Hexameric structure and assembly of the interieukin-6/IL-6 α-receptor/gp130 complex

Science

Volumn 300, Issue 5628, 2003, Pages 2101-2104

  Boulanger, Martin J ^a   Chow, Dar chone ^b   Brevnova, Elena E ^c   Garcia, K Christopher ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of Houston   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFACES (MATERIALS); THERMODYNAMICS; TOPOLOGY;

HEXAMERIC STRUCTURES;

CELLS;

GLYCOPROTEIN GP 130; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 6ALPHA RECEPTOR; UNCLASSIFIED DRUG;

BIOLOGY; SIGNALING;

ARTICLE; CELL SURFACE; CRYSTALLOGRAPHY; GEOMETRY; HUMAN; IMMUNOREGULATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN QUATERNARY STRUCTURE; THERMODYNAMICS;

ANTIGENS, CD; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYTOKINE RECEPTOR GP130; HUMANS; INTERLEUKIN-6; MACROMOLECULAR SUBSTANCES; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION; THERMODYNAMICS;

EID: 0038609651     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083901     Document Type: Article

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24. We gratefully acknowledge assistance and helpful discussions with G. McDermott, N. Goriatcheva, M. Martick, F. Bazan, S. Rose-John, J. Heath, and Y. Jones. We also acknowledge Stanford Synchrotron Radiation Laboratory and Advanced Light Source for x-ray resources. This study was supported by the NIH (AI51321), Cancer Research Institute, University of California-Davis Cancer Research Program, Pew Charitable Trusts, and American Heart Association. M.J.B. is supported by a National Sciences and Engineering Research Council of Canada postdoctoral fellowship. Coordinates of the asymmetric unit have been deposited in the Protein Data Bank with accession code 1P9M (RCSB019180). The complete biological hexameric assembly is also available from the authors.