Metallo-β-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding

European Journal of Medicinal Chemistry

Volumn 135, Issue , 2017, Pages 159-173

  Skagseth, Susann ^a   Akhter, Sundus ^a   Paulsen, Marianne H ^a   Muhammad, Zeeshan ^a   Lauksund, Silje ^b   Samuelsen, Ørjan ^a,b   Leiros, Hanna Kirsti S ^a   Bayer, Annette ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

Author keywords

Carboxylate bioisosters; Crystal structure; Inhibition properties; Metallo lactamase inhibitors; Thiols

Indexed keywords

ARGININE; BENZENE; BETA LACTAMASE INHIBITOR; BIOISOSTERE; CARBON; CARBOXYL GROUP; CARBOXYLIC ACID DERIVATIVE; DIETHYL 1 HYDROXY 4 PHENYLBUTAN 2 YLPHOSPHONATE; DIETHYL 1 HYDROXY 5 PHENYLPENTANE 2 YLPHOSPHONATE; DIETHYL 1 HYDROXY 6 PHENYLHEXANE 2 YLPHOSPHONATE; DIETHYL 1 MERCAPTO 5 PHENYLPENTAN 2 YLPHOSPHONATE; ETHYL 2 (DIETHOXYPHOSPHORYL) 4 PHENYLBUTANOATE; ETHYL 2 (DIETHOXYPHOSPHORYL) 6^PHENYLHEXANOATE; FUNCTIONAL GROUP; GERMAN IMIPENEMASE 1; HISTIDINE; MERCAPTO GROUP; MERCAPTOCARBOXYLIC ACID; MEROPENEM; METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE; PHENYL GROUP; PHENYLALANINE; PHOSPHONIC ACID ESTER; TETRAZOLE DERIVATIVE; THIOACETIC ACID; THIOL; TYROSINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZINC ION; BETA LACTAMASE; CARBOXYLIC ACID;

ARTICLE; BACTERIAL CELL; BINDING SITE; BIOLOGICAL ACTIVITY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION ASSAY; ESCHERICHIA COLI; HYDROPHOBICITY; IC50; KLEBSIELLA PNEUMONIAE; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PSEUDOMONAS AERUGINOSA; SUBSTITUTION REACTION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; BINDING SITES; CARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR STRUCTURE; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85018471501     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2017.04.035     Document Type: Article

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