Critical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 50, 2008, Pages 19845-19850

  Michel, Marie Laure ^a   Mendes da Cruz, Daniella ^a,b   Keller, Alexandre Castro ^a,c   Lochner, Matthias ^a   Schneider, Elke ^a   Dy, Michel ^a   Eberl, Gérard ^a   Leite de Moraes, Maria C ^a  

^a CNRS   (France)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

GalCer; CD1d; Cytokines; Thymic precursors

Indexed keywords

CD1D ANTIGEN; CD4 ANTIGEN; ENHANCED GREEN FLUORESCENT PROTEIN; INTERLEUKIN 17; RETINOIC ACID RELATED ORPHAN RECEPTOR GAMMA T; TETRAMER; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ALPHA GALACTOSYLCERAMIDE; ALPHA-GALACTOSYLCERAMIDE; GALACTOSYLCERAMIDE; GREEN FLUORESCENT PROTEIN; ORPHAN NUCLEAR RECEPTOR ROR GAMMA; ORPHAN NUCLEAR RECEPTOR ROR-GAMMA; RETINOIC ACID RECEPTOR; THYROID HORMONE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVITY; CELL DIFFERENTIATION; CELL MATURATION; CELL SUBPOPULATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE EXPRESSION; IMMUNOFLUORESCENCE; MALE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN VARIANT; STEM CELL; THYMUS; ANIMAL; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE;

MUS;

ANIMALS; CELL DIFFERENTIATION; GALACTOSYLCERAMIDES; GREEN FLUORESCENT PROTEINS; INTERLEUKIN-17; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, TRANSGENIC; NATURAL KILLER T-CELLS; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; THYMUS GLAND;

EID: 58149384437     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806472105     Document Type: Article

References (30)

1. Mosmann TR, Coffman RL (1989) TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties. Annu Rev Immunol 7:145-173.
2. Murphy KM, Reiner SL (2002) The lineage decisions of helper T cells. Nat Rev Immunol 2:933-944.
3. Langrish CL, et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201:233-240.
4. Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM (2006) Th17: An effector CD4 T cell lineage with regulatory T cell ties. Immunity 24:677-688.
5. Kawaguchi M, Adachi M, Oda N, Kokubu F, Huang S-K (2004) IL-17 cytokine family. J Allergy Clin Immunol 114:1265-1273.
6. Weaver CT, Hatton RD, Mangan PR, Harrington LE (2007) IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages. Annu Rev Immunol 25:821-852.
7. McGeachy MJ, Cua DJ (2008) Th17 cell differentiation: The long and winding road. Immunity 28:445-453.
8. Michel M-L, et al. (2007) Identification of an IL-17-producing NK1.1neg iNKT cell population involved in airway neutrophilia. J Exp Med 204:995-1001.
9. Kronenberg M (2005) Toward an understanding of NKT cell biology: Progress and paradoxes. Annu Rev Immunol 23:877-900.
10. Bendelac A, Savage PB, Teyton L (2007) The biology of NKT cells. Annu Rev Immunol 25:297-336.
11. Bendelac A (1995) Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes. J Exp Med 182:2091-2096.
12. Kawano T, et al. (1997) CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science 278:1626-1629.
13. Sharif S, et al. (2001) Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat Med 7:1057-1062.
14. Leite-de-Moraes MC, et al. (2002) Ligand-activated natural killer T lymphocytes promptly produce IL-3 and GM-CSF in vivo: Relevance to peripheral myeloid recruitment. Eur J Immunol 32:1897-1904.
15. Lisbonne M, et al. (2003) Cutting edge: Invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model. J Immunol 171:1637-1641.
16. Akbari O, et al. (2003) Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med 9:582-588.
17. Taniguchi M, Harada M, Kojo S, Nakayama T, Wakao H (2003) The regulatory role of Valpha14 NKT cells in innate and acquired immune response. Annu Rev Immunol 21:483-513.
18. Benlagha K, Kyin T, Beavis A, Teyton L, Bendelac A (2002) A thymic precursor to the NK T cell lineage. Science 296:553-555.
19. Pellicci DG, Hammond KJ, Uldrich AP, Baxter AG, Smyth MJ, Godfrey DI (2002) A natural killer T (NKT) cell developmental pathway involving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage. J Exp Med 195:835-844.
20. Godfrey DI, Berzins SP (2007) Control points in NKT-cell development. Nat Rev Immunol 7:505-518.
21. Egawa T, et al. (2005) Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity 22:705-716.
22. Bezbradica JS, Hill T, Stanic AK, Van Kaer L, Joyce S (2005) Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+stage of thymic ontogeny. Proc Natl Acad Sci USA 102:5114-5119.
23. Benlagha K, Wei DG, Veiga J, Teyton L, Bendelac A (2005) Characterization of the early stages of thymic NKT cell development. J Exp Med 202:485-492.
24. Ivanov II, et al. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126:1121-1133.
25. Rachitskaya AV, et al. (2008) Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol 180:5167-5171.
26. Coquet JM, et al. (2008) Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. Proc Natl Acad Sci USA 105:11287-11292.
27. Vicari A, et al. (1994) Interleukin 7 induces preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4+8- murine thymocytes positively selected by class I molecules. J Exp Med 180:653-661.
28. Pichavant M, et al. (2008) Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J Exp Med 205:385-393.
29. Cui J, et al. (1997) Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science 278:1623-1626.
30. Lochner M, et al. (2008) In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells. J Exp Med 205:1381-1393.