Interleukin-6: Designing specific therapeutics for a complex cytokine

Nature Reviews Drug Discovery

Volumn 17, Issue 6, 2018, Pages 395-412

  Garbers, Christoph ^a   Heink, Sylvia ^b   Korn, Thomas ^b,c   Rose John, Stefan ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c Technische Universität München Munich Cluster for Systems Neurology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BARICITINIB; C REACTIVE PROTEIN; CLAZAKIZUMAB; EBI 031; FILGOTINIB; GLYCOPROTEIN GP 130; GROWTH FACTOR; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; INTERLEUKIN 6 RECEPTOR; JANUS KINASE; NI 1201; OLAMKICEPT; OLOKIZUMAB; PF 04965842; RUXOLITINIB; SARILUMAB; SILTUXIMAB; SIRUKUMAB; STAT3 PROTEIN; TOCILIZUMAB; TOFACITINIB; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; UPADACITINIB; VOBARILIZUMAB; MONOCLONAL ANTIBODY;

ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; AUTOIMMUNITY; BINDING AFFINITY; BONE METABOLISM; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS; CYTOKINE RELEASE SYNDROME; DENDRITIC CELL; DISEASE EXACERBATION; DRUG APPROVAL; DRUG EFFICACY; DRUG INDICATION; DRUG TARGETING; ENERGY METABOLISM; ERDHEIM CHESTER DISEASE; GIANT CELL ARTERITIS; HOST RESISTANCE; HUMAN; IL 6 SIGNALING; IMMUNOPATHOGENESIS; INFLAMMATION; MULTIPLE MYELOMA; MYELOOPTIC NEUROPATHY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS; TH17 CELL; TREATMENT RESPONSE; ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOIMMUNE DISEASE; CLINICAL TRIAL (TOPIC); DRUG EFFECT; METABOLISM;

ANIMALS; ANTIBODIES, MONOCLONAL; ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; CLINICAL TRIALS AS TOPIC; HUMANS; INTERLEUKIN-6; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION;

EID: 85047867975     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd.2018.45     Document Type: Review

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