IL-6 contributes to the expression of RAGs in human mature B cells

Journal of Immunology

Volumn 179, Issue 10, 2007, Pages 6790-6798

  Hillion, Sophie ^a   Dueymes, Maryvonne ^a   Youinou, Pierre ^a   Jamin, Christophe ^a  

^a BREST UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; CD40 ANTIGEN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; RAG1 PROTEIN; RAG2 PROTEIN; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; IL6 PROTEIN, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR; NUCLEAR PROTEIN; RAG 1 PROTEIN; RAG-1 PROTEIN; RAG2 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; CELL POPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CAPPING PHENOMENON; CYTOLOGY; DRUG ANTAGONISM; ENZYMOLOGY; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; SHEEP; TONSIL;

ANIMALS; ANTIGENS, CD40; B-LYMPHOCYTES; DNA-BINDING PROTEINS; GENE REARRANGEMENT, B-LYMPHOCYTE; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; NUCLEAR PROTEINS; RECEPTOR AGGREGATION; RECEPTORS, ANTIGEN, B-CELL; SHEEP; TONSIL; UP-REGULATION;

EID: 38449094444     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.10.6790     Document Type: Article

References (50)

1. Oettinger, M. A., D. G. Schatz, C. Gorka, and D. Baltimore. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate VDJ recombination. Science 248: 1517-1523.
2. Faust, E. A., D. C. Saffran, D. Toksoz, D. A. Williams, and O. N. Witte. 1993. Distinctive growth requirements and gene expression patterns distinguish progenitor B cells from pre-B cells. J. Exp. Med. 177: 915-923.
3. Billips, L. G., C. A. Nunez, F. E. Bertrand III, A. K. Stankovic, G. L. Gartland, P. D. Burrows, and M. D. Cooper. 1995. Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors. J. Exp. Med. 182: 973-982.
4. Muraguchi, A., H. Tagoh, T. Kitagawa, T. Nagata, and H. Kishi. 1998. Stromal cells and cytokines in the induction of recombination activating gene (RAG) expression in a human lymphoid progenitor cell. Leuk. Lymphoma 30: 73-85.
5. Nemazee, D., and K. Buerki. 1989. Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras. Proc. Natl. Acad. Sci. USA 86: 8039-8043.
6. Goodnow, C. C., J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, R. A. Brink, H. Pritchard-Briscoe, J. S. Wotherspoon, R. H. Loblay, and K. Raphael. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334: 676-682.
7. Gay, D., T. Saunders, S. Camper, and M. Weigert. 1993. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177: 999-1008.
8. Tiegs, S. L., D. M. Russel, and D. Nemazee. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177: 1009-1020.
9. Hillion, S., C. Rochas, P. Youinou, and C. Jamin. 2005. Expression and reexpression of recombination activating genes: relevance to the development of autoimmune states. Ann. NY Acad. Sci. 1050: 10-18.
10. Jankovic, M., R. Casellas, N. Yannoutsos, H. Wardemann, and M. C. Nussenzweig. 2004. RAGs and regulation of autoantibodies. Annu. Rev. Immunol. 22: 485-501.
11. Hikida, M., M. Mori, T. Takai, K. Tomochika, K. Hamatani, and H. Ohmori. 1996. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science 274: 2092-2094.
12. Han, S., B. Zheng, D. G. Schatz, E. Spanopoulou, and G. Kelsoe. 1996. Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science 274: 2094-2097.
13. Meffre, E., R. Casellas, and M. C. Nussenzweig. 2000. Antibody regulation of B cell development. Nat. Immunol. 1: 379-385.
14. Hikida, M., M. Mori, T. Kawabata, T. Takai, and H. Ohmori. 1997. Characterization of B cells expressing recombination activating genes in germinal centers of immunized mouse lymph nodes. J. Immunol. 158: 2509-2512.
15. Igarashi, H., N. Kuwata, K. Kiyota, K. Sumita, T. Suda, S., Ono, S. R. Bauer, and N. Sakaguchi. 2001. Localization of recombination activating gene 1/green fluorescent protein (RAG1/GFP) expression in secondary lymphoid organs after immunization with T-dependent antigens in rag1/gfp knockin mice. Blood 97: 2680-2687.
16. Girschick, H. J., A. C. Grammer, T. Nanki, M. Mayo, and P. E. Lipsky. 2001. RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral blood. J. Immunol. 166: 377-386.
17. Giachino, C., Padovan, and E. A. Lanzavecchia. 1998. Re-expression of RAG-1 and RAG-2 genes and evidence for secondary rearrangements in human germinal center B lymphocytes. Eur. J. Immunol. 28: 3506-3513.
18. Hillion, S., A. Saraux, P. Youinou, and C. Jamin. 2005. Expression of RAGs in peripheral B cells outside germinal centers is associated with the expression of CD5. J. Immunol. 174: 5553-5561.
19. Hikida, M., Y. Nakayama, Y. Yamashita, Y. Kumazawa, S. I. Nishikawa, and H. Ohmori. 1998. Expression of recombination activating genes in germinal center B cells: involvement of interleukin 7 (IL-7) and the IL-7 receptor. J. Exp. Med. 188: 365-372.
20. Nagafuchi, H., H. Yoshikawa, Y. Takeba, K. Nara, K. Miura, M. S. Kurokawa, and N. Suzuki. 2004. Recombination activating genes (RAG) induce secondary Ig gene rearrangement in and subsequent apoptosis of human peripheral blood circulating B lymphocytes. Clin. Exp. Immunol. 136: 76-84.
21. Meffre, E., F. Papavasiliou, P. Cohen, O. de Bouteiller, D. Bell, H. Karasuyama, C. Schiff, J. Banchereau, Y. J. Liu, and M. C. Nussenzweig. 1998. Antigen receptor engagement turns off the VDJ recombination machinery in human tonsil B cells. J. Exp. Med. 188: 765-772.
22. Schultze, J., L. Michalak, S. Seamon, M. J. Dranoff, G. Jung, K. J. Daley, J. C. Delgado, J. G. Gribben, and L. M. Nadler. 1997. CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy. J. Clin. Invest. 100: 2757-2765.
23. Gartner, F., F. W. Alt, R. J. Monroe, and K. J. Seidl. 2000. Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice. J. Exp. Med. 192: 1745-1754.
24. Yu, W., H. Nagaoka, M. Jankovic, Z. Misulovin, H. Suh, A. Rolink, F. Melchers, E. Meffre, and M. C. Nussenzweig. 1999. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 400: 682-687.
25. Sims, G. P., R. Ettinger, Y. Shirota, C. H. Yarboro, G. G. Illei, and P. E. Lipsky. 2005. Identification and characterization of circulating human transitional B cells. Blood 105: 4390-4398.
26. Hertz, M., V. Kouskoff, T. Nakamura, and D. Nemazee. 1998. VDJ recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling. Nature 394: 292-295.
27. Li, Y., H. Li, and M. Weigert. 2002. Autoreactive B cells in the marginal zone that express dual receptors. J. Exp. Med. 195: 181-188.
28. Diamant, E., Z. Keren, and D. Melamed. 2005. CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing. Blood 105: 3247-3254.
29. - bone marrow B cells in vitro. Immunity 6: 429-436.
30. Armitage, R. J., S. F. Ziegler, M. P. Beckmann, R. L. Idzerda, L. S. Park, and W. C. Fanslow. 1991. Expression of receptors for interleukin 4 and interleukin 7 on human T cells. Adv. Exp. Med. Biol. 292: 121-130.
31. Ryan, D. H., B. L. Nuccie, I. Ritterman, J. L. Liesveld, C. N. Abboud, and R. A. Insel. 1997. Expression of interleukin-7 receptor by lineage-negative human bone marrow progenitors with enhanced lymphoid proliferative potential and B-lineage differentiation capacity. Blood 89: 929-940.
32. Skibinski, G., A. Skibinska, M. Deckers, and K. James. 1998. Tonsil stromal-cell lines expressing FDC-like properties: isolation, characterization, and interaction with B lymphocytes. Dev. Immunol. 6: 273-284.
33. Hirata, Y., T. Taga, M. Hibi, N. Nakano, T. Hirano, and T. Kishimoto. 1989. Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies. J. Immunol. 143: 2900-2906.
34. Chaouchi, N., A. Vazquez, P. Galanaud, and C. Leprince. 1995. B cell antigen receptor-mediated apoptosis. Importance of accessory molecules CD19 and CD22, and of surface IgM cross-linking. J. Immunol. 154: 3094-3104.
35. Pers, J. O., C. Jamin, R. Le Corre, P. M. Lydyard, and P. Youinou. 1998. Ligation of CD5 on resting B cells, but not on resting T cells, results in apoptosis. Eur. J. Immunol. 28: 4170-4176.
36. Baccam, M., S. Y. Woo, C. Winson, and G. A. Bishop. 2003. CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes: involvement of NF-kappa B, AP-1, and C/EBP. J. Immunol. 170: 3099-3108.
37. Monroe, R. J., F. Chen, R. Ferrini, L. Davidson, and F. W. Alt. 1999. RAG2 is regulated differentially in B and T cells by elements 5′ of the promoter. Proc. Natl. Acad. Sci. USA 96: 12713-12718.
38. Yannoutsos, N., V. Barreto, Z. Misulovin, A. Gazumyan, W. Yu, N. Rajewsky, B. R. Peixoto, T. Eisenreich, and M.C. Nussenzweig. 2004. A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer. Nat. Immunol. 5: 443-450.
39. Dono, M., V. L. Burgio, C. Tacchetti, A. Favre, A. Augliera, S. Zupo, G. Taborelli, N. Chiorazzi, C. E. Grossi, and M. Ferrarini. 1996. Subepithelial B cells in the human palatine tonsil, I: morphologic, cytochemical and phenotypic characterization. Eur. J. Immunol. 26: 2035-2042.
40. Bikah, G., J. Carey, J. R. Ciallella, A. Tarakhovsky, and S. Bondada. 1996. CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells. Science 274: 1906-1909.
41. Magari, M., T. Sawatari, Y. Kawano, M. Cascalho, M. Wabl, N. Kanayama, M. Hikida, and H. Ohmori. 2002. Contribution of light chain rearrangement in peripheral B cells to the generation of high-affinity antibodies. Eur. J. Immunol. 32: 957-966.
42. 1 arrest through induction of p27(Kip1), a cyclin-dependent kinase inhibitor, and neuron-like morphology in LNCaP prostate tumor cells. Biochem. Biophys. Res. Commun. 257: 609-614.
43. Stuart, R. A., A. J. Littlewood, P. J. Maddison, and N. D. Hall. 1995. Elevated serum interleukin-6 levels associated with active disease in systemic connective tissue disorders. Clin. Exp. Rheumatol. 13: 17-22.
44. Hirano, T., T. Matsuda, M. Turner, N. Miyasaka, G. Buchan, B. Tang, K. Sato, M. Shimizu, R. Maini, and M. Feldmann. 1988. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18: 1797-1801.
45. Grisius, M. M., D. K. Bermudez, and P. C. Fox. 1997. Salivary and serum interleukin 6 in primary Sjogren's syndrome. J. Rheumatol. 24: 1089-1091.
46. Girschick, H. J., A. C. Grammer, T. Nanki, E. Vazquez, and P. E. Lipsky. 2002. Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus. Arthritis Rheum. 46: 1255-1263.
47. Zhang, Z., X. Wu, B. H. Limbaugh, and S. L. Bridges, Jr. 2001. Expression of recombination-activating genes and terminal deoxynucleotidyl transferase and secondary rearrangement of immunoglobulin kappa light chains in rheumatoid arthritis synovial tissue. Arthritis Rheum. 44: 2275-2284.
48. Hillion, S., S. Garaud, V. Devauchelle, A. Bordron, C. Berthou, P. Youinou, and C. Jamin. 2007. Interleukin-6 is responsible for aberrant B-cell receptor-mediated regulation of RAG expression in systemic lupus erythematosus. Immunology 122: 371-380.
49. Itoh, K., E. Meffre, E. Albesiano, A. Farber, D. Dines, P. Stein, S. E. Asnis, R.A. Furie, R. I. Jain, and N. Chiorazzi. 2000. Immunoglobulin heavy chain variable region gene replacement as a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes. J. Exp. Med. 192: 1151-1164.
50. Armengol, M. P., M. Juan, A. Lucas-Martin, M. T. Fernandez-Figueras, D. Jaraquemada, T. Gallart, and R. Pujol-Borrell. 2001. Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers. Am. J. Pathol. 159: 861-873.