A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 13, 2005, Pages 4700-4705

  Song, Hui ^a   Wang, Renxiao ^a,b   Wang, Shaomeng ^a,b   Lin, Jiayuh ^c  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Breast carcinoma; Dimerization; STA 21

Indexed keywords

PROTEIN INHIBITOR; STA 21; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CANCER THERAPY; CARCINOGENESIS; CELL ASSAY; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DATA BASE; DIMERIZATION; DNA BINDING; DRUG SCREENING; EVALUATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOLECULAR WEIGHT; PRIORITY JOURNAL; SCREENING TEST; SIGNAL TRANSDUCTION;

BREAST NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; COMPUTATIONAL BIOLOGY; DATABASES, FACTUAL; DIMERIZATION; DNA-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LUCIFERASES; MODELS, MOLECULAR; PLASMIDS; POLYCYCLIC COMPOUNDS; PROTEIN BINDING; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 16344380754     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409894102     Document Type: Article

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