Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Nature Communications

Volumn 7, Issue , 2016, Pages

  Brem, Jürgen ^a   Cain, Ricky ^b   Cahill, Samuel ^a   McDonough, Michael A ^a   Clifton, Ian J ^a   Jiménez Castellanos, Juan Carlos ^c   Avison, Matthew B ^c   Spencer, James ^c   Fishwick, Colin W G ^b   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BORONIC ACID DERIVATIVE; CLOXACILLIN; CYCLIC BORONIC ACID DERIVATIVE; HYDROLASE; HYDROLASE INHIBITOR; MEROPENEM; METALLO BETA LACTAMASE; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 5; PENICILLIN DERIVATIVE; SERINE BETA LACTAMASE; UNCLASSIFIED DRUG; BETA LACTAMASE; ENZYME INHIBITOR; SERINE;

ANTIBIOTICS; ANTIMICROBIAL ACTIVITY; GENE; GENE EXPRESSION; INHIBITION; INHIBITOR; ORGANIC COMPOUND; PROTEIN;

AEROMONAS HYDROPHILA; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SENSITIZATION; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ESCHERICHIA COLI; HEK293 CELL LINE; HYDROGEN BOND; HYDROLYSIS; IC50; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOPHILICITY; PSEUDOMONAS AERUGINOSA; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CYCLIZATION; HUMAN; METABOLISM; MICROBIAL SENSITIVITY TEST; PRECLINICAL STUDY; STRUCTURE ACTIVITY RELATION;

BETA-LACTAMASES; BORONIC ACIDS; CYCLIZATION; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; MICROBIAL SENSITIVITY TESTS; PENICILLIN-BINDING PROTEINS; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84981356473     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12406     Document Type: Article

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