Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases

ACS Infectious Diseases

Volumn 4, Issue 3, 2018, Pages 360-372

  Büttner, Dominik ^a   Kramer, Jan S ^a   Klingler, Franca M ^a   Wittmann, Sandra K ^a   Hartmann, Markus R ^a   Kurz, Christian G ^a   Kohnhäuser, Daniel ^a   Weizel, Lilia ^a   Brüggerhoff, Astrid ^a   Frank, Denia ^b   Steinhilber, Dieter ^a   Wichelhaus, Thomas A ^b   Pogoryelov, Denys ^a   Proschak, Ewgenij ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAMASE INHIBITOR; THIOL DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG SYNTHESIS; ESCHERICHIA COLI; HELA CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC50; ISOTHERMAL TITRATION CALORIMETRY; KLEBSIELLA PNEUMONIAE; MICROWAVE IRRADIATION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; BETA-LACTAM RESISTANCE; DRUG DEVELOPMENT; DRUG EFFECT; ISOLATION AND PURIFICATION; PROCEDURES; SYNTHESIS;

BETA-LACTAM RESISTANCE; BETA-LACTAMASE INHIBITORS; DRUG DISCOVERY; SULFHYDRYL COMPOUNDS;

EID: 85037853157     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.7b00129     Document Type: Article

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