19, 2017, Pages 5133-5141

  Zhang, Jian ^a   Wang, Sanshan ^a   Wei, Qi ^b   Guo, Qianqian ^a   Bai, Yingjie ^a   Yang, Shaoqiang ^a   Song, Fuhang ^b   Zhang, Lixin ^c   Lei, Xiaoguang ^a  

^a PEKING UNIVERSITY   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

^c EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antibiotic resistance; Antibiotics; Aspergillomarasmine A; Metallo lactamases; NDM 1

Indexed keywords

ASPERGILLOMARASMINE A DERIVATIVE; BETA LACTAMASE INHIBITOR; MEROPENEM; METALLO BETA LACTAMASE; NATURAL PRODUCT; NEW DELHI METALLO BETA LACTAMASE; UNCLASSIFIED DRUG; VERONA INTEGRON ENCODED BETA LACTAMASE; ASPARTIC ACID; ASPERGILLOMARASMINE A; BETA LACTAMASE; BETA-LACTAMASE NDM-1;

ANTIBIOTIC RESISTANCE; ARTICLE; DRUG POTENTIATION; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; IN VITRO STUDY; IN VIVO STUDY; KLEBSIELLA PNEUMONIAE; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HUMAN; KLEBSIELLA INFECTIONS; METABOLISM; MICROBIOLOGY; SYNTHESIS;

ASPARTIC ACID; BETA-LACTAM RESISTANCE; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE;

EID: 85026780365     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2017.07.025     Document Type: Article

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