Interleukin-6 is a growth factor for nonmalignant human plasmablasts

Blood

Volumn 97, Issue 6, 2001, Pages 1817-1822

  Jego, Gaëtan ^a   Bataille, Régis ^a   Pellat Deceunynck, Catherine ^a  

^a INSTITUT DE BIOLOGIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MONOCLONAL ANTIBODY;

ARTICLE; B LYMPHOCYTE DIFFERENTIATION; BLAST CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MEMORY CELL; PLASMA CELL; PRIORITY JOURNAL;

EID: 0035869281     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.6.1817     Document Type: Article

References (40)

1. IgG1 plasmacytosis in interleukin 6 transgenic mice
2. Impaired immune and acute-phase responses in interleukin-6-deficient mice
3. The role of B cell proliferation in the generation of immunoglobulin-secreting cells in man
4. IL-4-dependent IgE switch in membrane IgA-positive human B cells
5. Generation of nondividing high rate Ig-secreting plasma cells in cultures of human B cells stimulated with anti-CD3-activated T cells
6. Generation of memory B cells and plasma cells in vitro
7. Memory B cells are biased towards terminal differentiation: A strategy that may prevent repertoire freezing
8. Generation of plasma cells from peripheral blood memory B cells: Synergistic effect of interleukin-10 and CD27/CD70 interaction
9. Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells
10. T cell-induced B cell blasts differentiate into plasma cells when cultured on bone marrow stroma with IL-3 and IL-10
11. The ability of synoviocytes to support terminal differentiation of activated B cells may explain plasma cell accumulation in rheumatoid synovium
12. VLA-4-fibronectin interaction is required for the terminal differentiation of human bone marrow cells capable of spontaneous and high rate immunoglobulin secretion
13. Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes
14. Memory, but not naive, peripheral blood B lymphocytes differentiate into Ig-secreting cells after CD40 ligation and co-stimulation with IL-4 and the differentiation factors IL-2, IL-10, and IL-3
15. Enhancement of terminal B lymphocyte differentiation in vitro by fibroblast-like stromal cells from human spleen
16. Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen
17. IL-2 dependence of the promotion of human B cell differentiation by IL-6 (BSF-2)
18. Expression of CD28 and CD40 in human myeloma cells: A comparative study with normal plasma cells
19. CD28, a marker associated with tumoral expansion in multiple myeloma
20. A plasmocyte selective monoclonal antibody (B-B4) recognizes syndecan-1
21. Adhesion molecules on human myeloma cells: Significant changes in expression related to malignancy, tumor spreading, and immortalization
22. Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis
23. Association between IL-6 and CD40 signaling: IL-6 induces phosphorylation of CD40 receptors
24. Cytokine mRNA expression during an in vitro response of human B lymphocytes: Kinetics of B cell tumor necrosis factor alpha, interleukin (IL)6, IL-10, and transforming growth factor beta 1 mRNAs
25. Demonstration that human B cells respond differently to interleukin 2 and B cell differentiation factor based on their stages of maturation
26. Demonstration of the involvement of interleukin 2 in the differentiation of Staphylococcus aureus Cowan I-stimulated B cells
27. The roles of interleukin 2 and interferon-gamma in human B cell activation, growth and differentiation
28. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
29. Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements
30. Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes
31. Inability to produce IL-6 is a functional feature of human germinal center B lymphocytes
32. Interleukin 6-producing gastric carcinoma with fever, hypergammaglobulinemia, and plasmacytosis in bone marrow
33. Constitutive production of interleukin-6 and immunologic features in cardiac myxomas
34. Reactive plasmacytoses, a new model for studying the biology of human plasma cell progenitors and precursors
35. Interleukin-6 in human multiple myeloma
36. Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma
37. Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop
38. New xenograft model of multiple myeloma and efficacy of a humanized antibody against human interleukin-6 receptor
39. Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy
40. Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes