Clinical Evolution of New Delhi Metallo-β-Lactamase (NDM) optimizes resistance under Zn(II) Deprivation

Antimicrobial Agents and Chemotherapy

Volumn 62, Issue 1, 2018, Pages

  Bahr, Guillermo ^a,b   Vitor Horen, Luisina ^a   Bethel, Christopher R ^c   Bonomo, Robert A ^c,d   Gonzalez, Lisandro J ^a,b   Vila, Alejandro J ^a,b,c  

^a Instituto de Biologia Molecular y Celular de Rosario   (Argentina)

^b UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibiotic resistance; Carbapenemase; Metallo lactamase; NDM; Nutritional immunity; Zn(II) limitation

Indexed keywords

BACTERIAL ENZYME; CEFEPIME; CEFOTAXIME; IMIPENEM; METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE 1; NEW DELHI METALLO BETA LACTAMASE 10; NEW DELHI METALLO BETA LACTAMASE 11; NEW DELHI METALLO BETA LACTAMASE 12; NEW DELHI METALLO BETA LACTAMASE 13; NEW DELHI METALLO BETA LACTAMASE 14; NEW DELHI METALLO BETA LACTAMASE 15; NEW DELHI METALLO BETA LACTAMASE 16; NEW DELHI METALLO BETA LACTAMASE 2; NEW DELHI METALLO BETA LACTAMASE 3; NEW DELHI METALLO BETA LACTAMASE 4; NEW DELHI METALLO BETA LACTAMASE 5; NEW DELHI METALLO BETA LACTAMASE 6; NEW DELHI METALLO BETA LACTAMASE 7; NEW DELHI METALLO BETA LACTAMASE 8; NEW DELHI METALLO BETA LACTAMASE 9; PIPERACILLIN; UNCLASSIFIED DRUG; ZINC; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; BETA-LACTAMASE NDM-1; CARBAPENEM DERIVATIVE; CARBAPENEMASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; BINDING AFFINITY; BLA GENE; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; CATALYTIC EFFICIENCY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME STABILITY; ESCHERICHIA COLI; IN VIVO STUDY; METAL BINDING; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EVOLUTION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; DRUG EFFECT; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTION; GENETICS; HUMAN; METABOLISM; MICROBIAL SENSITIVITY TEST; MULTIDRUG RESISTANCE; PROCEDURES;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; HUMANS; MICROBIAL SENSITIVITY TESTS; ZINC;

EID: 85039783818     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01849-17     Document Type: Article

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