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The origins, function, and regulation of T follicular helper cells
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IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation
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B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1
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Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
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Simpson, N., P. A. Gatenby, A. Wilson, S. Malik, D. A. Fulcher, S. G. Tangye, H. Manku, T. J. Vyse, G. Roncador, G. A. Huttley, et al. 2010. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum. 62: 234-244.
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Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage
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Human blood CXCR5(+) CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
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Morita, R., N. Schmitt, S. E. Bentebibel, R. Ranganathan, L. Bourdery, G. Zurawski, E. Foucat, M. Dullaers, S. Oh, N. Sabzghabaei, et al. 2011. Human blood CXCR5(+) CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 34: 108-121.
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Plasma cells negatively regulate the follicular helper T cell program
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IL-12 receptor b1 deficiency alters in vivo T follicular helper cell response in humans
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Schmitt, N., J. Bustamante, L. Bourdery, S. E. Bentebibel, S. Boisson-Dupuis, F. Hamlin, M. V. Tran, D. Blankenship, V. Pascual, D. A. Savino, et al. 2013. IL-12 receptor b1 deficiency alters in vivo T follicular helper cell response in humans. Blood 121: 3375-3385.
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Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: A randomized, double-blind, placebo-controlled study
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Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis
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Ma, J., C. Zhu, B. Ma, J. Tian, S. E. Baidoo, C. Mao, W. Wu, J. Chen, J. Tong, M. Yang, et al. 2012. Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clin. Dev. Immunol. 2012: 827480.
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