메뉴 건너뛰기




Volumn 12, Issue 8, 2013, Pages 611-629

Therapeutic modulators of STAT signalling for human diseases

Author keywords

[No Author keywords available]

Indexed keywords

4 [[(4 METHYLPHENYL)SULFONYLOXY]ACETAMIDO]SALICYLIC ACID; 5 CHLORO N2 [1 (5 FLUORO 2 PYRIMIDINYL)ETHYL] N4 (5 METHYL 1H PYRAZOL 3 YL) 2,4 PYRIMIDINEDIAMINE; ATIPRIMOD; AURANOFIN; BERBAMINE; BETULIC ACID; CAPSAICIN; CELASTROL; CRYPTOTANSHINONE; CURCUMIN; EMODIN; EVODIAMINE; FLUOROURACIL; HONOKIOL; INDIRUBIN; LEFLUNOMIDE; NAVELBINE; NIFLUMIC ACID; OLEANOLIC ACID; PACLITAXEL; PICEATANNOL; PIMOZIDE; PRAVASTATIN; RESVERATROL; SORAFENIB; STAT PROTEIN; TOFACITINIB; UNINDEXED DRUG; URSOLIC ACID; WITHAFERIN A;

EID: 84881267595     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4088     Document Type: Review
Times cited : (364)

References (207)
  • 1
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcriptional control and their impact on cellular function
    • Bromberg, J. & Darnell, J. E. Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19, 2468-2473 (2000).
    • (2000) Oncogene , vol.19 , pp. 2468-2473
    • Bromberg, J.1    Darnell Jr., J.E.2
  • 2
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell, J. E. Jr. STATs and gene regulation. Science 277, 1630-1635 (1997).
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell Jr., J.E.1
  • 3
    • 84859992161 scopus 로고    scopus 로고
    • The JAK-STAT pathway at twenty
    • Stark, G. R. & Darnell, J. E. Jr. The JAK-STAT pathway at twenty. Immunity 36, 503-514 (2012).
    • (2012) Immunity , vol.36 , pp. 503-514
    • Stark, G.R.1    Darnell Jr., J.E.2
  • 4
    • 33847418900 scopus 로고    scopus 로고
    • Transcription protein STAT1: Biology and relation to cancer
    • Adamkova, L., Souckova, K. & Kovarik, J. Transcription protein STAT1: Biology and relation to cancer. Folia Biol. 53, 1-6 (2007).
    • (2007) Folia Biol. , vol.53 , pp. 1-6
    • Adamkova, L.1    Souckova, K.2    Kovarik, J.3
  • 5
    • 0038195719 scopus 로고    scopus 로고
    • Molecular mechanisms regulating Th1 immune responses
    • Szabo, S. J. et al. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21, 713-758 (2003).
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 713-758
    • Szabo, S.J.1
  • 6
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    • Meraz, M. A. et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84, 431-442 (1996).
    • (1996) Cell , vol.84 , pp. 431-442
    • Meraz, M.A.1
  • 7
    • 34250316051 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development
    • Agrawal, S. et al. Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development. Circulation 115, 2939-2947 (2007).
    • (2007) Circulation , vol.115 , pp. 2939-2947
    • Agrawal, S.1
  • 8
    • 79961154447 scopus 로고    scopus 로고
    • Gain of function human STAT1 mutations impair IL 17 immunity and underlie chronic mucocutaneous candidiasis
    • Liu, L. et al. Gain of function human STAT1 mutations impair IL 17 immunity and underlie chronic mucocutaneous candidiasis. J. Exp. Med. 208, 1635-1648 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1635-1648
    • Liu, L.1
  • 9
    • 79960094057 scopus 로고    scopus 로고
    • STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis
    • van de Veerdonk, F. L. et al. STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N. Engl. J. Med. 365, 54-61 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 54-61
    • Van De Veerdonk, F.L.1
  • 10
    • 77950799520 scopus 로고    scopus 로고
    • STAT2 contributes to promotion of colorectal and skin carcinogenesis
    • Gamero, A. M. et al. STAT2 contributes to promotion of colorectal and skin carcinogenesis. Cancer Prev. Res. 3, 495-504 (2010).
    • (2010) Cancer Prev. Res. , vol.3 , pp. 495-504
    • Gamero, A.M.1
  • 11
    • 0030935260 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
    • Takeda, K. et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl Acad. Sci. USA 94, 3801-3804 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 3801-3804
    • Takeda, K.1
  • 12
    • 0032934156 scopus 로고    scopus 로고
    • Functional roles of STAT family proteins: Lessons from knockout mice
    • Akira, S. Functional roles of STAT family proteins: Lessons from knockout mice. Stem Cells 17, 138-146 (1999).
    • (1999) Stem Cells , vol.17 , pp. 138-146
    • Akira, S.1
  • 13
    • 0032213273 scopus 로고    scopus 로고
    • Stat3 activation is responsible for IL 6 dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3 deficient mice
    • Takeda, K. et al. Stat3 activation is responsible for IL 6 dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3 deficient mice. J. Immunol. 161, 4652-4660 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 4652-4660
    • Takeda, K.1
  • 14
    • 0033198793 scopus 로고    scopus 로고
    • Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
    • Sano, S. et al. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J. 18, 4657-4668 (1999).
    • (1999) EMBO J. , vol.18 , pp. 4657-4668
    • Sano, S.1
  • 15
    • 84892445618 scopus 로고    scopus 로고
    • Role of STAT3 in skin carcinogenesis: Insights gained from relevant mouse models
    • Macias, E., Rao, D. & Digiovanni, J. Role of STAT3 in skin carcinogenesis: Insights gained from relevant mouse models. J. Skin Cancer 2013, 684050 (2013).
    • (2013) J. Skin Cancer , vol.2013 , pp. 684050
    • Macias, E.1    Rao, D.2    Digiovanni, J.3
  • 16
    • 0034658698 scopus 로고    scopus 로고
    • STATs in oncogenesis
    • Bowman, T. et al. STATs in oncogenesis. Oncogene 19, 2474-2488 (2000).
    • (2000) Oncogene , vol.19 , pp. 2474-2488
    • Bowman, T.1
  • 17
    • 20944441928 scopus 로고    scopus 로고
    • Validating Stat3 in cancer therapy
    • Darnell, J. E. Validating Stat3 in cancer therapy. Nature Med. 11, 595-596 (2005).
    • (2005) Nature Med. , vol.11 , pp. 595-596
    • Darnell, J.E.1
  • 18
    • 20844444135 scopus 로고    scopus 로고
    • Targeting Stat3 in cancer therapy
    • Jing, N. & Tweardy, D. J. Targeting Stat3 in cancer therapy. Anticancer Drugs 16, 601-607 (2005).
    • (2005) Anticancer Drugs , vol.16 , pp. 601-607
    • Jing, N.1    Tweardy, D.J.2
  • 19
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer - new molecular targets come of age
    • Yu, H. & R. Jove, The STATs of cancer - new molecular targets come of age. Nature Rev. Cancer 4, 97-105 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 20
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner, R., Mora, L. B. & Jove, R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin. Cancer Res. 8, 945-954 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 21
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: Novel molecular targets for cancer drug discovery
    • Turkson, J. & Jove, R. STAT proteins: Novel molecular targets for cancer drug discovery. Oncogene 19, 6613-6626 (2000).
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 22
    • 64849111865 scopus 로고    scopus 로고
    • Targeting STAT3 in cancer: How successful are we? Expert Opin
    • Yue, P. & Turkson, J. Targeting STAT3 in cancer: How successful are we? Expert Opin. Investig. Drugs 18, 45-56 (2009).
    • (2009) Investig. Drugs , vol.18 , pp. 45-56
    • Yue, P.1    Turkson, J.2
  • 23
    • 5444237088 scopus 로고    scopus 로고
    • STAT proteins as novel targets for cancer drug discovery
    • Turkson, J. STAT proteins as novel targets for cancer drug discovery. Expert Opin. Ther. Targets. 8, 409-422 (2004).
    • (2004) Expert Opin. Ther. Targets. , vol.8 , pp. 409-422
    • Turkson, J.1
  • 24
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Kortylewski, M. et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nature Med. 11, 1314-1321 (2005).
    • (2005) Nature Med. , vol.11 , pp. 1314-1321
    • Kortylewski, M.1
  • 25
    • 11144357779 scopus 로고    scopus 로고
    • Regulation of the innate and adaptive immune responses by Stat 3 signaling in tumor cells
    • Wang, T. et al. Regulation of the innate and adaptive immune responses by Stat 3 signaling in tumor cells. Nature Med, 10, 48-54 (2004).
    • (2004) Nature Med , vol.10 , pp. 48-54
    • Wang, T.1
  • 26
    • 34250658084 scopus 로고    scopus 로고
    • Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
    • Siddiquee, K. et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc. Natl Acad. Sci. USA 104, 7391-7396 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 7391-7396
    • Siddiquee, K.1
  • 27
    • 38649129118 scopus 로고    scopus 로고
    • An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects
    • Siddiquee, K. A. et al. An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. ACS Chem. Biol. 2, 787-798 (2007).
    • (2007) ACS Chem. Biol. , vol.2 , pp. 787-798
    • Siddiquee, K.A.1
  • 28
    • 63949085226 scopus 로고    scopus 로고
    • Lack of toxicity of a STAT3 decoy oligonucleotide
    • Sen, M. et al. Lack of toxicity of a STAT3 decoy oligonucleotide. Cancer Chemother. Pharmacol. 63, 983-995 (2009).
    • (2009) Cancer Chemother. Pharmacol. , vol.63 , pp. 983-995
    • Sen, M.1
  • 29
    • 0032718891 scopus 로고    scopus 로고
    • Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo
    • Niu, G. et al. Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo. Cancer Res, 59, 5059-5063 (1999).
    • (1999) Cancer Res , vol.59 , pp. 5059-5063
    • Niu, G.1
  • 30
    • 0035977055 scopus 로고    scopus 로고
    • Phosphotyrosyl peptides block Stat3 mediated DNA binding activity gene regulation, and cell transformation
    • Turkson, J. et al. Phosphotyrosyl peptides block Stat3 mediated DNA binding activity, gene regulation, and cell transformation. J. Biol. Chem, 276, 45443-45455 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 45443-45455
    • Turkson, J.1
  • 31
    • 35348960378 scopus 로고    scopus 로고
    • STAT3 mutations in the hyper-IgE syndrome
    • Holland, S. M. et al. STAT3 mutations in the hyper-IgE syndrome. N. Engl. J. Med. 357, 1608-1619 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , pp. 1608-1619
    • Holland, S.M.1
  • 32
    • 84861023172 scopus 로고    scopus 로고
    • Somatic STAT3 mutations in large granular lymphocytic leukemia
    • Koskela, H. L. et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. N. Engl. J. Med, 366, 1905-1913 (2012).
    • (2012) N. Engl. J. Med , vol.366 , pp. 1905-1913
    • Koskela, H.L.1
  • 33
    • 84874074941 scopus 로고    scopus 로고
    • Identification of a novel STAT3 mutation in a patient with hyper-IgE syndrome
    • Mogensen, T. H., Jakobsen, M. A. & Larsen, C. S. Identification of a novel STAT3 mutation in a patient with hyper-IgE syndrome. Scand. J. Infect. Dis. 45, 235-238 (2013).
    • (2013) Scand. J. Infect. Dis. , vol.45 , pp. 235-238
    • Mogensen, T.H.1    Jakobsen, M.A.2    Larsen, C.S.3
  • 34
    • 78650178184 scopus 로고    scopus 로고
    • Th1 versus Th17: Are T cell cytokines relevant in multiple sclerosis? Biochim
    • Lovett-Racke, A. E., Yang, Y. & Racke, M. K. Th1 versus Th17: Are T cell cytokines relevant in multiple sclerosis? Biochim. Biophys. Acta 1812, 246-251 (2011).
    • (2011) Biophys. Acta , vol.1812 , pp. 246-251
    • Lovett-Racke, A.E.1    Yang, Y.2    Racke, M.K.3
  • 35
    • 0034789247 scopus 로고    scopus 로고
    • Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
    • Chitnis, T. et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest. 108, 739-747 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 739-747
    • Chitnis, T.1
  • 36
    • 79551573789 scopus 로고    scopus 로고
    • Targeting transcription factor Stat4 uncovers a role for interleukin 18 in the pathogenesis of severe lupus nephritis in mice
    • Menke, J. et al. Targeting transcription factor Stat4 uncovers a role for interleukin 18 in the pathogenesis of severe lupus nephritis in mice. Kidney Int. 79, 452-463 (2011).
    • (2011) Kidney Int. , vol.79 , pp. 452-463
    • Menke, J.1
  • 37
    • 0034657396 scopus 로고    scopus 로고
    • The role of Stat5a and Stat5b in signaling by IL 2 family cytokines
    • Lin, J. X. & Leonard, W. J. The role of Stat5a and Stat5b in signaling by IL 2 family cytokines. Oncogene 19, 2566-2576 (2000).
    • (2000) Oncogene , vol.19 , pp. 2566-2576
    • Lin, J.X.1    Leonard, W.J.2
  • 38
    • 0037217955 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells
    • Buitenhuis, M. et al. Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells. Blood. 101, 134-142 (2003).
    • (2003) Blood. , vol.101 , pp. 134-142
    • Buitenhuis, M.1
  • 39
    • 0030833570 scopus 로고    scopus 로고
    • Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
    • Udy, G. B. et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl Acad. Sci. USA 94, 7239-7244 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 7239-7244
    • Udy, G.B.1
  • 40
    • 0031774896 scopus 로고    scopus 로고
    • Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity
    • Imada, K. et al. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J. Exp. Med. 188, 2067-2074 (1998).
    • (1998) J. Exp. Med. , vol.188 , pp. 2067-2074
    • Imada, K.1
  • 41
    • 79953109597 scopus 로고    scopus 로고
    • The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors
    • Nelson, E. A. et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood 117, 3421-3429 (2011).
    • (2011) Blood , vol.117 , pp. 3421-3429
    • Nelson, E.A.1
  • 42
    • 0346024125 scopus 로고    scopus 로고
    • Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers
    • Cotarla, I. et al. Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers. Int. J. Cancer 108, 665-671 (2004).
    • (2004) Int. J. Cancer , vol.108 , pp. 665-671
    • Cotarla, I.1
  • 43
    • 0029810923 scopus 로고    scopus 로고
    • Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
    • Shuai, K. et al. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 13, 247-254 (1996).
    • (1996) Oncogene , vol.13 , pp. 247-254
    • Shuai, K.1
  • 44
    • 70349323403 scopus 로고    scopus 로고
    • Targeting signal transducer and activator of transcription signaling pathway in leukemias
    • Benekli, M., Baumann, H. & Wetzler, M. Targeting signal transducer and activator of transcription signaling pathway in leukemias. J. Clin. Oncol. 27, 4422-4432 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4422-4432
    • Benekli, M.1    Baumann, H.2    Wetzler, M.3
  • 45
    • 80555149872 scopus 로고    scopus 로고
    • A chemical biology approach to developing STAT inhibitors: Molecular strategies for accelerating clinical translation
    • Nelson, E. A. et al. A chemical biology approach to developing STAT inhibitors: Molecular strategies for accelerating clinical translation. Oncotarget 2, 518-524 (2011).
    • (2011) Oncotarget , vol.2 , pp. 518-524
    • Nelson, E.A.1
  • 46
    • 0027972046 scopus 로고
    • An interleukin-4 induced transcription factor: IL 4 Stat
    • Hou, J. et al. An interleukin-4 induced transcription factor: IL 4 Stat. Science 265, 1701-1706 (1994).
    • (1994) Science , vol.265 , pp. 1701-1706
    • Hou, J.1
  • 47
    • 77951890216 scopus 로고    scopus 로고
    • IL 4 regulates skin homeostasis and the predisposition toward allergic skin inflammation
    • Sehra, S. et al. IL 4 regulates skin homeostasis and the predisposition toward allergic skin inflammation. J. Immunol. 184, 3186-3190 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 3186-3190
    • Sehra, S.1
  • 48
    • 79951828807 scopus 로고    scopus 로고
    • STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease
    • Chapoval, S. P. et al. STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease. J. Immunol. 186, 2571-2583 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 2571-2583
    • Chapoval, S.P.1
  • 49
    • 53849139093 scopus 로고    scopus 로고
    • Interleukin 4, interleukin 13, signal transducer and activator of transcription factor 6, and allergic asthma
    • Kuperman, D. A. & Schleimer, R. P. Interleukin 4, interleukin 13, signal transducer and activator of transcription factor 6, and allergic asthma. Curr. Mol. Med. 8, 384-392 (2008).
    • (2008) Curr. Mol. Med. , vol.8 , pp. 384-392
    • Kuperman, D.A.1    Schleimer, R.P.2
  • 50
    • 59149107299 scopus 로고    scopus 로고
    • Interleukin 13 augments bronchial smooth muscle contractility with an up regulation of RhoA protein
    • Chiba, Y. et al. Interleukin 13 augments bronchial smooth muscle contractility with an up regulation of RhoA protein. Am. J. Respir. Cell. Mol. Biol. 40, 159-167 (2009).
    • (2009) Am. J. Respir. Cell. Mol. Biol. , vol.40 , pp. 159-167
    • Chiba, Y.1
  • 51
    • 70349870911 scopus 로고    scopus 로고
    • A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice
    • Chiba, Y. et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am. J. Respir. Cell. Mol. Biol. 41, 516-524 (2009).
    • (2009) Am. J. Respir. Cell. Mol. Biol. , vol.41 , pp. 516-524
    • Chiba, Y.1
  • 52
    • 34548165283 scopus 로고    scopus 로고
    • The IL 4/IL 13/Stat6 signaling pathway promotes luminal mammary epithelial cell development
    • Khaled, W. T. et al. The IL 4/IL 13/Stat6 signaling pathway promotes luminal mammary epithelial cell development. Development 134, 2739-2750 (2007).
    • (2007) Development , vol.134 , pp. 2739-2750
    • Khaled, W.T.1
  • 53
    • 84872065897 scopus 로고    scopus 로고
    • JAKs and stats in immunity, immunodeficiency, and cancer
    • O'Shea, J. J., Holland, S. M. & Staudt, L. M. JAKs and STATs in immunity, immunodeficiency, and cancer. N. Engl. J. Med. 368, 161-170 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 161-170
    • O'Shea, J.J.1    Holland, S.M.2    Staudt, L.M.3
  • 54
    • 84877095601 scopus 로고    scopus 로고
    • Molecular pathways: Jak/STAT pathway: Mutations, inhibitors, and resistance
    • Quintas-Cardama, A. & Verstovsek, S. Molecular pathways: Jak/STAT pathway: Mutations, inhibitors, and resistance. Clin. Cancer Res. 19, 1933-1940 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 1933-1940
    • Quintas-Cardama, A.1    Verstovsek, S.2
  • 55
    • 3543055012 scopus 로고    scopus 로고
    • Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity
    • Turkson, J. et al. Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Mol. Cancer Ther. 3, 261-269 (2004).
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 261-269
    • Turkson, J.1
  • 56
    • 27144475507 scopus 로고    scopus 로고
    • Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3 Development of a high-affinity peptide inhibitor
    • Coleman, D. R. et al. Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor. J. Med. Chem. 48, 6661-6670 (2005).
    • (2005) J. Med. Chem. , vol.48 , pp. 6661-6670
    • Coleman, D.R.1
  • 57
    • 0037294154 scopus 로고    scopus 로고
    • Identification of a high-affinity phosphopeptide inhibitor of Stat3
    • Ren, Z. et al. Identification of a high-affinity phosphopeptide inhibitor of Stat3. Bioorg. Med. Chem. Lett. 13, 633-636 (2003).
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 633-636
    • Ren, Z.1
  • 58
    • 33847682326 scopus 로고    scopus 로고
    • Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: Structural recognition of STAT SH2 domains
    • Gunning, P. T. et al. Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: Structural recognition of STAT SH2 domains. Bioorg. Med. Chem. Lett. 17, 1875-1878 (2007).
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 1875-1878
    • Gunning, P.T.1
  • 59
    • 39149090322 scopus 로고    scopus 로고
    • Structural basis for the binding of high affinity phosphopeptides to Stat3
    • McMurray, J. S., Structural basis for the binding of high affinity phosphopeptides to Stat3. Biopolymers 90, 69-79 (2008).
    • (2008) Biopolymers , vol.90 , pp. 69-79
    • McMurray, J.S.1
  • 60
    • 78149270544 scopus 로고    scopus 로고
    • A cell-permeable Stat3 SH2 domain mimetic inhibits Stat3 activation and induces antitumor cell effects in vitro
    • Zhao, W. Jaganathan, S. & Turkson, J. A cell-permeable Stat3 SH2 domain mimetic inhibits Stat3 activation and induces antitumor cell effects in vitro. J. Biol. Chem. 285, 35855-35865 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 35855-35865
    • Zhao, W.1    Jaganathan, S.2    Turkson, J.3
  • 61
    • 77956627676 scopus 로고    scopus 로고
    • Structure-based design of conformationally constrained, cell-permeable STAT3 inhibitors
    • Chen, J. et al. Structure-based design of conformationally constrained, cell-permeable STAT3 inhibitors. ACS Med. Chem. Lett. 1, 85-89 (2010).
    • (2010) ACS Med. Chem. Lett. , vol.1 , pp. 85-89
    • Chen, J.1
  • 62
    • 79957742210 scopus 로고    scopus 로고
    • Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3
    • Mandal, P. K. et al. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. J. Med. Chem. 54, 3549-3563 (2011).
    • (2011) J. Med. Chem. , vol.54 , pp. 3549-3563
    • Mandal, P.K.1
  • 63
    • 84873388087 scopus 로고    scopus 로고
    • A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis
    • Auzenne, E. J. et al. A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis. J. Exp. Ther. Oncol. 10, 155-162 (2012).
    • (2012) J. Exp. Ther. Oncol. , vol.10 , pp. 155-162
    • Auzenne, E.J.1
  • 64
    • 16344380754 scopus 로고    scopus 로고
    • A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
    • Song, H. et al. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc. Natl Acad. Sci. USA 102, 4700-4705 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 4700-4705
    • Song, H.1
  • 65
    • 58149267888 scopus 로고    scopus 로고
    • LLL 3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
    • Fuh, B. et al. LLL 3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model. Br. J. Cancer 100, 106-112 (2009).
    • (2009) Br. J. Cancer , vol.100 , pp. 106-112
    • Fuh, B.1
  • 66
    • 51349156533 scopus 로고    scopus 로고
    • Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening
    • Hao, W. et al. Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening. Bioorg. Med. Chem. Lett. 18, 4988-4992 (2008).
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 4988-4992
    • Hao, W.1
  • 67
    • 77649178678 scopus 로고    scopus 로고
    • A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3 dependent tumor processes
    • Zhang, X. et al. A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3 dependent tumor processes. Biochem. Pharmacol. 79, 1398-1409 (2010).
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 1398-1409
    • Zhang, X.1
  • 68
    • 84862193781 scopus 로고    scopus 로고
    • Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
    • Zhang, X. et al. Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proc. Natl Acad. Sci. USA 109, 9623-9628 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 9623-9628
    • Zhang, X.1
  • 69
    • 84875458307 scopus 로고    scopus 로고
    • A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation
    • Zhang, X. et al. A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation. Cancer Res. 73, 1922-1933 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 1922-1933
    • Zhang, X.1
  • 70
    • 62849104063 scopus 로고    scopus 로고
    • Chemical probes that competitively and selectively inhibit Stat3 activation
    • Xu, X. et al. Chemical probes that competitively and selectively inhibit Stat3 activation. PLoS ONE 4, e4783 (2009).
    • (2009) PLoS ONE , vol.4
    • Xu, X.1
  • 71
    • 84864673390 scopus 로고    scopus 로고
    • Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model
    • Dave, B. et al. Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS ONE 7, e30207 (2012).
    • (2012) PLoS ONE , vol.7
    • Dave, B.1
  • 72
    • 33750982120 scopus 로고    scopus 로고
    • Stattic: A small-molecule inhibitor of STAT3 activation and dimerization
    • Schust, J. et al. Stattic: A small-molecule inhibitor of STAT3 activation and dimerization. Chem. Biol. 13, 1235-1242 (2006).
    • (2006) Chem. Biol. , vol.13 , pp. 1235-1242
    • Schust, J.1
  • 73
    • 79955000497 scopus 로고    scopus 로고
    • Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation
    • Ashizawa, T. et al. Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation. Int. J. Oncol. 38, 1245-1252 (2011).
    • (2011) Int. J. Oncol. , vol.38 , pp. 1245-1252
    • Ashizawa, T.1
  • 74
    • 78649286584 scopus 로고    scopus 로고
    • Identification of a new series of STAT3 inhibitors by virtual screening
    • Matsuno, K. et al. Identification of a new series of STAT3 inhibitors by virtual screening. ACS Med. Chem. Lett. 1, 371-3755 (2010).
    • (2010) ACS Med. Chem. Lett. , vol.1 , pp. 371-3755
    • Matsuno, K.1
  • 75
    • 84873738776 scopus 로고    scopus 로고
    • Fragment-based drug design and identification of HJC0123 a novel orally bioavailable STAT3 inhibitor for cancer therapy
    • Chen, H. et al. Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy. Eur. J. Med. Chem. 62C, 498-507 (2013).
    • (2013) Eur. J. Med. Chem. , vol.62 C , pp. 498-507
    • Chen, H.1
  • 76
    • 84875209735 scopus 로고    scopus 로고
    • Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening
    • Zhang, M. et al. Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening. Bioorg. Med. Chem. Lett. 23, 2225-2229 (2013).
    • (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 2225-2229
    • Zhang, M.1
  • 77
    • 84878432714 scopus 로고    scopus 로고
    • OPB 31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells
    • Kim, M. J. et al. OPB 31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett. 335, 145-152 (2013).
    • (2013) Cancer Lett. , vol.335 , pp. 145-152
    • Kim, M.J.1
  • 78
    • 84861476075 scopus 로고    scopus 로고
    • Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signaling pathway
    • Yang, C. L. et al. Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signaling pathway. PLoS ONE 7, e37960 (2012).
    • (2012) PLoS ONE , vol.7
    • Yang, C.L.1
  • 79
    • 84863248624 scopus 로고    scopus 로고
    • Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth
    • Tu, S. P. et al. Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth. Cancer Prev. Res. 5, 205-215 (2012).
    • (2012) Cancer Prev. Res. , vol.5 , pp. 205-215
    • Tu, S.P.1
  • 80
    • 79953112475 scopus 로고    scopus 로고
    • The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines
    • Fossey, S. L. et al. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. BMC Cancer 11, 112 (2011).
    • (2011) BMC Cancer , vol.11 , pp. 112
    • Fossey, S.L.1
  • 81
    • 80655129638 scopus 로고    scopus 로고
    • HO 3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition
    • Selvendiran, K. et al. HO 3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition. Cancer Biol. Ther. 12, 837-845 (2011).
    • (2011) Cancer Biol. Ther. , vol.12 , pp. 837-845
    • Selvendiran, K.1
  • 82
    • 84863499934 scopus 로고    scopus 로고
    • HO 3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1 mutated ovarian cancer cells
    • Tierney, B. J. et al. HO 3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1 mutated ovarian cancer cells. Cancer Biol. Ther. 13, 766-775 (2012).
    • (2012) Cancer Biol. Ther. , vol.13 , pp. 766-775
    • Tierney, B.J.1
  • 83
    • 77950190311 scopus 로고    scopus 로고
    • Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells
    • Lin, L. et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res. 70, 2445-2454 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 2445-2454
    • Lin, L.1
  • 84
    • 84864350035 scopus 로고    scopus 로고
    • Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice
    • Onimoe, G. I. et al. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Invest. New Drugs 30, 916-926 (2012).
    • (2012) Invest. New Drugs , vol.30 , pp. 916-926
    • Onimoe, G.I.1
  • 85
    • 84859828700 scopus 로고    scopus 로고
    • Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12
    • Bid, H. K. et al. Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12. PLoS ONE 7, e35513 (2012).
    • (2012) PLoS ONE , vol.7
    • Bid, H.K.1
  • 86
    • 77955520465 scopus 로고    scopus 로고
    • A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
    • Lin, L. et al. A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. Mol. Cancer 9, 217 (2010).
    • (2010) Mol. Cancer , vol.9 , Issue.217
    • Lin, L.1
  • 87
    • 84864996651 scopus 로고    scopus 로고
    • Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines
    • Bill, M. A. et al. Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. PLoS ONE 7, e40724 (2012).
    • (2012) PLoS ONE , vol.7
    • Bill, M.A.1
  • 88
    • 84866022781 scopus 로고    scopus 로고
    • Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells
    • Nam, S. et al. Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Mol. Oncol. 6, 484-493 (2012).
    • (2012) Mol. Oncol. , vol.6 , pp. 484-493
    • Nam, S.1
  • 89
    • 80052962987 scopus 로고    scopus 로고
    • Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2 mediated JAK/STAT3 signaling in endothelial cell
    • Zhang, X. et al. Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2 mediated JAK/STAT3 signaling in endothelial cell. Int. J. Cancer 129, 2502-2511 (2011).
    • (2011) Int. J. Cancer , vol.129 , pp. 2502-2511
    • Zhang, X.1
  • 90
    • 20944435625 scopus 로고    scopus 로고
    • Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells
    • Nam, S. et al. Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells. Proc. Natl Acad. Sci. USA 102, 5998-6003 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 5998-6003
    • Nam, S.1
  • 91
    • 84868363095 scopus 로고    scopus 로고
    • A novel 7 bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling
    • Liu, L. et al. A novel 7 bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling. Cancer Biol. Ther. 13, 13 (2012).
    • (2012) Cancer Biol. Ther. , vol.13 , Issue.13
    • Liu, L.1
  • 92
    • 84878116135 scopus 로고    scopus 로고
    • Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells
    • Nam, S. et al. Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. Mol. Oncol. 7, 369-378 (2013).
    • (2013) Mol. Oncol. , vol.7 , pp. 369-378
    • Nam, S.1
  • 94
    • 73149109931 scopus 로고    scopus 로고
    • Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling
    • Li, T. et al. Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling. Int. Immunopharmacol. 10, 18-25 (2010).
    • (2010) Int. Immunopharmacol. , vol.10 , pp. 18-25
    • Li, T.1
  • 95
    • 57349090717 scopus 로고    scopus 로고
    • LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3 mediated matrix metalloproteinase 9 expression
    • Kim, J. E. et al. LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3 mediated matrix metalloproteinase 9 expression. Exp. Mol. Med. 40, 514-522 (2008).
    • (2008) Exp. Mol. Med. , vol.40 , pp. 514-522
    • Kim, J.E.1
  • 96
    • 84155184247 scopus 로고    scopus 로고
    • Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis
    • Yang, Y. P. et al. Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis. J. Cell. Physiol. 227, 976-993 (2012).
    • (2012) J. Cell. Physiol. , vol.227 , pp. 976-993
    • Yang, Y.P.1
  • 97
    • 78851469815 scopus 로고    scopus 로고
    • Chemosensitization of tumors by resveratrol
    • Gupta, S. C. et al. Chemosensitization of tumors by resveratrol. Ann. NY Acad. Sci. 1215, 150-160 (2011).
    • (2011) Ann. NY Acad. Sci. , vol.1215 , pp. 150-160
    • Gupta, S.C.1
  • 98
    • 84155167138 scopus 로고    scopus 로고
    • Biological activity of piceatannol: Leaving the shadow of resveratrol
    • Piotrowska, H. Kucinska, M. & Murias, M. Biological activity of piceatannol: Leaving the shadow of resveratrol. Mutat. Res. 750, 60-82 (2012).
    • (2012) Mutat. Res. , vol.750 , pp. 60-82
    • Piotrowska, H.1    Kucinska, M.2    Murias, M.3
  • 99
    • 80052079930 scopus 로고    scopus 로고
    • Resveratrol potentiates the cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells
    • Santandreu, F. M. et al. Resveratrol potentiates the cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells. Cell Physiol. Biochem. 28, 219-228 (2011).
    • (2011) Cell Physiol. Biochem. , vol.28 , pp. 219-228
    • Santandreu, F.M.1
  • 100
    • 84861553261 scopus 로고    scopus 로고
    • Protective effect of caffeic acid on paclitaxel induced anti-proliferation and apoptosis of lung cancer cells involves NF κB pathway
    • Lin, C. L. et al. Protective effect of caffeic acid on paclitaxel induced anti-proliferation and apoptosis of lung cancer cells involves NF κB pathway. Int. J. Mol. Sci. 13, 6236-6245 (2012).
    • (2012) Int. J. Mol. Sci. , vol.13 , pp. 6236-6245
    • Lin, C.L.1
  • 101
    • 34548059697 scopus 로고    scopus 로고
    • Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3 mediated VEGF expression in human renal carcinoma cells
    • Jung, J. E. et al. Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3 mediated VEGF expression in human renal carcinoma cells. Carcinogenesis 28, 1780-1787 (2007).
    • (2007) Carcinogenesis , vol.28 , pp. 1780-1787
    • Jung, J.E.1
  • 102
    • 77951707745 scopus 로고    scopus 로고
    • Inhibition of p-STAT3 enhances IFN-α efficacy against metastatic melanoma in a murine model
    • Kong, L. Y. et al. Inhibition of p-STAT3 enhances IFN-α efficacy against metastatic melanoma in a murine model. Clin. Cancer Res. 16, 2550-2561 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2550-2561
    • Kong, L.Y.1
  • 103
    • 84864326746 scopus 로고    scopus 로고
    • Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway
    • Sai, K. et al. Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway. J. Neurooncol. 107, 487-501 (2012).
    • (2012) J. Neurooncol. , vol.107 , pp. 487-501
    • Sai, K.1
  • 104
    • 63349085786 scopus 로고    scopus 로고
    • Capsaicin inhibits the IL 6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress
    • Lee, H. K. et al. Capsaicin inhibits the IL 6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress. Biochem. Biophys. Res. Commun. 382, 445-450 (2009).
    • (2009) Biochem. Biophys. Res. Commun. , vol.382 , pp. 445-450
    • Lee, H.K.1
  • 105
    • 58249119435 scopus 로고    scopus 로고
    • Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells
    • Shin, D. S. et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 69, 193-202 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 193-202
    • Shin, D.S.1
  • 106
    • 77958126831 scopus 로고    scopus 로고
    • Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling
    • Walker, S. R. et al. Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling. Mol. Pharmacol. 78, 903-908 (2010).
    • (2010) Mol. Pharmacol. , vol.78 , pp. 903-908
    • Walker, S.R.1
  • 107
    • 80054024030 scopus 로고    scopus 로고
    • Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF κB and STAT3 regulated gene products in multiple myeloma cells
    • Kannaiyan, R. et al. Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF κB and STAT3 regulated gene products in multiple myeloma cells. Br. J. Pharmacol. 164, 1506-1521 (2011).
    • (2011) Br. J. Pharmacol. , vol.164 , pp. 1506-1521
    • Kannaiyan, R.1
  • 108
    • 84864835881 scopus 로고    scopus 로고
    • Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo
    • Rajendran, P. et al. Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo. Cancer Prev. Res. 5, 631-643 (2012).
    • (2012) Cancer Prev. Res. , vol.5 , pp. 631-643
    • Rajendran, P.1
  • 109
    • 53949095627 scopus 로고    scopus 로고
    • Avicin D selectively induces apoptosis and downregulates p STAT 3 BCL 2, and survivin in cutaneous T cell lymphoma cells
    • Zhang, C. et al. Avicin D selectively induces apoptosis and downregulates p STAT 3, BCL 2, and survivin in cutaneous T cell lymphoma cells. J. Invest. Dermatol. 128, 2728-2735 (2008).
    • (2008) J. Invest. Dermatol. , vol.128 , pp. 2728-2735
    • Zhang, C.1
  • 110
    • 78149239365 scopus 로고    scopus 로고
    • Withaferin a inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells
    • Lee, J., Hahm, E. R. & Singh, S. V. Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells. Carcinogenesis 31, 1991-1998 (2010).
    • (2010) Carcinogenesis , vol.31 , pp. 1991-1998
    • Lee, J.1    Hahm, E.R.2    Singh, S.V.3
  • 111
    • 84867631835 scopus 로고    scopus 로고
    • Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells
    • Um, H. J. et al. Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells. Biochem. Biophys. Res. Commun. 427, 24-29 (2012).
    • (2012) Biochem. Biophys. Res. Commun. , vol.427 , pp. 24-29
    • Um, H.J.1
  • 112
    • 77953690135 scopus 로고    scopus 로고
    • Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP 1 in human multiple myeloma cells
    • Pandey, M. K., Sung, B. & Aggarwal, B. B. Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP 1 in human multiple myeloma cells. Int. J. Cancer 127, 282-292 (2010).
    • (2010) Int. J. Cancer , vol.127 , pp. 282-292
    • Pandey, M.K.1    Sung, B.2    Aggarwal, B.B.3
  • 113
    • 34548693457 scopus 로고    scopus 로고
    • Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells
    • Pathak, A. K. et al. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol. Cancer Res. 5, 943-955 (2007).
    • (2007) Mol. Cancer Res. , vol.5 , pp. 943-955
    • Pathak, A.K.1
  • 114
    • 79960009770 scopus 로고    scopus 로고
    • Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice
    • Shanmugam, M. K. et al. Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice. J. Mol. Med. 89, 713-727 (2011).
    • (2011) J. Mol. Med. , vol.89 , pp. 713-727
    • Shanmugam, M.K.1
  • 115
    • 0034597578 scopus 로고    scopus 로고
    • Synthetic oleanane and ursane triterpenoids with modified rings A and C: A series of highly active inhibitors of nitric oxide production in mouse macrophages
    • Honda, T. et al. Synthetic oleanane and ursane triterpenoids with modified rings A and C: A series of highly active inhibitors of nitric oxide production in mouse macrophages. J. Med. Chem. 43, 4233-4246 (2000).
    • (2000) J. Med. Chem. , vol.43 , pp. 4233-4246
    • Honda, T.1
  • 116
    • 58849152837 scopus 로고    scopus 로고
    • CDDO Me, a synthetic triterpenoid, inhibits expression of IL 6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells
    • Duan, Z. et al. CDDO Me, a synthetic triterpenoid, inhibits expression of IL 6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells. Cancer Chemother. Pharmacol. 63, 681-689 (2009).
    • (2009) Cancer Chemother. Pharmacol. , vol.63 , pp. 681-689
    • Duan, Z.1
  • 117
    • 77951968251 scopus 로고    scopus 로고
    • Oleanane triterpenoid CDDO Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway
    • Ryu, K. et al. Oleanane triterpenoid CDDO Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. BMC Cancer 10, 187 (2010).
    • (2010) BMC Cancer , vol.10 , pp. 187
    • Ryu, K.1
  • 118
    • 84866182600 scopus 로고    scopus 로고
    • The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice
    • Tran, K. et al. The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice. Cancer Prev. Res. 5, 726-734 (2012).
    • (2012) Cancer Prev. Res. , vol.5 , pp. 726-734
    • Tran, K.1
  • 119
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI 124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • Blaskovich, M. A. et al. Discovery of JSI 124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63, 1270-1279 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 1270-1279
    • Blaskovich, M.A.1
  • 120
    • 79959622792 scopus 로고    scopus 로고
    • Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133 positive cells
    • Hsu, H. S. et al. Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133 positive cells. Cancer 117, 2970-2985 (2011).
    • (2011) Cancer , vol.117 , pp. 2970-2985
    • Hsu, H.S.1
  • 121
    • 84860855712 scopus 로고    scopus 로고
    • Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells
    • Chang, C. J. et al. Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells. Childs Nerv. Syst. 28, 363-373 (2012).
    • (2012) Childs Nerv. Syst. , vol.28 , pp. 363-373
    • Chang, C.J.1
  • 122
    • 84859994573 scopus 로고    scopus 로고
    • Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells
    • Tseng, L. M. et al. Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells. J. Pharmacol. Exp. Ther. 341, 410-423 (2012).
    • (2012) J. Pharmacol. Exp. Ther. , vol.341 , pp. 410-423
    • Tseng, L.M.1
  • 123
    • 77953807862 scopus 로고    scopus 로고
    • Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin
    • Liu, T. et al. Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin. Eur. J. Pharmacol. 641, 15-22 (2010).
    • (2010) Eur. J. Pharmacol. , vol.641 , pp. 15-22
    • Liu, T.1
  • 124
    • 78649763564 scopus 로고    scopus 로고
    • Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2 mediated Jak2-STAT3 signaling pathway
    • Dong, Y. et al. Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2 mediated Jak2-STAT3 signaling pathway. Carcinogenesis 31, 2097-2104 (2010).
    • (2010) Carcinogenesis , vol.31 , pp. 2097-2104
    • Dong, Y.1
  • 125
    • 77949272182 scopus 로고    scopus 로고
    • Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling
    • Sun, C. et al. Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling. J. Cancer Res. Clin. Oncol. 136, 603-610 (2010).
    • (2010) J. Cancer Res. Clin. Oncol. , vol.136 , pp. 603-610
    • Sun, C.1
  • 126
    • 84863057259 scopus 로고    scopus 로고
    • Cucurbitacin E induces G(2)/M phase arrest through STAT3/p53/p21 signaling and provokes apoptosis via Fas/CD95 and mitochondria-dependent pathways in human bladder cancer T24 cells
    • Huang, W. W. et al. Cucurbitacin E induces G(2)/M phase arrest through STAT3/p53/p21 signaling and provokes apoptosis via Fas/CD95 and mitochondria-dependent pathways in human bladder cancer T24 cells. Evid. Based. Complement. Alternat. Med. 2012, 952762 (2012).
    • (2012) Evid. Based. Complement. Alternat. Med. , vol.2012 , pp. 952762
    • Huang, W.W.1
  • 127
    • 77951908366 scopus 로고    scopus 로고
    • Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells
    • Li, F. et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 292, 197-207 (2010).
    • (2010) Cancer Lett. , vol.292 , pp. 197-207
    • Li, F.1
  • 128
    • 34147152865 scopus 로고    scopus 로고
    • Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor
    • Muto, A. et al. Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor. Mol. Cancer Ther. 6, 987-994 (2007).
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 987-994
    • Muto, A.1
  • 129
    • 83455203366 scopus 로고    scopus 로고
    • Thymoquinone decreases F actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl XL expression
    • Badr, G., Mohany, M. & Abu-Tarboush, F. Thymoquinone decreases F actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl XL expression. Lipids Health Dis. 10, 236 (2011).
    • (2011) Lipids Health Dis , vol.10 , pp. 236
    • Badr, G.1    Mohany, M.2    Abu-Tarboush, F.3
  • 130
    • 77956325713 scopus 로고    scopus 로고
    • Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway
    • Li, F., Rajendran, P. & Sethi, G. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway. Br. J. Pharmacol. 161, 541-554 (2010).
    • (2010) Br. J. Pharmacol. , vol.161 , pp. 541-554
    • Li, F.1    Rajendran, P.2    Sethi, G.3
  • 131
    • 77951729083 scopus 로고    scopus 로고
    • Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors
    • Leeman-Neill, R. J. et al. Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors. Clin. Cancer Res. 16, 2571-2579 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2571-2579
    • Leeman-Neill, R.J.1
  • 132
    • 84862907992 scopus 로고    scopus 로고
    • Honokiol inhibits signal transducer and activator of transcription 3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP 1
    • Rajendran, P. et al. Honokiol inhibits signal transducer and activator of transcription 3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP 1. J. Cell. Physiol. 227, 2184-2195 (2012).
    • (2012) J. Cell. Physiol. , vol.227 , pp. 2184-2195
    • Rajendran, P.1
  • 133
    • 84865292443 scopus 로고    scopus 로고
    • Calpain/SHP 1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice
    • Liu, S. H. et al. Calpain/SHP 1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice. PLoS ONE 7, e43711 (2012).
    • (2012) PLoS ONE , vol.7
    • Liu, S.H.1
  • 134
    • 84870364791 scopus 로고    scopus 로고
    • Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells
    • Yang, J. et al. Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells. Cancer Lett. 325, 243-251 (2013).
    • (2013) Cancer Lett. , vol.325 , pp. 243-251
    • Yang, J.1
  • 135
    • 33745521795 scopus 로고    scopus 로고
    • Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar
    • Arbiser, J. L. et al. Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar. J. Invest. Dermatol. 126, 1396-1402 (2006).
    • (2006) J. Invest. Dermatol. , vol.126 , pp. 1396-1402
    • Arbiser, J.L.1
  • 136
    • 84871691803 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of new N alkylcarbazole derivatives as STAT3 inhibitors: Preliminary study
    • Saturnino, C. et al. Synthesis and biological evaluation of new N alkylcarbazole derivatives as STAT3 inhibitors: Preliminary study. Eur. J. Med. Chem. 60C, 112-119 (2012).
    • (2012) Eur. J. Med. Chem. , vol.60 C , pp. 112-119
    • Saturnino, C.1
  • 137
    • 81855185596 scopus 로고    scopus 로고
    • Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion
    • Sun, M. et al. Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. Prostate 72, 82-89 (2012).
    • (2012) Prostate , vol.72 , pp. 82-89
    • Sun, M.1
  • 138
    • 77958468408 scopus 로고    scopus 로고
    • γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP 1 and sensitizes tumor cells to chemotherapeutic agents
    • Kannappan, R., Yadav, V. R. & Aggarwal, B. B. γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP 1 and sensitizes tumor cells to chemotherapeutic agents. J. Biol. Chem. 285, 33520-33528 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 33520-33528
    • Kannappan, R.1    Yadav, V.R.2    Aggarwal, B.B.3
  • 139
    • 79954459349 scopus 로고    scopus 로고
    • γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signaling pathway in human hepatocellular carcinoma: Potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent
    • Rajendran, P. et al. γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signaling pathway in human hepatocellular carcinoma: Potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent. Br. J. Pharmacol. 163, 283-298 (2011).
    • (2011) Br. J. Pharmacol. , vol.163 , pp. 283-298
    • Rajendran, P.1
  • 140
    • 58649104212 scopus 로고    scopus 로고
    • Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP 1
    • Kunnumakkara, A. B. et al. Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP 1. Mol. Cancer Res. 7, 118-128 (2009).
    • (2009) Mol. Cancer Res. , vol.7 , pp. 118-128
    • Kunnumakkara, A.B.1
  • 141
    • 85008726865 scopus 로고    scopus 로고
    • Regulation of Janus-activated kinase 2 (JAK2) by diindolylmethane in ovarian cancer in vitro and in vivo
    • Kandala, P. K. & Srivastava, S. K. Regulation of Janus-activated kinase 2 (JAK2) by diindolylmethane in ovarian cancer in vitro and in vivo. Drug Discov. Ther. 6, 94-101 (2012).
    • (2012) Drug Discov. Ther. , vol.6 , pp. 94-101
    • Kandala, P.K.1    Srivastava, S.K.2
  • 142
    • 84877953451 scopus 로고    scopus 로고
    • Brevilin A, a novel natural product, inhibits Janus kinase activity and blocks STAT3 signaling in cancer cells
    • Chen, X. et al. Brevilin A, a novel natural product, inhibits Janus kinase activity and blocks STAT3 signaling in cancer cells. PLoS ONE 8, e63697 (2013).
    • (2013) PLoS ONE , vol.8
    • Chen, X.1
  • 143
    • 27744456908 scopus 로고    scopus 로고
    • Gamma interferon: A central mediator in atherosclerosis
    • Leon, M. L. & Zuckerman, S. H. Gamma interferon: A central mediator in atherosclerosis. Inflamm. Res. 54, 395-411 (2005).
    • (2005) Inflamm. Res. , vol.54 , pp. 395-411
    • Leon, M.L.1    Zuckerman, S.H.2
  • 144
    • 68849089686 scopus 로고    scopus 로고
    • Pravastatin attenuates interferon-γ action via modulation of STAT1 to prevent aortic atherosclerosis in apolipoprotein E knockout mice
    • Zhou, X. X., Gao, P. J. & Sun, B. G. Pravastatin attenuates interferon-γ action via modulation of STAT1 to prevent aortic atherosclerosis in apolipoprotein E knockout mice. Clin. Exp. Pharmacol. Physiol. 36, 373-379 (2009).
    • (2009) Clin. Exp. Pharmacol. Physiol. , vol.36 , pp. 373-379
    • Zhou, X.X.1    Gao, P.J.2    Sun, B.G.3
  • 145
    • 49049117007 scopus 로고    scopus 로고
    • Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-γ in experimental autoimmune encephalomyelitis
    • Ren, Y. et al. Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-γ in experimental autoimmune encephalomyelitis. J. Immunol. 181, 1491-1498 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 1491-1498
    • Ren, Y.1
  • 146
    • 0031610572 scopus 로고    scopus 로고
    • Role of Th1 and Th2 cells in autoimmune demyelinating disease
    • Nagelkerken, L. Role of Th1 and Th2 cells in autoimmune demyelinating disease. Braz. J. Med. Biol. Res. 31, 55-60 (1998).
    • (1998) Braz. J. Med. Biol. Res. , vol.31 , pp. 55-60
    • Nagelkerken, L.1
  • 147
    • 80755143824 scopus 로고    scopus 로고
    • Immunomodulatory effect of water extract of cinnamon on anti CD3 induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation
    • Lee, B. J. et al. Immunomodulatory effect of water extract of cinnamon on anti CD3 induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation. Immunopharmacol. Immunotoxicol. 33, 714-722 (2011).
    • (2011) Immunopharmacol. Immunotoxicol. , vol.33 , pp. 714-722
    • Lee, B.J.1
  • 148
    • 56349161083 scopus 로고    scopus 로고
    • Regulation of apoptosis by resveratrol through JAK/STAT and mitochondria mediated pathway in human epidermoid carcinoma A431 cells
    • Madan, E. et al. Regulation of apoptosis by resveratrol through JAK/STAT and mitochondria mediated pathway in human epidermoid carcinoma A431 cells. Biochem. Biophys. Res. Commun. 377, 1232-1237 (2008).
    • (2008) Biochem. Biophys. Res. Commun. , vol.377 , pp. 1232-1237
    • Madan, E.1
  • 149
    • 43149095374 scopus 로고    scopus 로고
    • Discovery of chromone-based inhibitors of the transcription factor STAT5
    • Muller, J. et al. Discovery of chromone-based inhibitors of the transcription factor STAT5. Chembiochem 9, 723-727 (2008).
    • (2008) Chembiochem , vol.9 , pp. 723-727
    • Muller, J.1
  • 150
    • 84862820219 scopus 로고    scopus 로고
    • Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling
    • Nam, S. et al. Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling. Mol. Oncol. 6, 276-283 (2012).
    • (2012) Mol. Oncol. , vol.6 , pp. 276-283
    • Nam, S.1
  • 151
    • 0035725741 scopus 로고    scopus 로고
    • Specific inhibition of interleukin-4 dependent Stat6 activation by an intracellularly delivered peptide
    • Stolzenberger, S. Haake, M. & Duschl, A. Specific inhibition of interleukin-4 dependent Stat6 activation by an intracellularly delivered peptide. Eur. J. Biochem. 268, 4809-4814 (2001).
    • (2001) Eur. J. Biochem. , vol.268 , pp. 4809-4814
    • Stolzenberger, S.1    Haake, M.2    Duschl, A.3
  • 152
    • 34848848833 scopus 로고    scopus 로고
    • Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT 6 peptide
    • McCusker, C. T. et al. Inhibition of experimental allergic airways disease by local application of a cell-penetrating dominant-negative STAT 6 peptide. J. Immunol. 179, 2556-2564 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 2556-2564
    • McCusker, C.T.1
  • 153
    • 80054030236 scopus 로고    scopus 로고
    • Effective treatment of experimental ragweed-induced asthma with STAT 6 IP, a topically delivered cell-penetrating peptide
    • Wang, Y. et al. Effective treatment of experimental ragweed-induced asthma with STAT 6 IP, a topically delivered cell-penetrating peptide. Clin. Exp. Allergy 41, 1622-1630 (2011).
    • (2011) Clin. Exp. Allergy , vol.41 , pp. 1622-1630
    • Wang, Y.1
  • 154
    • 0037926708 scopus 로고    scopus 로고
    • TMC 264, a novel inhibitor of STAT6 activation produced by Phoma sp TC 1674
    • Sakurai, M. et al. TMC 264, a novel inhibitor of STAT6 activation produced by Phoma sp. TC 1674. J. Antibiot. 56, 513-519 (2003).
    • (2003) J. Antibiot. , vol.56 , pp. 513-519
    • Sakurai, M.1
  • 155
    • 44849092971 scopus 로고    scopus 로고
    • Identification of 4 benzylamino 2-[(4 morpholin-4 ylphenyl)amino] pyrimidine-5 carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors
    • Nagashima, S. et al. Identification of 4 benzylamino 2-[(4 morpholin-4 ylphenyl)amino]pyrimidine-5 carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors. Bioorg. Med. Chem. 16, 6509-6521 (2008).
    • (2008) Bioorg. Med. Chem. , vol.16 , pp. 6509-6521
    • Nagashima, S.1
  • 156
    • 69949119703 scopus 로고    scopus 로고
    • Novel 7H pyrrolo [2,3 d]pyrimidine derivatives as potent and orally active STAT6 inhibitors
    • Nagashima, S. et al. Novel 7H pyrrolo[2,3 d]pyrimidine derivatives as potent and orally active STAT6 inhibitors. Bioorg. Med. Chem. 17, 6926-6936 (2009).
    • (2009) Bioorg. Med. Chem. , Issue.17 , pp. 6926-6936
    • Nagashima, S.1
  • 157
    • 33744919852 scopus 로고    scopus 로고
    • Niflumic acid suppresses interleukin-13 induced asthma phenotypes
    • Nakano, T. et al. Niflumic acid suppresses interleukin-13 induced asthma phenotypes. Am. J. Respir. Crit. Care Med. 173, 1216-1221 (2006).
    • (2006) Am. J. Respir. Crit. Care Med. , vol.173 , pp. 1216-1221
    • Nakano, T.1
  • 158
    • 84855779362 scopus 로고    scopus 로고
    • STAT6 phosphorylation inhibitors block eotaxin 3 secretion in bronchial epithelial cells
    • Zhou, L. et al. STAT6 phosphorylation inhibitors block eotaxin 3 secretion in bronchial epithelial cells. Bioorg. Med. Chem. 20, 750-758 (2012).
    • (2012) Bioorg. Med. Chem. , vol.20 , pp. 750-758
    • Zhou, L.1
  • 159
    • 79957923046 scopus 로고    scopus 로고
    • Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor
    • Manshouri, T. et al. Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor. Cancer Res. 71, 3831-3840 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 3831-3840
    • Manshouri, T.1
  • 160
    • 84856076374 scopus 로고    scopus 로고
    • Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor
    • Quintas-Cardama, A. et al. Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. Invest. New Drugs 29, 818-826 (2011).
    • (2011) Invest. New Drugs , vol.29 , pp. 818-826
    • Quintas-Cardama, A.1
  • 161
    • 77953725855 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
    • Kantarjian, H. et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 362, 2260-2270 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 2260-2270
    • Kantarjian, H.1
  • 162
    • 2542520755 scopus 로고    scopus 로고
    • Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
    • Duensing, A. et al. Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene 23, 3999-4006 (2004).
    • (2004) Oncogene , vol.23 , pp. 3999-4006
    • Duensing, A.1
  • 163
    • 77957191745 scopus 로고    scopus 로고
    • First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia
    • Ravandi, F. et al. First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia. Blood. 116, 2070-2077 (2010).
    • (2010) Blood. , vol.116 , pp. 2070-2077
    • Ravandi, F.1
  • 164
    • 34248166041 scopus 로고    scopus 로고
    • Dasatinib (BMS 354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells
    • Nam, S. et al. Dasatinib (BMS 354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells. Mol. Cancer Ther. 6, 1400-1405 (2007).
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1400-1405
    • Nam, S.1
  • 165
    • 79551629888 scopus 로고    scopus 로고
    • BCR-ABL1 independent PI3Kinase activation causing imatinib-resistance
    • Quentmeier, H. et al. BCR-ABL1 independent PI3Kinase activation causing imatinib-resistance. J. Hematol. Oncol. 4, 6 (2011).
    • (2011) J. Hematol. Oncol. , vol.4 , Issue.6
    • Quentmeier, H.1
  • 166
    • 84875909425 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of NSCLC
    • Pallis, A. G. & Syrigos, K. N. Epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of NSCLC. Lung Cancer 80, 120-130 (2013).
    • (2013) Lung Cancer , vol.80 , pp. 120-130
    • Pallis, A.G.1    Syrigos, K.N.2
  • 167
    • 79551711693 scopus 로고    scopus 로고
    • Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma
    • Leeman-Neill, R. J. et al. Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma. Cancer Prev. Res. (Phila) 4, 230-237 (2011).
    • (2011) Cancer Prev. Res. (Phila) , vol.4 , pp. 230-237
    • Leeman-Neill, R.J.1
  • 168
    • 77950545758 scopus 로고    scopus 로고
    • Combined γ-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells
    • Bachawal, S. V., Wali, V. B. & Sylvester, P. W. Combined γ-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells. Anticancer Res. 30, 429-437 (2010).
    • (2010) Anticancer Res. , vol.30 , pp. 429-437
    • Bachawal, S.V.1    Wali, V.B.2    Sylvester, P.W.3
  • 169
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
    • Cheng, A. L. et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 10, 25-34 (2009).
    • (2009) Lancet Oncol. , vol.10 , pp. 25-34
    • Cheng, A.L.1
  • 170
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet, J. M. et al. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359, 378-390 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 378-390
    • Llovet, J.M.1
  • 171
    • 84865659808 scopus 로고    scopus 로고
    • The monoclonal antibody CH12 enhances the sorafenib-mediated growth inhibition of hepatocellular carcinoma xenografts expressing epidermal growth factor receptor variant III
    • Yang, Y. et al. The monoclonal antibody CH12 enhances the sorafenib-mediated growth inhibition of hepatocellular carcinoma xenografts expressing epidermal growth factor receptor variant III. Neoplasia 14, 509-518 (2012).
    • (2012) Neoplasia , vol.14 , pp. 509-518
    • Yang, Y.1
  • 172
    • 77950833182 scopus 로고    scopus 로고
    • Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3
    • Yang, F. et al. Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3. Mol. Cancer Ther. 9, 953-962 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 953-962
    • Yang, F.1
  • 173
    • 84861152163 scopus 로고    scopus 로고
    • Sorafenib inhibits endogenous and IL 6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis
    • Yang, F. et al. Sorafenib inhibits endogenous and IL 6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis. Cancer Biol. Ther. 13, 534-541 (2012).
    • (2012) Cancer Biol. Ther. , vol.13 , pp. 534-541
    • Yang, F.1
  • 174
    • 84984589185 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma
    • Tai, W. T. et al. Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma. J. Hepatol. 55, 1041-1048 (2011).
    • (2011) J. Hepatol. , vol.55 , pp. 1041-1048
    • Tai, W.T.1
  • 175
    • 84984558781 scopus 로고    scopus 로고
    • Sorafenib and its derivative SC 49 sensitize hepatocellular carcinoma cells to CS 1008, a humanized anti TNFRSF10B (DR5) antibody
    • Chen, K. F. et al. Sorafenib and its derivative SC 49 sensitize hepatocellular carcinoma cells to CS 1008, a humanized anti TNFRSF10B (DR5) antibody. Br. J. Pharmacol. 168, 658-672 (2013).
    • (2013) Br. J. Pharmacol. , vol.168 , pp. 658-672
    • Chen, K.F.1
  • 176
    • 84984563938 scopus 로고    scopus 로고
    • Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP 1 phosphatase activity
    • Chen, K. F. et al. Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP 1 phosphatase activity. Eur. J. Med. Chem. 55, 220-227 (2012).
    • (2012) Eur. J. Med. Chem. , vol.55 , pp. 220-227
    • Chen, K.F.1
  • 177
    • 33750298971 scopus 로고    scopus 로고
    • Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells
    • Pedranzini, L. et al. Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res. 66, 9714-9721 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 9714-9721
    • Pedranzini, L.1
  • 178
    • 58149399350 scopus 로고    scopus 로고
    • Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3
    • Nelson, E. A. et al. Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood 112, 5095-5102 (2008).
    • (2008) Blood , vol.112 , pp. 5095-5102
    • Nelson, E.A.1
  • 179
    • 84892435346 scopus 로고    scopus 로고
    • The role of EGFR monoclonal antibodies (MoABs) cetuximab/panitumab, and BRAF inhibitors in BRAF mutated colorectal cancer
    • Muhammad, S. et al. The role of EGFR monoclonal antibodies (MoABs) cetuximab/panitumab, and BRAF inhibitors in BRAF mutated colorectal cancer. J. Gastrointest Oncol. 4, 72-81 (2013).
    • (2013) J. Gastrointest Oncol. , vol.4 , pp. 72-81
    • Muhammad, S.1
  • 180
    • 60749095127 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor monoclonal antibody cetuximab inhibits EGFR/HER 2 heterodimerization and activation
    • Patel, D. et al. Anti-epidermal growth factor receptor monoclonal antibody cetuximab inhibits EGFR/HER 2 heterodimerization and activation. Int. J. Oncol. 34, 25-32 (2009).
    • (2009) Int. J. Oncol. , vol.34 , pp. 25-32
    • Patel, D.1
  • 181
    • 79958202400 scopus 로고    scopus 로고
    • Phase II study of trastuzumab and cisplatin as first-line therapy in patients with HER2 positive advanced gastric or gastroesophageal junction cancer
    • Gravalos, C. et al. Phase II study of trastuzumab and cisplatin as first-line therapy in patients with HER2 positive advanced gastric or gastroesophageal junction cancer. Clin. Transl. Oncol. 13, 179-184 (2011).
    • (2011) Clin. Transl. Oncol. , vol.13 , pp. 179-184
    • Gravalos, C.1
  • 182
    • 38749149510 scopus 로고    scopus 로고
    • Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin
    • Kim, S. Y. et al. Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin. Int. J. Oncol. 32, 89-95 (2008).
    • (2008) Int. J. Oncol. , vol.32 , pp. 89-95
    • Kim, S.Y.1
  • 183
    • 80052163169 scopus 로고    scopus 로고
    • Inhibitory effects of the JAK inhibitor CP690,550 on human CD4+ T lymphocyte cytokine production
    • Migita, K. et al. Inhibitory effects of the JAK inhibitor CP690,550 on human CD4+ T lymphocyte cytokine production. BMC Immunol. 12, 51 (2011).
    • (2011) BMC Immunol , vol.12 , pp. 51
    • Migita, K.1
  • 184
    • 77950684805 scopus 로고    scopus 로고
    • Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: Therapeutic implications for the treatment of myeloproliferative neoplasms
    • Quintas-Cardama, A. et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: Therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 115, 3109-3117 (2010).
    • (2010) Blood , vol.115 , pp. 3109-3117
    • Quintas-Cardama, A.1
  • 185
    • 84856478208 scopus 로고    scopus 로고
    • STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma
    • Looyenga, B. D. et al. STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma. PLoS ONE 7, e30820 (2012).
    • (2012) PLoS ONE , vol.7
    • Looyenga, B.D.1
  • 186
    • 84863948323 scopus 로고    scopus 로고
    • The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma
    • Derenzini, E. et al. The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma. Blood Cancer J. 1, e46 (2011).
    • (2011) Blood Cancer J. , vol.1
    • Derenzini, E.1
  • 187
    • 70949094349 scopus 로고    scopus 로고
    • The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors
    • Hedvat, M. et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell. 16, 487-497 (2009).
    • (2009) Cancer Cell. , vol.16 , pp. 487-497
    • Hedvat, M.1
  • 188
    • 83355169687 scopus 로고    scopus 로고
    • Therapeutic potential of AZD1480 for the treatment of human glioblastoma
    • McFarland, B. C. et al. Therapeutic potential of AZD1480 for the treatment of human glioblastoma. Mol. Cancer Ther. 10, 2384-2393 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 2384-2393
    • McFarland, B.C.1
  • 189
    • 80155171655 scopus 로고    scopus 로고
    • Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480
    • Xin, H. et al. Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. Cancer Res. 71, 6601-6610 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 6601-6610
    • Xin, H.1
  • 190
    • 33750739781 scopus 로고    scopus 로고
    • Atiprimod blocks phosphorylation of JAK-STAT and inhibits proliferation of acute myeloid leukemia (AML) cells
    • Faderl, S. et al. Atiprimod blocks phosphorylation of JAK-STAT and inhibits proliferation of acute myeloid leukemia (AML) cells. Leuk. Res. 31, 91-95 (2007).
    • (2007) Leuk. Res. , vol.31 , pp. 91-95
    • Faderl, S.1
  • 191
    • 23044478114 scopus 로고    scopus 로고
    • Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells
    • Amit-Vazina, M. et al. Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells. Br. J. Cancer. 93, 70-80 (2005).
    • (2005) Br. J. Cancer. , vol.93 , pp. 70-80
    • Amit-Vazina, M.1
  • 192
    • 35948995412 scopus 로고    scopus 로고
    • Auranofin blocks interleukin 6 signaling by inhibiting phosphorylation of JAK1 and STAT3
    • Kim, N. H. et al. Auranofin blocks interleukin 6 signaling by inhibiting phosphorylation of JAK1 and STAT3. Immunology 122, 607-614 (2007).
    • (2007) Immunology , vol.122 , pp. 607-614
    • Kim, N.H.1
  • 193
    • 78751705649 scopus 로고    scopus 로고
    • The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF κB activity
    • Nakaya, A. et al. The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF κB activity. Leuk. Res. 35, 243-249 (2011).
    • (2011) Leuk. Res. , vol.35 , pp. 243-249
    • Nakaya, A.1
  • 194
    • 33745243692 scopus 로고    scopus 로고
    • Dasatinib (BMS 354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
    • Song, L. et al. Dasatinib (BMS 354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 66, 5542-5548 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 5542-5548
    • Song, L.1
  • 195
    • 79955780881 scopus 로고    scopus 로고
    • JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL 6 neutralizing antibodies can suppress JAK1 STAT3 signaling
    • Song, L. et al. JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL 6 neutralizing antibodies can suppress JAK1 STAT3 signaling. Mol. Cancer Ther. 10, 481-494 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 481-494
    • Song, L.1
  • 196
    • 84866254673 scopus 로고    scopus 로고
    • First in human trial of a STAT3 decoy oligonucleotide in head and neck tumors: Implications for cancer therapy
    • Sen, M. et al. First in human trial of a STAT3 decoy oligonucleotide in head and neck tumors: Implications for cancer therapy. Cancer Discov. 2, 694-705 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 694-705
    • Sen, M.1
  • 197
    • 84858230349 scopus 로고    scopus 로고
    • A STAT3 inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line
    • Souissi, I. et al. A STAT3 inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line. Mol. Cancer 11, 12 (2012).
    • (2012) Mol. Cancer , vol.11 , Issue.12
    • Souissi, I.1
  • 198
    • 70350503333 scopus 로고    scopus 로고
    • Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription 1 (STAT 1)
    • Huckel, M. et al. Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription 1 (STAT 1). Arthritis Res. Ther. 8, R17 (2006).
    • (2006) Arthritis Res. Ther. , vol.8
    • Huckel, M.1
  • 199
    • 52449133737 scopus 로고    scopus 로고
    • AP 1 and STAT 1 decoy oligodeoxynucleotides attenuate transplant vasculopathy in rat cardiac allografts
    • Stadlbauer, T. H. et al. AP 1 and STAT 1 decoy oligodeoxynucleotides attenuate transplant vasculopathy in rat cardiac allografts. Cardiovasc. Res. 79, 698-705 (2008).
    • (2008) Cardiovasc. Res. , vol.79 , pp. 698-705
    • Stadlbauer, T.H.1
  • 200
    • 79551638801 scopus 로고    scopus 로고
    • Targeted blockage of signal transducer and activator of transcription 5 signaling pathway with decoy oligodeoxynucleotides suppresses leukemic K562 cell growth
    • Wang, X. et al. Targeted blockage of signal transducer and activator of transcription 5 signaling pathway with decoy oligodeoxynucleotides suppresses leukemic K562 cell growth. DNA Cell Biol. 30, 71-78 (2011).
    • (2011) DNA Cell Biol. , vol.30 , pp. 71-78
    • Wang, X.1
  • 201
    • 64549129578 scopus 로고    scopus 로고
    • Inhibitory effects of decoy-ODN targeting activated STAT3 on human glioma growth in vivo
    • Shen, J., Li, R. & Li, G. Inhibitory effects of decoy-ODN targeting activated STAT3 on human glioma growth in vivo. In Vivo 23, 237-243 (2009).
    • (2009) Vivo , vol.23 , pp. 237-243
    • Shen, J.1    Li, R.2    Li, G.3
  • 202
    • 84866431328 scopus 로고    scopus 로고
    • Targeting Stat3 abrogates EGFR inhibitor resistance in cancer
    • Sen, M. et al. Targeting Stat3 abrogates EGFR inhibitor resistance in cancer. Clin. Cancer Res. 18, 4986-4996 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 4986-4996
    • Sen, M.1
  • 203
    • 34247480458 scopus 로고    scopus 로고
    • Antiproliferative mechanisms of a transcription factor decoy targeting signal transducer and activator of transcription (STAT) 3: The role of STAT1
    • Lui, V. W. et al. Antiproliferative mechanisms of a transcription factor decoy targeting signal transducer and activator of transcription (STAT) 3: The role of STAT1. Mol. Pharmacol. 71, 1435-1443 (2007).
    • (2007) Mol. Pharmacol. , vol.71 , pp. 1435-1443
    • Lui, V.W.1
  • 204
    • 85047695527 scopus 로고    scopus 로고
    • Constitutive Stat3 activity up regulates VEGF expression and tumor angiogenesis
    • Niu, G. et al. Constitutive Stat3 activity up regulates VEGF expression and tumor angiogenesis. Oncogene 21, 2000-2008 (2002).
    • (2002) Oncogene , vol.21 , pp. 2000-2008
    • Niu, G.1
  • 205
    • 7444238184 scopus 로고    scopus 로고
    • Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines
    • Barton, B. E. et al. Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines. Mol. Cancer Ther. 3, 1183-1191 (2004).
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1183-1191
    • Barton, B.E.1
  • 206
    • 33845771270 scopus 로고    scopus 로고
    • Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3
    • Li, W. C. et al. Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3. Clin. Cancer Res. 12, 7140-7148 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 7140-7148
    • Li, W.C.1
  • 207
    • 84878247636 scopus 로고    scopus 로고
    • Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys
    • Burel, S. A. et al. Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys. Nucleic Acid. Ther. 23, 213-227 (2013).
    • (2013) Nucleic Acid. Ther. , vol.23 , pp. 213-227
    • Burel, S.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.