Amino Acid Thioester Derivatives: A Highly Promising Scaffold for the Development of Metallo-β-lactamase L1 Inhibitors

ACS Medicinal Chemistry Letters

Volumn 6, Issue 6, 2015, Pages 660-664

  Liu, Xiao Long ^a   Shi, Ying ^a   Kang, Joon S ^b   Oelschlaeger, Peter ^c   Yang, Ke Wu ^a  

^a NORTHWEST UNIVERSITY   (China)

^b CALIFORNIA STATE POLYTECHNIC UNIVERSITY   (United States)

^c WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

Antibiotic resistance; inhibitor; L1; mercaptoacetic acid thioester; metallo lactamase; subclass B3

Indexed keywords

AMINO ACID DERIVATIVE; BETA LACTAMASE INHIBITOR; CARBOXYLIC ACID; CEFAZOLIN; MERCAPTOACETIC ACID THIOESTER AMINO ACID DERIVATIVE; METALLO BETA LACTAMASE; THIOESTER; THIOGLYCOLIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ZINC ION;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; IC50; INHIBITION CONSTANT; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; REDUCTION KINETICS; STRUCTURE ANALYSIS;

EID: 84935855840     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00098     Document Type: Article

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