Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy

Journal of Medicinal Chemistry

Volumn 50, Issue 23, 2007, Pages 5644-5654

  Venturelli, Alberto ^a   Tondi, Donatella ^a,b   Cancian, Laura ^a   Morandi, Federica ^a,b   Cannazza, Giuseppe ^a   Segatore, Bernardetta ^c   Prati, Fabio ^a   Amicosante, Gianfranco ^c   Shoichet, Brian K ^b   Costi, M Paola ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[B]THIOPHEN 2 YLBORONIC ACID; BENZOTHIOPHENE DERIVATIVE; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE AMPC; BORONIC ACID DERIVATIVE; CEFTAZIDIME; PINACOL 5 AMINOMETHYLBENZO[B]THIOPHEN 2 YLBORONATE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MEMBRANE; CELL CULTURE; CULTURE MEDIUM; DRUG PENETRATION; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; BORONIC ACIDS; CELL MEMBRANE PERMEABILITY; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; KINETICS; MEMBRANES, ARTIFICIAL; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 36148972412     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070643q     Document Type: Article

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