The emerging NDM carbapenemases

Trends in Microbiology

Volumn 19, Issue 12, 2011, Pages 588-595

  Nordmann, Patrice ^a   Poirel, Laurent ^a   Walsh, Timothy R ^b   Livermore, David M ^c  

^a INSERM   (France)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; AVIBACTAM; BAL 30072; CARBAPENEMASE; CHLORAMPHENICOL; CLAVULANIC ACID; COTRIMOXAZOLE; ENZYME VARIANT; FOSFOMYCIN; MONOBACTAM; NEW DELHI METALLO BETA LACTAMASE 1; NITROFURANTOIN; PROTEIN NDM 1; TAZOBACTAM; TETRACYCLINE DERIVATIVE; TIGECYCLINE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIAL GENE; BACTERIAL GENETICS; BIOCHEMISTRY; BLANDM 1 GENE; ENTEROBACTERIACEAE; ENZYME ANALYSIS; GENE TRANSFER; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; REVIEW; VIBRIONACEAE;

BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; DISEASE OUTBREAKS; ENTEROBACTERIACEAE; GENE TRANSFER, HORIZONTAL; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; PLASMIDS; PSEUDOMONAS; VIBRIONACEAE;

EID: 82355184536     PISSN: 0966842X     EISSN: 18784380     Source Type: Journal    
DOI: 10.1016/j.tim.2011.09.005     Document Type: Review

References (72)

1. NDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob. Agents Chemother. 2009, 53:5046-5054.
2. Cornaglia G., et al. Metallo β-lactamase: a last frontier for β-lactams?. Lancet Infect. Dis. 2011, 11:381-393.
3. Walsh T.R., et al. Metallo-β-lactamases: the quiet before the storm?. Clin. Microbiol. Rev. 2005, 18:306-325.
4. Queenan A.M., Bush K. Carbapenemases: the versatile β-lactamases. Clin. Microbiol. Rev. 2007, 20:440-458.
5. Kumarasamy K.K., et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 2010, 10:597-602.
6. Castanheira M., et al. Early dissemination of NDM-1 and OXA-181-producing Enterobacteriaceae in Indian hospitals: report from the SENTRY Antimicrobial Surveillance Program, 2006-2007. Antimicrob. Agents Chemother. 2011, 55:1274-1278.
7. Krishna B.V. New Delhi metallo-β-lactamases: a wake-up call for microbiologists. Indian J. Med. Microbiol. 2010, 28:265-266.
8. Mochon A.B., et al. New Delhi metallo β-lactamase (NDM-1) producing Klebsiella pneumoniae; case report and laboratory detection strategies. J. Clin. Microbiol. 2011, 49:1667-1670.
9. Muir A., Weinbren M.J. New Delhi metallo-β-lactamase: a cautionary tale. J. Hosp. Infect. 2010, 75:236-246.
10. Raghunath D. New metallo β-lactamase NDM-1. Indian J. Med. Res. 2010, 132:478-481.
11. Roy S., et al. Transmission of imipenem resistance determinants during the course of an outbreak of NDM-1 Escherichia coli in a sick newborn care unit. J. Antimicrob. Chemother. 2011, 10.1093/jac/dkr376.
12. Seema K., et al. Dissemination of the New Delhi metallo-β-lactamase-1 (NDM-1) among Enterobacteriaceae in a tertiary referral hospital in north India. J. Antimicrob. Chemother. 2011, 66:1646-1647.
13. Desphande P., et al. New Delhi metallo β-lactamase (NDM-1) in Enterobacteriaceae; treatment options with carbapenems compromised. J. Assoc. Physicians India 2010, 58:1-6.
14. Desphande P., et al. New Delhi metallo 1: have carbapenems met their doom?. Clin. Infect. Dis. 2010, 51:1222.
15. Perry J.D., et al. Prevalence of faecal carriage of Enterobacteriaceae with NDM-1 carbapenemase at military hospitals in Pakistan, and evaluation of two chromogenic media. J. Antimicrob. Chemother. 2011, 66:2288-2294.
16. Nordmann P., et al. Does broad-spectrum resistance due to NDM-1 herald the end of the antibiotic era for treatment caused by Gram negative bacteria?. J. Antimicrob. Chemother. 2011, 66:689-692.
17. Bogaerts P., et al. Global spread of New Delhi metallo-β-lactamase 1. Lancet Infect. Dis. 2010, 12:831-832.
18. Centers for Disease Control and Prevention (CDC) Detection of Enterobacteriaceae isolates carrying metallo-β-lactamase - United States. Morb. Mortal. Wkly. Rep. 2010, 59:750.
19. Chan H.L., et al. The perils of medical tourism: NDM-1 positive Escherichia coli febrile neutropenia in a medical tourist. Singapore Med. J. 2011, 52:299-302.
20. D'Andrea M.M., et al. Persistent carriage and infection by multiresistant Escherichia coli ST405 producing the NDM-1 carbapenemase: a report of the first Italian cases. J. Clin. Microbiol. 2011, 49:2755-2758.
21. Göttig S., et al. Global spread of New Delhi metallo-β-lactamase 1. Lancet Infect. Dis. 2010, 12:828-829.
22. Ho P.L., et al. Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong. PLoS ONE 2011, 6:e17989.
23. Hammerum A.M., et al. Global spread of New Delhi metallo-β-lactamase 1. Lancet Infect. Dis. 2010, 12:829-830.
24. Huo T.I. The first case of multidrug-resistant NDM-1-harboring Enterobacteriaceae in Taiwan: here comes the superbacteria!. J. Chin. Med. Assoc. 2010, 73:557-558.
25. Koh T.H., et al. Global spread of New Delhi metallo-β-lactamase. Lancet Infect. Dis. 2010, 12:828.
26. Mulvey M.R., et al. New Delhi metallo-β-lactamase in Klebsiella pneumoniae and Escherichia coli. Can. Emerg. Infect. Dis. 2011, 17:103-106.
27. Peirano G., et al. Characteristics of NDM-1 producing Escherichia coli isolates that belong to the successful and virulent clone ST131. Antimicrob. Agents Chemother. 2011, 55:2986-2988.
28. Poirel L., et al. NDM-1-producing Klebsiella pneumoniae isolated in the Sultanate of Oman. J. Antimicrob. Chemother. 2011, 66:304-306.
29. Poirel L., et al. International transfer of NDM-1-producing Klebsiella pneumoniae from Iraq to France. Antimicrob. Agents Chemother. 2011, 55:1821-1822.
30. Poirel L., et al. Global spread of New Delhi metallo-β-lactamase 1. Lancet Infect. Dis. 2010, 12:832.
31. Poirel L., et al. Molecular analysis of NDM-1-producing enterobacterial isolates from Geneva, Switzerland. J. Antimicrob. Chemother. 2011, 66:1730-1733.
32. Poirel L., et al. Emergence of metallo β-lactamase NDM-1 producing multidrug resistant Escherichia coli in Australia. Antimicrob. Agents Chemother. 2010, 54:4914-4916.
33. Poirel L., et al. Detection of NDM-1-producing Klebsiella pneumoniae in Kenya. Antimicrob. Agents Chemother. 2011, 55:934-936.
34. Poirel L., et al. Extremely drug-resistant Citrobacter freundii producing NDM-1 and other carbapenemases identified in a patient returning from India. Antimicrob. Agents Chemother. 2011, 55:447-448.
35. Sidjabat H., et al. Carbapenem resistance in Klebsiella pneumoniae due to the New Delhi metallo-β-lactamase. Clin. Infect. Dis. 2011, 52:481-484.
36. Poirel L., et al. NDM-1 producing Klebsiella pneumoniae in Mauritius. Antimicrob. Agent Chemother. 2011, 10.1128/AAC.05639-11.
37. Zarfel G., et al. Emergence of New Delhi metallo-β-lactamase. Austria Emerg. Infect. Dis. 2011, 17:129-130.
38. Kaase M., et al. NDM-2 carbapenemase in Acinetobacter baumannii from Egypt. J. Antimicrob. Chemother. 2011, 66:1260-1262.
39. Poirel L., et al. Emergence of NDM-1 producing Klebsiella pneumoniae in Morocco. J. Antimicrob. Chemother. 2011, 10.1093/jac/dkr384.
40. Nordmann P., et al. Emergence of an autochtonous NDM-1 producing Klebsiella pneumoniae in Europe. Clin. Infect. Dis. 2011, 10.1093/cid/cir720.
41. NDM-1 and armA in clinical isolates of Acinetobacter baumannii in India. J. Antimicrob. Chemother. 2011, 65:2253-2254.
42. IMP in pan-drug resistant Acinetobacter baumannii isolates in China. Clin. Infect. Dis. 2011, 52:692-693.
43. Chen Y., et al. Emergence of NDM-1 producing Acinetobacter baumannii in China. J. Antimicrob. Chemother. 2011, 66:1255-1259.
44. Livermore D.M., et al. Balkan NDM-1: escape or transplant?. Lancet Infect. Dis. 2011, 11:164.
45. Jovcic B., et al. Emergence of NDM-1 metallo β-lactamase in Pseudomonas aeruginosa clinical isolates. Antimicrob. Agents Chemother. 2011, 55:3929-3931.
46. Leverstein-Van Hall M.A., et al. Global spread of NDM-1. Lancet Infect. Dis. 2010, 10:830-831.
47. Walsh T.R., et al. Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. Lancet Infect. Dis. 2011, 11:355-362.
48. Poirel L., et al. Genetic features of the blaNDM-1 positive Enterobacteriaceae. Antimicrob. Agents Chemother. 2011, 55:5403-5407.
49. Samuelsen O., et al. Identification of NDM-1-producing Enterobacteriaceae in Norway. J. Antimicrob. Chemother. 2011, 66:670-672.
50. Berçot, B. et al. Updated multiplex PCR for detection of 16S rRNA methylases; high prevalence among NDM-1 producers. Diagn. Microbiol. Infect. Dis. doi:10.1016/j.diagmicrobio.2011.08.016.
51. Livermore D.M., et al. Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae. J. Antimicrob. Chemother. 2011, 66:48-53.
52. Poirel L., et al. Analysis of the resistosome of the multidrug resistant NDM-1 producing Escherichia coli by high-throughput genome sequencing. Antimicrob. Agents Chemother. 2011, 55:4224-4229.
53. CTX-M-62 linked to qnrB2. Antimicrob. Agents Chemother. 2010, 54:3039-3042.
54. Carattoli A., et al. Complete nucleotide sequence of the IncN plasmid pKOX105 encoding VIM-1, QnrS1 and SHV-12 proteins in Enterobacteriaceae from Bolzano, Italy compared with IncN plasmids encoding KPC enzymes in the USA. J. Antimicrob. Chemother. 2010, 65:2070-2075.
55. KPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. Antimicrob. Agents Chemother. 2009, 53:1998-2004.
56. Coupland G.M., et al. The origin of transfer (oriT) of the conjugative plasmid R46: characterization by deletion analysis and DNA sequencing. Mol. Gen. Genet. 1987, 208:219-225.
57. Mussi M.A., et al. Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins. Antimicrob. Agents Chemother. 2005, 49:1432-1440.
58. Livermore D.M., et al. What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin, and tigecycline. Int. J. Antimicrob. Agents 2011, 37:415-419.
59. Livermore D.M., et al. Activities of NXL104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae. Antimicrob. Agents Chemother. 2011, 55:390-394.
60. Nordmann P., et al. How to detect NDM-1 producers?. J. Clin. Microbiol. 2011, 49:718-731.
61. Clinical and Laboratory Standards Institute Performance Standards for Antimicrobial Susceptibility Testing: Twentieth Informational Supplement (M100-S20U) 2010, Clinical and Laboratory Standards Institute. http://www.clsi.org/source/orders/free/m100-s20.pdf.
62. Woodford N., et al. Comparison of BD Phoenix, Vitek 2 and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae. J. Clin. Microbiol. 2010, 48:2999-3002.
63. Pasteran F., et al. Controlling false-positive results obtained with the Hodge and Masuda assays for detection of class A carbapenemases in species of Enterobacteriaceae by incorporating boronic acid. J. Clin. Microbiol. 2010, 48:1323-1332.
64. Chu Y.W., et al. EDTA susceptibility leading to false detection of metallo β-lactamase in Pseudomonas aeruginosa by Etest and imipenem-EDTA disk method. Int. J. Antimicrob. Agents 2005, 26:340-341.
65. Naas T., et al. Evaluation of a DNA microarray (Check-MDR CT102) for rapid detection of TEM, SHV, and CTX-M extended-spectrum β-lactamases and of KPC, OXA-48, VIM, IMP, and NDM-1 carbapenemases. J. Clin. Microbiol. 2011, 49:1608-1613.
66. Jean S.S., Hsueh P.R. High burden of antimicrobial resistance in Asia. Int. J. Antimicrob. Agents 2011, 37:291-295.
67. Naas T., et al. Real time PCR for detection of NDM-1 carbapenemase genes from spiked stool samples. Antimicrob. Agents Chemother. 2011, 55:4038-4043.
68. Poirel L., et al. Long-term carriage of NDM-1-producing Escherichia coli. J. Antimicrob. Chemother. 2011, 66:2185-2186.
69. Tängden T., et al. Foreign travel is a major risk factor for colonization with Escherichia coli producing CTX-M-type extended-spectrum β-lactamase: a prospective study with Swedish volunteers. Antimicrob. Agents Chemother. 2010, 54:3564-3568.
70. Falagas M., et al. Therapeutic options with Enterobacteriaceae producing carbapenem-hydrolyzing enzymes. Future Microbiol. 2011, 6:653-666.
71. Bax B.D., et al. Type IIA topoisomerase inhibition by a new class of antibacterial agents. Nature 2010, 466:935-940.
72. Page M.G., et al. In vitro properties of BAL 30072, a novel siderophore sulfactam with activity against multiresistant Gram-negative bacilli. Antimicrob. Agents Chemother. 2010, 54:2291-2302.