Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 1, 1996, Pages 407-411

  Yoshida, Kanji ^a   Taga, Tetsuya ^a   Saito, Mikiyoshi ^a   Suematsu, Sachiko ^b   Kumanogoh, Atsushi ^a   Tanaka, Takashi ^a,b,c   Fujiwara, Hiroshi ^b,c   Hirata, Moritoshi ^c   Yamagami, Tamotsu ^c   Nakahata, Tatsutoshi ^d   Hirabayashi, Tomoko ^c   Yoneda, Yoshihiro ^c   Tanaka, Kazuhiko ^e   Wang, Wei Zhong ^f   Mori, Chisato ^f   Shiota, Kohei ^f   Yoshida, Nobuaki ^b   Kishimoto, Tadamitsu ^c  

^a OSAKA UNIVERSITY   (Japan)

^b RESEARCH INSTITUTE FOR MATERNAL AND CHILD HEALTH   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e CENTER FOR ADULT DISEASES   (Japan)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

hematopoiesis; myocardial development

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CYTOKINE; GLYCOPROTEIN; GLYCOPROTEIN GP 130; INTERLEUKIN 11; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; ONCOSTATIN M;

ANEMIA; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLONY FORMING UNIT S; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE TARGETING; HEART DEVELOPMENT; HEART MUSCLE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HYPOPLASIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY;

ANIMALS; ANTIGENS, CD; CYTOKINE RECEPTOR GP130; GENES, LETHAL; HEART; HEMATOPOIESIS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MUTAGENESIS, INSERTIONAL;

EID: 9044222888     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.1.407     Document Type: Article

References (30)

1. Kishimoto, T., Taga, T. & Akira, S. (1994) Cell 76, 253-262.
2. Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T. & Kishimoto, T. (1989) Cell 58, 573-581.
3. Pennica, D., Shaw, K. J., Swanson, T. A., Moore, M. W., Sheliton, D. L., Zioncheck, K. A., Rosenthal, A., Taga, T., Paoni, N. F. & Wood, W. I. (1995) J. Biol. Chem. 270, 10915-10922.
4. Murakami, M., Hibi, M., Nakagawa, M., Nakagawa, T., Yasukawa, K., Yamanishi, K., Taga, T. & Kishimoto, T. (1993) Science 260, 1808-1810.
5. Davis S., Aldrich, T. H., Stahl, N., Pan, L., Taga, T., Kishimoto, T., Ip, N. Y. & Yancopoulos, G. D. (1993) Science 260, 1805-1808.
6. Narazaki, M., Witthuhn, B. A., Yoshida, K., Silvennoinen, O., Yasukawa, K., Ihle, J. N., Kishimoto, T. & Taga, T. (1994) Proc. Natl. Acad. Sci. USA 91, 2285-2289.
7. Stahl, N., Boulton, T. G., Farruggella, T., Ip, N. Y., Davis, S., Witthuhn, B. A., Quelle, F. W., Silvennoinen, O., Barbieri, G., Pellegrini, S., Ihle, J. N. & Yancopoulos, G. D. (1994) Science 263, 92-95.
8. Stahl, N., Farruggella, J., Boulton, T. G., Zhong, Z., Darnel, J. E. & Yancopoulos, G. D. (1995) Science 267, 1349-1353.
9. Akira, S., Nishio, Y., Inoue, M., Wang, X.-J., Wei, S., Matsusaka, T., Yoshida, K., Sudo, T., Naruto, M. & Kishimoto, T. (1994) Cell 77, 63-71.
10. Lütticken, C., Wegenka, U. M., Yuan, J., Buschmann, J., Schindler, C., Ziemiecki, A., Harpur, A. G., Wilks, A. F., Yasukawa, K., Taga, T., Kishimoto, T., Barbieri, G., Pellegrini, S., Sendtner, M., Heinrich, P. C. & Horn, F. (1994) Science 263, 89-92.
11. Nakajima, T., Kinoshita, S., Sasagawa, T., Sasaki, K., Naruto, M., Kishimoto, T. & Akira, S. (1993) Proc. Natl. Acad. Sci. USA 90, 2207-2211.
12. Saito, M., Yoshida, K., Hibi, M., Taga, T. & Kishimoto, T. (1992) J. Immunol. 148, 4066-4071.
13. Stewart, C. L., Kaspar, P., Brunet, L. J., Bhatt, H., Gadi, I., Königen, F. & Abbondanzo, J. S. (1992) Nature (London) 359, 76-79.
14. Masu, Y., Wolf, E., Holtmann, B., Sendtner, M., Brem, G. & Thoenen, H. (1993) Nature (London) 365, 27-32.
15. Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H. & Köhler, G. (1994) Nature (London) 368, 339-342.
16. Mansour, S. L., Thomas, K. R. & Capecchi, M. R. (1988) Nature (London) 336, 348-352.
17. Hirota, H., Yoshida, K., Kishimoto, T. & Taga, T. (1995) Proc. Natl. Acad. Sci. USA 92, 4862-4866.
18. Yoshida, K., Chambers, I., Nichols, J., Smith, A. G., Saito, M., Yasukawa, K., Shoyab, M., Taga, T. & Kishimoto, T. (1994) Mech. Dev. 45, 163-171.
19. Rumyantsev, P. P. (1977) Int. Rev. Cytol. 91, 187-273.
20. Sucov, H. M., Dyson, E., Gumeringer, C. L., Price, J., Chien, K. R. & Evans, R. M. (1994) Genes Dev. 8, 1007-1018.
21. Kastner, P., Grondona, J. M., Mark, M., Gansmuller, A., Lemeur, M., Decimo, D., Vonesch, J. L., Dollé, P. & Chambon, P. (1994) Cell 78, 987-1003.
22. Chen, Z., Friedrich, G. A. & Soriano, P. (1994) Genes Dev. 8, 2293-2301.
23. Levéen, P., Peckny, M., Gebre-Medhin, S., Swolin, B., Larsson, E. & Betsholtz, C. (1994) Genes Dev. 8, 1875-1887.
24. Chien, K. R., Zhu, H., Knowlton, K. U., Miller-Hans, W., van Wilson, M., O'Brien, T. X. & Evans, S. M. (1993) Annu. Rev. Physiol. 55, 77-95.
25. Pennica, D., King, K., Shaw, K. J., Luis, E., Rullamas, J., Luoh, S.-M., Darbonne, W. C., Knutzon, D. S., Yen, R., Chien, K. R., Baker, J. B. & Wood, W. (1995) Proc. Natl. Acad. Sci. USA 92, 1142-1146.
26. Suzuki, H., Yasukawa, K., Saito, T., Narazaki, M., Hasegawa, A., Taga, T. & Kishimoto, T. (1993) Eur. J. Immunol. 23, 1078-1082.
27. Maeda, T. M., Yamaguchi, M., Taga, T., Kishimoto, T., Wada, K., Ikegami, H., Kurachi, H. & Miyake, A. (1994) Biochem. Biophys. Res. Commun. 205, 998-1003.
28. Russell, E. S. (1979) Adv. Genet. 20, 357-460.
29. Scott, E. W., Simon, M. C., Anastasi, J. & Singh, H. (1994) Science 265, 1573-1577.
30. Sui, X., Tsuji, K., Tanaka, R., Tajima, S., Muraoka, K., Ebihara, Y., Ikebuchi, K., Yasukawa, K., Taga, T., Kishimoto, T. & Nakahata, T. (1995) Proc. Natl. Acad. Sci. USA 92, 2859-2863.