Metal-induced isomerization yields an intracellular chelator that disrupts bacterial iron homeostasis

Chemistry and Biology

Volumn 21, Issue 1, 2014, Pages 136-145

  Falconer, Shannon B ^a   Wang, Wenliang ^a   Gehrke, Sebastian S ^a   Cuneo, Jessica D ^a   Britten, James F ^b   Wright, Gerard D ^a   Brown, Eric D ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE; ANTIINFECTIVE AGENT; COBALT; CUPROUS ION; EDETIC ACID; HETEROCYCLIC COMPOUND; IRON; MANGANESE; MEROCYANINE; METAL COMPLEX; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; NICKEL; PENTETIC ACID; SPIRO COMPOUND; THIADIAZOLE DERIVATIVE; TRANSITION ELEMENT; ZINC; BACTERIAL PROTEIN; BENZOPYRAN DERIVATIVE; INDOLE DERIVATIVE; INDOLINE; IRON CHELATING AGENT; IRON RESPONSE REGULATOR PROTEIN, BACTERIA; MOLECULAR LIBRARY; ORGANOMETALLIC COMPOUND; TRANSCRIPTION FACTOR;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL IRON HOMEOSTASIS; BACTERIAL STRAIN; BACTERIUM; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL BOND; CHEMICAL STRUCTURE; ESCHERICHIA COLI; GENE DELETION; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; HOMEOSTASIS; IRON CHELATION; ISOMERIZATION; MINIMUM INHIBITORY CONCENTRATION; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; METABOLISM; MOLECULAR LIBRARY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BACTERIA (MICROORGANISMS);

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BENZOPYRANS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI; HIGH-THROUGHPUT SCREENING ASSAYS; HOMEOSTASIS; INDOLES; IRON; IRON CHELATING AGENTS; ORGANOMETALLIC COMPOUNDS; SMALL MOLECULE LIBRARIES; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; TRANSCRIPTION FACTORS; TRANSITION ELEMENTS;

EID: 84892678751     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2013.11.007     Document Type: Article

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