IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

Journal of Clinical Investigation

Volumn 123, Issue 3, 2013, Pages 1019-1031

  Zhang, Hong ^a   Neuhöfer, Patrick ^a   Song, Liang ^a   Rabe, Björn ^b   Lesina, Marina ^a   Kurkowski, Magdalena U ^a   Treiber, Matthias ^a   Wartmann, Thomas ^c   Regnér, Sara ^d   Thorlacius, Henrik ^d   Saur, Dieter ^a   Weirich, Gregor ^a   Yoshimura, Akihiko ^e   Halangk, Walter ^c   Mizgerd, Joseph P ^f   Schmid, Roland M ^a   Rose John, Stefan ^b   Algül, Hana ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

^d LUND UNIVERSITY   (Sweden)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL1 CHEMOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 8; STAT1 PROTEIN; STAT3 PROTEIN;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DISEASE SEVERITY; GENE DELETION; IN VITRO STUDY; LETHALITY; LUNG EDEMA; LUNG INJURY; LUNG LAVAGE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ACINAR CELLS; ACUTE LUNG INJURY; AMINOSALICYLIC ACIDS; ANIMALS; BENZENESULFONATES; CHEMOKINE CXCL1; HUMANS; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYELOID CELLS; NF-KAPPA B; PANCREAS; PANCREATITIS; PHENYLUREA COMPOUNDS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, INTERLEUKIN-6; RECEPTORS, INTERLEUKIN-8B; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84874606609     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI64931     Document Type: Article

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