Discovery of a novel covalent non-β-lactam inhibitor of the metallo-β-lactamase NDM-1

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 13, 2016, Pages 2947-2953

  Christopeit, Tony ^a   Albert, Anastasia ^b   Leiros, Hanna Kirsti S ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b Norut Northern Research Institute   (Norway)

Author keywords

3 Formylchromone; Antibiotic resistance; Covalent docking; Mass spectrometry; Surface Plasmon Resonance (SPR)

Indexed keywords

BETA LACTAMASE INHIBITOR; CAPTOPRIL; LYSINE; MEROPENEM; METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE 1; UNCLASSIFIED DRUG; BETA LACTAMASE; BETA-LACTAMASE NDM-1; THIENAMYCIN DERIVATIVE;

ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG COMPETITION; DRUG DESIGN; DRUG IDENTIFICATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; INHIBITION CONSTANT; MOLECULAR DOCKING; NONHUMAN; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; GENETICS; KINETICS; METABOLISM; MOLECULAR MODEL; SYNTHESIS;

BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; CAPTOPRIL; CATALYTIC DOMAIN; DRUG DISCOVERY; ENZYME ACTIVATION; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SURFACE PLASMON RESONANCE; THIENAMYCINS;

EID: 84966508471     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.04.064     Document Type: Article

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