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Volumn 65, Issue 1, 2017, Pages 89-103

IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOPOIETIN 1; ATM PROTEIN; ATR PROTEIN; BETA CATENIN; CASPASE 3; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN GP 130; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HEME OXYGENASE 1; HISTONE H2AX; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P53; STAT3 PROTEIN; TUMOR NECROSIS FACTOR; VASCULOTROPIN;

EID: 85006018001     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.28874     Document Type: Article
Times cited : (132)

References (41)
  • 1
    • 84963541541 scopus 로고    scopus 로고
    • IL-6 pathway in the liver: from physiopathology to therapy
    • Schmidt-Arras D, Rose-John S. IL-6 pathway in the liver: from physiopathology to therapy. J Hepatol 2016;64:1403–1415.
    • (2016) J Hepatol , vol.64 , pp. 1403-1415
    • Schmidt-Arras, D.1    Rose-John, S.2
  • 2
    • 0038609651 scopus 로고    scopus 로고
    • Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
    • Boulanger MJ, Chow DC, Brevnova EE, Garcia KC. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science 2003;300:2101–2104.
    • (2003) Science , vol.300 , pp. 2101-2104
    • Boulanger, M.J.1    Chow, D.C.2    Brevnova, E.E.3    Garcia, K.C.4
  • 4
    • 34548856204 scopus 로고    scopus 로고
    • Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
    • Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, et al. Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood 2007;110:1748–1755.
    • (2007) Blood , vol.110 , pp. 1748-1755
    • Chalaris, A.1    Rabe, B.2    Paliga, K.3    Lange, H.4    Laskay, T.5    Fielding, C.A.6
  • 5
    • 77649271394 scopus 로고    scopus 로고
    • ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase
    • Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, et al. ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase. Biochim Biophys Acta 2010;1803:234–245.
    • (2010) Biochim Biophys Acta , vol.1803 , pp. 234-245
    • Chalaris, A.1    Gewiese, J.2    Paliga, K.3    Fleig, L.4    Schneede, A.5    Krieger, K.6
  • 6
    • 38949164424 scopus 로고    scopus 로고
    • Transgenic blockade of interleukin 6 transsignaling abrogates inflammation
    • Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, et al. Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood 2008;111:1021–1028.
    • (2008) Blood , vol.111 , pp. 1021-1028
    • Rabe, B.1    Chalaris, A.2    May, U.3    Waetzig, G.H.4    Seegert, D.5    Williams, A.S.6
  • 8
    • 79953756112 scopus 로고    scopus 로고
    • Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
    • Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel Gü et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 2011;19:456–469.
    • (2011) Cancer Cell , vol.19 , pp. 456-469
    • Lesina, M.1    Kurkowski, M.U.2    Ludes, K.3    Rose-John, S.4    Treiber, M.5    Klöppel, G.ü.6
  • 9
    • 84871986560 scopus 로고    scopus 로고
    • Medical therapies for hepatocellular carcinoma: a critical view of the evidence
    • Villanueva A, Hernandez-Gea V, Llovet JM, Medical therapies for hepatocellular carcinoma: a critical view of the evidence. Nat Rev Gastroenterol Hepatol 2013;10:34–42.
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , pp. 34-42
    • Villanueva, A.1    Hernandez-Gea, V.2    Llovet, J.M.3
  • 10
    • 0024312875 scopus 로고
    • High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production
    • Deviere J, Content J, Denys C, Vandenbussche P, Schandene L, Wybran J, et al., High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production. Clin Exp Immunol 1989;77:221–225.
    • (1989) Clin Exp Immunol , vol.77 , pp. 221-225
    • Deviere, J.1    Content, J.2    Denys, C.3    Vandenbussche, P.4    Schandene, L.5    Wybran, J.6
  • 11
    • 0027462253 scopus 로고
    • Interleukin 6 production by peripheral blood mononuclear cells in patients with chronic hepatitis B virus infection and primary biliary cirrhosis
    • Kakumu S, Shinagawa T, Ishikawa T, Yoshioka K, Wakita T, Ida N, Interleukin 6 production by peripheral blood mononuclear cells in patients with chronic hepatitis B virus infection and primary biliary cirrhosis. Gastroenterol Jpn 1993;28:18–24.
    • (1993) Gastroenterol Jpn , vol.28 , pp. 18-24
    • Kakumu, S.1    Shinagawa, T.2    Ishikawa, T.3    Yoshioka, K.4    Wakita, T.5    Ida, N.6
  • 13
    • 84906794845 scopus 로고    scopus 로고
    • Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer
    • Aleksandrova K, Boeing H, Nöthlings U, Jenab M, Fedirko V, Kaaks R, et al. Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer. Hepatology 2014;60:858–871.
    • (2014) Hepatology , vol.60 , pp. 858-871
    • Aleksandrova, K.1    Boeing, H.2    Nöthlings, U.3    Jenab, M.4    Fedirko, V.5    Kaaks, R.6
  • 14
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005;121:977–990.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 15
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007;317:121–124.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6
  • 16
    • 84862909192 scopus 로고    scopus 로고
    • Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer
    • Li Z, Tuteja G, Schug J, Kaestner KH. Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer. Cell 2012;148:72–83.
    • (2012) Cell , vol.148 , pp. 72-83
    • Li, Z.1    Tuteja, G.2    Schug, J.3    Kaestner, K.H.4
  • 17
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992;69:1237–1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 19
    • 84938633240 scopus 로고    scopus 로고
    • Regulation of the p53 response and its relationship to cancer
    • Meek DW. Regulation of the p53 response and its relationship to cancer. Biochem J 2015;469:325–346.
    • (2015) Biochem J , vol.469 , pp. 325-346
    • Meek, D.W.1
  • 20
    • 2942594540 scopus 로고    scopus 로고
    • Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53
    • Haneda M, Kojima E, Nishikimi A, Hasegawa T, Nakashima I, Isobe KI. Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53. FEBS Lett 2004;567:171–174.
    • (2004) FEBS Lett , vol.567 , pp. 171-174
    • Haneda, M.1    Kojima, E.2    Nishikimi, A.3    Hasegawa, T.4    Nakashima, I.5    Isobe, K.I.6
  • 21
    • 0034723170 scopus 로고    scopus 로고
    • The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53
    • Li L, Ljungman M, Dixon JE. The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. J Biol Chem 2000;275:2410–2414.
    • (2000) J Biol Chem , vol.275 , pp. 2410-2414
    • Li, L.1    Ljungman, M.2    Dixon, J.E.3
  • 22
    • 84928038734 scopus 로고    scopus 로고
    • Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways
    • Chen Z, Yi W, Morita Y, Wang H, Cong Y, Liu JP, et al. Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways. Nat Commun 2015;6:6808.
    • (2015) Nat Commun , vol.6 , pp. 6808
    • Chen, Z.1    Yi, W.2    Morita, Y.3    Wang, H.4    Cong, Y.5    Liu, J.P.6
  • 25
    • 84942636275 scopus 로고    scopus 로고
    • Macrophages regulate the systemic response to DNA damage by a cell nonautonomous mechanism
    • Geiger-Maor A, Guedj A, Even-Ram S, Smith Y, Galun E, Rachmilewitz J. Macrophages regulate the systemic response to DNA damage by a cell nonautonomous mechanism. Cancer Res 2015;75:2663–2673.
    • (2015) Cancer Res , vol.75 , pp. 2663-2673
    • Geiger-Maor, A.1    Guedj, A.2    Even-Ram, S.3    Smith, Y.4    Galun, E.5    Rachmilewitz, J.6
  • 26
    • 0035936026 scopus 로고    scopus 로고
    • Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors
    • Aydinlik H, Nguyen TD, Moennikes O, Buchmann A, Schwarz M. Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors. Oncogene 2001;20:7812–7816.
    • (2001) Oncogene , vol.20 , pp. 7812-7816
    • Aydinlik, H.1    Nguyen, T.D.2    Moennikes, O.3    Buchmann, A.4    Schwarz, M.5
  • 27
    • 84930928960 scopus 로고    scopus 로고
    • Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis
    • Dong B, Lee JS, Park YY, Yang F, Xu G, Huang W, et al. Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis. Nat Commun 2015;6:5944.
    • (2015) Nat Commun , vol.6 , pp. 5944
    • Dong, B.1    Lee, J.S.2    Park, Y.Y.3    Yang, F.4    Xu, G.5    Huang, W.6
  • 28
    • 79955580873 scopus 로고    scopus 로고
    • HCC and angiogenesis: possible targets and future directions
    • Zhu AX, Duda DG, Sahani DV, Jain RK. HCC and angiogenesis: possible targets and future directions. Nat Rev Clin Oncol 2011;8:292–301.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 292-301
    • Zhu, A.X.1    Duda, D.G.2    Sahani, D.V.3    Jain, R.K.4
  • 30
    • 57049182539 scopus 로고    scopus 로고
    • Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer
    • Cairo S, Armengol C, De Reyniès A, Wei Y, Thomas E, Renard CA, et al. Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer. Cancer Cell 2008;14:471–484.
    • (2008) Cancer Cell , vol.14 , pp. 471-484
    • Cairo, S.1    Armengol, C.2    De Reyniès, A.3    Wei, Y.4    Thomas, E.5    Renard, C.A.6
  • 31
    • 77950625278 scopus 로고    scopus 로고
    • Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity
    • Wang H, Park O, Lafdil F, Shen K, Horiguchi N, Yin S, et al. Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity. Hepatology 2010;51:1354–1362.
    • (2010) Hepatology , vol.51 , pp. 1354-1362
    • Wang, H.1    Park, O.2    Lafdil, F.3    Shen, K.4    Horiguchi, N.5    Yin, S.6
  • 32
    • 84924415012 scopus 로고    scopus 로고
    • Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance
    • Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, Estevez E, et al. Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance. Cell Metab 2015;21:403–416.
    • (2015) Cell Metab , vol.21 , pp. 403-416
    • Kraakman, M.J.1    Kammoun, H.L.2    Allen, T.L.3    Deswaerte, V.4    Henstridge, D.C.5    Estevez, E.6
  • 34
    • 84922018236 scopus 로고    scopus 로고
    • EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation
    • 1-7
    • Lanaya H, Natarajan A, Komposch K, Li L, Amberg N, Chen L, et al. EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation. Nat Cell Biol 2014;16:972–81, 1-7.
    • (2014) Nat Cell Biol , vol.16 , pp. 972-981
    • Lanaya, H.1    Natarajan, A.2    Komposch, K.3    Li, L.4    Amberg, N.5    Chen, L.6
  • 35
    • 84929607411 scopus 로고    scopus 로고
    • Cre-ativity in the liver: transgenic approaches to targeting hepatic nonparenchymal cells
    • Greenhalgh SN, Conroy KP, Henderson NC. Cre-ativity in the liver: transgenic approaches to targeting hepatic nonparenchymal cells. Hepatology 2015;61:2091–2099.
    • (2015) Hepatology , vol.61 , pp. 2091-2099
    • Greenhalgh, S.N.1    Conroy, K.P.2    Henderson, N.C.3
  • 36
    • 84903516068 scopus 로고    scopus 로고
    • Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice
    • Abram CL, Roberge GL, Hu Y, Lowell CA. Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice. J Immunol Methods 2014;408:89–100.
    • (2014) J Immunol Methods , vol.408 , pp. 89-100
    • Abram, C.L.1    Roberge, G.L.2    Hu, Y.3    Lowell, C.A.4
  • 37
    • 84907588596 scopus 로고    scopus 로고
    • Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis
    • Vannella KM, Barron L, Borthwick LA, Kindrachuk KN, Narasimhan PB, Hart KM, et al. Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis. PLoS Pathog 2014;10:e1004372.
    • (2014) PLoS Pathog , vol.10
    • Vannella, K.M.1    Barron, L.2    Borthwick, L.A.3    Kindrachuk, K.N.4    Narasimhan, P.B.5    Hart, K.M.6
  • 38
    • 84871576111 scopus 로고    scopus 로고
    • β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
    • Rosenbluh J, Nijhawan D, Cox AG, Li X, Neal JT, Schafer EJ, et al. β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell 2012;151:1457–1473.
    • (2012) Cell , vol.151 , pp. 1457-1473
    • Rosenbluh, J.1    Nijhawan, D.2    Cox, A.G.3    Li, X.4    Neal, J.T.5    Schafer, E.J.6
  • 39
    • 84872182482 scopus 로고    scopus 로고
    • IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling
    • Hoge J, Yan I, Jänner N, Schumacher V, Chalaris A, Steinmetz OM, et al. IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling. J Immunol 2013;190:703–711.
    • (2013) J Immunol , vol.190 , pp. 703-711
    • Hoge, J.1    Yan, I.2    Jänner, N.3    Schumacher, V.4    Chalaris, A.5    Steinmetz, O.M.6
  • 40
    • 84964318875 scopus 로고    scopus 로고
    • Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice
    • Hong J, Wang H, Shen G, Lin D, Lin Y, Ye N, et al. Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice. Sci Rep 2016;6:24397.
    • (2016) Sci Rep , vol.6 , pp. 24397
    • Hong, J.1    Wang, H.2    Shen, G.3    Lin, D.4    Lin, Y.5    Ye, N.6
  • 41
    • 84920285641 scopus 로고    scopus 로고
    • IL-6 biology: implications for clinical targeting in rheumatic disease
    • Calabrese LH, Rose-John S. IL-6 biology: implications for clinical targeting in rheumatic disease. Nat Rev Rheumatol 2014;10:720–727.
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 720-727
    • Calabrese, L.H.1    Rose-John, S.2


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