Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase

ACS Infectious Diseases

Volumn 1, Issue 11, 2016, Pages 544-554

  González, Mariano M ^a   Kosmopoulou, Magda ^b   Mojica, Maria F ^c   Castillo, Valerie ^d   Hinchliffe, Philip ^b   Pettinati, Ilaria ^e   Brem, Jürgen ^e   Schofield, Christopher J ^e   Mahler, Graciela ^d   Bonomo, Robert A ^c   Llarrull, Leticia I ^a   Spencer, James ^b   Vila, Alejandro J ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

antibiotic resistance; bisthiazolidines; inhibitors; metallo lactamase; NDM 1

Indexed keywords

2 MERCAPTOMETHYL 7 DIMETHYL 8 CARBOXYLATE 1 AZA 3,6 DITHIOBICYCLO[3.3.0]OCTANE; 8 CARBOXYLATE 2 MERCAPTOMETHYL 1 AZA 3,6 DITHIOBICYCLO[3.3.0]OCTANE; BETA LACTAM ANTIBIOTIC; BISTHIAZOLIDINE DERIVATIVE; ENZYME INHIBITOR; IMIPENEM; METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE CARBAPENEMASE INHIBITOR; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG HYDROLYSIS; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; FEMALE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; INHIBITION CONSTANT; METAL BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TIME-DEPENDENT INHIBITION;

EID: 84969261451     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.5b00046     Document Type: Article

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