Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers

Antimicrobial Agents and Chemotherapy

Volumn 60, Issue 1, 2016, Pages 142-150

  Brem, Jürgen ^a   Van Berkel, Sander S ^a   Zollman, David ^a   Lee, Sook Y ^a   Gileadi, Opher ^b   McHugh, Peter J ^c   Walsh, Timothy R ^d   McDonough, Michael A ^a   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Heath Hospital   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; BETA LACTAMASE BCII; BETA LACTAMASE IMP 1; BETA LACTAMASE VIM 2; CAPTOPRIL; CAPTOPRIL DERIVATIVE; CARBAPENEM; CEFTAZIDIME; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MEROPENEM; METALLO BETA LACTAMASE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BETA LACTAMASE INHIBITOR; BETA-LACTAMASE BCII; BETA-LACTAMASE IMP-1; CARBAPENEM DERIVATIVE; RECOMBINANT PROTEIN; VIM-2 BETA-LACTAMASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; IC50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STEREOISOMERISM; SYSTEMATIC REVIEW; CHEMISTRY; DRUG EFFECTS; DRUG REPOSITIONING; ENTEROBACTERIACEAE; ENZYMOLOGY; GENE EXPRESSION; GENETICS; HYDROLYSIS; KINETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR CLONING; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; CAPTOPRIL; CARBAPENEMS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DRUG REPOSITIONING; ENTEROBACTERIACEAE; GENE EXPRESSION; HYDROLYSIS; KINETICS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84957867042     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01335-15     Document Type: Article

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