Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. With carbapenemases, including NDM enzymes

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 1, 2013, Pages 153-158

  Livermore, David M ^a,b   Mushtaq, Shazad ^a   Morinaka, Akihiro ^c   Ida, Takashi ^c   Maebashi, Kazunori ^c   Hope, Russell ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

Biapenem; IMP lactamases; Metallo enzymes; NDM lactamases; VIM lactamases

Indexed keywords

ANTIBIOTIC AGENT; BIAPENEM; CARBAPENEMASE; CEFTAZIDIME; DISODIUM 2,3 DIETHYLMALEATE; DORIPENEM; IMIPENEM; ME 1071; MEROPENEM; UNCLASSIFIED DRUG;

ACINETOBACTER; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BINDING AFFINITY; COLUMN CHROMATOGRAPHY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; ENTEROBACTERIACEAE; ENZYME SUBSTRATE; HYDROLYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN EXPRESSION; SPECTROPHOTOMETRY;

ACINETOBACTER; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; DRUG SYNERGISM; ENTEROBACTERIACEAE; ENZYME INHIBITORS; HUMANS; MALEATES; MICROBIAL SENSITIVITY TESTS;

EID: 84871201908     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks350     Document Type: Article

References (17)

1. Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009; 9: 228-36.
2. Bush K. Alarming β-lactamases-mediated resistance in multidrugresistant Enterobacteriaceae. Curr Opin Microbiol 2010; 13: 558-64.
3. Carrer A, Poirel L, Yilmaz M et al. Spread of OXA-48-encoding plasmid in Turkey and beyond. Antimicrob Agents Chemother 2010; 54: 1369-73.
4. Lascols C, Hackel M, Marshall SH et al. Increasing prevalence and dissemination of NDM-1 metallo-β-lactamases in India: data from the SMART study (2009). J Antimicrob Chemother 2011; 66: 1992-7.
5. Walsh TR, Weeks J, Livermore DM et al. Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. Lancet Infect Dis 2011; 11: 355-62.
6. Kumarasamy KK, Toleman MA, Walsh TR et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 2010; 10: 597-602.
7. Vatopoulos A. High rates of metallo-β-lactamases-producing Klebsiella pneumoniae in Greece-a review of the current evidence. Euro Surveill 2008; 13: pii=8023.
8. Grundmann H, Livermore DM, Giske CG et al. Carbapenemnon-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts. Euro Surveill 2010; 15: pii=19711.
9. Livermore DM, Mushtaq S, Warner M et al. Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemaseproducing Enterobacteriaceae. Antimicrob Agents Chemother 2011; 55: 390-4.
10. Toney JH, Hammond GG, Fitzgerald PM et al. Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-β-lactamases. J Biol Chem 2001; 276: 31913-8.
11. Ishii Y, Eto M, Mano Y et al. In vitro potentiation of carbapenems with ME1071, a novel metallo-β-lactamases inhibitor, against metallo-β-lactamases-producing Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother 2010; 54: 3625-9.
12. Hiraiwa Y, Morinaka A, Fukushima T et al. Metallo-β-lactamases inhibitory activity of phthalic acid derivatives. Bioorg Med Chem Lett 2009; 19: 5162-5.
13. Abe T, Chikauchi K, Hiraiwa Y et al. CP3242, a novel metallo-b-actamase inhibitor: synthesis and structure-activity relationships. In: Abstracts of the Forty-seventh Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, 2007. Abstract F1-329, p. 225. American Society for Microbiology, Washington, DC, USA.
14. Clinical and Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically-Eighth Edition: Approved Standard M07-A8. CLSI, Wayne, PA, USA, 2009.
15. Laraki N, Franceschini N, Rossolini GM et al. Biochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-blactamase IMP-1 produced by Escherichia coli. Antimicrob Agents Chemother 1999; 43: 902-6.
16. Docquier JD, Lamotte-Brasseur J, Galleni M et al. On functional and structural heterogeneity of VIM-type metallo-β-lactamasess. J Antimicrob Chemother 2003; 51: 257-66.
17. Franceschini N, Caravelli B, Docquier JD et al. Purification and biochemical characterization of the VIM-1 metallo-β-lactamases. Antimicrob Agents Chemother 2000; 44: 3003-7.