-
1
-
-
15544384259
-
Antibacterial drug discovery: is it all downhill from here?
-
Projan SJ, Shlaes DM (2004) Antibacterial drug discovery: is it all downhill from here? Clin Microbiol Infect 4:18–22
-
(2004)
Clin Microbiol Infect
, vol.4
, pp. 18-22
-
-
Projan, S.J.1
Shlaes, D.M.2
-
2
-
-
84904856068
-
The challenge of antimicrobial resistance: new regulatory tools to support product development
-
COI: 1:CAS:528:DC%2BC2cXpslChtLw%3D, PID: 24823890
-
Tomayko JF, Rex JH, Tenero DM, Goldberger M, Eisenstein BI (2014) The challenge of antimicrobial resistance: new regulatory tools to support product development. Clin Pharmacol Ther 96(2):166–168
-
(2014)
Clin Pharmacol Ther
, vol.96
, Issue.2
, pp. 166-168
-
-
Tomayko, J.F.1
Rex, J.H.2
Tenero, D.M.3
Goldberger, M.4
Eisenstein, B.I.5
-
3
-
-
84878278251
-
10 × ’20 Progress—development of new drugs active against Gram-negative bacilli: an update from the Infectious Diseases Society of America
-
PID: 23599308
-
Boucher HW, Talbot GH, Benjamin DK, Bradley J, Guidos RJ, Jones RN, Murray BE, Bonomo RA, Gilbert D (2013) 10 × ’20 Progress—development of new drugs active against Gram-negative bacilli: an update from the Infectious Diseases Society of America. Clin Infect Dis 56(12):1685–1694
-
(2013)
Clin Infect Dis
, vol.56
, Issue.12
, pp. 1685-1694
-
-
Boucher, H.W.1
Talbot, G.H.2
Benjamin, D.K.3
Bradley, J.4
Guidos, R.J.5
Jones, R.N.6
Murray, B.E.7
Bonomo, R.A.8
Gilbert, D.9
-
4
-
-
57749107808
-
Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America
-
PID: 19035777
-
Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, Scheld M, Spellberg B, Bartlett J (2009) Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 48(1):1–12
-
(2009)
Clin Infect Dis
, vol.48
, Issue.1
, pp. 1-12
-
-
Boucher, H.W.1
Talbot, G.H.2
Bradley, J.S.3
Edwards, J.E.4
Gilbert, D.5
Rice, L.B.6
Scheld, M.7
Spellberg, B.8
Bartlett, J.9
-
7
-
-
84875657153
-
Is the GAIN Act a turning point in new antibiotic discovery?
-
COI: 1:CAS:528:DC%2BC3sXktVKgtrg%3D, PID: 23540332
-
Brown ED (2013) Is the GAIN Act a turning point in new antibiotic discovery? Can J Microbiol 59(3):153–156
-
(2013)
Can J Microbiol
, vol.59
, Issue.3
, pp. 153-156
-
-
Brown, E.D.1
-
8
-
-
84959919724
-
The Innovative Medicines Initiative’s New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance
-
PID: 26568581
-
Kostyanev T, Bonten MJ, O’Brien S, Steel H, Ross S, Francois B, Tacconelli E, Winterhalter M, Stavenger RA, Karlén A, Harbarth S, Hackett J, Jafri H, Vuong C, MacGowan A, Witschi A, Angyalosi G, Elborn JS, deWinter R, Goossens H (2015) The Innovative Medicines Initiative’s New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance. J Antimicrob Chemother 71(2):290–295
-
(2015)
J Antimicrob Chemother
, vol.71
, Issue.2
, pp. 290-295
-
-
Kostyanev, T.1
Bonten, M.J.2
O’Brien, S.3
Steel, H.4
Ross, S.5
Francois, B.6
Tacconelli, E.7
Winterhalter, M.8
Stavenger, R.A.9
Karlén, A.10
Harbarth, S.11
Hackett, J.12
Jafri, H.13
Vuong, C.14
MacGowan, A.15
Witschi, A.16
Angyalosi, G.17
Elborn, J.S.18
deWinter, R.19
Goossens, H.20
more..
-
9
-
-
84858282874
-
Accelerating resistance, inadequate antibacterial drug pipelines and international responses
-
COI: 1:CAS:528:DC%2BC38XjtVOhsrw%3D, PID: 22341298
-
Theuretzbacher U (2012) Accelerating resistance, inadequate antibacterial drug pipelines and international responses. Int J Antimicrob Agents 39(4):295–299
-
(2012)
Int J Antimicrob Agents
, vol.39
, Issue.4
, pp. 295-299
-
-
Theuretzbacher, U.1
-
10
-
-
84896402755
-
ND4BB: addressing the antimicrobial resistance crisis
-
COI: 1:CAS:528:DC%2BC2cXjvVyrsb0%3D
-
Rex JH (2014) ND4BB: addressing the antimicrobial resistance crisis. Nat Rev Microbiol 12:231–232
-
(2014)
Nat Rev Microbiol
, vol.12
, pp. 231-232
-
-
Rex, J.H.1
-
11
-
-
84886803095
-
Antibiotics in the clinical pipeline in 2013
-
COI: 1:CAS:528:DC%2BC3sXhs1yiu7vP, PID: 24002361
-
Butler MS, Blaskovich MA, Cooper MA (2013) Antibiotics in the clinical pipeline in 2013. J Antibiot 66:571–591
-
(2013)
J Antibiot
, vol.66
, pp. 571-591
-
-
Butler, M.S.1
Blaskovich, M.A.2
Cooper, M.A.3
-
12
-
-
84884961808
-
Investigational antimicrobial agents of 2013
-
COI: 1:CAS:528:DC%2BC3sXhvFeisbrN, PID: 24092856
-
Pucci MJ, Bush K (2013) Investigational antimicrobial agents of 2013. Clin Microbiol Rev 26(4):792–821
-
(2013)
Clin Microbiol Rev
, vol.26
, Issue.4
, pp. 792-821
-
-
Pucci, M.J.1
Bush, K.2
-
13
-
-
84896968084
-
New beta-lactamase inhibitors: a therapeutic renaissance in an MDR world
-
PID: 24379206
-
Drawz SM, Papp-Wallace KM, Bonomo RA (2014) New beta-lactamase inhibitors: a therapeutic renaissance in an MDR world. Antimicrob Agents Chemother 58(4):1835–1846
-
(2014)
Antimicrob Agents Chemother
, vol.58
, Issue.4
, pp. 1835-1846
-
-
Drawz, S.M.1
Papp-Wallace, K.M.2
Bonomo, R.A.3
-
14
-
-
84907586950
-
Discovery and development of new antibacterial agents targeting Gram-negative bacteria in the era of pandrug resistance: is the future promising?
-
COI: 1:CAS:528:DC%2BC2cXhs1Shtr3J, PID: 25277839
-
Page MGP, Bush K (2014) Discovery and development of new antibacterial agents targeting Gram-negative bacteria in the era of pandrug resistance: is the future promising? Curr Opin Pharmacol 18:91–97
-
(2014)
Curr Opin Pharmacol
, vol.18
, pp. 91-97
-
-
Page, M.G.P.1
Bush, K.2
-
15
-
-
77956123209
-
Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa
-
COI: 1:CAS:528:DC%2BC3cXht12ktL3L, PID: 20547785
-
Moya B, Zamorano L, Juan C, Ge Y, Oliver A (2010) Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa. Antimicrob Agents Chemother 54(9):3933–3937
-
(2010)
Antimicrob Agents Chemother
, vol.54
, Issue.9
, pp. 3933-3937
-
-
Moya, B.1
Zamorano, L.2
Juan, C.3
Ge, Y.4
Oliver, A.5
-
16
-
-
79955536362
-
Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes
-
COI: 1:CAS:528:DC%2BC3MXhsFClsLrI, PID: 21321149
-
Sader HS, Rhomberg PR, Farrell DJ, Jones RN (2011) Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes. Antimicrob Agents Chemother 55(5):2390–2394
-
(2011)
Antimicrob Agents Chemother
, vol.55
, Issue.5
, pp. 2390-2394
-
-
Sader, H.S.1
Rhomberg, P.R.2
Farrell, D.J.3
Jones, R.N.4
-
17
-
-
77955618992
-
Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae
-
COI: 1:CAS:528:DC%2BC3cXhtVansbjO, PID: 20595207
-
Livermore DM, Mushtaq S, Ge Y (2010) Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae. J Antimicrob Chemother 65(9):1972–1974
-
(2010)
J Antimicrob Chemother
, vol.65
, Issue.9
, pp. 1972-1974
-
-
Livermore, D.M.1
Mushtaq, S.2
Ge, Y.3
-
18
-
-
79955005040
-
In vitro activity of CXA-101 plus tazobactam (CXA-201) against CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae
-
COI: 1:CAS:528:DC%2BC3MXlt1Sgur0%3D, PID: 21513849
-
Titelman E, Karlsson IM, Ge Y, Giske CG (2011) In vitro activity of CXA-101 plus tazobactam (CXA-201) against CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae. Diagn Microbiol Infect Dis 70(1):137–141
-
(2011)
Diagn Microbiol Infect Dis
, vol.70
, Issue.1
, pp. 137-141
-
-
Titelman, E.1
Karlsson, I.M.2
Ge, Y.3
Giske, C.G.4
-
19
-
-
85016569483
-
Prescribing information for Zerbaxa
-
FDA (2015) Prescribing information for Zerbaxa. Food and Drug Administration. http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206829s001lbl.pdf. Accessed 28 June 2016
-
(2015)
Food and Drug Administration
-
-
-
20
-
-
85018193526
-
Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe
-
Coque TM, Baquero F, Canton R (2008) Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe. Euro Surveill 13(47):20
-
(2008)
Euro Surveill
, vol.13
, Issue.47
, pp. 20
-
-
Coque, T.M.1
Baquero, F.2
Canton, R.3
-
21
-
-
84928893993
-
In vitro antibacterial activity of the ceftazidime-avibactam combination against Enterobacteriaceae, including strains with well characterized β-lactamases
-
COI: 1:CAS:528:DC%2BC2MXkvFSgtrc%3D, PID: 25583732
-
Levasseur P, Girard A-M, Miossec C, Pace J, Coleman K (2015) In vitro antibacterial activity of the ceftazidime-avibactam combination against Enterobacteriaceae, including strains with well characterized β-lactamases. Antimicrob Agents Chemother 59:1931–1934
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 1931-1934
-
-
Levasseur, P.1
Girard, A.-M.2
Miossec, C.3
Pace, J.4
Coleman, K.5
-
22
-
-
84884764949
-
Kinetics of avibactam inhibition against class A, C, and D β-lactamases
-
COI: 1:CAS:528:DC%2BC3sXhsFemsr%2FL, PID: 23913691
-
Ehmann DE, Jahić H, Ross PL, Gu R-F, Hu J, Durand-Réville TF, Lahiri S, Thresher J, Livchak S, Gao N, Palmer T, Walkup GK, Fisher SL (2013) Kinetics of avibactam inhibition against class A, C, and D β-lactamases. J Biol Chem 288(39):27960–27971
-
(2013)
J Biol Chem
, vol.288
, Issue.39
, pp. 27960-27971
-
-
Ehmann, D.E.1
Jahić, H.2
Ross, P.L.3
Gu, R.-F.4
Hu, J.5
Durand-Réville, T.F.6
Lahiri, S.7
Thresher, J.8
Livchak, S.9
Gao, N.10
Palmer, T.11
Walkup, G.K.12
Fisher, S.L.13
-
23
-
-
84863905057
-
Avibactam is a covalent, reversible, non-beta-lactam beta-lactamase inhibitor
-
COI: 1:CAS:528:DC%2BC38Xht1Ciu73K, PID: 22753474
-
Ehmann DE, Jahic H, Ross PL, Gu RF, Hu J, Kern G, Walkup GK, Fisher SL (2012) Avibactam is a covalent, reversible, non-beta-lactam beta-lactamase inhibitor. Proc Natl Acad Sci USA 109(29):11663–11668
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.29
, pp. 11663-11668
-
-
Ehmann, D.E.1
Jahic, H.2
Ross, P.L.3
Gu, R.F.4
Hu, J.5
Kern, G.6
Walkup, G.K.7
Fisher, S.L.8
-
24
-
-
84931263717
-
-
USFaD Administration
-
USFaD Administration (2015) FDA approves new antibacterial drug Avycaz. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm435629.htm
-
(2015)
FDA approves new antibacterial drug Avycaz
-
-
-
27
-
-
84957895337
-
In vitro antimicrobial activity of a siderophore cephalosporin, S-649266, against Enterobacteriaceae clinical isolates, including carbapenem-resistant strains
-
COI: 1:CAS:528:DC%2BC28Xntlams7c%3D, PID: 26574013
-
Kohira N, West J, Ito A, Ito-Horiyama T, Nakamura R, Sato T, Rittenhouse S, Tsuji M, Yamano Y (2016) In vitro antimicrobial activity of a siderophore cephalosporin, S-649266, against Enterobacteriaceae clinical isolates, including carbapenem-resistant strains. Antimicrob Agents Chemother 60(2):729–734
-
(2016)
Antimicrob Agents Chemother
, vol.60
, Issue.2
, pp. 729-734
-
-
Kohira, N.1
West, J.2
Ito, A.3
Ito-Horiyama, T.4
Nakamura, R.5
Sato, T.6
Rittenhouse, S.7
Tsuji, M.8
Yamano, Y.9
-
28
-
-
77952614275
-
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli
-
COI: 1:CAS:528:DC%2BC3cXos1Ohtb4%3D, PID: 20308379
-
Page MGP, Dantier C, Desarbre E (2010) In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. Antimicrob Agents Chemother 54(6):2291–2302
-
(2010)
Antimicrob Agents Chemother
, vol.54
, Issue.6
, pp. 2291-2302
-
-
Page, M.G.P.1
Dantier, C.2
Desarbre, E.3
-
29
-
-
84884700230
-
In vitro activity of the novel monosulfactam BAL30072 alone and in combination with meropenem versus a diverse collection of important Gram-negative pathogens
-
COI: 1:CAS:528:DC%2BC3sXhtVKmsr7P, PID: 23837926
-
Hornsey M, Phee L, Stubbings W, Wareham DW (2013) In vitro activity of the novel monosulfactam BAL30072 alone and in combination with meropenem versus a diverse collection of important Gram-negative pathogens. Int J Antimicrob Agents 42(4):343–346
-
(2013)
Int J Antimicrob Agents
, vol.42
, Issue.4
, pp. 343-346
-
-
Hornsey, M.1
Phee, L.2
Stubbings, W.3
Wareham, D.W.4
-
30
-
-
84879488177
-
Activity of BAL30072 alone or combined with β-lactamase inhibitors or with meropenem against carbapenem-resistant Enterobacteriaceae and non-fermenters
-
COI: 1:CAS:528:DC%2BC3sXpsFCiu7k%3D, PID: 23449829
-
Mushtaq S, Woodford N, Hope R, Adkin R, Livermore DM (2013) Activity of BAL30072 alone or combined with β-lactamase inhibitors or with meropenem against carbapenem-resistant Enterobacteriaceae and non-fermenters. J Antimicrob Chemother 68:1601–1608
-
(2013)
J Antimicrob Chemother
, vol.68
, pp. 1601-1608
-
-
Mushtaq, S.1
Woodford, N.2
Hope, R.3
Adkin, R.4
Livermore, D.M.5
-
31
-
-
84960837126
-
In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria
-
COI: 1:CAS:528:DC%2BC28XhsFOitbbJ, PID: 26645269
-
Ito A, Kohira N, Bouchillon SK, West J, Rittenhouse S, Sader HS, Rhomberg PR, Jones RN, Yoshizawa H, Nakamura R, Tsuji M, Yamano Y (2016) In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria. J Antimicrob Chemother 71(3):670–677
-
(2016)
J Antimicrob Chemother
, vol.71
, Issue.3
, pp. 670-677
-
-
Ito, A.1
Kohira, N.2
Bouchillon, S.K.3
West, J.4
Rittenhouse, S.5
Sader, H.S.6
Rhomberg, P.R.7
Jones, R.N.8
Yoshizawa, H.9
Nakamura, R.10
Tsuji, M.11
Yamano, Y.12
-
32
-
-
84977110010
-
Stability of novel siderophore cephalosporin S-649266 against clinically relevant carbapenemases
-
PID: 27139465
-
Ito-Horiyama T, Ishii Y, Ito A, Sato T, Nakamura R, Fukuhara N, Tsuji M, Yamano Y, Yamaguchi K, Tateda K (2016) Stability of novel siderophore cephalosporin S-649266 against clinically relevant carbapenemases. Antimicrob Agents Chemother 60(7):4384–4386
-
(2016)
Antimicrob Agents Chemother
, vol.60
, Issue.7
, pp. 4384-4386
-
-
Ito-Horiyama, T.1
Ishii, Y.2
Ito, A.3
Sato, T.4
Nakamura, R.5
Fukuhara, N.6
Tsuji, M.7
Yamano, Y.8
Yamaguchi, K.9
Tateda, K.10
-
34
-
-
0025219010
-
Cir and Fiu proteins in the outer membrane of Escherichia coli catalyze transport of monomeric catechols: study with beta-lactam antibiotics containing catechol and analogous groups
-
COI: 1:CAS:528:DyaK3cXhsFGjsrw%3D, PID: 2407721
-
Nikaido H, Rosenberg EY (1990) Cir and Fiu proteins in the outer membrane of Escherichia coli catalyze transport of monomeric catechols: study with beta-lactam antibiotics containing catechol and analogous groups. J Bacteriol 172(3):1361–1367
-
(1990)
J Bacteriol
, vol.172
, Issue.3
, pp. 1361-1367
-
-
Nikaido, H.1
Rosenberg, E.Y.2
-
35
-
-
85016548132
-
S-649266, a novel siderophore cephalosporin: II. Impact of active transport via iron regulated outer membrane proteins on resistance selection. Abstract F-1563
-
Washington: DC
-
Ito A, Nishikawa T, Matsumoto S, Fukuhara N, Nakamura R, Tsuji M, Yamano Y, Shimada J (2014) S-649266, a novel siderophore cephalosporin: II. Impact of active transport via iron regulated outer membrane proteins on resistance selection. Abstract F-1563. Paper presented at the 54th Interscience conference on antimicrobial agents & chemotherapy, Washington, DC
-
(2014)
Paper presented at the 54th Interscience conference on antimicrobial agents & chemotherapy
-
-
Ito, A.1
Nishikawa, T.2
Matsumoto, S.3
Fukuhara, N.4
Nakamura, R.5
Tsuji, M.6
Yamano, Y.7
Shimada, J.8
-
36
-
-
84939785073
-
Activity of imipenem with relebactam against Gram-negative pathogens from New York City
-
COI: 1:CAS:528:DC%2BC2MXht1OjtbrK, PID: 26014931
-
Lapuebla A, Abdallah M, Olafisoye O, Cortes C, Urban C, Landman D, Quale J (2015) Activity of imipenem with relebactam against Gram-negative pathogens from New York City. Antimicrob Agents Chemother 59(8):5029–5031
-
(2015)
Antimicrob Agents Chemother
, vol.59
, Issue.8
, pp. 5029-5031
-
-
Lapuebla, A.1
Abdallah, M.2
Olafisoye, O.3
Cortes, C.4
Urban, C.5
Landman, D.6
Quale, J.7
-
37
-
-
84888787952
-
Activity of MK-7655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa
-
COI: 1:CAS:528:DC%2BC3sXhvVKns7vN, PID: 23696619
-
Livermore DM, Warner M, Mushtaq S (2013) Activity of MK-7655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa. J Antimicrob Chemother 68:2286–2290
-
(2013)
J Antimicrob Chemother
, vol.68
, pp. 2286-2290
-
-
Livermore, D.M.1
Warner, M.2
Mushtaq, S.3
-
38
-
-
84929340109
-
Discovery of a cyclic boronic acid beta-lactamase inhibitor (RPX7009) with utility vs Class A serine carbapenemases
-
COI: 1:CAS:528:DC%2BC2MXksl2gs7g%3D, PID: 25782055
-
Hecker SJ, Reddy KR, Totrov M, Hirst GC, Lomovskaya O, Griffith DC, King P, Tsivkovski R, Sun D, Sabet M, Tarazi Z, Clifton MC, Atkins K, Raymond A, Potts KT, Abendroth J, Boyer SH, Loutit JS, Morgan EE, Durso S, Dudley MN (2015) Discovery of a cyclic boronic acid beta-lactamase inhibitor (RPX7009) with utility vs Class A serine carbapenemases. J Med Chem 58(9):3682–3692
-
(2015)
J Med Chem
, vol.58
, Issue.9
, pp. 3682-3692
-
-
Hecker, S.J.1
Reddy, K.R.2
Totrov, M.3
Hirst, G.C.4
Lomovskaya, O.5
Griffith, D.C.6
King, P.7
Tsivkovski, R.8
Sun, D.9
Sabet, M.10
Tarazi, Z.11
Clifton, M.C.12
Atkins, K.13
Raymond, A.14
Potts, K.T.15
Abendroth, J.16
Boyer, S.H.17
Loutit, J.S.18
Morgan, E.E.19
Durso, S.20
Dudley, M.N.21
more..
-
39
-
-
84939812571
-
Activity of meropenem combined with RPX7009, a novel beta-lactamase inhibitor, against Gram-negative clinical isolates in New York City
-
COI: 1:CAS:528:DC%2BC2MXht1OjtLfN, PID: 26033723
-
Lapuebla A, Abdallah M, Olafisoye O, Cortes C, Urban C, Quale J, Landman D (2015) Activity of meropenem combined with RPX7009, a novel beta-lactamase inhibitor, against Gram-negative clinical isolates in New York City. Antimicrob Agents Chemother 59(8):4856–4860
-
(2015)
Antimicrob Agents Chemother
, vol.59
, Issue.8
, pp. 4856-4860
-
-
Lapuebla, A.1
Abdallah, M.2
Olafisoye, O.3
Cortes, C.4
Urban, C.5
Quale, J.6
Landman, D.7
-
40
-
-
84928374721
-
Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases
-
COI: 1:CAS:528:DC%2BC2MXjtFGgurg%3D, PID: 25737290
-
Papp-Wallace KM, Bajaksouzian S, Abdelhamed AM, Foster AN, Winkler ML, Gatta JA, Nichols WW, Testa R, Bonomo RA, Jacobs MR (2015) Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single beta-lactamases. Diagn Microbiol Infect Dis 82(1):65–69
-
(2015)
Diagn Microbiol Infect Dis
, vol.82
, Issue.1
, pp. 65-69
-
-
Papp-Wallace, K.M.1
Bajaksouzian, S.2
Abdelhamed, A.M.3
Foster, A.N.4
Winkler, M.L.5
Gatta, J.A.6
Nichols, W.W.7
Testa, R.8
Bonomo, R.A.9
Jacobs, M.R.10
-
41
-
-
84923240983
-
In vitro susceptibility of characterized β-lactamase-producing strains tested with avibactam combinations
-
COI: 1:CAS:528:DC%2BC2MXjtFaitr4%3D, PID: 25534728
-
Li H, Estabrook M, Jacoby GA, Nichols WW, Testa RT, Bush K (2015) In vitro susceptibility of characterized β-lactamase-producing strains tested with avibactam combinations. Antimicrob Agents Chemother 59(3):1789–1793
-
(2015)
Antimicrob Agents Chemother
, vol.59
, Issue.3
, pp. 1789-1793
-
-
Li, H.1
Estabrook, M.2
Jacoby, G.A.3
Nichols, W.W.4
Testa, R.T.5
Bush, K.6
-
42
-
-
84865424472
-
Activity of ceftaroline-avibactam tested against Gram-negative organism populations, including strains expressing one or more β-lactamases and methicillin-resistant Staphylococcus aureus carrying various staphylococcal cassette chromosome mec types
-
COI: 1:CAS:528:DC%2BC38Xht12mt7%2FL, PID: 22733066
-
Castanheira M, Sader HS, Farrell DJ, Mendes RE, Jones RN (2012) Activity of ceftaroline-avibactam tested against Gram-negative organism populations, including strains expressing one or more β-lactamases and methicillin-resistant Staphylococcus aureus carrying various staphylococcal cassette chromosome mec types. Antimicrob Agents Chemother 56(9):4779–4785
-
(2012)
Antimicrob Agents Chemother
, vol.56
, Issue.9
, pp. 4779-4785
-
-
Castanheira, M.1
Sader, H.S.2
Farrell, D.J.3
Mendes, R.E.4
Jones, R.N.5
-
44
-
-
84938859514
-
In vitro activity of ceftazidime, ceftaroline and aztreonam alone and in combination with avibactam against European Gram-negative and Gram-positive clinical isolates
-
COI: 1:CAS:528:DC%2BC2MXjt1altLY%3D, PID: 25748553
-
Testa R, Canton R, Giani T, Morosini MI, Nichols WW, Seifert H, Stefanik D, Rossolini GM, Nordmann P (2015) In vitro activity of ceftazidime, ceftaroline and aztreonam alone and in combination with avibactam against European Gram-negative and Gram-positive clinical isolates. Int J Antimicrob Agents 45(6):641–646
-
(2015)
Int J Antimicrob Agents
, vol.45
, Issue.6
, pp. 641-646
-
-
Testa, R.1
Canton, R.2
Giani, T.3
Morosini, M.I.4
Nichols, W.W.5
Seifert, H.6
Stefanik, D.7
Rossolini, G.M.8
Nordmann, P.9
-
45
-
-
84957900899
-
Multiyear, multinational survey of the incidence and global distribution of metallo-beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa
-
COI: 1:CAS:528:DC%2BC28XhtVKlsr3E, PID: 26643349
-
Kazmierczak KM, Rabine S, Hackel M, McLaughlin RE, Biedenbach DJ, Bouchillon SK, Sahm DF, Bradford PA (2016) Multiyear, multinational survey of the incidence and global distribution of metallo-beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Antimicrob Agents Chemother 60(2):1067–1078
-
(2016)
Antimicrob Agents Chemother
, vol.60
, Issue.2
, pp. 1067-1078
-
-
Kazmierczak, K.M.1
Rabine, S.2
Hackel, M.3
McLaughlin, R.E.4
Biedenbach, D.J.5
Bouchillon, S.K.6
Sahm, D.F.7
Bradford, P.A.8
-
46
-
-
84949035632
-
Activity of OP0595/beta-lactam combinations against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing beta-lactamases
-
COI: 1:CAS:528:DC%2BC28XjsFyjurc%3D, PID: 26311835
-
Livermore DM, Mushtaq S, Warner M, Woodford N (2015) Activity of OP0595/beta-lactam combinations against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing beta-lactamases. J Antimicrob Chemother 70(11):3032–3041
-
(2015)
J Antimicrob Chemother
, vol.70
, Issue.11
, pp. 3032-3041
-
-
Livermore, D.M.1
Mushtaq, S.2
Warner, M.3
Woodford, N.4
-
47
-
-
85016646427
-
-
Paper presented at the Microbe, Boston, MA
-
Khande HN, Joshi PR, Palwe SR, Bhagwat SS, Patel MV (2016) WCK 5222 [cefepime (FEP)-WCK 5107 (zidebactam, ZID)]: activity against ESBL, class C, and KPC-expressing enterics and Pseudomonas (PA) expressing AmpC (PA AmpC) or OXA β-lactamases (PA OXA). Abstract SUNDAY-442. Paper presented at the Microbe 2016, Boston, MA
-
(2016)
(2016) WCK 5222 [cefepime (FEP)-WCK 5107 (zidebactam, ZID)]: activity against ESBL, class C, and KPC-expressing enterics and Pseudomonas (PA) expressing AmpC (PA AmpC) or OXA β-lactamases (PA OXA). Abstract SUNDAY-442
-
-
Khande, H.N.1
Joshi, P.R.2
Palwe, S.R.3
Bhagwat, S.S.4
Patel, M.V.5
-
48
-
-
85016621720
-
-
Paper presented at the Microbe, Boston, MA
-
Deshpande PK, Bhavsar SB, Joshi SN, Pawar SS, Kale RP, Mishra A, Jadhav SB, Pavase LS, Gupta SV, Yeole RD, Rane VP, Ahirrao VK, Bhagwat SS, Patel MV (2016) WCK 5107 (Zidebactam, Zid): structure activity relationship (Sar) of novel bicyclo acyl hydrazide (Bch) pharmacophore active against Gram-negatives including Pseudomonas (Pa). Abstract FRIDAY-479. Paper presented at the Microbe 2016, Boston, MA
-
(2016)
(2016) WCK 5107 (Zidebactam, Zid): structure activity relationship (Sar) of novel bicyclo acyl hydrazide (Bch) pharmacophore active against Gram-negatives including Pseudomonas (Pa). Abstract FRIDAY-479
-
-
Deshpande, P.K.1
Bhavsar, S.B.2
Joshi, S.N.3
Pawar, S.S.4
Kale, R.P.5
Mishra, A.6
Jadhav, S.B.7
Pavase, L.S.8
Gupta, S.V.9
Yeole, R.D.10
Rane, V.P.11
Ahirrao, V.K.12
Bhagwat, S.S.13
Patel, M.V.14
-
49
-
-
84943800632
-
OP0595, a new diazabicyclooctane: mode of action as a serine β-lactamase inhibitor, antibiotic and β-lactam ‘enhancer’
-
COI: 1:CAS:528:DC%2BC2MXhsleru7zI, PID: 26089439
-
Morinaka A, Tsutsumi Y, Yamada M, Suzuki K, Watanabe T, Abe T, Furuuchi T, Inamura S, Sakamaki Y, Mitsuhashi N, Ida T, Livermore DM (2015) OP0595, a new diazabicyclooctane: mode of action as a serine β-lactamase inhibitor, antibiotic and β-lactam ‘enhancer’. J Antimicrob Chemother 70(10):2779–2786
-
(2015)
J Antimicrob Chemother
, vol.70
, Issue.10
, pp. 2779-2786
-
-
Morinaka, A.1
Tsutsumi, Y.2
Yamada, M.3
Suzuki, K.4
Watanabe, T.5
Abe, T.6
Furuuchi, T.7
Inamura, S.8
Sakamaki, Y.9
Mitsuhashi, N.10
Ida, T.11
Livermore, D.M.12
-
50
-
-
85016598314
-
-
Paper presented at the Microbe, Boston, MA
-
Livermore DM, Mushtaq S, Warner M, Vickers A, Woodford N (2016) Activity of combinations of cefepime with zidebactam (WCK 5107), a novel triple-action diazabicyclooctane. SUNDAY-439. Paper presented at the Microbe 2016, Boston, MA
-
(2016)
(2016) Activity of combinations of cefepime with zidebactam (WCK 5107), a novel triple-action diazabicyclooctane. SUNDAY-439
-
-
Livermore, D.M.1
Mushtaq, S.2
Warner, M.3
Vickers, A.4
Woodford, N.5
-
51
-
-
85008394375
-
In vitro activity of cefepime/AAI101 and comparators against cefepime non-susceptible Enterobacteriaceae
-
PID: 26295262
-
Crandon JL, Nicolau DP (2015) In vitro activity of cefepime/AAI101 and comparators against cefepime non-susceptible Enterobacteriaceae. Pathogens 4(3):620–625
-
(2015)
Pathogens
, vol.4
, Issue.3
, pp. 620-625
-
-
Crandon, J.L.1
Nicolau, D.P.2
-
52
-
-
85016638758
-
-
MONDAY-4282. Paper presented at the Microbe 2016, Boston, MA
-
Jacobs MR, Bajaksouzian S, Papp-Wallace KM, Bonomo RA (2016) In vitro activity of cefepime combined with tazobactam (Wck 4282) against a challenge set of Esbl and carbapenemase producing Gram negative species. MONDAY-4282. Paper presented at the Microbe 2016, Boston, MA
-
(2016)
In vitro activity of cefepime combined with tazobactam (Wck 4282) against a challenge set of Esbl and carbapenemase producing Gram negative species
-
-
Jacobs, M.R.1
Bajaksouzian, S.2
Papp-Wallace, K.M.3
Bonomo, R.A.4
-
54
-
-
85016606241
-
-
Paper presented at the Microbe, Boston, MA
-
Patil VJ, Tadiparthi R, Birajdar SS, Dond BD, Shaikh MU, Dekhane DV, Pawar MJ, Bhagwat SS, Patel MV (2016) WCK 4234: synthesis and structure-activity relationship (SAR) identifying a novel β-lactamase inhibitor active against Acinetobacter expressing OXA-carbapenemases (Ab-Oxa). Paper presented at the Microbe 2016, Boston, MA
-
(2016)
(2016) WCK 4234: synthesis and structure-activity relationship (SAR) identifying a novel β-lactamase inhibitor active against Acinetobacter expressing OXA-carbapenemases (Ab-Oxa)
-
-
Patil, V.J.1
Tadiparthi, R.2
Birajdar, S.S.3
Dond, B.D.4
Shaikh, M.U.5
Dekhane, D.V.6
Pawar, M.J.7
Bhagwat, S.S.8
Patel, M.V.9
-
55
-
-
85016579302
-
-
Paper presented at the Microbe, Boston, MA
-
Shapiro AB, Guler S, Carter N, McLeod M, Jonge BD, McLaughlin R, Huynh H, Gao N, Durand-Reville T, Miller A, Mueller J, Tommasi R (2016) ETX2514, a novel, rationally designed inhibitor of class A, C and D β-lactamases, for the treatment of Gram-negative infections. Paper presented at the Microbe 2016, Boston, MA
-
(2016)
Tommasi R (2016) ETX2514, a novel, rationally designed inhibitor of class A, C and D β-lactamases, for the treatment of Gram-negative infections
-
-
Shapiro, A.B.1
Guler, S.2
Carter, N.3
McLeod, M.4
Jonge, B.D.5
McLaughlin, R.6
Huynh, H.7
Gao, N.8
Durand-Reville, T.9
Miller, A.10
Mueller, J.11
-
56
-
-
84857175339
-
Antistaphylococcal activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic
-
COI: 1:CAS:528:DC%2BC38XjsVKltL8%3D, PID: 22203585
-
Blais J, Lewis SR, Krause KM, Benton BM (2012) Antistaphylococcal activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic. Antimicrob Agents Chemother 56(3):1584–1587
-
(2012)
Antimicrob Agents Chemother
, vol.56
, Issue.3
, pp. 1584-1587
-
-
Blais, J.1
Lewis, S.R.2
Krause, K.M.3
Benton, B.M.4
-
57
-
-
85016621224
-
-
Theravance. Accessed 1 July 2016
-
Theravance (2016) Theravance Biopharma programs. http://www.theravance.com/bacterial. Accessed 1 July 2016
-
(2016)
Theravance Biopharma programs
-
-
-
58
-
-
84864751101
-
Inhibition of lipopolysaccharide transport to the outer membrane in Pseudomonas aeruginosa by peptidomimetic antibiotics
-
COI: 1:CAS:528:DC%2BC38XhtVCjtLvO, PID: 22807320
-
Werneburg M, Zerbe K, Juhas M, Bigler L, Stalder U, Kaech A, Ziegler U, Obrecht D, Eberl L, Robinson J (2012) Inhibition of lipopolysaccharide transport to the outer membrane in Pseudomonas aeruginosa by peptidomimetic antibiotics. ChemBioChem 13:1767–1775
-
(2012)
ChemBioChem
, vol.13
, pp. 1767-1775
-
-
Werneburg, M.1
Zerbe, K.2
Juhas, M.3
Bigler, L.4
Stalder, U.5
Kaech, A.6
Ziegler, U.7
Obrecht, D.8
Eberl, L.9
Robinson, J.10
-
59
-
-
84906081308
-
Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16
-
PID: 24936592
-
Mensa B, Howell GL, Scott R, DeGrado WF (2014) Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16. Antimicrob Agents Chemother 58(9):5136–5145
-
(2014)
Antimicrob Agents Chemother
, vol.58
, Issue.9
, pp. 5136-5145
-
-
Mensa, B.1
Howell, G.L.2
Scott, R.3
DeGrado, W.F.4
-
60
-
-
85016633212
-
-
Paper presented at the Microbe, Boston, MA
-
Corbett D, Wise A, Birchall S, Trimby E, Smith J, Lister T, Vaara M (2016) Potentiation of antibiotic activity by a novel cationic peptide, SPR741. Abstract SATURDAY-492. Paper presented at the Microbe 2016, Boston, MA
-
(2016)
Potentiation of antibiotic activity by a novel cationic peptide, SPR741. Abstract SATURDAY-492
-
-
Corbett, D.1
Wise, A.2
Birchall, S.3
Trimby, E.4
Smith, J.5
Lister, T.6
Vaara, M.7
-
61
-
-
85016590374
-
Developing safer polymyxins (Pms): structure-activity (SAR) and structure-toxicity (Str) relationships of modifications to positions 6 and 7
-
Boston: MA
-
Roberts KD, Wang J, Yu H, Wang L, Lomovskaya O, Griffith D, Hecker S, Dudley M, Thompson PE, Nation RL, Velkov T, Li J (2016) Developing safer polymyxins (Pms): structure-activity (SAR) and structure-toxicity (Str) relationships of modifications to positions 6 and 7. Abstract SATURDAY-434 Paper presented at the Microbe 2016, Boston, MA
-
(2016)
Abstract SATURDAY-434 Paper presented at the Microbe 2016
-
-
Roberts, K.D.1
Wang, J.2
Yu, H.3
Wang, L.4
Lomovskaya, O.5
Griffith, D.6
Hecker, S.7
Dudley, M.8
Thompson, P.E.9
Nation, R.L.10
Velkov, T.11
Li, J.12
-
62
-
-
85016575720
-
-
Paper presented at the Microbe 2016, Boston, MA
-
Lomovskaya O, Rubio-Aparicio D, Nelson K, Roberts KD, Thompson PE, Nation RL, Velkov T, Li J, Hecker SJ, Griffith DC, Dudley MN (2016) In vitro activity of Faddi-287, a representative of a novel series of polymyxins (Pm) with reduced nephrotoxic potential. Paper presented at the Microbe 2016, Boston, MA
-
(2016)
In vitro activity of Faddi-287, a representative of a novel series of polymyxins (Pm) with reduced nephrotoxic potential
-
-
Lomovskaya, O.1
Rubio-Aparicio, D.2
Nelson, K.3
Roberts, K.D.4
Thompson, P.E.5
Nation, R.L.6
Velkov, T.7
Li, J.8
Hecker, S.J.9
Griffith, D.C.10
Dudley, M.N.11
-
63
-
-
84939138677
-
Discovery of novel DNA gyrase inhibiting spiropyrimidinetriones: benzisoxazole fusion with N-linked oxazolidinone substituents leading to a clinical candidate (ETX0914)
-
COI: 1:CAS:528:DC%2BC2MXhtFCrurvL, PID: 26158756
-
Basarab GS, Doig P, Galullo V, Kern G, Kimzey A, Kutschke A, Newman JP, Morningstar M, Mueller J, Otterson L, Vishwanathan K, Zhou F, Gowravaram M (2015) Discovery of novel DNA gyrase inhibiting spiropyrimidinetriones: benzisoxazole fusion with N-linked oxazolidinone substituents leading to a clinical candidate (ETX0914). J Med Chem 58(15):6264–6282
-
(2015)
J Med Chem
, vol.58
, Issue.15
, pp. 6264-6282
-
-
Basarab, G.S.1
Doig, P.2
Galullo, V.3
Kern, G.4
Kimzey, A.5
Kutschke, A.6
Newman, J.P.7
Morningstar, M.8
Mueller, J.9
Otterson, L.10
Vishwanathan, K.11
Zhou, F.12
Gowravaram, M.13
-
64
-
-
84937047439
-
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases
-
COI: 1:CAS:528:DC%2BC2MXhtlCjsLvE, PID: 26168713
-
Basarab GS, Kern GH, McNulty J, Mueller JP, Lawrence K, Vishwanathan K, Alm RA, Barvian K, Doig P, Galullo V, Gardner H, Gowravaram M, Huband M, Kimzey A, Morningstar M, Kutschke A, Lahiri SD, Perros M, Singh R, Schuck VJ, Tommasi R, Walkup G, Newman JV (2015) Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases. Sci Rep 5:11827
-
(2015)
Sci Rep
, vol.5
, pp. 11827
-
-
Basarab, G.S.1
Kern, G.H.2
McNulty, J.3
Mueller, J.P.4
Lawrence, K.5
Vishwanathan, K.6
Alm, R.A.7
Barvian, K.8
Doig, P.9
Galullo, V.10
Gardner, H.11
Gowravaram, M.12
Huband, M.13
Kimzey, A.14
Morningstar, M.15
Kutschke, A.16
Lahiri, S.D.17
Perros, M.18
Singh, R.19
Schuck, V.J.20
Tommasi, R.21
Walkup, G.22
Newman, J.V.23
more..
-
65
-
-
84939825759
-
Pharmacodynamic profile of GSK2140944 against methicillin-resistant Staphylococcus aureus in a murine lung infection model
-
COI: 1:CAS:528:DC%2BC2MXht1OjtbrF, PID: 26055376
-
So W, Crandon JL, Nicolau DP (2015) Pharmacodynamic profile of GSK2140944 against methicillin-resistant Staphylococcus aureus in a murine lung infection model. Antimicrob Agents Chemother 59(8):4956–4961
-
(2015)
Antimicrob Agents Chemother
, vol.59
, Issue.8
, pp. 4956-4961
-
-
So, W.1
Crandon, J.L.2
Nicolau, D.P.3
-
66
-
-
84964687175
-
The metabolism and disposition of GSK2140944 in healthy human subjects
-
COI: 1:CAS:528:DC%2BC2MXhvVygtLfM, PID: 26586303
-
Negash K, Andonian C, Felgate C, Chen C, Goljer I, Squillaci B, Nguyen D, Pirhalla J, Lev M, Schubert E, Tiffany C, Hossain M, Ho M (2016) The metabolism and disposition of GSK2140944 in healthy human subjects. Xenobiotica 46(8):683–702
-
(2016)
Xenobiotica
, vol.46
, Issue.8
, pp. 683-702
-
-
Negash, K.1
Andonian, C.2
Felgate, C.3
Chen, C.4
Goljer, I.5
Squillaci, B.6
Nguyen, D.7
Pirhalla, J.8
Lev, M.9
Schubert, E.10
Tiffany, C.11
Hossain, M.12
Ho, M.13
-
67
-
-
84903762701
-
Determination of disk diffusion and MIC quality control guidelines for GSK2140944, a novel bacterial type II topoisomerase inhibitor antimicrobial agent
-
PID: 24759716
-
Ross JE, Scangarella-Oman NE, Flamm RK, Jones RN (2014) Determination of disk diffusion and MIC quality control guidelines for GSK2140944, a novel bacterial type II topoisomerase inhibitor antimicrobial agent. J Clin Microbiol 52(7):2629–2632
-
(2014)
J Clin Microbiol
, vol.52
, Issue.7
, pp. 2629-2632
-
-
Ross, J.E.1
Scangarella-Oman, N.E.2
Flamm, R.K.3
Jones, R.N.4
-
69
-
-
33749343276
-
Nadifloxacin: a quinolone for topical treatment for skin infections and potential for systemic use of its active isomer, WCK771
-
COI: 1:CAS:528:DC%2BD28XhtVartbbF, PID: 17020421
-
Jacobs MR, Appelbaum PA (2006) Nadifloxacin: a quinolone for topical treatment for skin infections and potential for systemic use of its active isomer, WCK771. Expert Opin Pharmacother 7:1957–1966
-
(2006)
Expert Opin Pharmacother
, vol.7
, pp. 1957-1966
-
-
Jacobs, M.R.1
Appelbaum, P.A.2
-
70
-
-
80051811622
-
Human pharmacokinetics and safety profile of finafloxacin, a new fluoroquinolone antibiotic, inhHealthy volunteers
-
COI: 1:CAS:528:DC%2BC3MXhtFaitr%2FP, PID: 21709093
-
Patel H, Andresen A, Vente A, Heilmann H-D, Stubbings W, Seiberling M, Lopez-Lazaro L, Pokorny R, Labischinski H (2011) Human pharmacokinetics and safety profile of finafloxacin, a new fluoroquinolone antibiotic, inhHealthy volunteers. Antimicrob Agents Chemother 55:4386–4393
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 4386-4393
-
-
Patel, H.1
Andresen, A.2
Vente, A.3
Heilmann, H.-D.4
Stubbings, W.5
Seiberling, M.6
Lopez-Lazaro, L.7
Pokorny, R.8
Labischinski, H.9
-
71
-
-
84939990273
-
Finafloxacin: first global approval
-
COI: 1:CAS:528:DC%2BC2MXlslChsbk%3D, PID: 25808831
-
McKeage K (2015) Finafloxacin: first global approval. Drugs 75(6):687–693
-
(2015)
Drugs
, vol.75
, Issue.6
, pp. 687-693
-
-
McKeage, K.1
-
72
-
-
80051819333
-
In vitro spectrum of activity of finafloxacin, a novel, pH-activated fluoroquinolone, under standard and acidic conditions
-
COI: 1:CAS:528:DC%2BC3MXhtFaitr%2FI, PID: 21709094
-
Stubbings W, Leow P, Yong GC, Goh F, Korber-Irrgang B, Kresken M, Endermann R, Labischinski H (2011) In vitro spectrum of activity of finafloxacin, a novel, pH-activated fluoroquinolone, under standard and acidic conditions. Antimicrob Agents Chemother 55(9):4394–4397
-
(2011)
Antimicrob Agents Chemother
, vol.55
, Issue.9
, pp. 4394-4397
-
-
Stubbings, W.1
Leow, P.2
Yong, G.C.3
Goh, F.4
Korber-Irrgang, B.5
Kresken, M.6
Endermann, R.7
Labischinski, H.8
-
73
-
-
84862015266
-
Safety and clinical pharmacokinetics of nemonoxacin, a novel non-fluorinated quinolone, in healthy Chinese volunteers following single and multiple oral doses
-
COI: 1:CAS:528:DC%2BC38XhtFyqu7vE, PID: 22650326
-
Guo B, Wu X, Zhang Y, Shi Y, Yu J, Cao G, Zhang J (2012) Safety and clinical pharmacokinetics of nemonoxacin, a novel non-fluorinated quinolone, in healthy Chinese volunteers following single and multiple oral doses. Clin Drug Investig 32:475–486
-
(2012)
Clin Drug Investig
, vol.32
, pp. 475-486
-
-
Guo, B.1
Wu, X.2
Zhang, Y.3
Shi, Y.4
Yu, J.5
Cao, G.6
Zhang, J.7
-
74
-
-
84945551240
-
Zabofloxacin versus moxifloxacin in patients with COPD exacerbation: a multicenter, double-blind, double-dummy, randomized, controlled, Phase III, non-inferiority trial
-
PID: 26543359
-
Rhee CK, Chang JH, Choi EG, Kim HK, Kwon YS, Kyung SY, Lee JH, Park MJ, Yoo KH, Oh YM (2015) Zabofloxacin versus moxifloxacin in patients with COPD exacerbation: a multicenter, double-blind, double-dummy, randomized, controlled, Phase III, non-inferiority trial. Int J Chron Obstruct Pulmon Dis 10:2265–2275
-
(2015)
Int J Chron Obstruct Pulmon Dis
, vol.10
, pp. 2265-2275
-
-
Rhee, C.K.1
Chang, J.H.2
Choi, E.G.3
Kim, H.K.4
Kwon, Y.S.5
Kyung, S.Y.6
Lee, J.H.7
Park, M.J.8
Yoo, K.H.9
Oh, Y.M.10
-
75
-
-
85016627639
-
-
Paper presented at the Microbe, Boston, MA
-
Totsuka K, Odajima M, Nakauchi M, Sesoko S, Nakashima M (2016) Phase I study to determine the safety and pharmacokinetics (PK) of single and multiple oral doses of lascufloxacin (AM-1977) in healthy subjects. Abstract SUNDAY-467. Paper presented at the Microbe 2016, Boston, MA
-
(2016)
(2016) Phase I study to determine the safety and pharmacokinetics (PK) of single and multiple oral doses of lascufloxacin (AM-1977) in healthy subjects. Abstract SUNDAY-467
-
-
Totsuka, K.1
Odajima, M.2
Nakauchi, M.3
Sesoko, S.4
Nakashima, M.5
-
76
-
-
85016627639
-
-
Paper presented at the Microbe, Boston, MA
-
Totsuka K, Odajima M, Nakauchi M, Sesoko S, Nakashima M (2016) Phase I study to determine the safety and pharmacokinetics (PK) of single and multiple intravenous (Iv) infusion of lascufloxacin (AM-1977) in healthy subjects. Abstract SUNDAY-470. Paper presented at the Microbe 2016, Boston, MA
-
(2016)
(2016) Phase I study to determine the safety and pharmacokinetics (PK) of single and multiple intravenous (Iv) infusion of lascufloxacin (AM-1977) in healthy subjects. Abstract SUNDAY-470
-
-
Totsuka, K.1
Odajima, M.2
Nakauchi, M.3
Sesoko, S.4
Nakashima, M.5
-
77
-
-
84922972155
-
Delafloxacin for the treatment of respiratory and skin infections
-
COI: 1:CAS:528:DC%2BC2MXisVKrtL8%3D
-
Bassetti M, Della-Siega P, Pecori D, Scarparo C, Righi E (2015) Delafloxacin for the treatment of respiratory and skin infections. Expert Opin Investig Drug 24:433–442
-
(2015)
Expert Opin Investig Drug
, vol.24
, pp. 433-442
-
-
Bassetti, M.1
Della-Siega, P.2
Pecori, D.3
Scarparo, C.4
Righi, E.5
-
78
-
-
84960395203
-
Efficacy and safety of AFN-1252, the first Staphylococcus-specific antibacterial agent, in the treatment of acute bacterial skin and skin structure infections, including those in patients with significant comorbidities
-
COI: 1:CAS:528:DC%2BC28XhsF2ntbnF
-
Hafkin B, Kaplan N, Murphy B (2016) Efficacy and safety of AFN-1252, the first Staphylococcus-specific antibacterial agent, in the treatment of acute bacterial skin and skin structure infections, including those in patients with significant comorbidities. Antimicrob Agents Chemother 60(3):1695–1701
-
(2016)
Antimicrob Agents Chemother
, vol.60
, Issue.3
, pp. 1695-1701
-
-
Hafkin, B.1
Kaplan, N.2
Murphy, B.3
-
79
-
-
34548118787
-
Antistaphylococcal activities of CG400549, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor
-
COI: 1:CAS:528:DC%2BD2sXpt1Clsr0%3D, PID: 17606482
-
Park HS, Yoon YM, Jung SJ, Kim CM, Kim JM, Kwak JH (2007) Antistaphylococcal activities of CG400549, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor. J Antimicrob Chemother 60(3):568–574
-
(2007)
J Antimicrob Chemother
, vol.60
, Issue.3
, pp. 568-574
-
-
Park, H.S.1
Yoon, Y.M.2
Jung, S.J.3
Kim, C.M.4
Kim, J.M.5
Kwak, J.H.6
-
80
-
-
33644508373
-
Dihydrofolate reductase inhibitors as antibacterial agents
-
COI: 1:CAS:528:DC%2BD28XitVKju74%3D, PID: 16359642
-
Hawser S, Lociuro S, Islam K (2006) Dihydrofolate reductase inhibitors as antibacterial agents. Biochem Pharmacol 71(7):941–948
-
(2006)
Biochem Pharmacol
, vol.71
, Issue.7
, pp. 941-948
-
-
Hawser, S.1
Lociuro, S.2
Islam, K.3
-
81
-
-
84255195549
-
Understanding the regulatory hurdles for antibacterial drug development in the post-Ketek world
-
Echols RM (2011) Understanding the regulatory hurdles for antibacterial drug development in the post-Ketek world. Ann N Y Acad Sci 1:153–161
-
(2011)
Ann N Y Acad Sci
, vol.1
, pp. 153-161
-
-
Echols, R.M.1
-
83
-
-
78649634087
-
The in vitro evaluation of solithromycin (CEM-101) against pathogens isolated in the United States and Europe (2009)
-
PID: 20831882
-
Farrell DJ, Castanheira M, Sader HS, Jones RN (2010) The in vitro evaluation of solithromycin (CEM-101) against pathogens isolated in the United States and Europe (2009). J Infect 61(6):476–483
-
(2010)
J Infect
, vol.61
, Issue.6
, pp. 476-483
-
-
Farrell, D.J.1
Castanheira, M.2
Sader, H.S.3
Jones, R.N.4
-
84
-
-
84958884211
-
The role of solithromycin in the management of bacterial community-acquired pneumonia
-
Van Bambeke F, Tulkens PM (2016) The role of solithromycin in the management of bacterial community-acquired pneumonia. Expert Rev Antiinfective Ther 14(3):311–324
-
(2016)
Expert Rev Antiinfective Ther
, vol.14
, Issue.3
, pp. 311-324
-
-
Van Bambeke, F.1
Tulkens, P.M.2
-
85
-
-
84255201077
-
Antibiotics in development targeting protein synthesis
-
Sutcliffe JA (2011) Antibiotics in development targeting protein synthesis. Ann N Y Acad Sci 1:122–152
-
(2011)
Ann N Y Acad Sci
, vol.1
, pp. 122-152
-
-
Sutcliffe, J.A.1
-
86
-
-
84962436650
-
Tetracycline antibiotics and resistance
-
PID: 26989065
-
Grossman TH (2016) Tetracycline antibiotics and resistance. Cold Spring Harb Perspect Med 6(4):a025387
-
(2016)
Cold Spring Harb Perspect Med
, vol.6
, Issue.4
, pp. a025387
-
-
Grossman, T.H.1
-
87
-
-
84893487652
-
In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline
-
COI: 1:CAS:528:DC%2BC2cXjtVSrur8%3D, PID: 24295985
-
Macone AB, Caruso BK, Leahy RG, Donatelli J, Weir S, Draper MP, Tanaka SK, Levy SB (2014) In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline. Antimicrob Agents Chemother 58(2):1127–1135
-
(2014)
Antimicrob Agents Chemother
, vol.58
, Issue.2
, pp. 1127-1135
-
-
Macone, A.B.1
Caruso, B.K.2
Leahy, R.G.3
Donatelli, J.4
Weir, S.5
Draper, M.P.6
Tanaka, S.K.7
Levy, S.B.8
-
89
-
-
84905393404
-
Carbapenem-resistant Klebsiella pneumoniae strains exhibit diversity in aminoglycoside-modifying enzymes, which exert differing effects on plazomicin and other agents
-
PID: 24867988
-
Almaghrabi R, Clancy CJ, Doi Y, Hao B, Chen L, Shields RK, Press EG, Iovine NM, Townsend BM, Wagener MM, Kreiswirth B, Nguyen MH (2014) Carbapenem-resistant Klebsiella pneumoniae strains exhibit diversity in aminoglycoside-modifying enzymes, which exert differing effects on plazomicin and other agents. Antimicrob Agents Chemother 58(8):4443–4451
-
(2014)
Antimicrob Agents Chemother
, vol.58
, Issue.8
, pp. 4443-4451
-
-
Almaghrabi, R.1
Clancy, C.J.2
Doi, Y.3
Hao, B.4
Chen, L.5
Shields, R.K.6
Press, E.G.7
Iovine, N.M.8
Townsend, B.M.9
Wagener, M.M.10
Kreiswirth, B.11
Nguyen, M.H.12
-
90
-
-
84885921693
-
Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens
-
COI: 1:CAS:528:DC%2BC3sXhs1KjtrzM, PID: 23979750
-
Sutcliffe JA, O’Brien W, Fyfe C, Grossman TH (2013) Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens. Antimicrob Agents Chemother 57(11):5548–5558
-
(2013)
Antimicrob Agents Chemother
, vol.57
, Issue.11
, pp. 5548-5558
-
-
Sutcliffe, J.A.1
O’Brien, W.2
Fyfe, C.3
Grossman, T.H.4
-
91
-
-
78650378928
-
Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates
-
COI: 1:CAS:528:DC%2BC3cXhsFylurvN, PID: 21078604
-
Livermore DM, Mushtaq S, Warner M, Zhang JC, Maharjan S, Doumith M, Woodford N (2011) Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates. J Antimicrob Chemother 66(1):48–53
-
(2011)
J Antimicrob Chemother
, vol.66
, Issue.1
, pp. 48-53
-
-
Livermore, D.M.1
Mushtaq, S.2
Warner, M.3
Zhang, J.C.4
Maharjan, S.5
Doumith, M.6
Woodford, N.7
-
92
-
-
85016636692
-
Tetraphase announces top-line results From IGNITE2 Phase 3 clinical trial of eravacycline in cUTI
-
Pharmaceuticals T (2015) Tetraphase announces top-line results From IGNITE2 Phase 3 clinical trial of eravacycline in cUTI. Sept 8:2015
-
(2015)
Sept
, vol.8
, pp. 2015
-
-
Pharmaceuticals, T.1
-
93
-
-
85016569591
-
-
Paper presented at the Microbe, Boston, MA
-
Tsai L, Zervos M, Miller L, Tenke P, Marsh A, Mohr J, Luepke K, Horn P (2016) Intravenous eravacycline with transition to oral therapy for treatment of complicated urinary tract infections (cUTI) including pyelonephritis: Results from a randomized, double-blind, multicenter, Phase 3 trial (IGNITE2). Abstract MONDAY-264. Paper presented at the Microbe 2016, Boston, MA
-
(2016)
(2016) Intravenous eravacycline with transition to oral therapy for treatment of complicated urinary tract infections (cUTI) including pyelonephritis: Results from a randomized, double-blind, multicenter, Phase 3 trial (IGNITE2). Abstract MONDAY-264
-
-
Tsai, L.1
Zervos, M.2
Miller, L.3
Tenke, P.4
Marsh, A.5
Mohr, J.6
Luepke, K.7
Horn, P.8
-
94
-
-
85016578373
-
Tetraphase Pharmaceuticals provides update on eravacycline regulatory and development status
-
Tetraphase Pharmaceuticals (2016) Tetraphase Pharmaceuticals provides update on eravacycline regulatory and development status. 12 May 2016
-
(2016)
12 May 2016
-
-
Pharmaceuticals, T.1
-
95
-
-
84882334233
-
Antimicrobial activity of the pleuromutilin antibiotic BC-3781 against bacterial pathogens isolated in the SENTRY antimicrobial surveillance program in 2010
-
COI: 1:CAS:528:DC%2BC3sXhtlSns7bF, PID: 23836172
-
Paukner S, Sader HS, Ivezic-Schoenfeld Z, Jones RN (2013) Antimicrobial activity of the pleuromutilin antibiotic BC-3781 against bacterial pathogens isolated in the SENTRY antimicrobial surveillance program in 2010. Antimicrob Agents Chemother 57(9):4489–4495
-
(2013)
Antimicrob Agents Chemother
, vol.57
, Issue.9
, pp. 4489-4495
-
-
Paukner, S.1
Sader, H.S.2
Ivezic-Schoenfeld, Z.3
Jones, R.N.4
-
96
-
-
84857183374
-
Antimicrobial activity of the investigational pleuromutilin compound BC-3781 tested against Gram-positive organisms commonly associated with acute bacterial skin and skin structure infections
-
COI: 1:CAS:528:DC%2BC38XjsVKltb8%3D, PID: 22232289
-
Sader HS, Biedenbach DJ, Paukner S, Ivezic-Schoenfeld Z, Jones RN (2012) Antimicrobial activity of the investigational pleuromutilin compound BC-3781 tested against Gram-positive organisms commonly associated with acute bacterial skin and skin structure infections. Antimicrob Agents Chemother 56(3):1619–1623
-
(2012)
Antimicrob Agents Chemother
, vol.56
, Issue.3
, pp. 1619-1623
-
-
Sader, H.S.1
Biedenbach, D.J.2
Paukner, S.3
Ivezic-Schoenfeld, Z.4
Jones, R.N.5
-
97
-
-
84859590529
-
Antimicrobial activity of the novel pleuromutilin antibiotic BC-3781 against organisms responsible for community-acquired respiratory tract infections (CARTIs)
-
COI: 1:CAS:528:DC%2BC38Xlt1GnsLs%3D, PID: 22287234
-
Sader HS, Paukner S, Ivezic-Schoenfeld Z, Biedenbach DJ, Schmitz FJ, Jones RN (2012) Antimicrobial activity of the novel pleuromutilin antibiotic BC-3781 against organisms responsible for community-acquired respiratory tract infections (CARTIs). J Antimicrob Chemother 67(5):1170–1175
-
(2012)
J Antimicrob Chemother
, vol.67
, Issue.5
, pp. 1170-1175
-
-
Sader, H.S.1
Paukner, S.2
Ivezic-Schoenfeld, Z.3
Biedenbach, D.J.4
Schmitz, F.J.5
Jones, R.N.6
-
98
-
-
85016628320
-
TP-271 is a potent, broad-spectrum fluorocycline with activity against community-acquired bacterial respiratory and biothreat pathogens
-
Paper presented at the Interscience conference on antimicrobial agents & chemotherapy, San Francisco, CA
-
Grossman TH, Fyfe C, Brien WO, Hackel M, Sutcliffe JA (2012) TP-271 is a potent, broad-spectrum fluorocycline with activity against community-acquired bacterial respiratory and biothreat pathogens. Abstract F-1525. Paper presented at the Interscience conference on antimicrobial agents & chemotherapy, San Francisco, CA
-
(2012)
Abstract F-1525
-
-
Grossman, T.H.1
Fyfe, C.2
Brien, W.O.3
Hackel, M.4
Sutcliffe, J.A.5
-
99
-
-
85016625834
-
Tetraphase Pharmaceuticals initiates Phase 1 clinical trial for TP-271
-
Tetraphase Pharmaceuticals (2016) Tetraphase Pharmaceuticals initiates Phase 1 clinical trial for TP-271. 19 Jan 2016
-
(2016)
19 Jan 2016
-
-
Pharmaceuticals, T.1
-
100
-
-
84890914803
-
Efficient antibacterial agents: a review of the synthesis, biological evaluation and mechanism of pleuromutilin derivatives
-
COI: 1:CAS:528:DC%2BC2cXitlarug%3D%3D, PID: 24200363
-
Shang R, Wang J, Guo W, Liang J (2013) Efficient antibacterial agents: a review of the synthesis, biological evaluation and mechanism of pleuromutilin derivatives. Curr Top Med Chem 13(24):3013–3025
-
(2013)
Curr Top Med Chem
, vol.13
, Issue.24
, pp. 3013-3025
-
-
Shang, R.1
Wang, J.2
Guo, W.3
Liang, J.4
-
101
-
-
85016571249
-
-
Paper presented at the Microbe, Boston, MA
-
Satav JS, Takalkar SS, Kulkarni AM, Bhagwat SS, Patel MV (2016) WCK 4873 (Nafithromycin): in vitro and in vivo activity of novel lactone-ketolide, against clinically relevant S. pneumoniae (SPN) resistotypes and methicillin-sensitive S. aureus (MSSA). Abstract SATURDAY-456. Paper presented at the Microbe 2016, Boston, MA
-
(2016)
(2016) WCK 4873 (Nafithromycin): in vitro and in vivo activity of novel lactone-ketolide, against clinically relevant S. pneumoniae (SPN) resistotypes and methicillin-sensitive S. aureus (MSSA). Abstract SATURDAY-456
-
-
Satav, J.S.1
Takalkar, S.S.2
Kulkarni, A.M.3
Bhagwat, S.S.4
Patel, M.V.5
-
102
-
-
85016645150
-
-
Paper presented at the MMcrobe, Boston, MA
-
Chugh R, Gupta M, Iwanowski P, Bhatia A (2016) Nafithromycin Phase 1 multiple ascending dose study in healthy subjects. Abstract MONDAY-513. Paper presented at the MMcrobe 2016, Boston, MA
-
(2016)
(2016) Nafithromycin Phase 1 multiple ascending dose study in healthy subjects. Abstract MONDAY-513
-
-
Chugh, R.1
Gupta, M.2
Iwanowski, P.3
Bhatia, A.4
-
103
-
-
0033402097
-
Penicillin-binding protein-mediated resistance in pneumococci and staphylococci
-
COI: 1:CAS:528:DyaK1MXhvVOktrg%3D, PID: 10081507
-
Chambers HF (1999) Penicillin-binding protein-mediated resistance in pneumococci and staphylococci. J Infect Dis 179(Suppl 2):S353–S359
-
(1999)
J Infect Dis
, vol.179
, pp. S353-S359
-
-
Chambers, H.F.1
-
104
-
-
0021940223
-
A perspective on the present contribution of beta-lactamases to bacterial resistance with particular reference to induction of beta-lactamase and its clinical significance
-
COI: 1:STN:280:DyaL2M7nslWjtA%3D%3D, PID: 3872725
-
Neu HC, Chin NX (1985) A perspective on the present contribution of beta-lactamases to bacterial resistance with particular reference to induction of beta-lactamase and its clinical significance. Chemioterapia 4(1):63–70
-
(1985)
Chemioterapia
, vol.4
, Issue.1
, pp. 63-70
-
-
Neu, H.C.1
Chin, N.X.2
-
105
-
-
33747795961
-
What’s new in antibiotic resistance? Focus on beta-lactamases
-
COI: 1:CAS:528:DC%2BD28XoslOgur0%3D
-
Babic M, Hujer AM, Bonomo RA (2006) What’s new in antibiotic resistance? Focus on beta-lactamases. Drug Resist Updates 9(3):142–156
-
(2006)
Drug Resist Updates
, vol.9
, Issue.3
, pp. 142-156
-
-
Babic, M.1
Hujer, A.M.2
Bonomo, R.A.3
-
106
-
-
79952111025
-
Bench-to-bedside review: the role of beta-lactamases in antibiotic-resistant Gram-negative infections
-
PID: 20594363
-
Bush K (2010) Bench-to-bedside review: the role of beta-lactamases in antibiotic-resistant Gram-negative infections. Crit Care 14(3):224–231
-
(2010)
Crit Care
, vol.14
, Issue.3
, pp. 224-231
-
-
Bush, K.1
-
107
-
-
35848954104
-
Resistance mechanisms of multiresistant Pseudomonas aeruginosa strains from Germany and correlation with hypermutation
-
COI: 1:CAS:528:DC%2BD2sXht1ygtL3P, PID: 17876002
-
Henrichfreise B, Wiegand I, Pfister W, Wiedemann B (2007) Resistance mechanisms of multiresistant Pseudomonas aeruginosa strains from Germany and correlation with hypermutation. Antimicrob Agents Chemother 51(11):4062–4070
-
(2007)
Antimicrob Agents Chemother
, vol.51
, Issue.11
, pp. 4062-4070
-
-
Henrichfreise, B.1
Wiegand, I.2
Pfister, W.3
Wiedemann, B.4
-
108
-
-
84963720944
-
Association of novel nonsynonymous single nucleotide polymorphisms in ampD with cephalosporin resistance and phylogenetic variations in ampC, ampR, ompF, and ompC in Enterobacter cloacae isolates that are highly resistant to carbapenems
-
PID: 26856839
-
Babouee Flury B, Ellington MJ, Hopkins KL, Turton JF, Doumith M, Loy R, Staves P, Hinic V, Frei R, Woodford N (2016) Association of novel nonsynonymous single nucleotide polymorphisms in ampD with cephalosporin resistance and phylogenetic variations in ampC, ampR, ompF, and ompC in Enterobacter cloacae isolates that are highly resistant to carbapenems. Antimicrob Agents Chemother 60(4):2383–2390
-
(2016)
Antimicrob Agents Chemother
, vol.60
, Issue.4
, pp. 2383-2390
-
-
Babouee Flury, B.1
Ellington, M.J.2
Hopkins, K.L.3
Turton, J.F.4
Doumith, M.5
Loy, R.6
Staves, P.7
Hinic, V.8
Frei, R.9
Woodford, N.10
-
109
-
-
84882270910
-
Carbapenemases: partners in crime
-
PID: 27873609
-
Bush K (2013) Carbapenemases: partners in crime. J Glob Antimicrob Resist 1:7–16
-
(2013)
J Glob Antimicrob Resist
, vol.1
, pp. 7-16
-
-
Bush, K.1
-
110
-
-
0033561956
-
Inhibitor resistant class A beta-lactamases
-
COI: 1:CAS:528:DyaK1MXlt1Whs7c%3D, PID: 10331993
-
Bonomo RA, Rice LB (1999) Inhibitor resistant class A beta-lactamases. Front Biosci 4:e34–e41
-
(1999)
Front Biosci
, vol.4
, pp. e34-e41
-
-
Bonomo, R.A.1
Rice, L.B.2
-
111
-
-
84929587395
-
Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U.S. hospitals (2011 to 2013) and characterization of β-lactamase-producing strains
-
COI: 1:CAS:528:DC%2BC2MXptlKmt7w%3D, PID: 25845862
-
Castanheira M, Mills JC, Costello SE, Jones RN, Sader HS (2015) Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U.S. hospitals (2011 to 2013) and characterization of β-lactamase-producing strains. Antimicrob Agents Chemother 59:3509–3517
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 3509-3517
-
-
Castanheira, M.1
Mills, J.C.2
Costello, S.E.3
Jones, R.N.4
Sader, H.S.5
-
112
-
-
84921797970
-
Unexpected challenges in treating multidrug-resistant Gram-negative bacteria: resistance to ceftazidime-avibactam in archived isolates of Pseudomonas aeruginosa
-
COI: 1:CAS:528:DC%2BC2MXit1KrsLY%3D, PID: 25451057
-
Winkler ML, Papp-Wallace KM, Hujer AM, Domitrovic TN, Hujer KM, Hurless KN, Tuohy M, Halld G, Bonomo RA (2015) Unexpected challenges in treating multidrug-resistant Gram-negative bacteria: resistance to ceftazidime-avibactam in archived isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother 59(2):1020–1029
-
(2015)
Antimicrob Agents Chemother
, vol.59
, Issue.2
, pp. 1020-1029
-
-
Winkler, M.L.1
Papp-Wallace, K.M.2
Hujer, A.M.3
Domitrovic, T.N.4
Hujer, K.M.5
Hurless, K.N.6
Tuohy, M.7
Halld, G.8
Bonomo, R.A.9
-
113
-
-
85016606800
-
-
Abstract FRIDAY-480. Paper presented at the Microbe 2016, Boston, MA
-
Clowes A, Lam M, Hamula C, Dingle T (2016) In vitro susceptibility of a collection of carbapenem-resistant Enterobacteriaceae and Pseudomonas aeruginosa to ceftazidime/avibactam and ceftolozane/tazobactam. Abstract FRIDAY-480. Paper presented at the Microbe 2016, Boston, MA
-
(2016)
In vitro susceptibility of a collection of carbapenem-resistant Enterobacteriaceae and Pseudomonas aeruginosa to ceftazidime/avibactam and ceftolozane/tazobactam
-
-
Clowes, A.1
Lam, M.2
Hamula, C.3
Dingle, T.4
-
114
-
-
84929742152
-
Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3
-
COI: 1:CAS:528:DC%2BC2MXhsFegs7jN, PID: 25634992
-
Alm RA, Johnstone MR, Lahiri SD (2015) Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3. J Antimicrob Chemother 70(5):1420–1428
-
(2015)
J Antimicrob Chemother
, vol.70
, Issue.5
, pp. 1420-1428
-
-
Alm, R.A.1
Johnstone, M.R.2
Lahiri, S.D.3
-
115
-
-
84930510339
-
Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC
-
COI: 1:CAS:528:DC%2BC2MXhsFaiurfI, PID: 25645206
-
Lahiri SD, Walkup GK, Whiteaker JD, Palmer T, McCormack K, Tanudra MA, Nash TJ, Thresher J, Johnstone MR, Hajec L, Livchak S, McLaughlin RE, Alm RA (2015) Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC. J Antimicrob Chemother 70(6):1650–1658
-
(2015)
J Antimicrob Chemother
, vol.70
, Issue.6
, pp. 1650-1658
-
-
Lahiri, S.D.1
Walkup, G.K.2
Whiteaker, J.D.3
Palmer, T.4
McCormack, K.5
Tanudra, M.A.6
Nash, T.J.7
Thresher, J.8
Johnstone, M.R.9
Hajec, L.10
Livchak, S.11
McLaughlin, R.E.12
Alm, R.A.13
-
116
-
-
84940901399
-
In vitro selection of ceftazidime-avibactam resistance in Enterobacteriaceae with KPC-3 carbapenemase
-
COI: 1:CAS:528:DC%2BC2MXhtlyit7rO, PID: 26100712
-
Livermore DM, Warner M, Jamrozy D, Mushtaq S, Nichols WW, Mustafa N, Woodford N (2015) In vitro selection of ceftazidime-avibactam resistance in Enterobacteriaceae with KPC-3 carbapenemase. Antimicrob Agents Chemother 59(9):5324–5330
-
(2015)
Antimicrob Agents Chemother
, vol.59
, Issue.9
, pp. 5324-5330
-
-
Livermore, D.M.1
Warner, M.2
Jamrozy, D.3
Mushtaq, S.4
Nichols, W.W.5
Mustafa, N.6
Woodford, N.7
-
117
-
-
84941168496
-
Mutations in ß-lactamase AmpC increase resistance of Pseudomonas aeruginosa isolates to antipseudomonal cephalosporins
-
COI: 1:CAS:528:DC%2BC28Xht1yhurw%3D, PID: 26248364
-
Berrazeg M, Jeannot K, Enguéné VYN, Broutin I, Loeffert S, Fournier D, Plésiat P (2015) Mutations in ß-lactamase AmpC increase resistance of Pseudomonas aeruginosa isolates to antipseudomonal cephalosporins. Antimicrob Agents Chemother 59(10):6248–6255
-
(2015)
Antimicrob Agents Chemother
, vol.59
, Issue.10
, pp. 6248-6255
-
-
Berrazeg, M.1
Jeannot, K.2
Enguéné, V.Y.N.3
Broutin, I.4
Loeffert, S.5
Fournier, D.6
Plésiat, P.7
-
118
-
-
84908582594
-
Mutation-driven beta-lactam resistance mechanisms among contemporary ceftazidime-nonsusceptible Pseudomonas aeruginosa isolates from U.S. hospitals
-
PID: 25182652
-
Castanheira M, Mills JC, Farrell DJ, Jones RN (2014) Mutation-driven beta-lactam resistance mechanisms among contemporary ceftazidime-nonsusceptible Pseudomonas aeruginosa isolates from U.S. hospitals. Antimicrob Agents Chemother 58(11):6844–6850
-
(2014)
Antimicrob Agents Chemother
, vol.58
, Issue.11
, pp. 6844-6850
-
-
Castanheira, M.1
Mills, J.C.2
Farrell, D.J.3
Jones, R.N.4
-
119
-
-
84901280909
-
Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of AmpC
-
PID: 24637685
-
Cabot G, Bruchmann S, Mulet X, Zamorano L, Moya B, Juan C, Haussler S, Oliver A (2014) Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of AmpC. Antimicrob Agents Chemother 58(6):3091–3099
-
(2014)
Antimicrob Agents Chemother
, vol.58
, Issue.6
, pp. 3091-3099
-
-
Cabot, G.1
Bruchmann, S.2
Mulet, X.3
Zamorano, L.4
Moya, B.5
Juan, C.6
Haussler, S.7
Oliver, A.8
-
120
-
-
84940937491
-
Effects of Klebsiella pneumoniae carbapenemase subtypes, etended-spectrum β-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae
-
COI: 1:CAS:528:DC%2BC2MXhtlyit7%2FI, PID: 26169413
-
Shields RK, Clancy CJ, Hao B, Chen L, Press EG, Iovine NM, Kreiswirth BN, Nguyen MH (2015) Effects of Klebsiella pneumoniae carbapenemase subtypes, etended-spectrum β-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae. Antimicrob Agents Chemother 59:5793–5797
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 5793-5797
-
-
Shields, R.K.1
Clancy, C.J.2
Hao, B.3
Chen, L.4
Press, E.G.5
Iovine, N.M.6
Kreiswirth, B.N.7
Nguyen, M.H.8
-
121
-
-
84942903035
-
First report of ceftazidime-avibactam resistance in a KPC-3 expressing Klebsiella pneumoniae
-
Humphries RM, Yang S, Hemarajata P, Ward KW, Hindler JA, Miller SA, Gregson A (2015) First report of ceftazidime-avibactam resistance in a KPC-3 expressing Klebsiella pneumoniae. Antimicrob Agents Chemother (Posted Online 20 July 2015)
-
(2015)
Antimicrob Agents Chemother (Posted Online 20 July
, pp. 2015
-
-
Humphries, R.M.1
Yang, S.2
Hemarajata, P.3
Ward, K.W.4
Hindler, J.A.5
Miller, S.A.6
Gregson, A.7
-
122
-
-
85016619705
-
-
American Society for Microbiology, Boston, MA
-
Haidar G, Clancy CJ, Shields RK, Doi Y, Potoski BA, Nguyen MH (2016) Ceftolozane-tazobactam (C/T) is effective against most multidrug-resistant (Mdr) P. aeruginosa (pa) infections, but resistance may emerge on therapy. Abstract SUNDAY-331. Microbe 2016. American Society for Microbiology, Boston, MA
-
(2016)
(2016) Ceftolozane-tazobactam (C/T) is effective against most multidrug-resistant (Mdr) P. aeruginosa (pa) infections, but resistance may emerge on therapy. Abstract SUNDAY-331. Microbe
-
-
Haidar, G.1
Clancy, C.J.2
Shields, R.K.3
Doi, Y.4
Potoski, B.A.5
Nguyen, M.H.6
-
123
-
-
84945444280
-
Mechanisms of drug resistance: quinolone resistance
-
COI: 1:CAS:528:DC%2BC2MXhslOksbrI, PID: 26190223
-
Hooper DC, Jacoby GA (2015) Mechanisms of drug resistance: quinolone resistance. Ann N Y Acad Sci 1354:12–31
-
(2015)
Ann N Y Acad Sci
, vol.1354
, pp. 12-31
-
-
Hooper, D.C.1
Jacoby, G.A.2
-
124
-
-
77957764600
-
Synthesis and spectrum of the neoglycoside ACHN-490
-
COI: 1:CAS:528:DC%2BC3cXhsVCitrzO, PID: 20805391
-
Aggen JB, Armstrong ES, Goldblum AA, Dozzo P, Linsell MS, Gliedt MJ, Hildebrandt DJ, Feeney LA, Kubo A, Matias RD, Lopez S, Gomez M, Wlasichuk KB, Diokno R, Miller GH, Moser HE (2010) Synthesis and spectrum of the neoglycoside ACHN-490. Antimicrob Agents Chemother 54(11):4636–4642
-
(2010)
Antimicrob Agents Chemother
, vol.54
, Issue.11
, pp. 4636-4642
-
-
Aggen, J.B.1
Armstrong, E.S.2
Goldblum, A.A.3
Dozzo, P.4
Linsell, M.S.5
Gliedt, M.J.6
Hildebrandt, D.J.7
Feeney, L.A.8
Kubo, A.9
Matias, R.D.10
Lopez, S.11
Gomez, M.12
Wlasichuk, K.B.13
Diokno, R.14
Miller, G.H.15
Moser, H.E.16
-
125
-
-
84957433508
-
Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study
-
PID: 26603172
-
Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, Yu LF, Gu D, Ren H, Chen X, Lv L, He D, Zhou H, Liang Z, Liu JH, Shen J (2016) Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 16(2):161–168
-
(2016)
Lancet Infect Dis
, vol.16
, Issue.2
, pp. 161-168
-
-
Liu, Y.Y.1
Wang, Y.2
Walsh, T.R.3
Yi, L.X.4
Zhang, R.5
Spencer, J.6
Doi, Y.7
Tian, G.8
Dong, B.9
Huang, X.10
Yu, L.F.11
Gu, D.12
Ren, H.13
Chen, X.14
Lv, L.15
He, D.16
Zhou, H.17
Liang, Z.18
Liu, J.H.19
Shen, J.20
more..
-
126
-
-
0030239964
-
Bacterial lipopolysaccharides—themes and variations
-
COI: 1:CAS:528:DyaK2sXhvFCmtbk%3D, PID: 9082453
-
Wilkinson SG (1996) Bacterial lipopolysaccharides—themes and variations. Prog Lipid Res 35:283–343
-
(1996)
Prog Lipid Res
, vol.35
, pp. 283-343
-
-
Wilkinson, S.G.1
-
127
-
-
0347479229
-
Molecular basis of bacterial outer membrane permeability revisited
-
COI: 1:CAS:528:DC%2BD2cXmt1Sqsg%3D%3D, PID: 14665678
-
Nikaido H (2003) Molecular basis of bacterial outer membrane permeability revisited. Microbiol Mol Biol Rev 67:593–656
-
(2003)
Microbiol Mol Biol Rev
, vol.67
, pp. 593-656
-
-
Nikaido, H.1
-
128
-
-
84870187315
-
The role of the outer membrane of Gram-negative bacteria in antibiotic resistance: Ajax’ Shield or Achilles’ heel?
-
Springer, Berlin
-
Page MGP (2012) The role of the outer membrane of Gram-negative bacteria in antibiotic resistance: Ajax’ Shield or Achilles’ heel? In: Handbook of experimental pharmacology, vol 211. Springer, Berlin
-
(2012)
Handbook of experimental pharmacology
, vol.211
-
-
Page, M.G.P.1
-
129
-
-
0017227534
-
Outer membrane of Salmonella typhimurium. Transmembrane diffusion of some hydrophobic substances
-
COI: 1:CAS:528:DyaE28XhsVOguro%3D, PID: 769835
-
Nikaido H (1976) Outer membrane of Salmonella typhimurium. Transmembrane diffusion of some hydrophobic substances. Biochim Biophys Acta 433:118–132
-
(1976)
Biochim Biophys Acta
, vol.433
, pp. 118-132
-
-
Nikaido, H.1
-
130
-
-
0029199795
-
Isolation of antibiotic hypersusceptibility mutants of Acinetobacter spp. by selection for DNA release
-
COI: 1:CAS:528:DyaK2MXmt1Sntbk%3D, PID: 7540714
-
Palomar J, Puig M, Montilla R, Loren JG, Vinas M (1995) Isolation of antibiotic hypersusceptibility mutants of Acinetobacter spp. by selection for DNA release. Microbios 82:21–26
-
(1995)
Microbios
, vol.82
, pp. 21-26
-
-
Palomar, J.1
Puig, M.2
Montilla, R.3
Loren, J.G.4
Vinas, M.5
-
131
-
-
0031741283
-
The lipopolysaccharide of Bordetella bronchiseptica acts as a protective shield against antimicrobial peptides
-
COI: 1:CAS:528:DyaK1cXnvVCht7c%3D, PID: 9826332
-
Banemann A, Deppisch H, Gross R (1998) The lipopolysaccharide of Bordetella bronchiseptica acts as a protective shield against antimicrobial peptides. Infect Immun 66:5607–5612
-
(1998)
Infect Immun
, vol.66
, pp. 5607-5612
-
-
Banemann, A.1
Deppisch, H.2
Gross, R.3
-
132
-
-
0345528960
-
Structure of bacterial lipopolysaccharides
-
COI: 1:CAS:528:DC%2BD3sXps1egtrg%3D, PID: 14670707
-
Caroff M, Karibian D (2003) Structure of bacterial lipopolysaccharides. Carbohydr Res 338:2431–2447
-
(2003)
Carbohydr Res
, vol.338
, pp. 2431-2447
-
-
Caroff, M.1
Karibian, D.2
-
133
-
-
0021989093
-
Molecular basis of bacterial outer membrane permeability
-
COI: 1:CAS:528:DyaL2MXhvVWqur4%3D, PID: 2580220
-
Nikaido H, Vaara M (1985) Molecular basis of bacterial outer membrane permeability. Microbiol Rev 49(1):1–32
-
(1985)
Microbiol Rev
, vol.49
, Issue.1
, pp. 1-32
-
-
Nikaido, H.1
Vaara, M.2
-
135
-
-
0026604214
-
Comparison of the phenotypes of the lpxA and lpxD mutants of Escherichia coli
-
COI: 1:CAS:528:DyaK38XisFWqtbY%3D, PID: 1503445
-
Vuorio R, Vaara M (1992) Comparison of the phenotypes of the lpxA and lpxD mutants of Escherichia coli. Antimicrob Agents Chemother 36:826–829
-
(1992)
Antimicrob Agents Chemother
, vol.36
, pp. 826-829
-
-
Vuorio, R.1
Vaara, M.2
-
136
-
-
0027409501
-
Outer membrane permeability barrier to azithromycin, clarithromycin, and roxithromycin in Gram-negative enteric bacteria
-
COI: 1:CAS:528:DyaK3sXhsVehurg%3D
-
Vaara M (1993) Outer membrane permeability barrier to azithromycin, clarithromycin, and roxithromycin in Gram-negative enteric bacteria. Antimicrobial Agents Chemother 37(2):354–356
-
(1993)
Antimicrobial Agents Chemother
, vol.37
, Issue.2
, pp. 354-356
-
-
Vaara, M.1
-
137
-
-
0035900775
-
An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-l-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor
-
COI: 1:CAS:528:DC%2BD3MXptleltr0%3D, PID: 11535604
-
Trent MS, Ribeiro AA, Lin S, Cotter RJ, Raetz CR (2001) An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-l-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor. J Biol Chem 276(46):43122–43131
-
(2001)
J Biol Chem
, vol.276
, Issue.46
, pp. 43122-43131
-
-
Trent, M.S.1
Ribeiro, A.A.2
Lin, S.3
Cotter, R.J.4
Raetz, C.R.5
-
138
-
-
3042513872
-
The PmrA-regulated pmrC gene mediates phosphoethanolamine modification of lipid A and polymyxin resistance in Salmonella enterica
-
COI: 1:CAS:528:DC%2BD2cXlt1Omsrw%3D, PID: 15205413
-
Lee H, Hsu FF, Turk J, Groisman EA (2004) The PmrA-regulated pmrC gene mediates phosphoethanolamine modification of lipid A and polymyxin resistance in Salmonella enterica. J Bacteriol 186:4124–4133
-
(2004)
J Bacteriol
, vol.186
, pp. 4124-4133
-
-
Lee, H.1
Hsu, F.F.2
Turk, J.3
Groisman, E.A.4
-
139
-
-
37249025572
-
An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli
-
COI: 1:CAS:528:DC%2BD2sXhtlKrsbjM, PID: 17928292
-
Yan A, Guan Z, Raetz CRH (2007) An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. J Biol Chem 282:36077–36089
-
(2007)
J Biol Chem
, vol.282
, pp. 36077-36089
-
-
Yan, A.1
Guan, Z.2
Raetz, C.R.H.3
-
140
-
-
13144306075
-
Role of Mg2 + and pH in the modification of Salmonella lipid A after endocytosis by macrophage tumour cells
-
COI: 1:CAS:528:DC%2BD2MXhtVWgt7Y%3D
-
Gibbons HS, Kalb SR, Cotter RJ, Raetz CRH (2005) Role of Mg2 + and pH in the modification of Salmonella lipid A after endocytosis by macrophage tumour cells. Molec Microbiol 55:425–440
-
(2005)
Molec Microbiol
, vol.55
, pp. 425-440
-
-
Gibbons, H.S.1
Kalb, S.R.2
Cotter, R.J.3
Raetz, C.R.H.4
-
141
-
-
0023193236
-
Role of porins in intrinsic antibiotic resistance of Pseudomonas cepacia
-
COI: 1:CAS:528:DyaL2sXpvFSmsA%3D%3D, PID: 3032087
-
Parr TR Jr, Moore RA, Moore LV, Hancock REW (1987) Role of porins in intrinsic antibiotic resistance of Pseudomonas cepacia. Antimicrob Agents Chemother 31:121–123
-
(1987)
Antimicrob Agents Chemother
, vol.31
, pp. 121-123
-
-
Parr, T.R.1
Moore, R.A.2
Moore, L.V.3
Hancock, R.E.W.4
-
142
-
-
0032959773
-
Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids
-
COI: 1:CAS:528:DyaK1MXjtVejsr0%3D, PID: 10223918
-
Ochs MM, McCusker MP, Bains M, Hancock RE (1999) Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids. Antimicrob Agents Chemother 43(5):1085–1090
-
(1999)
Antimicrob Agents Chemother
, vol.43
, Issue.5
, pp. 1085-1090
-
-
Ochs, M.M.1
McCusker, M.P.2
Bains, M.3
Hancock, R.E.4
-
143
-
-
0042856480
-
The role of Serratia marcescens porins in antibiotic resistance
-
COI: 1:CAS:528:DC%2BD3sXmvFamsrc%3D, PID: 12959404
-
Ruiz N, Montero T, Hernandez-Borrell J, Vinas M (2003) The role of Serratia marcescens porins in antibiotic resistance. Microb Drug Resist 9:257–264
-
(2003)
Microb Drug Resist
, vol.9
, pp. 257-264
-
-
Ruiz, N.1
Montero, T.2
Hernandez-Borrell, J.3
Vinas, M.4
-
144
-
-
33645215828
-
Porin-mediated antibiotic resistance in Neisseria gonorrhoeae: ion, solute, and antibiotic permeation through PIB proteins with penB mutations
-
COI: 1:CAS:528:DC%2BD28XjtVantLo%3D, PID: 16547016
-
Olesky M, Zhao S, Rosenberg RL, Nicholas RA (2006) Porin-mediated antibiotic resistance in Neisseria gonorrhoeae: ion, solute, and antibiotic permeation through PIB proteins with penB mutations. J Bacteriol 188:2300–2308
-
(2006)
J Bacteriol
, vol.188
, pp. 2300-2308
-
-
Olesky, M.1
Zhao, S.2
Rosenberg, R.L.3
Nicholas, R.A.4
-
145
-
-
34447556772
-
Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii
-
COI: 1:CAS:528:DC%2BD2sXnvVahtLs%3D, PID: 17324960
-
Vila J, Marti S, Sanchez-Céspedes J (2007) Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii. J Antimicrob Chemother 59:1210–1215
-
(2007)
J Antimicrob Chemother
, vol.59
, pp. 1210-1215
-
-
Vila, J.1
Marti, S.2
Sanchez-Céspedes, J.3
-
147
-
-
0035139485
-
Carbapenem resistance mechanisms in Pseudomonas aeruginosa clinical isolates
-
COI: 1:CAS:528:DC%2BD3MXmsVGltw%3D%3D, PID: 11158744
-
Pai H, Kim J-W, Kim J, Lee JH, Choe KW, Gotoh N (2001) Carbapenem resistance mechanisms in Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother 45:480–484
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 480-484
-
-
Pai, H.1
Kim, J.-W.2
Kim, J.3
Lee, J.H.4
Choe, K.W.5
Gotoh, N.6
-
148
-
-
84958092458
-
Molecular basis of filtering carbapenems by porins from β-lactam-resistant clinical strains of Escherichia coli
-
COI: 1:CAS:528:DC%2BC28XitVOqtrs%3D, PID: 26645688
-
Bajaj H, Scorciapino MA, Moynié L, Page MG, Naismith JH, Ceccarelli M, Winterhalter M (2016) Molecular basis of filtering carbapenems by porins from β-lactam-resistant clinical strains of Escherichia coli. J Biol Chem 291:2837–2847
-
(2016)
J Biol Chem
, vol.291
, pp. 2837-2847
-
-
Bajaj, H.1
Scorciapino, M.A.2
Moynié, L.3
Page, M.G.4
Naismith, J.H.5
Ceccarelli, M.6
Winterhalter, M.7
-
149
-
-
0031856680
-
The pharmacodynamics of beta-lactams
-
COI: 1:CAS:528:DyaK1cXkvVOksbY%3D, PID: 9675443
-
Turnidge JD (1998) The pharmacodynamics of beta-lactams. Clin Infect Dis 27(1):10–22
-
(1998)
Clin Infect Dis
, vol.27
, Issue.1
, pp. 10-22
-
-
Turnidge, J.D.1
-
150
-
-
2142760947
-
Antimicrobial pharmacodynamics: critical interactions of ‘bug and drug’
-
COI: 1:CAS:528:DC%2BD2cXit12nt74%3D, PID: 15031728
-
Drusano GL (2004) Antimicrobial pharmacodynamics: critical interactions of ‘bug and drug’. Nat Rev Microbiol 2:289–300
-
(2004)
Nat Rev Microbiol
, vol.2
, pp. 289-300
-
-
Drusano, G.L.1
-
151
-
-
0031952586
-
Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men
-
COI: 1:CAS:528:DyaK1cXltVaqtw%3D%3D, PID: 9455502
-
Craig WA (1998) Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis 26:1–12
-
(1998)
Clin Infect Dis
, vol.26
, pp. 1-12
-
-
Craig, W.A.1
-
152
-
-
35948933385
-
Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo
-
COI: 1:CAS:528:DC%2BD2sXhtVais7fJ, PID: 17576831
-
Mouton JW, Punt N, Vinks AA (2007) Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo. Antimicrob Agents Chemother 51:3449–3451
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 3449-3451
-
-
Mouton, J.W.1
Punt, N.2
Vinks, A.A.3
-
153
-
-
84863393482
-
The role of pharmacokinetics/pharmacodynamics in setting clinical MIC breakpoints: the EUCAST approach
-
COI: 1:CAS:528:DC%2BC38XmvValtbo%3D, PID: 22264314
-
Mouton JW, Brown DF, Apfalter P, Cantón R, Giske CG, Ivanova M, MacGowan AP, Rodloff A, Soussy CJ, Steinbakk M, Kahlmeter G (2012) The role of pharmacokinetics/pharmacodynamics in setting clinical MIC breakpoints: the EUCAST approach. Clin Microbiol Infect 18:E37–E45
-
(2012)
Clin Microbiol Infect
, vol.18
, pp. E37-E45
-
-
Mouton, J.W.1
Brown, D.F.2
Apfalter, P.3
Cantón, R.4
Giske, C.G.5
Ivanova, M.6
MacGowan, A.P.7
Rodloff, A.8
Soussy, C.J.9
Steinbakk, M.10
Kahlmeter, G.11
-
154
-
-
84875273480
-
Optimal exposures of ceftazidime predict the probability of microbiological and clinical outcome in the treatment of nosocomial pneumonia
-
COI: 1:CAS:528:DC%2BC3sXjslGnurY%3D, PID: 23190766
-
Muller AE, Punt N, Mouton JW (2013) Optimal exposures of ceftazidime predict the probability of microbiological and clinical outcome in the treatment of nosocomial pneumonia. J Antimicrob Chemother 68:900–906
-
(2013)
J Antimicrob Chemother
, vol.68
, pp. 900-906
-
-
Muller, A.E.1
Punt, N.2
Mouton, J.W.3
-
155
-
-
84898653072
-
Exposure to ceftobiprole is associated with microbiological eradication and clinical cure in patients with nosocomial pneumonia
-
COI: 1:CAS:528:DC%2BC2cXovFOktLc%3D, PID: 24514085
-
Muller AE, Punt N, Mouton JW (2014) Exposure to ceftobiprole is associated with microbiological eradication and clinical cure in patients with nosocomial pneumonia. Antimicrob Agents Chemother 58:2512–2519
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 2512-2519
-
-
Muller, A.E.1
Punt, N.2
Mouton, J.W.3
-
156
-
-
84906935346
-
Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients
-
De Waele JJ, Lipman J, Akova M, Bassetti M, Dimopoulos G, Kaukonen M, Koulenti D, Martin M, Montravers P, Rello J, Rhodes A, Udy AA, Starr T, Wallis SC, Roberts JA (2014) Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients. Int Care Med 40:1340–1351
-
(2014)
Int Care Med
, vol.40
, pp. 1340-1351
-
-
De Waele, J.J.1
Lipman, J.2
Akova, M.3
Bassetti, M.4
Dimopoulos, G.5
Kaukonen, M.6
Koulenti, D.7
Martin, M.8
Montravers, P.9
Rello, J.10
Rhodes, A.11
Udy, A.A.12
Starr, T.13
Wallis, S.C.14
Roberts, J.A.15
-
157
-
-
84901006498
-
Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions
-
PID: 24768475
-
Roberts JA, Abdul-Aziz MH, Lipman J, Mouton JW, Vinks AA, Felton TW, Hope WW, Farkas A, Neely MN, Schentag JJ, Drusano G, Frey OR, Theuretzbacher U, Kuti JL (2014) Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions. Lancet Infect Dis 14:498–509
-
(2014)
Lancet Infect Dis
, vol.14
, pp. 498-509
-
-
Roberts, J.A.1
Abdul-Aziz, M.H.2
Lipman, J.3
Mouton, J.W.4
Vinks, A.A.5
Felton, T.W.6
Hope, W.W.7
Farkas, A.8
Neely, M.N.9
Schentag, J.J.10
Drusano, G.11
Frey, O.R.12
Theuretzbacher, U.13
Kuti, J.L.14
-
158
-
-
0027980315
-
Pharmacodynamics of piperacillin alone and in combination with tazobactam against piperacillin-resistant and -susceptible organisms in an in vitro model of infection
-
COI: 1:CAS:528:DyaK2cXmt1Witrs%3D, PID: 7840569
-
Strayer AH, Gilbert DH, Pivarnik P, Medeiros AA, Zinner SH, Dudley MN (1994) Pharmacodynamics of piperacillin alone and in combination with tazobactam against piperacillin-resistant and -susceptible organisms in an in vitro model of infection. Antimicrob Agents Chemother 38(10):2351–2356
-
(1994)
Antimicrob Agents Chemother
, vol.38
, Issue.10
, pp. 2351-2356
-
-
Strayer, A.H.1
Gilbert, D.H.2
Pivarnik, P.3
Medeiros, A.A.4
Zinner, S.H.5
Dudley, M.N.6
-
159
-
-
84946567642
-
A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens
-
COI: 1:CAS:528:DC%2BC2MXhsFOjsrvN, PID: 26498989
-
Bush K (2015) A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens. Int J Antimicrob Agents 46(5):483–493
-
(2015)
Int J Antimicrob Agents
, vol.46
, Issue.5
, pp. 483-493
-
-
Bush, K.1
-
160
-
-
84875175772
-
In vivo activities of ceftolozane, a new cephalosporin, with and without tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae, including strains with extended-spectrum beta-lactamases, in the thighs of neutropenic mice
-
COI: 1:CAS:528:DC%2BC3sXltVKku7k%3D, PID: 23274659
-
Craig WA, Andes DR (2013) In vivo activities of ceftolozane, a new cephalosporin, with and without tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae, including strains with extended-spectrum beta-lactamases, in the thighs of neutropenic mice. Antimicrob Agents Chemother 57(4):1577–1582
-
(2013)
Antimicrob Agents Chemother
, vol.57
, Issue.4
, pp. 1577-1582
-
-
Craig, W.A.1
Andes, D.R.2
-
161
-
-
84877867715
-
Pharmacokinetics-pharmacodynamics of tazobactam in combination with ceftolozane in an in vitro infection model
-
COI: 1:CAS:528:DC%2BC3sXoslyrtrc%3D, PID: 23629705
-
VanScoy B, Mendes RE, Nicasio AM, Castanheira M, Bulik CC, Okusanya OO, Bhavnani SM, Forrest A, Jones RN, Friedrich LV, Steenbergen JN, Ambrose PG (2013) Pharmacokinetics-pharmacodynamics of tazobactam in combination with ceftolozane in an in vitro infection model. Antimicrob Agents Chemother 57(6):2809–2814
-
(2013)
Antimicrob Agents Chemother
, vol.57
, Issue.6
, pp. 2809-2814
-
-
VanScoy, B.1
Mendes, R.E.2
Nicasio, A.M.3
Castanheira, M.4
Bulik, C.C.5
Okusanya, O.O.6
Bhavnani, S.M.7
Forrest, A.8
Jones, R.N.9
Friedrich, L.V.10
Steenbergen, J.N.11
Ambrose, P.G.12
-
162
-
-
84860188286
-
A novel modeling framework to guide design of optimal dosing strategies for beta-lactamase inhibitors
-
COI: 1:CAS:528:DC%2BC38XmsVKkur8%3D, PID: 22330927
-
Bhagunde P, Chang K-T, Hirsch EB, Ledesma KR, Nikolaou M, Tam VH (2012) A novel modeling framework to guide design of optimal dosing strategies for beta-lactamase inhibitors. Antimicrob Agents Chemother 56:2237–2240
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 2237-2240
-
-
Bhagunde, P.1
Chang, K.-T.2
Hirsch, E.B.3
Ledesma, K.R.4
Nikolaou, M.5
Tam, V.H.6
-
163
-
-
84921919307
-
Pharmacodynamics of imipenem in combination with β-lactamase inhibitor MK7655 in a murine thigh model
-
PID: 25403667
-
Mavridou E, Melchers RJB, vanMil ACHAM, Mangin E, Motyl MR, Mouton JW (2015) Pharmacodynamics of imipenem in combination with β-lactamase inhibitor MK7655 in a murine thigh model. Antimicrob Agents Chemother 59:790–795
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 790-795
-
-
Mavridou, E.1
Melchers, R.J.B.2
vanMil, A.C.H.A.M.3
Mangin, E.4
Motyl, M.R.5
Mouton, J.W.6
-
164
-
-
84946599494
-
Pharmacokinetics/pharmacodynamics of a beta-lactam and beta-lactamase inhibitor combination: a novel approach for aztreonam/avibactam
-
COI: 1:CAS:528:DC%2BC2MXhsF2nsrnO, PID: 26024868
-
Singh R, Kim A, Tanudra MA, Harris JJ, McLaughlin RE, Patey S, O’Donnell JP, Bradford PA, Eakin AE (2015) Pharmacokinetics/pharmacodynamics of a beta-lactam and beta-lactamase inhibitor combination: a novel approach for aztreonam/avibactam. J Antimicrob Chemother 70(9):2618–2626
-
(2015)
J Antimicrob Chemother
, vol.70
, Issue.9
, pp. 2618-2626
-
-
Singh, R.1
Kim, A.2
Tanudra, M.A.3
Harris, J.J.4
McLaughlin, R.E.5
Patey, S.6
O’Donnell, J.P.7
Bradford, P.A.8
Eakin, A.E.9
-
165
-
-
84976902404
-
In vitro pharmacokinetics/pharmacodynamics of the combination of avibactam and aztreonam against MDR organisms
-
COI: 1:CAS:528:DC%2BC28XhsFeisL%2FL, PID: 27107096
-
Sy SKB, Beaudoin M-E, Zhuang L, Löblein KI, Lux C, Kissel M, Tremmel R, Frank C, Strasser S, Heuberger JAAC, Mulder MB, Schuck VJ, Derendorf H (2016) In vitro pharmacokinetics/pharmacodynamics of the combination of avibactam and aztreonam against MDR organisms. J Antimicrob Chemother 71:1866–1880
-
(2016)
J Antimicrob Chemother
, vol.71
, pp. 1866-1880
-
-
Sy, S.K.B.1
Beaudoin, M.-E.2
Zhuang, L.3
Löblein, K.I.4
Lux, C.5
Kissel, M.6
Tremmel, R.7
Frank, C.8
Strasser, S.9
Heuberger, J.A.A.C.10
Mulder, M.B.11
Schuck, V.J.12
Derendorf, H.13
-
166
-
-
0023959639
-
The new monobactams: chemistry and biology
-
COI: 1:CAS:528:DyaL1cXmt1Wqtb0%3D, PID: 3360965
-
Sykes RB, Koster WH, Bonner DP (1988) The new monobactams: chemistry and biology. J Clin Pharmacol 28(2):113–119
-
(1988)
J Clin Pharmacol
, vol.28
, Issue.2
, pp. 113-119
-
-
Sykes, R.B.1
Koster, W.H.2
Bonner, D.P.3
-
167
-
-
0025266307
-
In vitro antibacterial activity and interactions with beta-lactamases and penicillin-binding proteins of the new monocarbam antibiotic U-78608
-
COI: 1:CAS:528:DyaK3cXkt1Srs74%3D, PID: 2193625
-
Zurenko GE, Truesdell SE, Yagi BH, Mourey RJ, Laborde AL (1990) In vitro antibacterial activity and interactions with beta-lactamases and penicillin-binding proteins of the new monocarbam antibiotic U-78608. Antimicrob Agents Chemother 34(5):884–888
-
(1990)
Antimicrob Agents Chemother
, vol.34
, Issue.5
, pp. 884-888
-
-
Zurenko, G.E.1
Truesdell, S.E.2
Yagi, B.H.3
Mourey, R.J.4
Laborde, A.L.5
-
168
-
-
78650656571
-
Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa
-
COI: 1:CAS:528:DC%2BC3MXntVKq, PID: 21135211
-
Han S, Zaniewski RP, Marr ES, Lacey BM, Tomaras AP, Evdokimov A, Miller JR, Shanmugasundaram V (2010) Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. Proc Natl Acad Sci USA 107(51):22002–22007
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.51
, pp. 22002-22007
-
-
Han, S.1
Zaniewski, R.P.2
Marr, E.S.3
Lacey, B.M.4
Tomaras, A.P.5
Evdokimov, A.6
Miller, J.R.7
Shanmugasundaram, V.8
-
169
-
-
84924706111
-
Discovery of efficacious Pseudomonas aeruginosa-targeted siderophore-conjugated monocarbams by application of a semi-mechanistic pharmacokinetic/pharmacodynamic model
-
COI: 1:CAS:528:DC%2BC2MXit1Sguro%3D, PID: 25658376
-
Murphy-Benenato KE, Bhagunde PR, Chen A, Davis HE, Durand-Reville TF, Ehmann DE, Galullo V, Harris JJ, Hatoum-Mokdad H, Jahic H, Kim A, Manjunatha MR, Manyak EL, Mueller J, Patey S, Quiroga O, Rooney M, Sha L, Shapiro AB, Sylvester M, Tan B, Tsai AS, Uria-Nickelsen M, Wu Y, Zambrowski M, Zhao SX (2015) Discovery of efficacious Pseudomonas aeruginosa-targeted siderophore-conjugated monocarbams by application of a semi-mechanistic pharmacokinetic/pharmacodynamic model. J Med Chem 58(5):2195–2205
-
(2015)
J Med Chem
, vol.58
, Issue.5
, pp. 2195-2205
-
-
Murphy-Benenato, K.E.1
Bhagunde, P.R.2
Chen, A.3
Davis, H.E.4
Durand-Reville, T.F.5
Ehmann, D.E.6
Galullo, V.7
Harris, J.J.8
Hatoum-Mokdad, H.9
Jahic, H.10
Kim, A.11
Manjunatha, M.R.12
Manyak, E.L.13
Mueller, J.14
Patey, S.15
Quiroga, O.16
Rooney, M.17
Sha, L.18
Shapiro, A.B.19
Sylvester, M.20
Tan, B.21
Tsai, A.S.22
Uria-Nickelsen, M.23
Wu, Y.24
Zambrowski, M.25
Zhao, S.X.26
more..
-
171
-
-
84869207420
-
Clinically relevant Gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam
-
COI: 1:CAS:528:DC%2BC38XhslKls7%2FO, PID: 23027195
-
McPherson CJ, Aschenbrenner LM, Lacey BM, Fahnoe KC, Lemmon MM, Finegan SM, Tadakamalla B, O’Donnell JP, Mueller JP, Tomaras AP (2012) Clinically relevant Gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam. Antimicrob Agents Chemother 56(12):6334–6342
-
(2012)
Antimicrob Agents Chemother
, vol.56
, Issue.12
, pp. 6334-6342
-
-
McPherson, C.J.1
Aschenbrenner, L.M.2
Lacey, B.M.3
Fahnoe, K.C.4
Lemmon, M.M.5
Finegan, S.M.6
Tadakamalla, B.7
O’Donnell, J.P.8
Mueller, J.P.9
Tomaras, A.P.10
-
172
-
-
84954570572
-
Pharmacodynamic profiling of a siderophore-conjugated monocarbam in Pseudomonas aeruginosa: assessing the risk for resistance and attenuated efficacy
-
COI: 1:CAS:528:DC%2BC28XptFajtro%3D, PID: 26438502
-
Kim A, Kutschke A, Ehmann DE, Patey SA, Crandon JL, Gorseth E, Miller AA, McLaughlin RE, Blinn CM, Chen A, Nayar AS, Dangel B, Tsai AS, Rooney MT, Murphy-Benenato KE, Eakin AE, Nicolau DP (2015) Pharmacodynamic profiling of a siderophore-conjugated monocarbam in Pseudomonas aeruginosa: assessing the risk for resistance and attenuated efficacy. Antimicrob Agents Chemother 59(12):7743–7752
-
(2015)
Antimicrob Agents Chemother
, vol.59
, Issue.12
, pp. 7743-7752
-
-
Kim, A.1
Kutschke, A.2
Ehmann, D.E.3
Patey, S.A.4
Crandon, J.L.5
Gorseth, E.6
Miller, A.A.7
McLaughlin, R.E.8
Blinn, C.M.9
Chen, A.10
Nayar, A.S.11
Dangel, B.12
Tsai, A.S.13
Rooney, M.T.14
Murphy-Benenato, K.E.15
Eakin, A.E.16
Nicolau, D.P.17
-
173
-
-
84876213849
-
Involvement of Fe uptake systems and AmpC β-lactamase in susceptibility to the siderophore monosulfactam BAL30072 in Pseudomonas aeruginosa
-
PID: 23422914
-
van Delden C, Page MG, Kohler T (2013) Involvement of Fe uptake systems and AmpC β-lactamase in susceptibility to the siderophore monosulfactam BAL30072 in Pseudomonas aeruginosa. Antimicrob Agents Chemother 57(5):2095–2102
-
(2013)
Antimicrob Agents Chemother
, vol.57
, Issue.5
, pp. 2095-2102
-
-
van Delden, C.1
Page, M.G.2
Kohler, T.3
-
174
-
-
84882330931
-
Adaptation-based resistance to siderophore-conjugated antibacterial agents by Pseudomonas aeruginosa
-
COI: 1:CAS:528:DC%2BC3sXhtlSns7vM, PID: 23774440
-
Tomaras AP, Crandon JL, McPherson CJ, Banevicius MA, Finegan SM, Irvine RL, Brown MF, O’Donnell JP, Nicolau DP (2013) Adaptation-based resistance to siderophore-conjugated antibacterial agents by Pseudomonas aeruginosa. Antimicrob Agents Chemother 57(9):4197–4207
-
(2013)
Antimicrob Agents Chemother
, vol.57
, Issue.9
, pp. 4197-4207
-
-
Tomaras, A.P.1
Crandon, J.L.2
McPherson, C.J.3
Banevicius, M.A.4
Finegan, S.M.5
Irvine, R.L.6
Brown, M.F.7
O’Donnell, J.P.8
Nicolau, D.P.9
-
175
-
-
85016645674
-
The role of iron transport in the activity of the siderophore sulfactam BAL30072 against Pseudomonas aeruginosa—P 1241 Abstracts of 20th ECCMID Clin Microbiol Infect 16
-
Page M, Müller C, Hofer B, Desarbre E, Dreier J, Vidal F (2010) The role of iron transport in the activity of the siderophore sulfactam BAL30072 against Pseudomonas aeruginosa—P 1241 Abstracts of 20th ECCMID Clin Microbiol Infect 16. Suppl 2:S1–S720
-
(2010)
Suppl
, vol.2
, pp. 1-720
-
-
Page, M.1
Müller, C.2
Hofer, B.3
Desarbre, E.4
Dreier, J.5
Vidal, F.6
-
176
-
-
85099362084
-
KPC-3 mutations during treatment of carbapenem-resistant Klebsiella pneumoniae infections
-
(published online 28 Dec 2016)
-
KPC-3 mutations during treatment of carbapenem-resistant Klebsiella pneumoniae infections. Antimicrob Agents Chemother (published online 28 Dec 2016)
-
(2016)
Antimicrob Agents Chemother
-
-
Shields, R.K.1
Chen, L.2
Cheng, S.3
Chavda, K.D.4
Press, E.G.5
Snyder, A.6
Pandey, R.7
Doi, Y.8
Kreiswirth, B.N.9
Nguyen, M.H.10
Clancy, C.J.11
|