Azolylthioacetamide: A highly promising scaffold for the development of metallo-β-lactamase inhibitors

ACS Medicinal Chemistry Letters

Volumn 6, Issue 4, 2015, Pages 455-460

  Yang, Shao Kang ^a   Kang, Joon S ^b   Oelschlaeger, Peter ^c   Yang, Ke Wu ^a  

^a NORTHWEST UNIVERSITY   (China)

^b CALIFORNIA STATE POLYTECHNIC UNIVERSITY   (United States)

^c WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

Antibiotic resistance; azolylthioacetamide; ImiS; inhibitor; metallo lactamase; subclass B2

Indexed keywords

ASPARAGINE; BACTERIAL PROTEIN; BETA LACTAMASE INHIBITOR; CARBOXYL GROUP; CEFALEXIN; IMIPENEM; LYSINE; METALLO BETA LACTAMASE; METALLO BETA LACTAMASE INHIBITOR; PROTEIN CCRA; PROTEIN CPHA; PROTEIN IMIS; PYRROLE DERIVATIVE; THIOACETAMIDE DERIVATIVE; UNCLASSIFIED DRUG; ZINC;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION;

EID: 84927600380     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500534c     Document Type: Article

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