Rhodanine as a Potent Scaffold for the Development of Broad-Spectrum Metallo-β-lactamase Inhibitors

ACS Medicinal Chemistry Letters

Volumn 9, Issue 4, 2018, Pages 359-364

  Xiang, Yang ^a   Chen, Cheng ^a   Wang, Wen Ming ^a   Xu, Li Wei ^a   Yang, Ke Wu ^a   Oelschlaeger, Peter ^b   He, Yuan ^a  

^a NORTHWEST UNIVERSITY   (China)

^b WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

Antibiotic resistance; broad spectrum inhibitor; metallo lactamases; rhodanine

Indexed keywords

BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CEFAZOLIN; IMIPENEM; METALLO BETA LACTAMASE; METALLO BETA LACTAMASE INHIBITOR; MOLECULAR SCAFFOLD; RHODANINE; THIOENOLATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; CYTOTOXICITY ASSAY; DOSE RESPONSE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION;

EID: 85045295514     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.7b00548     Document Type: Article

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