Phenylboronic Acid Derivatives as Validated Leads Active in Clinical Strains Overexpressing KPC-2: A Step against Bacterial Resistance

ChemMedChem

Volumn 13, Issue 7, 2018, Pages 713-724

  Celenza, Giuseppe ^b   Vicario, Mattia ^c   Bellio, Pierangelo ^b   Linciano, Pasquale ^a   Perilli, Mariagrazia ^b   Oliver, Antonio ^d   Blazquez, Jesús ^e   Cendron, Laura ^c   Tondi, Donatella ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

^e CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

bacterial resistance; boron; cell viability; inhibitors; X ray diffraction

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; AZTREONAM; BENZENEBORONIC ACID; BENZENEBORONIC ACID DERIVATIVE; CARBAPENEMASE; CEFOTAXIME; KPC 2 CARBAPENEMASE; MEROPENEM; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; BETA-LACTAMASE KPC-2, KLEBSIELLA PNEUMONIAE; BORONIC ACID DERIVATIVE; PROTEIN BINDING;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BINDING AFFINITY; CELL VIABILITY ASSAY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME KINETICS; HUMAN; HUMAN CELL; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; FIBROBLAST; KINETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MOUSE; SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; BORONIC ACIDS; CATALYTIC DOMAIN; CELL LINE; DRUG SYNERGISM; FIBROBLASTS; HUMANS; KINETICS; MICE; MICROBIAL SENSITIVITY TESTS; PROTEIN BINDING;

EID: 85042174559     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201700788     Document Type: Article

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