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Volumn 13, Issue 7, 2017, Pages 399-409

The role of IL-6 in host defence against infections: Immunobiology and clinical implications

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ADALIMUMAB; CERTOLIZUMAB PEGOL; CLAZAKIZUMAB; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; GLYCOPROTEIN GP 130 IMMUNOGLOBULIN FC FRAGMENT FUSION PROTEIN; GOLIMUMAB; HYBRID PROTEIN; INFLIXIMAB; INFLUENZA VACCINE; INTERLEUKIN 6; METHOTREXATE; MICRORNA; NI 1201; OLAMKICEPT; OLOKIZUMAB; PLACEBO; PNEUMOCOCCUS VACCINE; PREDNISONE; RITUXIMAB; RUXOLITINIB; SARILUMAB; SILTUXIMAB; SIRUKUMAB; TOCILIZUMAB; TOFACITINIB; TUMOR NECROSIS FACTOR INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VOBARILIZUMAB; IL6 PROTEIN, HUMAN; MONOCLONAL ANTIBODY;

EID: 85021014942     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2017.83     Document Type: Review
Times cited : (335)

References (125)
  • 1
    • 84928568835 scopus 로고    scopus 로고
    • IL-6 as a keystone cytokine in health and disease
    • Hunter, C. A. & Jones, S. A. IL-6 as a keystone cytokine in health and disease. Nat. Immunol. 16, 448-457 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 448-457
    • Hunter, C.A.1    Jones, S.A.2
  • 2
    • 84920285641 scopus 로고    scopus 로고
    • IL-6 biology: Implications for clinical targeting in rheumatic disease
    • Calabrese, L. H. & Rose-John, S. IL-6 biology: implications for clinical targeting in rheumatic disease. Nat. Rev. Rheumatol. 10, 720-727 (2014).
    • (2014) Nat. Rev. Rheumatol. , vol.10 , pp. 720-727
    • Calabrese, L.H.1    Rose-John, S.2
  • 3
    • 80052137402 scopus 로고    scopus 로고
    • Integrated safety in tocilizumab clinical trials
    • Schiff, M. H. et al. Integrated safety in tocilizumab clinical trials. Arthritis Res. Ther. 13, R141 (2011).
    • (2011) Arthritis Res. Ther. , vol.13 , pp. R141
    • Schiff, M.H.1
  • 4
    • 34249686582 scopus 로고    scopus 로고
    • Guidelines for assessing immunocompetency in clinical trials for autoimmune diseases
    • Looney, R. J. et al. Guidelines for assessing immunocompetency in clinical trials for autoimmune diseases. Clin. Immunol. 123, 235-243 (2007).
    • (2007) Clin. Immunol. , vol.123 , pp. 235-243
    • Looney, R.J.1
  • 5
    • 84941941387 scopus 로고    scopus 로고
    • Interleukin-6: Biology, signaling and strategies of blockade
    • Schaper, F. & Rose-John, S. Interleukin-6: biology, signaling and strategies of blockade. Cytokine Growth Factor Rev. 26, 475-487 (2015).
    • (2015) Cytokine Growth Factor Rev. , vol.26 , pp. 475-487
    • Schaper, F.1    Rose-John, S.2
  • 6
    • 84864229482 scopus 로고    scopus 로고
    • The interleukin 6 pathway and atherosclerosis
    • Scheller, J. & Rose-John, S. The interleukin 6 pathway and atherosclerosis. Lancet 380, 338 (2012).
    • (2012) Lancet , vol.380 , pp. 338
    • Scheller, J.1    Rose-John, S.2
  • 7
    • 80052358980 scopus 로고    scopus 로고
    • Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
    • Jones, S. A., Scheller, J. & Rose-John, S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J. Clin. Invest. 121, 3375-3383 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 3375-3383
    • Jones, S.A.1    Scheller, J.2    Rose-John, S.3
  • 8
    • 0035160256 scopus 로고    scopus 로고
    • Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
    • Jostock, T. et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur. J. Biochem. 268, 160-167 (2001).
    • (2001) Eur. J. Biochem. , vol.268 , pp. 160-167
    • Jostock, T.1
  • 10
    • 0029837991 scopus 로고    scopus 로고
    • Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV
    • Moore, P. S., Boshoff, C., Weiss, R. A. & Chang, Y. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274, 1739-1744 (1996).
    • (1996) Science , vol.274 , pp. 1739-1744
    • Moore, P.S.1    Boshoff, C.2    Weiss, R.A.3    Chang, Y.4
  • 11
    • 77956262040 scopus 로고    scopus 로고
    • Castleman's disease-A two compartment model of HHV8 infection
    • Schulte, K. M. & Talat, N. Castleman's disease-a two compartment model of HHV8 infection. Nat. Rev. Clin. Oncol. 7, 533-543 (2010).
    • (2010) Nat. Rev. Clin. Oncol. , vol.7 , pp. 533-543
    • Schulte, K.M.1    Talat, N.2
  • 12
    • 0030852894 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit
    • Molden, J., Chang, Y., You, Y., Moore, P. S. & Goldsmith, M. A. A. Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. J. Biol. Chem. 272, 19625-19631 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 19625-19631
    • Molden, J.1    Chang, Y.2    You, Y.3    Moore, P.S.4    Goldsmith, M.A.A.5
  • 13
    • 0342264579 scopus 로고    scopus 로고
    • IL-6 receptor independent stimulation of human gp130 by viral IL-6
    • Mullberg, J. et al. IL-6 receptor independent stimulation of human gp130 by viral IL-6. J. Immunol. 164, 4672-4677 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 4672-4677
    • Mullberg, J.1
  • 14
    • 0030890718 scopus 로고    scopus 로고
    • Gp130 and the interleukin-6 family of cytokines
    • Taga, T. & Kishimoto, T. gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 15, 797-819 (1997).
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 797-819
    • Taga, T.1    Kishimoto, T.2
  • 15
    • 65349181345 scopus 로고    scopus 로고
    • Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor
    • Adam, N. et al. Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor. J. Virol. 83, 5117-5126 (2009).
    • (2009) J. Virol. , vol.83 , pp. 5117-5126
    • Adam, N.1
  • 16
    • 0035896394 scopus 로고    scopus 로고
    • Structure of an extracellular gp130 cytokine receptor signaling complex
    • Chow, D., He, X., Snow, A. L., Rose-John, S. & Garcia, K. C. Structure of an extracellular gp130 cytokine receptor signaling complex. Science 291, 2150-2155 (2001).
    • (2001) Science , vol.291 , pp. 2150-2155
    • Chow, D.1    He, X.2    Snow, A.L.3    Rose-John, S.4    Garcia, K.C.5
  • 17
    • 84925518929 scopus 로고    scopus 로고
    • Insights into cytokine-receptor interactions from cytokine engineering
    • Spangler, J. B., Moraga, I., Mendoza, J. L. & Garcia, K. C. Insights into cytokine-receptor interactions from cytokine engineering. Annu. Rev. Immunol. 33, 139-167 (2015).
    • (2015) Annu. Rev. Immunol. , vol.33 , pp. 139-167
    • Spangler, J.B.1    Moraga, I.2    Mendoza, J.L.3    Garcia, K.C.4
  • 18
    • 84861851475 scopus 로고    scopus 로고
    • HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice
    • Suthaus, J. et al. HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. Blood 119, 5173-5181 (2012).
    • (2012) Blood , vol.119 , pp. 5173-5181
    • Suthaus, J.1
  • 19
    • 27144488346 scopus 로고    scopus 로고
    • Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease
    • Nishimoto, N. et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood 106, 2627-2632 (2005).
    • (2005) Blood , vol.106 , pp. 2627-2632
    • Nishimoto, N.1
  • 20
    • 0028328436 scopus 로고
    • Impaired immune and acute-phase responses in interleukin-6-deficient mice
    • Kopf, M. et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368, 339-342 (1994).
    • (1994) Nature , vol.368 , pp. 339-342
    • Kopf, M.1
  • 22
    • 81055157812 scopus 로고    scopus 로고
    • Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection
    • Harker, J. A., Lewis, G. M., Mack, L. & Zuniga, E. I. Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science 334, 825-829 (2011).
    • (2011) Science , vol.334 , pp. 825-829
    • Harker, J.A.1    Lewis, G.M.2    Mack, L.3    Zuniga, E.I.4
  • 23
    • 84969218900 scopus 로고    scopus 로고
    • Innate and adaptive immune regulation during chronic viral infections
    • Zuniga, E. I., Macal, M., Lewis, G. M. & Harker, J. A. Innate and adaptive immune regulation during chronic viral infections. Annu. Rev. Virol. 2, 573-597 (2015).
    • (2015) Annu. Rev. Virol. , vol.2 , pp. 573-597
    • Zuniga, E.I.1    Macal, M.2    Lewis, G.M.3    Harker, J.A.4
  • 24
    • 73149094329 scopus 로고    scopus 로고
    • Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection
    • Hosel, M. et al. Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection. Hepatology 50, 1773-1782 (2009).
    • (2009) Hepatology , vol.50 , pp. 1773-1782
    • Hosel, M.1
  • 25
    • 84859842089 scopus 로고    scopus 로고
    • Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung
    • Dienz, O. et al. Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung. Mucosal Immunol. 5, 258-266 (2012).
    • (2012) Mucosal Immunol. , vol.5 , pp. 258-266
    • Dienz, O.1
  • 26
    • 40349111101 scopus 로고    scopus 로고
    • Interleukin-6 is crucial for recall of influenza-specific memory CD4 T cells
    • Longhi, M. P. et al. Interleukin-6 is crucial for recall of influenza-specific memory CD4 T cells. PLoS Pathog. 4, e1000006 (2008).
    • (2008) PLoS Pathog. , vol.4 , pp. e1000006
    • Longhi, M.P.1
  • 27
    • 84892456901 scopus 로고    scopus 로고
    • IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo
    • Smith, K. A. & Maizels, R. M. IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo. Eur. J. Immunol. 44, 150-161 (2014).
    • (2014) Eur. J. Immunol. , vol.44 , pp. 150-161
    • Smith, K.A.1    Maizels, R.M.2
  • 28
    • 68149183241 scopus 로고    scopus 로고
    • IL-6 is required for airway mucus production induced by inhaled fungal allergens
    • Neveu, W. A. et al. IL-6 is required for airway mucus production induced by inhaled fungal allergens. J. Immunol. 183, 1732-1738 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 1732-1738
    • Neveu, W.A.1
  • 29
    • 84872182482 scopus 로고    scopus 로고
    • IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling
    • Hoge, J. et al. IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling. J. Immunol. 190, 703-711 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 703-711
    • Hoge, J.1
  • 30
    • 0030856428 scopus 로고    scopus 로고
    • Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia
    • van der Poll, T. et al. Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia. J. Infect. Dis. 176, 439-444 (1997).
    • (1997) J. Infect. Dis. , vol.176 , pp. 439-444
    • Van Der Poll, T.1
  • 31
    • 0034685759 scopus 로고    scopus 로고
    • Involvement of the acute phase protein ?1-acid glycoprotein in nonspecific resistance to a lethal gram-negative infection
    • Hochepied, T., Van Molle, W., Bergeri, F. G., Baumann, H. & Libert, C. Involvement of the acute phase protein ?1-acid glycoprotein in nonspecific resistance to a lethal gram-negative infection. J. Biol. Chem. 275, 14903-14909 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 14903-14909
    • Hochepied, T.1    Van Molle, W.2    Bergeri, F.G.3    Baumann, H.4    Libert, C.5
  • 32
    • 34548856204 scopus 로고    scopus 로고
    • Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
    • Chalaris, A. et al. Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood 110, 1748-1755 (2007).
    • (2007) Blood , vol.110 , pp. 1748-1755
    • Chalaris, A.1
  • 33
    • 84992381703 scopus 로고    scopus 로고
    • Circulating soluble IL-6R but not ADAM17 activation drives mononuclear cell migration in tissue inflammation
    • Schumacher, N. et al. Circulating soluble IL-6R but not ADAM17 activation drives mononuclear cell migration in tissue inflammation. J. Immunol. 197, 3705-3715 (2016).
    • (2016) J. Immunol. , vol.197 , pp. 3705-3715
    • Schumacher, N.1
  • 34
    • 0034960582 scopus 로고    scopus 로고
    • Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
    • Hurst, S. M. et al. Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 14, 705-714 (2001).
    • (2001) Immunity , vol.14 , pp. 705-714
    • Hurst, S.M.1
  • 35
    • 0033545342 scopus 로고    scopus 로고
    • Acute-phase proteins and other systemic responses to inflammation
    • Gabay, C. & Kushner, I. Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med. 340, 448-454 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 448-454
    • Gabay, C.1    Kushner, I.2
  • 36
    • 0023432812 scopus 로고
    • Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells
    • Gauldie, J., Richards, C., Harnish, D., Lansdorp, P. & Baumann, H. Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc. Natl Acad. Sci. USA 84, 7251-7255 (1987).
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 7251-7255
    • Gauldie, J.1    Richards, C.2    Harnish, D.3    Lansdorp, P.4    Baumann, H.5
  • 37
    • 0037301226 scopus 로고    scopus 로고
    • Alpha(1)-acid glycoprotein: An acute phase protein with inflammatory and immunomodulating properties
    • Hochepied, T., Berger, F. G., Baumann, H. & Libert, C. Alpha(1)-acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties. Cytokine Growth Factor Rev. 14, 25-34 (2003).
    • (2003) Cytokine Growth Factor Rev. , vol.14 , pp. 25-34
    • Hochepied, T.1    Berger, F.G.2    Baumann, H.3    Libert, C.4
  • 38
    • 84901979435 scopus 로고    scopus 로고
    • C-reactive protein is essential for innate resistance to pneumococcal infection
    • Simons, J. P. et al. C-reactive protein is essential for innate resistance to pneumococcal infection. Immunology 142, 414-420 (2014).
    • (2014) Immunology , vol.142 , pp. 414-420
    • Simons, J.P.1
  • 39
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann, T. R. & Coffman, R. L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145-173 (1989).
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 40
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua, D. J. et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421, 744-748 (2003).
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1
  • 41
    • 84922534448 scopus 로고    scopus 로고
    • IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function
    • Bottcher, J. P. et al. IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function. Cell Rep. 8, 1318-1327 (2014).
    • (2014) Cell Rep. , vol.8 , pp. 1318-1327
    • Bottcher, J.P.1
  • 42
    • 36248951161 scopus 로고    scopus 로고
    • Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
    • Stumhofer, J. S. et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 8, 1363-1371 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 1363-1371
    • Stumhofer, J.S.1
  • 43
    • 79961077100 scopus 로고    scopus 로고
    • Mechanisms controlling Th17 cytokine expression and host defense
    • McAleer, J. P. & Kolls, J. K. Mechanisms controlling Th17 cytokine expression and host defense. J. Leukoc. Biol. 90, 263-270 (2011).
    • (2011) J. Leukoc. Biol. , vol.90 , pp. 263-270
    • McAleer, J.P.1    Kolls, J.K.2
  • 44
    • 84969754451 scopus 로고    scopus 로고
    • Heterogeneity of human CD4+ T cells against microbes
    • Sallusto, F. Heterogeneity of human CD4+ T cells against microbes. Annu. Rev. Immunol. 34, 317-334 (2016).
    • (2016) Annu. Rev. Immunol. , vol.34 , pp. 317-334
    • Sallusto, F.1
  • 45
    • 85007313308 scopus 로고    scopus 로고
    • Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines
    • Rolvering, C. et al. Crosstalk between different family members: IL27 recapitulates IFNgamma responses in HCC cells, but is inhibited by IL6-type cytokines. Biochim. Biophys. Acta 1864, 516-526 (2016).
    • (2016) Biochim. Biophys. Acta , vol.1864 , pp. 516-526
    • Rolvering, C.1
  • 46
  • 47
    • 84877610527 scopus 로고    scopus 로고
    • Suppression of elevations in serum C reactive protein levels by anti-IL-6 autoantibodies in two patients with severe bacterial infections
    • Nanki, T. et al. Suppression of elevations in serum C reactive protein levels by anti-IL-6 autoantibodies in two patients with severe bacterial infections. Ann. Rheum. Dis. 72, 1100-1102 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 1100-1102
    • Nanki, T.1
  • 48
    • 40449106777 scopus 로고    scopus 로고
    • Recurrent staphylococcal cellulitis and subcutaneous abscesses in a child with autoantibodies against IL-6
    • Puel, A. et al. Recurrent staphylococcal cellulitis and subcutaneous abscesses in a child with autoantibodies against IL-6. J. Immunol. 180, 647-654 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 647-654
    • Puel, A.1
  • 49
    • 84916894941 scopus 로고    scopus 로고
    • Hyper-IgE syndromes: Recent advances in pathogenesis, diagnostics and clinical care
    • Farmand, S. & Sundin, M. Hyper-IgE syndromes: recent advances in pathogenesis, diagnostics and clinical care. Curr. Opin. Hematol. 22, 12-22 (2015).
    • (2015) Curr. Opin. Hematol. , vol.22 , pp. 12-22
    • Farmand, S.1    Sundin, M.2
  • 50
    • 84946485705 scopus 로고    scopus 로고
    • The ying and yang of STAT3 in human disease
    • Vogel, T. P., Milner, J. D. & Cooper, M. A. The ying and yang of STAT3 in human disease. J. Clin. Immunol. 35, 615-623 (2015).
    • (2015) J. Clin. Immunol. , vol.35 , pp. 615-623
    • Vogel, T.P.1    Milner, J.D.2    Cooper, M.A.3
  • 51
    • 84952874829 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials
    • Strand, V. et al. Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials. Arthritis Res. Ther. 17, 362 (2015).
    • (2015) Arthritis Res. Ther. , vol.17 , pp. 362
    • Strand, V.1
  • 53
    • 84873624088 scopus 로고    scopus 로고
    • An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer
    • Garbers, C. et al. An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer. J. Biol. Chem. 288, 4346-4354 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 4346-4354
    • Garbers, C.1
  • 54
    • 85019144284 scopus 로고    scopus 로고
    • Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): A randomised, double-blind, parallel-group phase III trial
    • Burmester, G. R. et al. Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, parallel-group phase III trial. Ann. Rheum. Dis. 76, 840-847 (2016).
    • (2016) Ann. Rheum. Dis. , vol.76 , pp. 840-847
    • Burmester, G.R.1
  • 55
    • 84905192115 scopus 로고    scopus 로고
    • Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: Outcomes of a randomised phase IIb study
    • Genovese, M. C. et al. Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised phase IIb study. Ann. Rheum. Dis. 73, 1607-1615 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 1607-1615
    • Genovese, M.C.1
  • 56
    • 84983500182 scopus 로고    scopus 로고
    • The efficacy and safety of clazakizumab, an anti-interleukin-6 monoclonal antibody, in a phase IIb study of adults with active psoriatic arthritis
    • Mease, P. J. et al. The efficacy and safety of clazakizumab, an anti-interleukin-6 monoclonal antibody, in a phase IIb study of adults with active psoriatic arthritis. Arthritis Rheumatol. 68, 2163-2173 (2016).
    • (2016) Arthritis Rheumatol. , vol.68 , pp. 2163-2173
    • Mease, P.J.1
  • 57
    • 84905164026 scopus 로고    scopus 로고
    • Sirukumab, a human anti-interleukin-6 monoclonal antibody: A randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy
    • Smolen, J. S., Weinblatt, M. E., Sheng, S., Zhuang, Y. & Hsu, B. Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy. Ann. Rheum. Dis. 73, 1616-1625 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 1616-1625
    • Smolen, J.S.1    Weinblatt, M.E.2    Sheng, S.3    Zhuang, Y.4    Hsu, B.5
  • 58
    • 84952638330 scopus 로고    scopus 로고
    • Efficacy and safety of olokizumab in Asian patients with moderate-to-severe rheumatoid arthritis, previously exposed to anti-TNF therapy: Results from a randomized phase II trial
    • Takeuchi, T. et al. Efficacy and safety of olokizumab in Asian patients with moderate-to-severe rheumatoid arthritis, previously exposed to anti-TNF therapy: results from a randomized phase II trial. Mod. Rheumatol. 26, 15-23 (2016).
    • (2016) Mod. Rheumatol. , vol.26 , pp. 15-23
    • Takeuchi, T.1
  • 59
    • 84958092782 scopus 로고    scopus 로고
    • The efficacy and safety of subcutaneous clazakizumab in patients with moderate-to-severe rheumatoid arthritis and an inadequate response to methotrexate: Results from a multinational, phase IIb, randomized, doubleblind, placebo/active-controlled, dose-ranging study
    • Weinblatt, M. E. et al. The efficacy and safety of subcutaneous clazakizumab in patients with moderate-to-severe rheumatoid arthritis and an inadequate response to methotrexate: results from a multinational, phase IIb, randomized, doubleblind, placebo/active-controlled, dose-ranging study. Arthritis Rheumatol. 67, 2591-2600 (2015).
    • (2015) Arthritis Rheumatol. , vol.67 , pp. 2591-2600
    • Weinblatt, M.E.1
  • 60
    • 84868484220 scopus 로고    scopus 로고
    • Tocilizumab in patients with active rheumatoid arthritis and inadequate responses to DMARDs and/or TNF inhibitors: A large, open-label study close to clinical practice
    • Bykerk, V. P. et al. Tocilizumab in patients with active rheumatoid arthritis and inadequate responses to DMARDs and/or TNF inhibitors: a large, open-label study close to clinical practice. Ann. Rheum. Dis. 71, 1950-1954 (2016).
    • (2016) Ann. Rheum. Dis. , vol.71 , pp. 1950-1954
    • Bykerk, V.P.1
  • 61
    • 84963741145 scopus 로고    scopus 로고
    • ROUTINE-A prospective, multicentre, non-interventional, observational study to evaluate the safety and effectiveness of intravenous tocilizumab for the treatment of active rheumatoid arthritis in daily practice in Germany
    • Iking-Konert, C. et al. ROUTINE-a prospective, multicentre, non-interventional, observational study to evaluate the safety and effectiveness of intravenous tocilizumab for the treatment of active rheumatoid arthritis in daily practice in Germany. Rheumatology (Oxford) 55, 624-635 (2016).
    • (2016) Rheumatology (Oxford) , vol.55 , pp. 624-635
    • Iking-Konert, C.1
  • 62
    • 84978516357 scopus 로고    scopus 로고
    • Effectiveness and safety of tocilizumab in achieving clinical and functional remission, and sustaining efficacy in biologics-naive patients with rheumatoid arthritis: The FIRST Bio study
    • Ishiguro, N. et al. Effectiveness and safety of tocilizumab in achieving clinical and functional remission, and sustaining efficacy in biologics-naive patients with rheumatoid arthritis: the FIRST Bio study. Mod. Rheumatol. 27, 217-226 (2016).
    • (2016) Mod. Rheumatol. , vol.27 , pp. 217-226
    • Ishiguro, N.1
  • 63
    • 84891795508 scopus 로고    scopus 로고
    • Effectiveness and safety of tocilizumab: Postmarketing surveillance of 7901 patients with rheumatoid arthritis in Japan
    • Koike, T. et al. Effectiveness and safety of tocilizumab: postmarketing surveillance of 7901 patients with rheumatoid arthritis in Japan. J. Rheumatol. 41, 15-23 (2014).
    • (2014) J. Rheumatol. , vol.41 , pp. 15-23
    • Koike, T.1
  • 64
    • 84935001577 scopus 로고    scopus 로고
    • Risk of hospitalised infection in rheumatoid arthritis patients receiving biologics following a previous infection while on treatment with anti-TNF therapy
    • Yun, H. et al. Risk of hospitalised infection in rheumatoid arthritis patients receiving biologics following a previous infection while on treatment with anti-TNF therapy. Ann. Rheum. Dis. 74, 1065-1071 (2015).
    • (2015) Ann. Rheum. Dis. , vol.74 , pp. 1065-1071
    • Yun, H.1
  • 65
    • 84992623468 scopus 로고    scopus 로고
    • Brief report: Risk of gastrointestinal perforation among rheumatoid arthritis patients receiving tofacitinib, tocilizumab, or other biologic treatments
    • Xie, F., Yun, H., Bernatsky, S. & Curtis, J. R. Brief report: risk of gastrointestinal perforation among rheumatoid arthritis patients receiving tofacitinib, tocilizumab, or other biologic treatments. Arthritis Rheumatol. 68, 2612-2617 (2016).
    • (2016) Arthritis Rheumatol. , vol.68 , pp. 2612-2617
    • Xie, F.1    Yun, H.2    Bernatsky, S.3    Curtis, J.R.4
  • 66
    • 82755160877 scopus 로고    scopus 로고
    • Postmarketing surveillance of tocilizumab for rheumatoid arthritis in Japan: Interim analysis of 3881 patients
    • Koike, T. et al. Postmarketing surveillance of tocilizumab for rheumatoid arthritis in Japan: interim analysis of 3881 patients. Ann. Rheum. Dis. 70, 2148-2151 (2011).
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 2148-2151
    • Koike, T.1
  • 67
    • 84928553933 scopus 로고    scopus 로고
    • Risks of herpes zoster in patients with rheumatoid arthritis according to biologic diseasemodifying therapy
    • Yun, H. et al. Risks of herpes zoster in patients with rheumatoid arthritis according to biologic diseasemodifying therapy. Arthritis Care Res. (Hoboken) 67, 731-736 (2015).
    • (2015) Arthritis Care Res. (Hoboken) , vol.67 , pp. 731-736
    • Yun, H.1
  • 68
    • 84863989782 scopus 로고    scopus 로고
    • Unchanged serum viral load and liver function during tocilizumab treatment in a patient with rheumatoid arthritis and hepatitis C virus infection
    • Nagashima, T., Maruyama, A., Kamata, Y. & Minota, S. Unchanged serum viral load and liver function during tocilizumab treatment in a patient with rheumatoid arthritis and hepatitis C virus infection. Rheumatol. Int. 32, 2231-2232 (2012).
    • (2012) Rheumatol. Int. , vol.32 , pp. 2231-2232
    • Nagashima, T.1    Maruyama, A.2    Kamata, Y.3    Minota, S.4
  • 69
    • 56649094588 scopus 로고    scopus 로고
    • Long-term tocilizumab therapy in a patient with rheumatoid arthritis and chronic hepatitis B
    • Nagashima, T. & Minota, S. Long-term tocilizumab therapy in a patient with rheumatoid arthritis and chronic hepatitis B. Rheumatology (Oxford) 47, 1838-1840 (2008).
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 1838-1840
    • Nagashima, T.1    Minota, S.2
  • 70
    • 84855681277 scopus 로고    scopus 로고
    • A patient with rheumatoid arthritis treated with tocilizumab together with lamivudine prophylaxis after remission of infliximab-reactivated hepatitis B
    • Tsuboi, H. et al. A patient with rheumatoid arthritis treated with tocilizumab together with lamivudine prophylaxis after remission of infliximab-reactivated hepatitis B. Mod. Rheumatol. 21, 701-705 (2011).
    • (2011) Mod. Rheumatol. , vol.21 , pp. 701-705
    • Tsuboi, H.1
  • 71
    • 84897352169 scopus 로고    scopus 로고
    • Reactivation of hepatitis B virus in rheumatoid arthritis patients treated with biological disease-modifying antirheumatic drugs
    • Nakamura, J. et al. Reactivation of hepatitis B virus in rheumatoid arthritis patients treated with biological disease-modifying antirheumatic drugs. Int. J. Rheum. Dis. 19, 470-475 (2016).
    • (2016) Int. J. Rheum. Dis. , vol.19 , pp. 470-475
    • Nakamura, J.1
  • 72
    • 84990943459 scopus 로고    scopus 로고
    • Cytokines and T-cell homeostasis in HIV infection
    • Freeman, M. L. et al. Cytokines and T-cell homeostasis in HIV infection. J. Infect. Dis. 214 (Suppl. 2), S51-S57 (2016).
    • (2016) J. Infect. Dis. , vol.214 , pp. S51-S57
    • Freeman, M.L.1
  • 73
    • 85021024634 scopus 로고    scopus 로고
    • US National Library of Medicine. ClinicalTrials.gov
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02049437 (2017).
    • (2017)
  • 74
    • 84902959388 scopus 로고    scopus 로고
    • Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo
    • Wright, H. L., Cross, A. L., Edwards, S. W. & Moots, R. J. Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo. Rheumatology (Oxford) 53, 1321-1331 (2014).
    • (2014) Rheumatology (Oxford) , vol.53 , pp. 1321-1331
    • Wright, H.L.1    Cross, A.L.2    Edwards, S.W.3    Moots, R.J.4
  • 75
    • 84877275257 scopus 로고    scopus 로고
    • Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): A randomised, double-blind, controlled phase 4 trial
    • Gabay, C. et al. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet 381, 1541-1550 (2013).
    • (2013) Lancet , vol.381 , pp. 1541-1550
    • Gabay, C.1
  • 76
    • 60149100932 scopus 로고    scopus 로고
    • Masked early symptoms of pneumonia in patients with rheumatoid arthritis during tocilizumab treatment: A report of two cases
    • Fujiwara, H. et al. Masked early symptoms of pneumonia in patients with rheumatoid arthritis during tocilizumab treatment: a report of two cases. Mod. Rheumatol. 19, 64-68 (2009).
    • (2009) Mod. Rheumatol. , vol.19 , pp. 64-68
    • Fujiwara, H.1
  • 77
    • 84863659978 scopus 로고    scopus 로고
    • The absence of typical pneumonia symptoms in a patient with rheumatoid arthritis during tocilizumab and steroid treatment
    • Yanagawa, Y., Hirano, Y., Kato, H. & Iba, T. The absence of typical pneumonia symptoms in a patient with rheumatoid arthritis during tocilizumab and steroid treatment. BMJ Case Rep. 2012, bcr0220125835 (2012).
    • (2012) BMJ Case Rep. , vol.2012 , pp. 5835
    • Yanagawa, Y.1    Hirano, Y.2    Kato, H.3    Iba, T.4
  • 78
    • 84924286319 scopus 로고    scopus 로고
    • Effects of biological and non-biological immunomodulatory therapies on the immunogenicity of vaccines in patients with rheumatic diseases
    • McMahan, Z. H. & Bingham, C. O. III. Effects of biological and non-biological immunomodulatory therapies on the immunogenicity of vaccines in patients with rheumatic diseases. Arthritis Res. Ther. 16, 506 (2014).
    • (2014) Arthritis Res. Ther. , vol.16 , pp. 506
    • McMahan, Z.H.1    Bingham, C.O.2
  • 79
    • 84880134524 scopus 로고    scopus 로고
    • Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tocilizumab therapy
    • Mori, S. et al. Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tocilizumab therapy. Ann. Rheum. Dis. 72, 1362-1366 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 1362-1366
    • Mori, S.1
  • 80
    • 84900460391 scopus 로고    scopus 로고
    • Immune response to influenza vaccine and pneumococcal polysaccharide vaccine under IL-6 signal inhibition therapy with tocilizumab
    • Tsuru, T. et al. Immune response to influenza vaccine and pneumococcal polysaccharide vaccine under IL-6 signal inhibition therapy with tocilizumab. Mod. Rheumatol. 24, 511-516 (2014).
    • (2014) Mod. Rheumatol. , vol.24 , pp. 511-516
    • Tsuru, T.1
  • 81
    • 84892522544 scopus 로고    scopus 로고
    • Impact of anti-rheumatic treatment on immunogenicity of pandemic H1N1 influenza vaccine in patients with arthritis
    • Kapetanovic, M. C. et al. Impact of anti-rheumatic treatment on immunogenicity of pandemic H1N1 influenza vaccine in patients with arthritis. Arthritis Res. Ther. 16, R2 (2014).
    • (2014) Arthritis Res. Ther. , vol.16 , pp. R2
    • Kapetanovic, M.C.1
  • 82
    • 84868510039 scopus 로고    scopus 로고
    • Impact of tocilizumab therapy on antibody response to influenza vaccine in patients with rheumatoid arthritis
    • Mori, S. et al. Impact of tocilizumab therapy on antibody response to influenza vaccine in patients with rheumatoid arthritis. Ann. Rheum. Dis. 71, 2006-2010 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 2006-2010
    • Mori, S.1
  • 83
    • 84926465540 scopus 로고    scopus 로고
    • Humoral immune response to vaccines in patients with rheumatoid arthritis treated with tocilizumab: Results of a randomised controlled trial (VISARA)
    • Bingham, C. O. III et al. Humoral immune response to vaccines in patients with rheumatoid arthritis treated with tocilizumab: results of a randomised controlled trial (VISARA). Ann. Rheum. Dis. 74, 818-822 (2015).
    • (2015) Ann. Rheum. Dis. , vol.74 , pp. 818-822
    • Bingham, C.O.1
  • 84
    • 0042834261 scopus 로고    scopus 로고
    • Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: Blockade of arthritis severity by soluble glycoprotein 130
    • Nowell, M. A. et al. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. J. Immunol. 171, 3202-3209 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 3202-3209
    • Nowell, M.A.1
  • 85
    • 59849091830 scopus 로고    scopus 로고
    • Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis
    • Nowell, M. A. et al. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. J. Immunol. 182, 613-622 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 613-622
    • Nowell, M.A.1
  • 86
    • 33646469222 scopus 로고    scopus 로고
    • Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis
    • Richards, P. J. et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum. 54, 1662-1672 (2006).
    • (2006) Arthritis Rheum. , vol.54 , pp. 1662-1672
    • Richards, P.J.1
  • 87
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
    • Atreya, R. et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat. Med. 6, 583-538 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 538-583
    • Atreya, R.1
  • 88
    • 33747774200 scopus 로고    scopus 로고
    • STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice
    • Mitsuyama, K. et al. STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. Gut 55, 1263-1269 (2006).
    • (2006) Gut , vol.55 , pp. 1263-1269
    • Mitsuyama, K.1
  • 89
    • 84856221966 scopus 로고    scopus 로고
    • Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice
    • Schuett, H. et al. Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice. Arterioscler Thromb. Vasc. Biol. 32, 281-290 (2012).
    • (2012) Arterioscler Thromb. Vasc. Biol. , vol.32 , pp. 281-290
    • Schuett, H.1
  • 90
    • 84941301482 scopus 로고    scopus 로고
    • Allergen-induced IL-6 transsignaling activates gammadelta T cells to promote type 2 and type 17 airway inflammation
    • Ullah, M. A. et al. Allergen-induced IL-6 transsignaling activates gammadelta T cells to promote type 2 and type 17 airway inflammation. J. Allergy Clin. Immunol. 136, 1065-1073 (2015).
    • (2015) J. Allergy Clin. Immunol. , vol.136 , pp. 1065-1073
    • Ullah, M.A.1
  • 91
    • 84924415012 scopus 로고    scopus 로고
    • Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance
    • Kraakman, M. J. et al. Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance. Cell Metab. 21, 403-416 (2015).
    • (2015) Cell Metab. , vol.21 , pp. 403-416
    • Kraakman, M.J.1
  • 92
    • 85007478193 scopus 로고    scopus 로고
    • Therapeutic targeting of the IL-6 trans-signalling/mTORC1 axis in pulmonary emphysema
    • Ruwanpura, S. M. et al. Therapeutic targeting of the IL-6 trans-signalling/mTORC1 axis in pulmonary emphysema. Am. J. Respir. Crit. Care Med. 194, 1494-1505 (2016).
    • (2016) Am. J. Respir. Crit. Care Med. , vol.194 , pp. 1494-1505
    • Ruwanpura, S.M.1
  • 93
    • 84918799940 scopus 로고    scopus 로고
    • Neutrophil-derived cytokines: Facts beyond expression
    • Tecchio, C., Micheletti, A. & Cassatella, M. A. Neutrophil-derived cytokines: facts beyond expression. Front. Immunol. 5, 508 (2014).
    • (2014) Front. Immunol. , vol.5 , pp. 508
    • Tecchio, C.1    Micheletti, A.2    Cassatella, M.A.3
  • 94
    • 84899124414 scopus 로고    scopus 로고
    • Signalling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
    • Mauer, J. et al. Signalling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat. Immunol. 15, 423-430 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 423-430
    • Mauer, J.1
  • 95
    • 0030891228 scopus 로고    scopus 로고
    • Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
    • Romano, M. et al. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6, 315-325 (1997).
    • (1997) Immunity , vol.6 , pp. 315-325
    • Romano, M.1
  • 96
    • 0032846613 scopus 로고    scopus 로고
    • Novel path to activation of vascular smooth muscle cells: Up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor
    • Klouche, M., Bhakdi, S., Hemmes, M. & Rose-John, S. Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J. Immunol. 163, 4583-4589 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 4583-4589
    • Klouche, M.1    Bhakdi, S.2    Hemmes, M.3    Rose-John, S.4
  • 98
    • 84898070133 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGFbeta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein
    • O'Reilly, S., Ciechomska, M., Cant, R. & van Laar, J. M. Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGFbeta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein. J. Biol. Chem. 289, 9952-9960 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 9952-9960
    • O'Reilly, S.1    Ciechomska, M.2    Cant, R.3    Van Laar, J.M.4
  • 99
    • 84892476632 scopus 로고    scopus 로고
    • Interleukin-6 signaling drives fibrosis in unresolved inflammation
    • Fielding, C. A. et al. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40, 40-50 (2014).
    • (2014) Immunity , vol.40 , pp. 40-50
    • Fielding, C.A.1
  • 100
    • 84929944191 scopus 로고    scopus 로고
    • Fever and the thermal regulation of immunity: The immune system feels the heat
    • Evans, S. S., Repasky, E. A. & Fisher, D. T. Fever and the thermal regulation of immunity: the immune system feels the heat. Nat. Rev. Immunol. 15, 335-349 (2015).
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 335-349
    • Evans, S.S.1    Repasky, E.A.2    Fisher, D.T.3
  • 101
    • 0031852288 scopus 로고    scopus 로고
    • IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • Eugster, H. P., Frei, K., Kopf, M., Lassmann, H. & Fontana, A. IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. Eur. J. Immunol. 28, 2178-2187 (1998).
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2178-2187
    • Eugster, H.P.1    Frei, K.2    Kopf, M.3    Lassmann, H.4    Fontana, A.5
  • 102
    • 0028675983 scopus 로고
    • Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system
    • Bernad, A. et al. Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system. Immunity 1, 725-731 (1994).
    • (1994) Immunity , vol.1 , pp. 725-731
    • Bernad, A.1
  • 103
    • 0029007193 scopus 로고
    • Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: Correlation with inefficient neutrophilia
    • Dalrymple, S. A. et al. Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect. Immun. 63, 2262-2268 (1995).
    • (1995) Infect. Immun. , vol.63 , pp. 2262-2268
    • Dalrymple, S.A.1
  • 104
    • 0029913685 scopus 로고    scopus 로고
    • Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans
    • Romani, L. et al. Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans. J. Exp. Med. 183, 1345-1355 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 1345-1355
    • Romani, L.1
  • 105
    • 0030058649 scopus 로고    scopus 로고
    • Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: A study on IL-6-deficient mice
    • Chai, Z., Gatti, S., Toniatti, C., Poli, V. & Bartfai, T. Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice. J. Exp. Med. 183, 311-316 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 311-316
    • Chai, Z.1    Gatti, S.2    Toniatti, C.3    Poli, V.4    Bartfai, T.5
  • 106
    • 84997637138 scopus 로고    scopus 로고
    • Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells
    • Heink, S. et al. Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat. Immunol. 18, 74-85 (2016).
    • (2016) Nat. Immunol. , vol.18 , pp. 74-85
    • Heink, S.1
  • 107
    • 77953645116 scopus 로고    scopus 로고
    • Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor
    • McFarland-Mancini, M. M. et al. Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. J. Immunol. 184, 7219-7228 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 7219-7228
    • McFarland-Mancini, M.M.1
  • 108
    • 77956335194 scopus 로고    scopus 로고
    • Interleukin-6 signaling in liverparenchymal cells suppresses hepatic inflammation and improves systemic insulin action
    • Wunderlich, F. T. et al. Interleukin-6 signaling in liverparenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab. 12, 237-249 (2010).
    • (2010) Cell Metab. , vol.12 , pp. 237-249
    • Wunderlich, F.T.1
  • 109
    • 9044222888 scopus 로고    scopus 로고
    • Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders
    • Yoshida, K. et al. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl Acad. Sci. USA 93, 407-411 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 407-411
    • Yoshida, K.1
  • 110
    • 0032539008 scopus 로고    scopus 로고
    • Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects
    • Betz, U. A. et al. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. J. Exp. Med. 188, 1955-1965 (1998).
    • (1998) J. Exp. Med. , vol.188 , pp. 1955-1965
    • Betz, U.A.1
  • 111
    • 0043167910 scopus 로고    scopus 로고
    • Lack of gp130 expression in hepatocytes promotes liver injury
    • Streetz, K. L. et al. Lack of gp130 expression in hepatocytes promotes liver injury. Gastroenterology 125, 532-543 (2003).
    • (2003) Gastroenterology , vol.125 , pp. 532-543
    • Streetz, K.L.1
  • 112
    • 34547764285 scopus 로고    scopus 로고
    • Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man
    • Luchtefeld, M. et al. Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man. J. Exp. Med. 204, 1935-1944 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1935-1944
    • Luchtefeld, M.1
  • 113
    • 77954399377 scopus 로고    scopus 로고
    • Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function
    • Sander, L. E. et al. Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function. J. Exp. Med. 207, 1453-1464 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1453-1464
    • Sander, L.E.1
  • 114
    • 0036233585 scopus 로고    scopus 로고
    • Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
    • O'Shea, J. J., Gadina, M. & Schreiber, R. D. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 109 (Suppl. 1), S121-S131 (2002).
    • (2002) Cell , vol.109 , pp. S121-S131
    • O'Shea, J.J.1    Gadina, M.2    Schreiber, R.D.3
  • 115
    • 84971260757 scopus 로고    scopus 로고
    • Janus kinase 1 is essential for inflammatory cytokine signaling and mammary gland remodeling
    • Sakamoto, K. et al. Janus kinase 1 is essential for inflammatory cytokine signaling and mammary gland remodeling. Mol. Cell. Biol. 36, 1673-1690 (2016).
    • (2016) Mol. Cell. Biol. , vol.36 , pp. 1673-1690
    • Sakamoto, K.1
  • 116
    • 84954197710 scopus 로고    scopus 로고
    • Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases
    • Schwartz, D. M., Bonelli, M., Gadina, M. & O'Shea, J. J. Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases. Nat. Rev. Rheumatol. 12, 25-36 (2016).
    • (2016) Nat. Rev. Rheumatol. , vol.12 , pp. 25-36
    • Schwartz, D.M.1    Bonelli, M.2    Gadina, M.3    O'Shea, J.J.4
  • 117
    • 0036338213 scopus 로고    scopus 로고
    • STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation
    • Lee, C. K. et al. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity 17, 63-72 (2002).
    • (2002) Immunity , vol.17 , pp. 63-72
    • Lee, C.K.1
  • 118
    • 77951434599 scopus 로고    scopus 로고
    • STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction
    • Nguyen-Jackson, H., Panopoulos, A. D., Zhang, H., Li, H. S. & Watowich, S. S. STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction. Blood 115, 3354-3363 (2010).
    • (2010) Blood , vol.115 , pp. 3354-3363
    • Nguyen-Jackson, H.1    Panopoulos, A.D.2    Zhang, H.3    Li, H.S.4    Watowich, S.S.5
  • 120
    • 1342346569 scopus 로고    scopus 로고
    • SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling
    • Kimura, A. et al. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J. Biol. Chem. 279, 6905-6910 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 6905-6910
    • Kimura, A.1
  • 121
    • 0032515018 scopus 로고    scopus 로고
    • An essential role for ectodomain shedding in mammalian development
    • Peschon, J. J. et al. An essential role for ectodomain shedding in mammalian development. Science 282, 1281-1284 (1998).
    • (1998) Science , vol.282 , pp. 1281-1284
    • Peschon, J.J.1
  • 122
    • 38449086094 scopus 로고    scopus 로고
    • Cutting edge: TNF-alphaconverting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock
    • Horiuchi, K. et al. Cutting edge: TNF-alphaconverting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J. Immunol. 179, 2686-2689 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 2686-2689
    • Horiuchi, K.1
  • 123
    • 77955348535 scopus 로고    scopus 로고
    • Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
    • Chalaris, A. et al. Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J. Exp. Med. 207, 1617-1624 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1617-1624
    • Chalaris, A.1
  • 124
    • 85055607205 scopus 로고    scopus 로고
    • ADAM17 substrate release in proximal tubule drives kidney fibrosis
    • Kefaloyianni, E. et al. ADAM17 substrate release in proximal tubule drives kidney fibrosis. JCI Insight 1, e87023 (2016).
    • (2016) JCI Insight , vol.1 , pp. e87023
    • Kefaloyianni, E.1
  • 125
    • 85007252576 scopus 로고    scopus 로고
    • Adam17-deficiency promotes atherosclerosis by enhanced TNFR2 signaling in mice
    • Nicolaou, A. et al. Adam17-deficiency promotes atherosclerosis by enhanced TNFR2 signaling in mice. Arterioscler. Thromb. Vasc. Biol. 37, 247-257 (2016).
    • (2016) Arterioscler. Thromb. Vasc. Biol. , vol.37 , pp. 247-257
    • Nicolaou, A.1


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