-
1
-
-
0034657336
-
The role of STATs in transcriptional control and their impact on cellular function
-
Bromberg, J. & Darnell, J. E. Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19, 2468-2473 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 2468-2473
-
-
Bromberg, J.1
Darnell Jr., J.E.2
-
2
-
-
0030840464
-
STATs and gene regulation
-
Darnell, J. E. Jr. STATs and gene regulation. Science 277, 1630-1635 (1997).
-
(1997)
Science
, vol.277
, pp. 1630-1635
-
-
Darnell Jr., J.E.1
-
3
-
-
84859992161
-
The JAK-STAT pathway at twenty
-
Stark, G. R. & Darnell, J. E. Jr. The JAK-STAT pathway at twenty. Immunity 36, 503-514 (2012).
-
(2012)
Immunity
, vol.36
, pp. 503-514
-
-
Stark, G.R.1
Darnell Jr., J.E.2
-
4
-
-
33847418900
-
Transcription protein STAT1: Biology and relation to cancer
-
Adamkova, L., Souckova, K. & Kovarik, J. Transcription protein STAT1: Biology and relation to cancer. Folia Biol. 53, 1-6 (2007).
-
(2007)
Folia Biol.
, vol.53
, pp. 1-6
-
-
Adamkova, L.1
Souckova, K.2
Kovarik, J.3
-
5
-
-
0038195719
-
Molecular mechanisms regulating Th1 immune responses
-
Szabo, S. J. et al. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21, 713-758 (2003).
-
(2003)
Annu. Rev. Immunol.
, vol.21
, pp. 713-758
-
-
Szabo, S.J.1
-
6
-
-
13344282731
-
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
-
Meraz, M. A. et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84, 431-442 (1996).
-
(1996)
Cell
, vol.84
, pp. 431-442
-
-
Meraz, M.A.1
-
7
-
-
34250316051
-
Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development
-
Agrawal, S. et al. Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development. Circulation 115, 2939-2947 (2007).
-
(2007)
Circulation
, vol.115
, pp. 2939-2947
-
-
Agrawal, S.1
-
8
-
-
79961154447
-
Gain of function human STAT1 mutations impair IL 17 immunity and underlie chronic mucocutaneous candidiasis
-
Liu, L. et al. Gain of function human STAT1 mutations impair IL 17 immunity and underlie chronic mucocutaneous candidiasis. J. Exp. Med. 208, 1635-1648 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1635-1648
-
-
Liu, L.1
-
9
-
-
79960094057
-
STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis
-
van de Veerdonk, F. L. et al. STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N. Engl. J. Med. 365, 54-61 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 54-61
-
-
Van De Veerdonk, F.L.1
-
10
-
-
77950799520
-
STAT2 contributes to promotion of colorectal and skin carcinogenesis
-
Gamero, A. M. et al. STAT2 contributes to promotion of colorectal and skin carcinogenesis. Cancer Prev. Res. 3, 495-504 (2010).
-
(2010)
Cancer Prev. Res.
, vol.3
, pp. 495-504
-
-
Gamero, A.M.1
-
11
-
-
0030935260
-
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
-
Takeda, K. et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl Acad. Sci. USA 94, 3801-3804 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 3801-3804
-
-
Takeda, K.1
-
12
-
-
0032934156
-
Functional roles of STAT family proteins: Lessons from knockout mice
-
Akira, S. Functional roles of STAT family proteins: Lessons from knockout mice. Stem Cells 17, 138-146 (1999).
-
(1999)
Stem Cells
, vol.17
, pp. 138-146
-
-
Akira, S.1
-
13
-
-
0032213273
-
Stat3 activation is responsible for IL 6 dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3 deficient mice
-
Takeda, K. et al. Stat3 activation is responsible for IL 6 dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3 deficient mice. J. Immunol. 161, 4652-4660 (1998).
-
(1998)
J. Immunol.
, vol.161
, pp. 4652-4660
-
-
Takeda, K.1
-
14
-
-
0033198793
-
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
-
Sano, S. et al. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J. 18, 4657-4668 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 4657-4668
-
-
Sano, S.1
-
15
-
-
84892445618
-
Role of STAT3 in skin carcinogenesis: Insights gained from relevant mouse models
-
Macias, E., Rao, D. & Digiovanni, J. Role of STAT3 in skin carcinogenesis: Insights gained from relevant mouse models. J. Skin Cancer 2013, 684050 (2013).
-
(2013)
J. Skin Cancer
, vol.2013
, pp. 684050
-
-
Macias, E.1
Rao, D.2
Digiovanni, J.3
-
16
-
-
0034658698
-
STATs in oncogenesis
-
Bowman, T. et al. STATs in oncogenesis. Oncogene 19, 2474-2488 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 2474-2488
-
-
Bowman, T.1
-
17
-
-
20944441928
-
Validating Stat3 in cancer therapy
-
Darnell, J. E. Validating Stat3 in cancer therapy. Nature Med. 11, 595-596 (2005).
-
(2005)
Nature Med.
, vol.11
, pp. 595-596
-
-
Darnell, J.E.1
-
18
-
-
20844444135
-
Targeting Stat3 in cancer therapy
-
Jing, N. & Tweardy, D. J. Targeting Stat3 in cancer therapy. Anticancer Drugs 16, 601-607 (2005).
-
(2005)
Anticancer Drugs
, vol.16
, pp. 601-607
-
-
Jing, N.1
Tweardy, D.J.2
-
19
-
-
1042302005
-
The STATs of cancer - new molecular targets come of age
-
Yu, H. & R. Jove, The STATs of cancer - new molecular targets come of age. Nature Rev. Cancer 4, 97-105 (2004).
-
(2004)
Nature Rev. Cancer
, vol.4
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
20
-
-
0036554816
-
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
-
Buettner, R., Mora, L. B. & Jove, R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin. Cancer Res. 8, 945-954 (2002).
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 945-954
-
-
Buettner, R.1
Mora, L.B.2
Jove, R.3
-
21
-
-
0034722896
-
STAT proteins: Novel molecular targets for cancer drug discovery
-
Turkson, J. & Jove, R. STAT proteins: Novel molecular targets for cancer drug discovery. Oncogene 19, 6613-6626 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 6613-6626
-
-
Turkson, J.1
Jove, R.2
-
22
-
-
64849111865
-
Targeting STAT3 in cancer: How successful are we? Expert Opin
-
Yue, P. & Turkson, J. Targeting STAT3 in cancer: How successful are we? Expert Opin. Investig. Drugs 18, 45-56 (2009).
-
(2009)
Investig. Drugs
, vol.18
, pp. 45-56
-
-
Yue, P.1
Turkson, J.2
-
23
-
-
5444237088
-
STAT proteins as novel targets for cancer drug discovery
-
Turkson, J. STAT proteins as novel targets for cancer drug discovery. Expert Opin. Ther. Targets. 8, 409-422 (2004).
-
(2004)
Expert Opin. Ther. Targets.
, vol.8
, pp. 409-422
-
-
Turkson, J.1
-
24
-
-
28644445445
-
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
-
Kortylewski, M. et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nature Med. 11, 1314-1321 (2005).
-
(2005)
Nature Med.
, vol.11
, pp. 1314-1321
-
-
Kortylewski, M.1
-
25
-
-
11144357779
-
Regulation of the innate and adaptive immune responses by Stat 3 signaling in tumor cells
-
Wang, T. et al. Regulation of the innate and adaptive immune responses by Stat 3 signaling in tumor cells. Nature Med, 10, 48-54 (2004).
-
(2004)
Nature Med
, vol.10
, pp. 48-54
-
-
Wang, T.1
-
26
-
-
34250658084
-
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
-
Siddiquee, K. et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc. Natl Acad. Sci. USA 104, 7391-7396 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 7391-7396
-
-
Siddiquee, K.1
-
27
-
-
38649129118
-
An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects
-
Siddiquee, K. A. et al. An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. ACS Chem. Biol. 2, 787-798 (2007).
-
(2007)
ACS Chem. Biol.
, vol.2
, pp. 787-798
-
-
Siddiquee, K.A.1
-
28
-
-
63949085226
-
Lack of toxicity of a STAT3 decoy oligonucleotide
-
Sen, M. et al. Lack of toxicity of a STAT3 decoy oligonucleotide. Cancer Chemother. Pharmacol. 63, 983-995 (2009).
-
(2009)
Cancer Chemother. Pharmacol.
, vol.63
, pp. 983-995
-
-
Sen, M.1
-
29
-
-
0032718891
-
Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo
-
Niu, G. et al. Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo. Cancer Res, 59, 5059-5063 (1999).
-
(1999)
Cancer Res
, vol.59
, pp. 5059-5063
-
-
Niu, G.1
-
30
-
-
0035977055
-
Phosphotyrosyl peptides block Stat3 mediated DNA binding activity gene regulation, and cell transformation
-
Turkson, J. et al. Phosphotyrosyl peptides block Stat3 mediated DNA binding activity, gene regulation, and cell transformation. J. Biol. Chem, 276, 45443-45455 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 45443-45455
-
-
Turkson, J.1
-
31
-
-
35348960378
-
STAT3 mutations in the hyper-IgE syndrome
-
Holland, S. M. et al. STAT3 mutations in the hyper-IgE syndrome. N. Engl. J. Med. 357, 1608-1619 (2007).
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 1608-1619
-
-
Holland, S.M.1
-
32
-
-
84861023172
-
Somatic STAT3 mutations in large granular lymphocytic leukemia
-
Koskela, H. L. et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. N. Engl. J. Med, 366, 1905-1913 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 1905-1913
-
-
Koskela, H.L.1
-
33
-
-
84874074941
-
Identification of a novel STAT3 mutation in a patient with hyper-IgE syndrome
-
Mogensen, T. H., Jakobsen, M. A. & Larsen, C. S. Identification of a novel STAT3 mutation in a patient with hyper-IgE syndrome. Scand. J. Infect. Dis. 45, 235-238 (2013).
-
(2013)
Scand. J. Infect. Dis.
, vol.45
, pp. 235-238
-
-
Mogensen, T.H.1
Jakobsen, M.A.2
Larsen, C.S.3
-
34
-
-
78650178184
-
Th1 versus Th17: Are T cell cytokines relevant in multiple sclerosis? Biochim
-
Lovett-Racke, A. E., Yang, Y. & Racke, M. K. Th1 versus Th17: Are T cell cytokines relevant in multiple sclerosis? Biochim. Biophys. Acta 1812, 246-251 (2011).
-
(2011)
Biophys. Acta
, vol.1812
, pp. 246-251
-
-
Lovett-Racke, A.E.1
Yang, Y.2
Racke, M.K.3
-
35
-
-
0034789247
-
Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
-
Chitnis, T. et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest. 108, 739-747 (2001).
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 739-747
-
-
Chitnis, T.1
-
36
-
-
79551573789
-
Targeting transcription factor Stat4 uncovers a role for interleukin 18 in the pathogenesis of severe lupus nephritis in mice
-
Menke, J. et al. Targeting transcription factor Stat4 uncovers a role for interleukin 18 in the pathogenesis of severe lupus nephritis in mice. Kidney Int. 79, 452-463 (2011).
-
(2011)
Kidney Int.
, vol.79
, pp. 452-463
-
-
Menke, J.1
-
37
-
-
0034657396
-
The role of Stat5a and Stat5b in signaling by IL 2 family cytokines
-
Lin, J. X. & Leonard, W. J. The role of Stat5a and Stat5b in signaling by IL 2 family cytokines. Oncogene 19, 2566-2576 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 2566-2576
-
-
Lin, J.X.1
Leonard, W.J.2
-
38
-
-
0037217955
-
Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells
-
Buitenhuis, M. et al. Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells. Blood. 101, 134-142 (2003).
-
(2003)
Blood.
, vol.101
, pp. 134-142
-
-
Buitenhuis, M.1
-
39
-
-
0030833570
-
Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
-
Udy, G. B. et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl Acad. Sci. USA 94, 7239-7244 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 7239-7244
-
-
Udy, G.B.1
-
40
-
-
0031774896
-
Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity
-
Imada, K. et al. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J. Exp. Med. 188, 2067-2074 (1998).
-
(1998)
J. Exp. Med.
, vol.188
, pp. 2067-2074
-
-
Imada, K.1
-
41
-
-
79953109597
-
The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors
-
Nelson, E. A. et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood 117, 3421-3429 (2011).
-
(2011)
Blood
, vol.117
, pp. 3421-3429
-
-
Nelson, E.A.1
-
42
-
-
0346024125
-
Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers
-
Cotarla, I. et al. Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers. Int. J. Cancer 108, 665-671 (2004).
-
(2004)
Int. J. Cancer
, vol.108
, pp. 665-671
-
-
Cotarla, I.1
-
43
-
-
0029810923
-
Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
-
Shuai, K. et al. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 13, 247-254 (1996).
-
(1996)
Oncogene
, vol.13
, pp. 247-254
-
-
Shuai, K.1
-
44
-
-
70349323403
-
Targeting signal transducer and activator of transcription signaling pathway in leukemias
-
Benekli, M., Baumann, H. & Wetzler, M. Targeting signal transducer and activator of transcription signaling pathway in leukemias. J. Clin. Oncol. 27, 4422-4432 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 4422-4432
-
-
Benekli, M.1
Baumann, H.2
Wetzler, M.3
-
45
-
-
80555149872
-
A chemical biology approach to developing STAT inhibitors: Molecular strategies for accelerating clinical translation
-
Nelson, E. A. et al. A chemical biology approach to developing STAT inhibitors: Molecular strategies for accelerating clinical translation. Oncotarget 2, 518-524 (2011).
-
(2011)
Oncotarget
, vol.2
, pp. 518-524
-
-
Nelson, E.A.1
-
46
-
-
0027972046
-
An interleukin-4 induced transcription factor: IL 4 Stat
-
Hou, J. et al. An interleukin-4 induced transcription factor: IL 4 Stat. Science 265, 1701-1706 (1994).
-
(1994)
Science
, vol.265
, pp. 1701-1706
-
-
Hou, J.1
-
47
-
-
77951890216
-
IL 4 regulates skin homeostasis and the predisposition toward allergic skin inflammation
-
Sehra, S. et al. IL 4 regulates skin homeostasis and the predisposition toward allergic skin inflammation. J. Immunol. 184, 3186-3190 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 3186-3190
-
-
Sehra, S.1
-
48
-
-
79951828807
-
STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease
-
Chapoval, S. P. et al. STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease. J. Immunol. 186, 2571-2583 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 2571-2583
-
-
Chapoval, S.P.1
-
49
-
-
53849139093
-
Interleukin 4, interleukin 13, signal transducer and activator of transcription factor 6, and allergic asthma
-
Kuperman, D. A. & Schleimer, R. P. Interleukin 4, interleukin 13, signal transducer and activator of transcription factor 6, and allergic asthma. Curr. Mol. Med. 8, 384-392 (2008).
-
(2008)
Curr. Mol. Med.
, vol.8
, pp. 384-392
-
-
Kuperman, D.A.1
Schleimer, R.P.2
-
50
-
-
59149107299
-
Interleukin 13 augments bronchial smooth muscle contractility with an up regulation of RhoA protein
-
Chiba, Y. et al. Interleukin 13 augments bronchial smooth muscle contractility with an up regulation of RhoA protein. Am. J. Respir. Cell. Mol. Biol. 40, 159-167 (2009).
-
(2009)
Am. J. Respir. Cell. Mol. Biol.
, vol.40
, pp. 159-167
-
-
Chiba, Y.1
-
51
-
-
70349870911
-
A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice
-
Chiba, Y. et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am. J. Respir. Cell. Mol. Biol. 41, 516-524 (2009).
-
(2009)
Am. J. Respir. Cell. Mol. Biol.
, vol.41
, pp. 516-524
-
-
Chiba, Y.1
-
52
-
-
34548165283
-
The IL 4/IL 13/Stat6 signaling pathway promotes luminal mammary epithelial cell development
-
Khaled, W. T. et al. The IL 4/IL 13/Stat6 signaling pathway promotes luminal mammary epithelial cell development. Development 134, 2739-2750 (2007).
-
(2007)
Development
, vol.134
, pp. 2739-2750
-
-
Khaled, W.T.1
-
53
-
-
84872065897
-
JAKs and stats in immunity, immunodeficiency, and cancer
-
O'Shea, J. J., Holland, S. M. & Staudt, L. M. JAKs and STATs in immunity, immunodeficiency, and cancer. N. Engl. J. Med. 368, 161-170 (2013).
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 161-170
-
-
O'Shea, J.J.1
Holland, S.M.2
Staudt, L.M.3
-
54
-
-
84877095601
-
Molecular pathways: Jak/STAT pathway: Mutations, inhibitors, and resistance
-
Quintas-Cardama, A. & Verstovsek, S. Molecular pathways: Jak/STAT pathway: Mutations, inhibitors, and resistance. Clin. Cancer Res. 19, 1933-1940 (2013).
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 1933-1940
-
-
Quintas-Cardama, A.1
Verstovsek, S.2
-
55
-
-
3543055012
-
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity
-
Turkson, J. et al. Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Mol. Cancer Ther. 3, 261-269 (2004).
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 261-269
-
-
Turkson, J.1
-
56
-
-
27144475507
-
Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3 Development of a high-affinity peptide inhibitor
-
Coleman, D. R. et al. Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor. J. Med. Chem. 48, 6661-6670 (2005).
-
(2005)
J. Med. Chem.
, vol.48
, pp. 6661-6670
-
-
Coleman, D.R.1
-
57
-
-
0037294154
-
Identification of a high-affinity phosphopeptide inhibitor of Stat3
-
Ren, Z. et al. Identification of a high-affinity phosphopeptide inhibitor of Stat3. Bioorg. Med. Chem. Lett. 13, 633-636 (2003).
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 633-636
-
-
Ren, Z.1
-
58
-
-
33847682326
-
Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: Structural recognition of STAT SH2 domains
-
Gunning, P. T. et al. Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: Structural recognition of STAT SH2 domains. Bioorg. Med. Chem. Lett. 17, 1875-1878 (2007).
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 1875-1878
-
-
Gunning, P.T.1
-
59
-
-
39149090322
-
Structural basis for the binding of high affinity phosphopeptides to Stat3
-
McMurray, J. S., Structural basis for the binding of high affinity phosphopeptides to Stat3. Biopolymers 90, 69-79 (2008).
-
(2008)
Biopolymers
, vol.90
, pp. 69-79
-
-
McMurray, J.S.1
-
60
-
-
78149270544
-
A cell-permeable Stat3 SH2 domain mimetic inhibits Stat3 activation and induces antitumor cell effects in vitro
-
Zhao, W. Jaganathan, S. & Turkson, J. A cell-permeable Stat3 SH2 domain mimetic inhibits Stat3 activation and induces antitumor cell effects in vitro. J. Biol. Chem. 285, 35855-35865 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 35855-35865
-
-
Zhao, W.1
Jaganathan, S.2
Turkson, J.3
-
61
-
-
77956627676
-
Structure-based design of conformationally constrained, cell-permeable STAT3 inhibitors
-
Chen, J. et al. Structure-based design of conformationally constrained, cell-permeable STAT3 inhibitors. ACS Med. Chem. Lett. 1, 85-89 (2010).
-
(2010)
ACS Med. Chem. Lett.
, vol.1
, pp. 85-89
-
-
Chen, J.1
-
62
-
-
79957742210
-
Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3
-
Mandal, P. K. et al. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. J. Med. Chem. 54, 3549-3563 (2011).
-
(2011)
J. Med. Chem.
, vol.54
, pp. 3549-3563
-
-
Mandal, P.K.1
-
63
-
-
84873388087
-
A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis
-
Auzenne, E. J. et al. A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis. J. Exp. Ther. Oncol. 10, 155-162 (2012).
-
(2012)
J. Exp. Ther. Oncol.
, vol.10
, pp. 155-162
-
-
Auzenne, E.J.1
-
64
-
-
16344380754
-
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
-
Song, H. et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc. Natl Acad. Sci. USA 102, 4700-4705 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 4700-4705
-
-
Song, H.1
-
65
-
-
58149267888
-
LLL 3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
-
Fuh, B. et al. LLL 3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model. Br. J. Cancer 100, 106-112 (2009).
-
(2009)
Br. J. Cancer
, vol.100
, pp. 106-112
-
-
Fuh, B.1
-
66
-
-
51349156533
-
Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening
-
Hao, W. et al. Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening. Bioorg. Med. Chem. Lett. 18, 4988-4992 (2008).
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 4988-4992
-
-
Hao, W.1
-
67
-
-
77649178678
-
A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3 dependent tumor processes
-
Zhang, X. et al. A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3 dependent tumor processes. Biochem. Pharmacol. 79, 1398-1409 (2010).
-
(2010)
Biochem. Pharmacol.
, vol.79
, pp. 1398-1409
-
-
Zhang, X.1
-
68
-
-
84862193781
-
Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
-
Zhang, X. et al. Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proc. Natl Acad. Sci. USA 109, 9623-9628 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 9623-9628
-
-
Zhang, X.1
-
69
-
-
84875458307
-
A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation
-
Zhang, X. et al. A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation. Cancer Res. 73, 1922-1933 (2013).
-
(2013)
Cancer Res.
, vol.73
, pp. 1922-1933
-
-
Zhang, X.1
-
70
-
-
62849104063
-
Chemical probes that competitively and selectively inhibit Stat3 activation
-
Xu, X. et al. Chemical probes that competitively and selectively inhibit Stat3 activation. PLoS ONE 4, e4783 (2009).
-
(2009)
PLoS ONE
, vol.4
-
-
Xu, X.1
-
71
-
-
84864673390
-
Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model
-
Dave, B. et al. Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS ONE 7, e30207 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Dave, B.1
-
72
-
-
33750982120
-
Stattic: A small-molecule inhibitor of STAT3 activation and dimerization
-
Schust, J. et al. Stattic: A small-molecule inhibitor of STAT3 activation and dimerization. Chem. Biol. 13, 1235-1242 (2006).
-
(2006)
Chem. Biol.
, vol.13
, pp. 1235-1242
-
-
Schust, J.1
-
73
-
-
79955000497
-
Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation
-
Ashizawa, T. et al. Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation. Int. J. Oncol. 38, 1245-1252 (2011).
-
(2011)
Int. J. Oncol.
, vol.38
, pp. 1245-1252
-
-
Ashizawa, T.1
-
74
-
-
78649286584
-
Identification of a new series of STAT3 inhibitors by virtual screening
-
Matsuno, K. et al. Identification of a new series of STAT3 inhibitors by virtual screening. ACS Med. Chem. Lett. 1, 371-3755 (2010).
-
(2010)
ACS Med. Chem. Lett.
, vol.1
, pp. 371-3755
-
-
Matsuno, K.1
-
75
-
-
84873738776
-
Fragment-based drug design and identification of HJC0123 a novel orally bioavailable STAT3 inhibitor for cancer therapy
-
Chen, H. et al. Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy. Eur. J. Med. Chem. 62C, 498-507 (2013).
-
(2013)
Eur. J. Med. Chem.
, vol.62 C
, pp. 498-507
-
-
Chen, H.1
-
76
-
-
84875209735
-
Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening
-
Zhang, M. et al. Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening. Bioorg. Med. Chem. Lett. 23, 2225-2229 (2013).
-
(2013)
Bioorg. Med. Chem. Lett.
, vol.23
, pp. 2225-2229
-
-
Zhang, M.1
-
77
-
-
84878432714
-
OPB 31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells
-
Kim, M. J. et al. OPB 31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett. 335, 145-152 (2013).
-
(2013)
Cancer Lett.
, vol.335
, pp. 145-152
-
-
Kim, M.J.1
-
78
-
-
84861476075
-
Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signaling pathway
-
Yang, C. L. et al. Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signaling pathway. PLoS ONE 7, e37960 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Yang, C.L.1
-
79
-
-
84863248624
-
Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth
-
Tu, S. P. et al. Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth. Cancer Prev. Res. 5, 205-215 (2012).
-
(2012)
Cancer Prev. Res.
, vol.5
, pp. 205-215
-
-
Tu, S.P.1
-
80
-
-
79953112475
-
The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines
-
Fossey, S. L. et al. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. BMC Cancer 11, 112 (2011).
-
(2011)
BMC Cancer
, vol.11
, pp. 112
-
-
Fossey, S.L.1
-
81
-
-
80655129638
-
HO 3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition
-
Selvendiran, K. et al. HO 3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition. Cancer Biol. Ther. 12, 837-845 (2011).
-
(2011)
Cancer Biol. Ther.
, vol.12
, pp. 837-845
-
-
Selvendiran, K.1
-
82
-
-
84863499934
-
HO 3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1 mutated ovarian cancer cells
-
Tierney, B. J. et al. HO 3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1 mutated ovarian cancer cells. Cancer Biol. Ther. 13, 766-775 (2012).
-
(2012)
Cancer Biol. Ther.
, vol.13
, pp. 766-775
-
-
Tierney, B.J.1
-
83
-
-
77950190311
-
Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells
-
Lin, L. et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res. 70, 2445-2454 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 2445-2454
-
-
Lin, L.1
-
84
-
-
84864350035
-
Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice
-
Onimoe, G. I. et al. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Invest. New Drugs 30, 916-926 (2012).
-
(2012)
Invest. New Drugs
, vol.30
, pp. 916-926
-
-
Onimoe, G.I.1
-
85
-
-
84859828700
-
Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12
-
Bid, H. K. et al. Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12. PLoS ONE 7, e35513 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Bid, H.K.1
-
86
-
-
77955520465
-
A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
-
Lin, L. et al. A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. Mol. Cancer 9, 217 (2010).
-
(2010)
Mol. Cancer
, vol.9
, Issue.217
-
-
Lin, L.1
-
87
-
-
84864996651
-
Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines
-
Bill, M. A. et al. Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. PLoS ONE 7, e40724 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Bill, M.A.1
-
88
-
-
84866022781
-
Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells
-
Nam, S. et al. Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Mol. Oncol. 6, 484-493 (2012).
-
(2012)
Mol. Oncol.
, vol.6
, pp. 484-493
-
-
Nam, S.1
-
89
-
-
80052962987
-
Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2 mediated JAK/STAT3 signaling in endothelial cell
-
Zhang, X. et al. Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2 mediated JAK/STAT3 signaling in endothelial cell. Int. J. Cancer 129, 2502-2511 (2011).
-
(2011)
Int. J. Cancer
, vol.129
, pp. 2502-2511
-
-
Zhang, X.1
-
90
-
-
20944435625
-
Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells
-
Nam, S. et al. Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells. Proc. Natl Acad. Sci. USA 102, 5998-6003 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 5998-6003
-
-
Nam, S.1
-
91
-
-
84868363095
-
A novel 7 bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling
-
Liu, L. et al. A novel 7 bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling. Cancer Biol. Ther. 13, 13 (2012).
-
(2012)
Cancer Biol. Ther.
, vol.13
, Issue.13
-
-
Liu, L.1
-
92
-
-
84878116135
-
Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells
-
Nam, S. et al. Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. Mol. Oncol. 7, 369-378 (2013).
-
(2013)
Mol. Oncol.
, vol.7
, pp. 369-378
-
-
Nam, S.1
-
93
-
-
58149346175
-
Resveratrol addiction: To die or not to die
-
Shakibaei, M., Harikumar, K. B. & Aggarwal,B. B. Resveratrol addiction: To die or not to die. Mol. Nutr. Food Res. 53, 115-128 (2009).
-
(2009)
Mol. Nutr. Food Res.
, vol.53
, pp. 115-128
-
-
Shakibaei, M.1
Harikumar, K.B.2
Aggarwal, B.B.3
-
94
-
-
73149109931
-
Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling
-
Li, T. et al. Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling. Int. Immunopharmacol. 10, 18-25 (2010).
-
(2010)
Int. Immunopharmacol.
, vol.10
, pp. 18-25
-
-
Li, T.1
-
95
-
-
57349090717
-
LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3 mediated matrix metalloproteinase 9 expression
-
Kim, J. E. et al. LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3 mediated matrix metalloproteinase 9 expression. Exp. Mol. Med. 40, 514-522 (2008).
-
(2008)
Exp. Mol. Med.
, vol.40
, pp. 514-522
-
-
Kim, J.E.1
-
96
-
-
84155184247
-
Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis
-
Yang, Y. P. et al. Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis. J. Cell. Physiol. 227, 976-993 (2012).
-
(2012)
J. Cell. Physiol.
, vol.227
, pp. 976-993
-
-
Yang, Y.P.1
-
97
-
-
78851469815
-
Chemosensitization of tumors by resveratrol
-
Gupta, S. C. et al. Chemosensitization of tumors by resveratrol. Ann. NY Acad. Sci. 1215, 150-160 (2011).
-
(2011)
Ann. NY Acad. Sci.
, vol.1215
, pp. 150-160
-
-
Gupta, S.C.1
-
98
-
-
84155167138
-
Biological activity of piceatannol: Leaving the shadow of resveratrol
-
Piotrowska, H. Kucinska, M. & Murias, M. Biological activity of piceatannol: Leaving the shadow of resveratrol. Mutat. Res. 750, 60-82 (2012).
-
(2012)
Mutat. Res.
, vol.750
, pp. 60-82
-
-
Piotrowska, H.1
Kucinska, M.2
Murias, M.3
-
99
-
-
80052079930
-
Resveratrol potentiates the cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells
-
Santandreu, F. M. et al. Resveratrol potentiates the cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells. Cell Physiol. Biochem. 28, 219-228 (2011).
-
(2011)
Cell Physiol. Biochem.
, vol.28
, pp. 219-228
-
-
Santandreu, F.M.1
-
100
-
-
84861553261
-
Protective effect of caffeic acid on paclitaxel induced anti-proliferation and apoptosis of lung cancer cells involves NF κB pathway
-
Lin, C. L. et al. Protective effect of caffeic acid on paclitaxel induced anti-proliferation and apoptosis of lung cancer cells involves NF κB pathway. Int. J. Mol. Sci. 13, 6236-6245 (2012).
-
(2012)
Int. J. Mol. Sci.
, vol.13
, pp. 6236-6245
-
-
Lin, C.L.1
-
101
-
-
34548059697
-
Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3 mediated VEGF expression in human renal carcinoma cells
-
Jung, J. E. et al. Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3 mediated VEGF expression in human renal carcinoma cells. Carcinogenesis 28, 1780-1787 (2007).
-
(2007)
Carcinogenesis
, vol.28
, pp. 1780-1787
-
-
Jung, J.E.1
-
102
-
-
77951707745
-
Inhibition of p-STAT3 enhances IFN-α efficacy against metastatic melanoma in a murine model
-
Kong, L. Y. et al. Inhibition of p-STAT3 enhances IFN-α efficacy against metastatic melanoma in a murine model. Clin. Cancer Res. 16, 2550-2561 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 2550-2561
-
-
Kong, L.Y.1
-
103
-
-
84864326746
-
Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway
-
Sai, K. et al. Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway. J. Neurooncol. 107, 487-501 (2012).
-
(2012)
J. Neurooncol.
, vol.107
, pp. 487-501
-
-
Sai, K.1
-
104
-
-
63349085786
-
Capsaicin inhibits the IL 6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress
-
Lee, H. K. et al. Capsaicin inhibits the IL 6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress. Biochem. Biophys. Res. Commun. 382, 445-450 (2009).
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.382
, pp. 445-450
-
-
Lee, H.K.1
-
105
-
-
58249119435
-
Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells
-
Shin, D. S. et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 69, 193-202 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 193-202
-
-
Shin, D.S.1
-
106
-
-
77958126831
-
Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling
-
Walker, S. R. et al. Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling. Mol. Pharmacol. 78, 903-908 (2010).
-
(2010)
Mol. Pharmacol.
, vol.78
, pp. 903-908
-
-
Walker, S.R.1
-
107
-
-
80054024030
-
Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF κB and STAT3 regulated gene products in multiple myeloma cells
-
Kannaiyan, R. et al. Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF κB and STAT3 regulated gene products in multiple myeloma cells. Br. J. Pharmacol. 164, 1506-1521 (2011).
-
(2011)
Br. J. Pharmacol.
, vol.164
, pp. 1506-1521
-
-
Kannaiyan, R.1
-
108
-
-
84864835881
-
Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo
-
Rajendran, P. et al. Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo. Cancer Prev. Res. 5, 631-643 (2012).
-
(2012)
Cancer Prev. Res.
, vol.5
, pp. 631-643
-
-
Rajendran, P.1
-
109
-
-
53949095627
-
Avicin D selectively induces apoptosis and downregulates p STAT 3 BCL 2, and survivin in cutaneous T cell lymphoma cells
-
Zhang, C. et al. Avicin D selectively induces apoptosis and downregulates p STAT 3, BCL 2, and survivin in cutaneous T cell lymphoma cells. J. Invest. Dermatol. 128, 2728-2735 (2008).
-
(2008)
J. Invest. Dermatol.
, vol.128
, pp. 2728-2735
-
-
Zhang, C.1
-
110
-
-
78149239365
-
Withaferin a inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells
-
Lee, J., Hahm, E. R. & Singh, S. V. Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells. Carcinogenesis 31, 1991-1998 (2010).
-
(2010)
Carcinogenesis
, vol.31
, pp. 1991-1998
-
-
Lee, J.1
Hahm, E.R.2
Singh, S.V.3
-
111
-
-
84867631835
-
Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells
-
Um, H. J. et al. Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells. Biochem. Biophys. Res. Commun. 427, 24-29 (2012).
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.427
, pp. 24-29
-
-
Um, H.J.1
-
112
-
-
77953690135
-
Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP 1 in human multiple myeloma cells
-
Pandey, M. K., Sung, B. & Aggarwal, B. B. Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP 1 in human multiple myeloma cells. Int. J. Cancer 127, 282-292 (2010).
-
(2010)
Int. J. Cancer
, vol.127
, pp. 282-292
-
-
Pandey, M.K.1
Sung, B.2
Aggarwal, B.B.3
-
113
-
-
34548693457
-
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells
-
Pathak, A. K. et al. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol. Cancer Res. 5, 943-955 (2007).
-
(2007)
Mol. Cancer Res.
, vol.5
, pp. 943-955
-
-
Pathak, A.K.1
-
114
-
-
79960009770
-
Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice
-
Shanmugam, M. K. et al. Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. J. Mol. Med. 89, 713-727 (2011).
-
(2011)
J. Mol. Med.
, vol.89
, pp. 713-727
-
-
Shanmugam, M.K.1
-
115
-
-
0034597578
-
Synthetic oleanane and ursane triterpenoids with modified rings A and C: A series of highly active inhibitors of nitric oxide production in mouse macrophages
-
Honda, T. et al. Synthetic oleanane and ursane triterpenoids with modified rings A and C: A series of highly active inhibitors of nitric oxide production in mouse macrophages. J. Med. Chem. 43, 4233-4246 (2000).
-
(2000)
J. Med. Chem.
, vol.43
, pp. 4233-4246
-
-
Honda, T.1
-
116
-
-
58849152837
-
CDDO Me, a synthetic triterpenoid, inhibits expression of IL 6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells
-
Duan, Z. et al. CDDO Me, a synthetic triterpenoid, inhibits expression of IL 6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells. Cancer Chemother. Pharmacol. 63, 681-689 (2009).
-
(2009)
Cancer Chemother. Pharmacol.
, vol.63
, pp. 681-689
-
-
Duan, Z.1
-
117
-
-
77951968251
-
Oleanane triterpenoid CDDO Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway
-
Ryu, K. et al. Oleanane triterpenoid CDDO Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. BMC Cancer 10, 187 (2010).
-
(2010)
BMC Cancer
, vol.10
, pp. 187
-
-
Ryu, K.1
-
118
-
-
84866182600
-
The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice
-
Tran, K. et al. The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice. Cancer Prev. Res. 5, 726-734 (2012).
-
(2012)
Cancer Prev. Res.
, vol.5
, pp. 726-734
-
-
Tran, K.1
-
119
-
-
0037444373
-
Discovery of JSI 124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
-
Blaskovich, M. A. et al. Discovery of JSI 124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63, 1270-1279 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 1270-1279
-
-
Blaskovich, M.A.1
-
120
-
-
79959622792
-
Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133 positive cells
-
Hsu, H. S. et al. Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133 positive cells. Cancer 117, 2970-2985 (2011).
-
(2011)
Cancer
, vol.117
, pp. 2970-2985
-
-
Hsu, H.S.1
-
121
-
-
84860855712
-
Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells
-
Chang, C. J. et al. Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells. Childs Nerv. Syst. 28, 363-373 (2012).
-
(2012)
Childs Nerv. Syst.
, vol.28
, pp. 363-373
-
-
Chang, C.J.1
-
122
-
-
84859994573
-
Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells
-
Tseng, L. M. et al. Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells. J. Pharmacol. Exp. Ther. 341, 410-423 (2012).
-
(2012)
J. Pharmacol. Exp. Ther.
, vol.341
, pp. 410-423
-
-
Tseng, L.M.1
-
123
-
-
77953807862
-
Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin
-
Liu, T. et al. Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin. Eur. J. Pharmacol. 641, 15-22 (2010).
-
(2010)
Eur. J. Pharmacol.
, vol.641
, pp. 15-22
-
-
Liu, T.1
-
124
-
-
78649763564
-
Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2 mediated Jak2-STAT3 signaling pathway
-
Dong, Y. et al. Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2 mediated Jak2-STAT3 signaling pathway. Carcinogenesis 31, 2097-2104 (2010).
-
(2010)
Carcinogenesis
, vol.31
, pp. 2097-2104
-
-
Dong, Y.1
-
125
-
-
77949272182
-
Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling
-
Sun, C. et al. Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling. J. Cancer Res. Clin. Oncol. 136, 603-610 (2010).
-
(2010)
J. Cancer Res. Clin. Oncol.
, vol.136
, pp. 603-610
-
-
Sun, C.1
-
126
-
-
84863057259
-
Cucurbitacin E induces G(2)/M phase arrest through STAT3/p53/p21 signaling and provokes apoptosis via Fas/CD95 and mitochondria-dependent pathways in human bladder cancer T24 cells
-
Huang, W. W. et al. Cucurbitacin E induces G(2)/M phase arrest through STAT3/p53/p21 signaling and provokes apoptosis via Fas/CD95 and mitochondria-dependent pathways in human bladder cancer T24 cells. Evid. Based. Complement. Alternat. Med. 2012, 952762 (2012).
-
(2012)
Evid. Based. Complement. Alternat. Med.
, vol.2012
, pp. 952762
-
-
Huang, W.W.1
-
127
-
-
77951908366
-
Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells
-
Li, F. et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 292, 197-207 (2010).
-
(2010)
Cancer Lett.
, vol.292
, pp. 197-207
-
-
Li, F.1
-
128
-
-
34147152865
-
Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor
-
Muto, A. et al. Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor. Mol. Cancer Ther. 6, 987-994 (2007).
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 987-994
-
-
Muto, A.1
-
129
-
-
83455203366
-
Thymoquinone decreases F actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl XL expression
-
Badr, G., Mohany, M. & Abu-Tarboush, F. Thymoquinone decreases F actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl XL expression. Lipids Health Dis. 10, 236 (2011).
-
(2011)
Lipids Health Dis
, vol.10
, pp. 236
-
-
Badr, G.1
Mohany, M.2
Abu-Tarboush, F.3
-
130
-
-
77956325713
-
Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway
-
Li, F., Rajendran, P. & Sethi, G. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway. Br. J. Pharmacol. 161, 541-554 (2010).
-
(2010)
Br. J. Pharmacol.
, vol.161
, pp. 541-554
-
-
Li, F.1
Rajendran, P.2
Sethi, G.3
-
131
-
-
77951729083
-
Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors
-
Leeman-Neill, R. J. et al. Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors. Clin. Cancer Res. 16, 2571-2579 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 2571-2579
-
-
Leeman-Neill, R.J.1
-
132
-
-
84862907992
-
Honokiol inhibits signal transducer and activator of transcription 3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP 1
-
Rajendran, P. et al. Honokiol inhibits signal transducer and activator of transcription 3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP 1. J. Cell. Physiol. 227, 2184-2195 (2012).
-
(2012)
J. Cell. Physiol.
, vol.227
, pp. 2184-2195
-
-
Rajendran, P.1
-
133
-
-
84865292443
-
Calpain/SHP 1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice
-
Liu, S. H. et al. Calpain/SHP 1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice. PLoS ONE 7, e43711 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Liu, S.H.1
-
134
-
-
84870364791
-
Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells
-
Yang, J. et al. Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells. Cancer Lett. 325, 243-251 (2013).
-
(2013)
Cancer Lett.
, vol.325
, pp. 243-251
-
-
Yang, J.1
-
135
-
-
33745521795
-
Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar
-
Arbiser, J. L. et al. Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar. J. Invest. Dermatol. 126, 1396-1402 (2006).
-
(2006)
J. Invest. Dermatol.
, vol.126
, pp. 1396-1402
-
-
Arbiser, J.L.1
-
136
-
-
84871691803
-
Synthesis and biological evaluation of new N alkylcarbazole derivatives as STAT3 inhibitors: Preliminary study
-
Saturnino, C. et al. Synthesis and biological evaluation of new N alkylcarbazole derivatives as STAT3 inhibitors: Preliminary study. Eur. J. Med. Chem. 60C, 112-119 (2012).
-
(2012)
Eur. J. Med. Chem.
, vol.60 C
, pp. 112-119
-
-
Saturnino, C.1
-
137
-
-
81855185596
-
Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion
-
Sun, M. et al. Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. Prostate 72, 82-89 (2012).
-
(2012)
Prostate
, vol.72
, pp. 82-89
-
-
Sun, M.1
-
138
-
-
77958468408
-
γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP 1 and sensitizes tumor cells to chemotherapeutic agents
-
Kannappan, R., Yadav, V. R. & Aggarwal, B. B. γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP 1 and sensitizes tumor cells to chemotherapeutic agents. J. Biol. Chem. 285, 33520-33528 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 33520-33528
-
-
Kannappan, R.1
Yadav, V.R.2
Aggarwal, B.B.3
-
139
-
-
79954459349
-
γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signaling pathway in human hepatocellular carcinoma: Potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent
-
Rajendran, P. et al. γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signaling pathway in human hepatocellular carcinoma: Potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent. Br. J. Pharmacol. 163, 283-298 (2011).
-
(2011)
Br. J. Pharmacol.
, vol.163
, pp. 283-298
-
-
Rajendran, P.1
-
140
-
-
58649104212
-
Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP 1
-
Kunnumakkara, A. B. et al. Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP 1. Mol. Cancer Res. 7, 118-128 (2009).
-
(2009)
Mol. Cancer Res.
, vol.7
, pp. 118-128
-
-
Kunnumakkara, A.B.1
-
141
-
-
85008726865
-
Regulation of Janus-activated kinase 2 (JAK2) by diindolylmethane in ovarian cancer in vitro and in vivo
-
Kandala, P. K. & Srivastava, S. K. Regulation of Janus-activated kinase 2 (JAK2) by diindolylmethane in ovarian cancer in vitro and in vivo. Drug Discov. Ther. 6, 94-101 (2012).
-
(2012)
Drug Discov. Ther.
, vol.6
, pp. 94-101
-
-
Kandala, P.K.1
Srivastava, S.K.2
-
142
-
-
84877953451
-
Brevilin A, a novel natural product, inhibits Janus kinase activity and blocks STAT3 signaling in cancer cells
-
Chen, X. et al. Brevilin A, a novel natural product, inhibits Janus kinase activity and blocks STAT3 signaling in cancer cells. PLoS ONE 8, e63697 (2013).
-
(2013)
PLoS ONE
, vol.8
-
-
Chen, X.1
-
143
-
-
27744456908
-
Gamma interferon: A central mediator in atherosclerosis
-
Leon, M. L. & Zuckerman, S. H. Gamma interferon: A central mediator in atherosclerosis. Inflamm. Res. 54, 395-411 (2005).
-
(2005)
Inflamm. Res.
, vol.54
, pp. 395-411
-
-
Leon, M.L.1
Zuckerman, S.H.2
-
144
-
-
68849089686
-
Pravastatin attenuates interferon-γ action via modulation of STAT1 to prevent aortic atherosclerosis in apolipoprotein E knockout mice
-
Zhou, X. X., Gao, P. J. & Sun, B. G. Pravastatin attenuates interferon-γ action via modulation of STAT1 to prevent aortic atherosclerosis in apolipoprotein E knockout mice. Clin. Exp. Pharmacol. Physiol. 36, 373-379 (2009).
-
(2009)
Clin. Exp. Pharmacol. Physiol.
, vol.36
, pp. 373-379
-
-
Zhou, X.X.1
Gao, P.J.2
Sun, B.G.3
-
145
-
-
49049117007
-
Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-γ in experimental autoimmune encephalomyelitis
-
Ren, Y. et al. Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-γ in experimental autoimmune encephalomyelitis. J. Immunol. 181, 1491-1498 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 1491-1498
-
-
Ren, Y.1
-
146
-
-
0031610572
-
Role of Th1 and Th2 cells in autoimmune demyelinating disease
-
Nagelkerken, L. Role of Th1 and Th2 cells in autoimmune demyelinating disease. Braz. J. Med. Biol. Res. 31, 55-60 (1998).
-
(1998)
Braz. J. Med. Biol. Res.
, vol.31
, pp. 55-60
-
-
Nagelkerken, L.1
-
147
-
-
80755143824
-
Immunomodulatory effect of water extract of cinnamon on anti CD3 induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation
-
Lee, B. J. et al. Immunomodulatory effect of water extract of cinnamon on anti CD3 induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation. Immunopharmacol. Immunotoxicol. 33, 714-722 (2011).
-
(2011)
Immunopharmacol. Immunotoxicol.
, vol.33
, pp. 714-722
-
-
Lee, B.J.1
-
148
-
-
56349161083
-
Regulation of apoptosis by resveratrol through JAK/STAT and mitochondria mediated pathway in human epidermoid carcinoma A431 cells
-
Madan, E. et al. Regulation of apoptosis by resveratrol through JAK/STAT and mitochondria mediated pathway in human epidermoid carcinoma A431 cells. Biochem. Biophys. Res. Commun. 377, 1232-1237 (2008).
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.377
, pp. 1232-1237
-
-
Madan, E.1
-
149
-
-
43149095374
-
Discovery of chromone-based inhibitors of the transcription factor STAT5
-
Muller, J. et al. Discovery of chromone-based inhibitors of the transcription factor STAT5. Chembiochem 9, 723-727 (2008).
-
(2008)
Chembiochem
, vol.9
, pp. 723-727
-
-
Muller, J.1
-
150
-
-
84862820219
-
Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling
-
Nam, S. et al. Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling. Mol. Oncol. 6, 276-283 (2012).
-
(2012)
Mol. Oncol.
, vol.6
, pp. 276-283
-
-
Nam, S.1
-
151
-
-
0035725741
-
Specific inhibition of interleukin-4 dependent Stat6 activation by an intracellularly delivered peptide
-
Stolzenberger, S. Haake, M. & Duschl, A. Specific inhibition of interleukin-4 dependent Stat6 activation by an intracellularly delivered peptide. Eur. J. Biochem. 268, 4809-4814 (2001).
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 4809-4814
-
-
Stolzenberger, S.1
Haake, M.2
Duschl, A.3
-
152
-
-
34848848833
-
Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT 6 peptide
-
McCusker, C. T. et al. Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT 6 peptide. J. Immunol. 179, 2556-2564 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 2556-2564
-
-
McCusker, C.T.1
-
153
-
-
80054030236
-
Effective treatment of experimental ragweed-induced asthma with STAT 6 IP, a topically delivered cell-penetrating peptide
-
Wang, Y. et al. Effective treatment of experimental ragweed-induced asthma with STAT 6 IP, a topically delivered cell-penetrating peptide. Clin. Exp. Allergy 41, 1622-1630 (2011).
-
(2011)
Clin. Exp. Allergy
, vol.41
, pp. 1622-1630
-
-
Wang, Y.1
-
154
-
-
0037926708
-
TMC 264, a novel inhibitor of STAT6 activation produced by Phoma sp TC 1674
-
Sakurai, M. et al. TMC 264, a novel inhibitor of STAT6 activation produced by Phoma sp. TC 1674. J. Antibiot. 56, 513-519 (2003).
-
(2003)
J. Antibiot.
, vol.56
, pp. 513-519
-
-
Sakurai, M.1
-
155
-
-
44849092971
-
Identification of 4 benzylamino 2-[(4 morpholin-4 ylphenyl)amino] pyrimidine-5 carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors
-
Nagashima, S. et al. Identification of 4 benzylamino 2-[(4 morpholin-4 ylphenyl)amino]pyrimidine-5 carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors. Bioorg. Med. Chem. 16, 6509-6521 (2008).
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 6509-6521
-
-
Nagashima, S.1
-
156
-
-
69949119703
-
Novel 7H pyrrolo [2,3 d]pyrimidine derivatives as potent and orally active STAT6 inhibitors
-
Nagashima, S. et al. Novel 7H pyrrolo[2,3 d]pyrimidine derivatives as potent and orally active STAT6 inhibitors. Bioorg. Med. Chem. 17, 6926-6936 (2009).
-
(2009)
Bioorg. Med. Chem.
, Issue.17
, pp. 6926-6936
-
-
Nagashima, S.1
-
157
-
-
33744919852
-
Niflumic acid suppresses interleukin-13 induced asthma phenotypes
-
Nakano, T. et al. Niflumic acid suppresses interleukin-13 induced asthma phenotypes. Am. J. Respir. Crit. Care Med. 173, 1216-1221 (2006).
-
(2006)
Am. J. Respir. Crit. Care Med.
, vol.173
, pp. 1216-1221
-
-
Nakano, T.1
-
158
-
-
84855779362
-
STAT6 phosphorylation inhibitors block eotaxin 3 secretion in bronchial epithelial cells
-
Zhou, L. et al. STAT6 phosphorylation inhibitors block eotaxin 3 secretion in bronchial epithelial cells. Bioorg. Med. Chem. 20, 750-758 (2012).
-
(2012)
Bioorg. Med. Chem.
, vol.20
, pp. 750-758
-
-
Zhou, L.1
-
159
-
-
79957923046
-
Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor
-
Manshouri, T. et al. Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res. 71, 3831-3840 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 3831-3840
-
-
Manshouri, T.1
-
160
-
-
84856076374
-
Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor
-
Quintas-Cardama, A. et al. Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest. New Drugs 29, 818-826 (2011).
-
(2011)
Invest. New Drugs
, vol.29
, pp. 818-826
-
-
Quintas-Cardama, A.1
-
161
-
-
77953725855
-
Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
-
Kantarjian, H. et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 362, 2260-2270 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 2260-2270
-
-
Kantarjian, H.1
-
162
-
-
2542520755
-
Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
-
Duensing, A. et al. Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene 23, 3999-4006 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 3999-4006
-
-
Duensing, A.1
-
163
-
-
77957191745
-
First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia
-
Ravandi, F. et al. First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia. Blood. 116, 2070-2077 (2010).
-
(2010)
Blood.
, vol.116
, pp. 2070-2077
-
-
Ravandi, F.1
-
164
-
-
34248166041
-
Dasatinib (BMS 354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells
-
Nam, S. et al. Dasatinib (BMS 354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells. Mol. Cancer Ther. 6, 1400-1405 (2007).
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 1400-1405
-
-
Nam, S.1
-
165
-
-
79551629888
-
BCR-ABL1 independent PI3Kinase activation causing imatinib-resistance
-
Quentmeier, H. et al. BCR-ABL1 independent PI3Kinase activation causing imatinib-resistance. J. Hematol. Oncol. 4, 6 (2011).
-
(2011)
J. Hematol. Oncol.
, vol.4
, Issue.6
-
-
Quentmeier, H.1
-
166
-
-
84875909425
-
Epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of NSCLC
-
Pallis, A. G. & Syrigos, K. N. Epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of NSCLC. Lung Cancer 80, 120-130 (2013).
-
(2013)
Lung Cancer
, vol.80
, pp. 120-130
-
-
Pallis, A.G.1
Syrigos, K.N.2
-
167
-
-
79551711693
-
Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma
-
Leeman-Neill, R. J. et al. Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma. Cancer Prev. Res. (Phila) 4, 230-237 (2011).
-
(2011)
Cancer Prev. Res. (Phila)
, vol.4
, pp. 230-237
-
-
Leeman-Neill, R.J.1
-
168
-
-
77950545758
-
Combined γ-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells
-
Bachawal, S. V., Wali, V. B. & Sylvester, P. W. Combined γ-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells. Anticancer Res. 30, 429-437 (2010).
-
(2010)
Anticancer Res.
, vol.30
, pp. 429-437
-
-
Bachawal, S.V.1
Wali, V.B.2
Sylvester, P.W.3
-
169
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
-
Cheng, A. L. et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 10, 25-34 (2009).
-
(2009)
Lancet Oncol.
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
-
170
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet, J. M. et al. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359, 378-390 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
-
171
-
-
84865659808
-
The monoclonal antibody CH12 enhances the sorafenib-mediated growth inhibition of hepatocellular carcinoma xenografts expressing epidermal growth factor receptor variant III
-
Yang, Y. et al. The monoclonal antibody CH12 enhances the sorafenib-mediated growth inhibition of hepatocellular carcinoma xenografts expressing epidermal growth factor receptor variant III. Neoplasia 14, 509-518 (2012).
-
(2012)
Neoplasia
, vol.14
, pp. 509-518
-
-
Yang, Y.1
-
172
-
-
77950833182
-
Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3
-
Yang, F. et al. Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3. Mol. Cancer Ther. 9, 953-962 (2010).
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 953-962
-
-
Yang, F.1
-
173
-
-
84861152163
-
Sorafenib inhibits endogenous and IL 6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis
-
Yang, F. et al. Sorafenib inhibits endogenous and IL 6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis. Cancer Biol. Ther. 13, 534-541 (2012).
-
(2012)
Cancer Biol. Ther.
, vol.13
, pp. 534-541
-
-
Yang, F.1
-
174
-
-
84984589185
-
Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma
-
Tai, W. T. et al. Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma. J. Hepatol. 55, 1041-1048 (2011).
-
(2011)
J. Hepatol.
, vol.55
, pp. 1041-1048
-
-
Tai, W.T.1
-
175
-
-
84984558781
-
Sorafenib and its derivative SC 49 sensitize hepatocellular carcinoma cells to CS 1008, a humanized anti TNFRSF10B (DR5) antibody
-
Chen, K. F. et al. Sorafenib and its derivative SC 49 sensitize hepatocellular carcinoma cells to CS 1008, a humanized anti TNFRSF10B (DR5) antibody. Br. J. Pharmacol. 168, 658-672 (2013).
-
(2013)
Br. J. Pharmacol.
, vol.168
, pp. 658-672
-
-
Chen, K.F.1
-
176
-
-
84984563938
-
Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP 1 phosphatase activity
-
Chen, K. F. et al. Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP 1 phosphatase activity. Eur. J. Med. Chem. 55, 220-227 (2012).
-
(2012)
Eur. J. Med. Chem.
, vol.55
, pp. 220-227
-
-
Chen, K.F.1
-
177
-
-
33750298971
-
Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells
-
Pedranzini, L. et al. Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res. 66, 9714-9721 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 9714-9721
-
-
Pedranzini, L.1
-
178
-
-
58149399350
-
Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3
-
Nelson, E. A. et al. Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood 112, 5095-5102 (2008).
-
(2008)
Blood
, vol.112
, pp. 5095-5102
-
-
Nelson, E.A.1
-
179
-
-
84892435346
-
The role of EGFR monoclonal antibodies (MoABs) cetuximab/panitumab, and BRAF inhibitors in BRAF mutated colorectal cancer
-
Muhammad, S. et al. The role of EGFR monoclonal antibodies (MoABs) cetuximab/panitumab, and BRAF inhibitors in BRAF mutated colorectal cancer. J. Gastrointest Oncol. 4, 72-81 (2013).
-
(2013)
J. Gastrointest Oncol.
, vol.4
, pp. 72-81
-
-
Muhammad, S.1
-
180
-
-
60749095127
-
Anti-epidermal growth factor receptor monoclonal antibody cetuximab inhibits EGFR/HER 2 heterodimerization and activation
-
Patel, D. et al. Anti-epidermal growth factor receptor monoclonal antibody cetuximab inhibits EGFR/HER 2 heterodimerization and activation. Int. J. Oncol. 34, 25-32 (2009).
-
(2009)
Int. J. Oncol.
, vol.34
, pp. 25-32
-
-
Patel, D.1
-
181
-
-
79958202400
-
Phase II study of trastuzumab and cisplatin as first-line therapy in patients with HER2 positive advanced gastric or gastroesophageal junction cancer
-
Gravalos, C. et al. Phase II study of trastuzumab and cisplatin as first-line therapy in patients with HER2 positive advanced gastric or gastroesophageal junction cancer. Clin. Transl. Oncol. 13, 179-184 (2011).
-
(2011)
Clin. Transl. Oncol.
, vol.13
, pp. 179-184
-
-
Gravalos, C.1
-
182
-
-
38749149510
-
Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin
-
Kim, S. Y. et al. Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin. Int. J. Oncol. 32, 89-95 (2008).
-
(2008)
Int. J. Oncol.
, vol.32
, pp. 89-95
-
-
Kim, S.Y.1
-
183
-
-
80052163169
-
Inhibitory effects of the JAK inhibitor CP690,550 on human CD4+ T lymphocyte cytokine production
-
Migita, K. et al. Inhibitory effects of the JAK inhibitor CP690,550 on human CD4+ T lymphocyte cytokine production. BMC Immunol. 12, 51 (2011).
-
(2011)
BMC Immunol
, vol.12
, pp. 51
-
-
Migita, K.1
-
184
-
-
77950684805
-
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: Therapeutic implications for the treatment of myeloproliferative neoplasms
-
Quintas-Cardama, A. et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: Therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 115, 3109-3117 (2010).
-
(2010)
Blood
, vol.115
, pp. 3109-3117
-
-
Quintas-Cardama, A.1
-
185
-
-
84856478208
-
STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma
-
Looyenga, B. D. et al. STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma. PLoS ONE 7, e30820 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Looyenga, B.D.1
-
186
-
-
84863948323
-
The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma
-
Derenzini, E. et al. The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma. Blood Cancer J. 1, e46 (2011).
-
(2011)
Blood Cancer J.
, vol.1
-
-
Derenzini, E.1
-
187
-
-
70949094349
-
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors
-
Hedvat, M. et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell. 16, 487-497 (2009).
-
(2009)
Cancer Cell.
, vol.16
, pp. 487-497
-
-
Hedvat, M.1
-
188
-
-
83355169687
-
Therapeutic potential of AZD1480 for the treatment of human glioblastoma
-
McFarland, B. C. et al. Therapeutic potential of AZD1480 for the treatment of human glioblastoma. Mol. Cancer Ther. 10, 2384-2393 (2011).
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 2384-2393
-
-
McFarland, B.C.1
-
189
-
-
80155171655
-
Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480
-
Xin, H. et al. Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. Cancer Res. 71, 6601-6610 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 6601-6610
-
-
Xin, H.1
-
190
-
-
33750739781
-
Atiprimod blocks phosphorylation of JAK-STAT and inhibits proliferation of acute myeloid leukemia (AML) cells
-
Faderl, S. et al. Atiprimod blocks phosphorylation of JAK-STAT and inhibits proliferation of acute myeloid leukemia (AML) cells. Leuk. Res. 31, 91-95 (2007).
-
(2007)
Leuk. Res.
, vol.31
, pp. 91-95
-
-
Faderl, S.1
-
191
-
-
23044478114
-
Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells
-
Amit-Vazina, M. et al. Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells. Br. J. Cancer. 93, 70-80 (2005).
-
(2005)
Br. J. Cancer.
, vol.93
, pp. 70-80
-
-
Amit-Vazina, M.1
-
192
-
-
35948995412
-
Auranofin blocks interleukin 6 signaling by inhibiting phosphorylation of JAK1 and STAT3
-
Kim, N. H. et al. Auranofin blocks interleukin 6 signaling by inhibiting phosphorylation of JAK1 and STAT3. Immunology 122, 607-614 (2007).
-
(2007)
Immunology
, vol.122
, pp. 607-614
-
-
Kim, N.H.1
-
193
-
-
78751705649
-
The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF κB activity
-
Nakaya, A. et al. The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF κB activity. Leuk. Res. 35, 243-249 (2011).
-
(2011)
Leuk. Res.
, vol.35
, pp. 243-249
-
-
Nakaya, A.1
-
194
-
-
33745243692
-
Dasatinib (BMS 354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
-
Song, L. et al. Dasatinib (BMS 354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 66, 5542-5548 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 5542-5548
-
-
Song, L.1
-
195
-
-
79955780881
-
JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL 6 neutralizing antibodies can suppress JAK1 STAT3 signaling
-
Song, L. et al. JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL 6 neutralizing antibodies can suppress JAK1 STAT3 signaling. Mol. Cancer Ther. 10, 481-494 (2011).
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 481-494
-
-
Song, L.1
-
196
-
-
84866254673
-
First in human trial of a STAT3 decoy oligonucleotide in head and neck tumors: Implications for cancer therapy
-
Sen, M. et al. First in human trial of a STAT3 decoy oligonucleotide in head and neck tumors: Implications for cancer therapy. Cancer Discov. 2, 694-705 (2012).
-
(2012)
Cancer Discov.
, vol.2
, pp. 694-705
-
-
Sen, M.1
-
197
-
-
84858230349
-
A STAT3 inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line
-
Souissi, I. et al. A STAT3 inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line. Mol. Cancer 11, 12 (2012).
-
(2012)
Mol. Cancer
, vol.11
, Issue.12
-
-
Souissi, I.1
-
198
-
-
70350503333
-
Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription 1 (STAT 1)
-
Huckel, M. et al. Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription 1 (STAT 1). Arthritis Res. Ther. 8, R17 (2006).
-
(2006)
Arthritis Res. Ther.
, vol.8
-
-
Huckel, M.1
-
199
-
-
52449133737
-
AP 1 and STAT 1 decoy oligodeoxynucleotides attenuate transplant vasculopathy in rat cardiac allografts
-
Stadlbauer, T. H. et al. AP 1 and STAT 1 decoy oligodeoxynucleotides attenuate transplant vasculopathy in rat cardiac allografts. Cardiovasc. Res. 79, 698-705 (2008).
-
(2008)
Cardiovasc. Res.
, vol.79
, pp. 698-705
-
-
Stadlbauer, T.H.1
-
200
-
-
79551638801
-
Targeted blockage of signal transducer and activator of transcription 5 signaling pathway with decoy oligodeoxynucleotides suppresses leukemic K562 cell growth
-
Wang, X. et al. Targeted blockage of signal transducer and activator of transcription 5 signaling pathway with decoy oligodeoxynucleotides suppresses leukemic K562 cell growth. DNA Cell Biol. 30, 71-78 (2011).
-
(2011)
DNA Cell Biol.
, vol.30
, pp. 71-78
-
-
Wang, X.1
-
201
-
-
64549129578
-
Inhibitory effects of decoy-ODN targeting activated STAT3 on human glioma growth in vivo
-
Shen, J., Li, R. & Li, G. Inhibitory effects of decoy-ODN targeting activated STAT3 on human glioma growth in vivo. In Vivo 23, 237-243 (2009).
-
(2009)
Vivo
, vol.23
, pp. 237-243
-
-
Shen, J.1
Li, R.2
Li, G.3
-
202
-
-
84866431328
-
Targeting Stat3 abrogates EGFR inhibitor resistance in cancer
-
Sen, M. et al. Targeting Stat3 abrogates EGFR inhibitor resistance in cancer. Clin. Cancer Res. 18, 4986-4996 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 4986-4996
-
-
Sen, M.1
-
203
-
-
34247480458
-
Antiproliferative mechanisms of a transcription factor decoy targeting signal transducer and activator of transcription (STAT) 3: The role of STAT1
-
Lui, V. W. et al. Antiproliferative mechanisms of a transcription factor decoy targeting signal transducer and activator of transcription (STAT) 3: The role of STAT1. Mol. Pharmacol. 71, 1435-1443 (2007).
-
(2007)
Mol. Pharmacol.
, vol.71
, pp. 1435-1443
-
-
Lui, V.W.1
-
204
-
-
85047695527
-
Constitutive Stat3 activity up regulates VEGF expression and tumor angiogenesis
-
Niu, G. et al. Constitutive Stat3 activity up regulates VEGF expression and tumor angiogenesis. Oncogene 21, 2000-2008 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 2000-2008
-
-
Niu, G.1
-
205
-
-
7444238184
-
Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines
-
Barton, B. E. et al. Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines. Mol. Cancer Ther. 3, 1183-1191 (2004).
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 1183-1191
-
-
Barton, B.E.1
-
206
-
-
33845771270
-
Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3
-
Li, W. C. et al. Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3. Clin. Cancer Res. 12, 7140-7148 (2006).
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 7140-7148
-
-
Li, W.C.1
-
207
-
-
84878247636
-
Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys
-
Burel, S. A. et al. Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys. Nucleic Acid. Ther. 23, 213-227 (2013).
-
(2013)
Nucleic Acid. Ther.
, vol.23
, pp. 213-227
-
-
Burel, S.A.1
|