-
1
-
-
0025990288
-
Elevated levels of endogenous IL-6 in systemic lupus erythematosus: A putative role in pathogenesis
-
Linker-Israeli M, Deans RJ, Wallace DJ, Prehn J, Ozeri-Chen T, Klinenberg JR,. Elevated levels of endogenous IL-6 in systemic lupus erythematosus: a putative role in pathogenesis. J Immunol 1991; 147: 117-23.
-
(1991)
J Immunol
, vol.147
, pp. 117-123
-
-
Linker-Israeli, M.1
Deans, R.J.2
Wallace, D.J.3
Prehn, J.4
Ozeri-Chen, T.5
Klinenberg, J.R.6
-
2
-
-
0026712445
-
Plasma concentration of IL-6 in systemic lupus erythematosus; An indicator of disease activity?
-
Spronk PE, ter Borg EJ, Limburg PC, Kallenberg CG,. Plasma concentration of IL-6 in systemic lupus erythematosus; an indicator of disease activity? Clin Exp Immunol 1992; 90: 106-10.
-
(1992)
Clin Exp Immunol
, vol.90
, pp. 106-110
-
-
Spronk, P.E.1
Ter Borg, E.J.2
Limburg, P.C.3
Kallenberg, C.G.4
-
3
-
-
0027513607
-
Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases
-
Al-Janadi M, al-Balla S, al-Dalaan A, Raziuddin S,. Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases. J Clin Immunol 1993; 13: 58-67.
-
(1993)
J Clin Immunol
, vol.13
, pp. 58-67
-
-
Al-Janadi, M.1
Al-Balla, S.2
Al-Dalaan, A.3
Raziuddin, S.4
-
4
-
-
0028949892
-
Elevated serum interleukin-6 levels associated with active disease in systemic connective tissue disorders
-
Stuart RA, Littlewood AJ, Maddison PJ, Hall ND,. Elevated serum interleukin-6 levels associated with active disease in systemic connective tissue disorders. Clin Exp Rheumatol 1995; 13: 17-22.
-
(1995)
Clin Exp Rheumatol
, vol.13
, pp. 17-22
-
-
Stuart, R.A.1
Littlewood, A.J.2
Maddison, P.J.3
Hall, N.D.4
-
5
-
-
0028328436
-
Impaired immune and acute-phase responses in interleukin-6-deficient mice
-
Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 1994; 368: 339-42.
-
(1994)
Nature
, vol.368
, pp. 339-342
-
-
Kopf, M.1
Baumann, H.2
Freer, G.3
Freudenberg, M.4
Lamers, M.5
Kishimoto, T.6
-
6
-
-
0027984754
-
Defective inflammatory response in interleukin 6-deficient mice
-
Fattori E, Cappelletti M, Costa P, Sellitto C, Cantoni L, Carelli M, et al. Defective inflammatory response in interleukin 6-deficient mice. J Exp Med 1994; 180: 1243-50.
-
(1994)
J Exp Med
, vol.180
, pp. 1243-1250
-
-
Fattori, E.1
Cappelletti, M.2
Costa, P.3
Sellitto, C.4
Cantoni, L.5
Carelli, M.6
-
7
-
-
0029007193
-
Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: Correlation with inefficient neutrophilia
-
Dalrymple SA, Lucian LA, Slattery R, McNeil T, Aud DM, Fuchino S, et al. Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect Immun 1995; 63: 2262-8.
-
(1995)
Infect Immun
, vol.63
, pp. 2262-2268
-
-
Dalrymple, S.A.1
Lucian, L.A.2
Slattery, R.3
McNeil, T.4
Aud, D.M.5
Fuchino, S.6
-
8
-
-
0029913685
-
Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans
-
Romani L, Mencacci A, Cenci E, Spaccapelo R, Toniatti C, Puccetti P, et al. Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans. J Exp Med 1996; 183: 1345-55.
-
(1996)
J Exp Med
, vol.183
, pp. 1345-1355
-
-
Romani, L.1
Mencacci, A.2
Cenci, E.3
Spaccapelo, R.4
Toniatti, C.5
Puccetti, P.6
-
9
-
-
0032536542
-
Interleukin 6 is required for the development of collagen-induced arthritis
-
Alonzi T, Fattori E, Lazzaro D, Costa P, Probert L, Kollias G, et al. Interleukin 6 is required for the development of collagen-induced arthritis. J Exp Med 1998; 187: 461-8.
-
(1998)
J Exp Med
, vol.187
, pp. 461-468
-
-
Alonzi, T.1
Fattori, E.2
Lazzaro, D.3
Costa, P.4
Probert, L.5
Kollias, G.6
-
10
-
-
13144259627
-
Interleukin 6 plays a key role in the development of antigen-induced arthritis
-
Ohshima S, Saeki Y, Mima T, Sasai M, Nishioka K, Nomura S, et al. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc Natl Acad Sci U S A 1998; 95: 8222-6.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 8222-8226
-
-
Ohshima, S.1
Saeki, Y.2
Mima, T.3
Sasai, M.4
Nishioka, K.5
Nomura, S.6
-
11
-
-
0031852288
-
IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
-
Eugster HP, Frei K, Kopf M, Lassmann H, Fontana A,. IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. Eur J Immunol 1998; 28: 2178-87.
-
(1998)
Eur J Immunol
, vol.28
, pp. 2178-2187
-
-
Eugster, H.P.1
Frei, K.2
Kopf, M.3
Lassmann, H.4
Fontana, A.5
-
12
-
-
0031920882
-
IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein
-
Okuda Y, Sakoda S, Bernard CC, Fujimura H, Saeki Y, Kishimoto T, et al. IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein. Int Immunol 1998; 10: 703-8.
-
(1998)
Int Immunol
, vol.10
, pp. 703-708
-
-
Okuda, Y.1
Sakoda, S.2
Bernard, C.C.3
Fujimura, H.4
Saeki, Y.5
Kishimoto, T.6
-
13
-
-
0032534730
-
IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells
-
Samoilova EB, Horton JL, Hilliard B, Liu TS, Chen Y,. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol 1998; 161: 6480-6.
-
(1998)
J Immunol
, vol.161
, pp. 6480-6486
-
-
Samoilova, E.B.1
Horton, J.L.2
Hilliard, B.3
Liu, T.S.4
Chen, Y.5
-
14
-
-
79953319576
-
Effectiveness and safety of the interleukin 6-receptor antagonist tocilizumab after 4 and 24 weeks in patients with active rheumatoid arthritis: The first phase IIIb real-life study (TAMARA)
-
Burmester GR, Feist E, Kellner H, Braun J, Iking-Konert C, Rubbert-Roth A,. Effectiveness and safety of the interleukin 6-receptor antagonist tocilizumab after 4 and 24 weeks in patients with active rheumatoid arthritis: the first phase IIIb real-life study (TAMARA). Ann Rheum Dis 2011; 70: 755-9.
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 755-759
-
-
Burmester, G.R.1
Feist, E.2
Kellner, H.3
Braun, J.4
Iking-Konert, C.5
Rubbert-Roth, A.6
-
15
-
-
79953680176
-
Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: Results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year
-
Kremer JM, Blanco R, Brzosko M, Burgos-Vargas R, Halland AM, Vernon E, et al. Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year. Arthritis Rheum 2011; 63: 609-21.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 609-621
-
-
Kremer, J.M.1
Blanco, R.2
Brzosko, M.3
Burgos-Vargas, R.4
Halland, A.M.5
Vernon, E.6
-
16
-
-
84858751079
-
Lupus: Novel therapies in clinical development
-
Chugh PK,. Lupus: novel therapies in clinical development. Eur J Intern Med 2012; 23: 212-8.
-
(2012)
Eur J Intern Med
, vol.23
, pp. 212-218
-
-
Chugh, P.K.1
-
17
-
-
80054096258
-
Ending the 50-year drought of FDA drug approval for SLE
-
Merrill JT,. Ending the 50-year drought of FDA drug approval for SLE. Bull NYU Hosp Jt Dis 2011; 69: 238-42.
-
(2011)
Bull NYU Hosp Jt Dis
, vol.69
, pp. 238-242
-
-
Merrill, J.T.1
-
18
-
-
0030890718
-
Gp130 and the interleukin-6 family of cytokines
-
Taga T, Kishimoto T,. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 1997; 15: 797-819.
-
(1997)
Annu Rev Immunol
, vol.15
, pp. 797-819
-
-
Taga, T.1
Kishimoto, T.2
-
19
-
-
0026828552
-
Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
-
Lust JA, Donovan KA, Kline MP, Greipp PR, Kyle RA, Maihle NJ,. Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine 1992; 4: 96-100.
-
(1992)
Cytokine
, vol.4
, pp. 96-100
-
-
Lust, J.A.1
Donovan, K.A.2
Kline, M.P.3
Greipp, P.R.4
Kyle, R.A.5
Maihle, N.J.6
-
20
-
-
0028270409
-
The soluble human IL-6 receptor: Mutational characterization of the proteolytic cleavage site
-
Mullberg J, Oberthur W, Lottspeich F, Mehl E, Dittrich E, Graeve L, et al. The soluble human IL-6 receptor: mutational characterization of the proteolytic cleavage site. J Immunol 1994; 152: 4958-68.
-
(1994)
J Immunol
, vol.152
, pp. 4958-4968
-
-
Mullberg, J.1
Oberthur, W.2
Lottspeich, F.3
Mehl, E.4
Dittrich, E.5
Graeve, L.6
-
21
-
-
0035160256
-
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
-
Jostock T, Mullberg J, Ozbek S, Atreya R, Blinn G, Voltz N, et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem 2001; 268: 160-7.
-
(2001)
Eur J Biochem
, vol.268
, pp. 160-167
-
-
Jostock, T.1
Mullberg, J.2
Ozbek, S.3
Atreya, R.4
Blinn, G.5
Voltz, N.6
-
22
-
-
55249092252
-
Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130
-
Tenhumberg S, Waetzig GH, Chalaris A, Rabe B, Seegert D, Scheller J, et al. Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130. J Biol Chem 2008; 283: 27200-7.
-
(2008)
J Biol Chem
, vol.283
, pp. 27200-27207
-
-
Tenhumberg, S.1
Waetzig, G.H.2
Chalaris, A.3
Rabe, B.4
Seegert, D.5
Scheller, J.6
-
23
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
-
Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, Wirtz S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat Med 2000; 6: 583-8.
-
(2000)
Nat Med
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
Mullberg, J.4
Jostock, T.5
Wirtz, S.6
-
24
-
-
0042834261
-
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: Blockade of arthritis severity by soluble glycoprotein 130
-
Nowell MA, Richards PJ, Horiuchi S, Yamamoto N, Rose-John S, Topley N, et al. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. J Immunol 2003; 171: 3202-9.
-
(2003)
J Immunol
, vol.171
, pp. 3202-3209
-
-
Nowell, M.A.1
Richards, P.J.2
Horiuchi, S.3
Yamamoto, N.4
Rose-John, S.5
Topley, N.6
-
25
-
-
33646469222
-
Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis
-
Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum 2006; 54: 1662-72.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 1662-1672
-
-
Richards, P.J.1
Nowell, M.A.2
Horiuchi, S.3
McLoughlin, R.M.4
Fielding, C.A.5
Grau, S.6
-
26
-
-
38949164424
-
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation
-
Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, et al. Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood 2008; 111: 1021-8.
-
(2008)
Blood
, vol.111
, pp. 1021-1028
-
-
Rabe, B.1
Chalaris, A.2
May, U.3
Waetzig, G.H.4
Seegert, D.5
Williams, A.S.6
-
27
-
-
80052358980
-
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
-
Jones SA, Scheller J, Rose-John S,. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest 2011; 121: 3375-83.
-
(2011)
J Clin Invest
, vol.121
, pp. 3375-3383
-
-
Jones, S.A.1
Scheller, J.2
Rose-John, S.3
-
28
-
-
0028784215
-
Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
-
Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, et al. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 1995; 83: 301-11.
-
(1995)
Cell
, vol.83
, pp. 301-311
-
-
Hibbs, M.L.1
Tarlinton, D.M.2
Armes, J.3
Grail, D.4
Hodgson, G.5
Maglitto, R.6
-
29
-
-
0028806216
-
Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
-
Nishizumi H, Taniuchi I, Yamanashi Y, Kitamura D, Ilic D, Mori S, et al. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity 1995; 3: 549-60.
-
(1995)
Immunity
, vol.3
, pp. 549-560
-
-
Nishizumi, H.1
Taniuchi, I.2
Yamanashi, Y.3
Kitamura, D.4
Ilic, D.5
Mori, S.6
-
30
-
-
77949322552
-
Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6
-
Tsantikos E, Oracki SA, Quilici C, Anderson GP, Tarlinton DM, Hibbs ML,. Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6. J Immunol 2010; 184: 1348-60.
-
(2010)
J Immunol
, vol.184
, pp. 1348-1360
-
-
Tsantikos, E.1
Oracki, S.A.2
Quilici, C.3
Anderson, G.P.4
Tarlinton, D.M.5
Hibbs, M.L.6
-
31
-
-
79958048246
-
The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis
-
Koh AE, Njoroge SW, Feliu M, Cook A, Selig MK, Latchman YE, et al. The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis. J Autoimmun 2011; 37: 48-57.
-
(2011)
J Autoimmun
, vol.37
, pp. 48-57
-
-
Koh, A.E.1
Njoroge, S.W.2
Feliu, M.3
Cook, A.4
Selig, M.K.5
Latchman, Y.E.6
-
32
-
-
84864806973
-
Genetic interdependence of Lyn and negative regulators of B cell receptor signaling in autoimmune disease development
-
Tsantikos E, Maxwell MJ, Kountouri N, Harder KW, Tarlinton DM, Hibbs ML,. Genetic interdependence of Lyn and negative regulators of B cell receptor signaling in autoimmune disease development. J Immunol 2012; 189: 1726-36.
-
(2012)
J Immunol
, vol.189
, pp. 1726-1736
-
-
Tsantikos, E.1
Maxwell, M.J.2
Kountouri, N.3
Harder, K.W.4
Tarlinton, D.M.5
Hibbs, M.L.6
-
33
-
-
77955343903
-
Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice
-
Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, et al. Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med 2010; 207: 1757-73.
-
(2010)
J Exp Med
, vol.207
, pp. 1757-1773
-
-
Scapini, P.1
Hu, Y.2
Chu, C.L.3
Migone, T.S.4
Defranco, A.L.5
Cassatella, M.A.6
-
34
-
-
22144492213
-
IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
-
McLoughlin RM, Jenkins BJ, Grail D, Williams AS, Fielding CA, Parker CR, et al. IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proc Natl Acad Sci U S A 2005; 102: 9589-94.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 9589-9594
-
-
McLoughlin, R.M.1
Jenkins, B.J.2
Grail, D.3
Williams, A.S.4
Fielding, C.A.5
Parker, C.R.6
-
35
-
-
77949881389
-
Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells
-
Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, et al. Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J Immunol 2010; 184: 2130-9.
-
(2010)
J Immunol
, vol.184
, pp. 2130-2139
-
-
Jones, G.W.1
McLoughlin, R.M.2
Hammond, V.J.3
Parker, C.R.4
Williams, J.D.5
Malhotra, R.6
-
36
-
-
78149474747
-
Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity
-
Lissilaa R, Buatois V, Magistrelli G, Williams AS, Jones GW, Herren S, et al. Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity. J Immunol 2010; 185: 5512-21.
-
(2010)
J Immunol
, vol.185
, pp. 5512-5521
-
-
Lissilaa, R.1
Buatois, V.2
Magistrelli, G.3
Williams, A.S.4
Jones, G.W.5
Herren, S.6
-
37
-
-
70149103642
-
Perturbation of the CD4 T cell compartment and expansion of regulatory T cells in autoimmune-prone Lyn-deficient mice
-
Tsantikos E, Quilici C, Harder KW, Wang B, Zhu HJ, Anderson GP, et al. Perturbation of the CD4 T cell compartment and expansion of regulatory T cells in autoimmune-prone Lyn-deficient mice. J Immunol 2009; 183: 2484-94.
-
(2009)
J Immunol
, vol.183
, pp. 2484-2494
-
-
Tsantikos, E.1
Quilici, C.2
Harder, K.W.3
Wang, B.4
Zhu, H.J.5
Anderson, G.P.6
-
38
-
-
77953212872
-
Basophils and the T helper 2 environment can promote the development of lupus nephritis
-
Charles N, Hardwick D, Daugas E, Illei GG, Rivera J,. Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med 2010; 16: 701-7.
-
(2010)
Nat Med
, vol.16
, pp. 701-707
-
-
Charles, N.1
Hardwick, D.2
Daugas, E.3
Illei, G.G.4
Rivera, J.5
-
39
-
-
84869890124
-
Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background
-
Lau M, Tsantikos E, Maxwell MJ, Tarlinton DM, Anderson GP, Hibbs ML,. Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background. J Autoimmun 2012; 39: 388-97.
-
(2012)
J Autoimmun
, vol.39
, pp. 388-397
-
-
Lau, M.1
Tsantikos, E.2
Maxwell, M.J.3
Tarlinton, D.M.4
Anderson, G.P.5
Hibbs, M.L.6
-
40
-
-
84862016703
-
Taming lupus - A new understanding of pathogenesis is leading to clinical advances
-
Liu Z, Davidson A,. Taming lupus-a new understanding of pathogenesis is leading to clinical advances. Nat Med 2012; 18: 871-82.
-
(2012)
Nat Med
, vol.18
, pp. 871-882
-
-
Liu, Z.1
Davidson, A.2
-
41
-
-
79952070370
-
Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: A randomised, placebo-controlled, phase 3 trial
-
Navarra SV, Guzman RM, Gallacher AE, Hall S, Levy RA, Jimenez RE, et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 2011; 377: 721-31.
-
(2011)
Lancet
, vol.377
, pp. 721-731
-
-
Navarra, S.V.1
Guzman, R.M.2
Gallacher, A.E.3
Hall, S.4
Levy, R.A.5
Jimenez, R.E.6
-
43
-
-
75749113331
-
Tocilizumab in systemic lupus erythematosus: Data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase i dosage-escalation study
-
Illei GG, Shirota Y, Yarboro CH, Daruwalla J, Tackey E, Takada K, et al. Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study. Arthritis Rheum 2010; 62: 542-52.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 542-552
-
-
Illei, G.G.1
Shirota, Y.2
Yarboro, C.H.3
Daruwalla, J.4
Tackey, E.5
Takada, K.6
-
44
-
-
33747774200
-
STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice
-
Mitsuyama K, Matsumoto S, Rose-John S, Suzuki A, Hara T, Tomiyasu N, et al. STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. Gut 2006; 55: 1263-9.
-
(2006)
Gut
, vol.55
, pp. 1263-1269
-
-
Mitsuyama, K.1
Matsumoto, S.2
Rose-John, S.3
Suzuki, A.4
Hara, T.5
Tomiyasu, N.6
-
45
-
-
77949326158
-
Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
-
Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M, et al. Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. J Immunol 2010; 184: 1543-51.
-
(2010)
J Immunol
, vol.184
, pp. 1543-1551
-
-
Matsumoto, S.1
Hara, T.2
Mitsuyama, K.3
Yamamoto, M.4
Tsuruta, O.5
Sata, M.6
-
46
-
-
84856221966
-
Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice
-
Schuett H, Oestreich R, Waetzig GH, Annema W, Luchtefeld M, Hillmer A, et al. Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice. Arterioscler Thromb Vasc Biol 2012; 32: 281-90.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 281-290
-
-
Schuett, H.1
Oestreich, R.2
Waetzig, G.H.3
Annema, W.4
Luchtefeld, M.5
Hillmer, A.6
-
47
-
-
84861192191
-
Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease
-
Maxwell MJ, Tsantikos E, Kong AM, Vanhaesebroeck B, Tarlinton DM, Hibbs ML,. Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease. J Autoimmun 2012; 38: 381-91.
-
(2012)
J Autoimmun
, vol.38
, pp. 381-391
-
-
Maxwell, M.J.1
Tsantikos, E.2
Kong, A.M.3
Vanhaesebroeck, B.4
Tarlinton, D.M.5
Hibbs, M.L.6
-
49
-
-
0029764359
-
Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5
-
Wang Y, Hu Q, Madri JA, Rollins SA, Chodera A, Matis LA,. Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Proc Natl Acad Sci U S A 1996; 93: 8563-8.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 8563-8568
-
-
Wang, Y.1
Hu, Q.2
Madri, J.A.3
Rollins, S.A.4
Chodera, A.5
Matis, L.A.6
-
50
-
-
78651410434
-
The development of atypical hemolytic uremic syndrome depends on complement C5
-
De Jorge EG, Macor P, Paixao-Cavalcante D, Rose KL, Tedesco F, Cook HT, et al. The development of atypical hemolytic uremic syndrome depends on complement C5. J Am Soc Nephrol 2011; 22: 137-45.
-
(2011)
J Am Soc Nephrol
, vol.22
, pp. 137-145
-
-
De Jorge, E.G.1
Macor, P.2
Paixao-Cavalcante, D.3
Rose, K.L.4
Tedesco, F.5
Cook, H.T.6
|