Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors

ACS Infectious Diseases

Volumn 4, Issue 9, 2018, Pages 1407-1422

  Schnaars, Christian ^a   Kildahl Andersen, Geir ^a   Prandina, Anthony ^a,b   Popal, Roya ^a   Radix, Sylvie ^b   Le Borgne, Marc ^b   Gjøen, Tor ^a   Andresen, Adriana Magalhães Santos ^a   Heikal, Adam ^a   Økstad, Ole Andreas ^a   Fröhlich, Christopher ^c,d   Samuelsen, Ørjan ^c,d   Lauksund, Silje ^c   Jordheim, Lars Petter ^b   Rongved, Pål ^a   Åstrand, Ove Alexander Høgmoen ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITÉ LYON 1   (France)

^c UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^d UNIVERSITY OF TROMSØ   (Norway)

Author keywords

antimicrobial resistance; enzyme inhibition kinetics; metallo lactamase inhibitor; resistance frequency; toxicity; zinc chelator

Indexed keywords

1 [5 (AMINOMETHYL)PYRIDIN 2 YL] N,N BIS(PYRIDIN 2 YLMETHYL)METHANAMINE; 1 [5 (AMINOMETHYL)PYRIDIN 2 YL] N,N BIS(PYRIDIN 2 YLMETHYL)METHANAMINE HYDROCHLORIDE; 1 [5 (AZIDOMETHYL)PYRIDIN 2 YL] N,N BIS(PYRIDIN 2 YLMETHYL)METHANAMINE; 2 AMINO N [ 1 (((6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)PYRIDIN 3 YL)METHYL)AMINO) 1 OXOPROPAN 2 YL]PROPANAMIDE; 2 [4 (6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)NICOTINAMIDO) PHENYL]ACETIC ACID; 6 [(BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL]NICOTINIC ACID; 6 [(BIS(PYRIDINE 2 YLMETHYL)AMINO)METHYL] NICOTINATE; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CHELATING AGENT; METHYL 2 [ 2 (2 (4 (6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)NICOTINAMIDO)PHENYL)ACETAMIDO)PROPANAMIDO]PROPANOATE; METHYL 2 [ 2 (6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)NICOTINAMIDO]PROPANOATE; METHYL 2 [2 (6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)NICOTINAMIDO)ACETAMIDO]ACETATE; METHYL 2 [4 (6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL) NICOTINAMIDO)PHENYL]ACETATE; METHYL 6 [(BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL]NICOTINATE; N (6 AMINOHEXYL) 6 [(BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL]NICOTINAMIDE; N ALLYL 6 [(BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL]NICOTINAMIDE; N [4 (2 ( 2 ( 2 AMINOPROPANAMIDO)PROPANAMIDO)ETHYL)PHENYL] 6 [(BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL]NICOTAMIDE HYDROCHLORIDE; N [4 (2 AMINOETHYL)PHENYL) 6 [(BIS(PYRIDIN 2 YLMETHYL) AMINO)METHYL]NICOTINAMIDE; N [6 ( 2 ( 2 AMINOPROPANAMIDO)PROPANAMIDO)HEXYL] 6 [(BIS(PYRIDIN 2 YLMETHY)AMINO)METHYL]NICOTINAMIDE; TERT BUTYL 4 [6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL) NICOTINAMIDO]PHENETHYLCARBAMATE; TERT BUTYL 4 [6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)NICOTINOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL [ 1 (( 1 ((6 (6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)NICOTINAMIDO)HEXYL)AMINO) 1 OXOPROPAN 2 YL)AMINO) 1 OXOPROPAN 2 YL]CARBAMATE; TERT BUTYL [2 (1 (6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)NICOTINOYL)PIPERIDIN 4 YL)ETHYL]CARBAMATE; TERT BUTYL [6 (6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)NICOTINAMIDO)HEXYL]CARBAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; [4 (2 AMINOETHYL)PIPERIDIN 1 YL][6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)PYRIDIN 3 YL]METHANONE; [6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)PYRIDIN 3 YL] (PIPERAZIN 1 YL)METHANONE; [6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)PYRIDIN 3 YL] METHANOL; [6 ((BIS(PYRIDIN 2 YLMETHYL)AMINO)METHYL)PYRIDIN 3 YL]METHYLMETHANESULFONATE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; MEROPENEM; ZINC;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERICIDAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HEP-G2 CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; KLEBSIELLA PNEUMONIAE; LIVER CELL CARCINOMA; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; SOLID PHASE EXTRACTION; TOXICITY TESTING; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; GENETICS; KLEBSIELLA INFECTION; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PRECLINICAL STUDY; PSEUDOMONAS INFECTION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; CHELATING AGENTS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MEROPENEM; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; ZINC;

EID: 85050610186     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.8b00137     Document Type: Article

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