-
1
-
-
84862297475
-
Mechanism of oxidative stress in neurodegeneration
-
Gandhi S and Abramov AY (2012) Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev 2012, 428010.
-
(2012)
Oxid Med Cell Longev
, vol.2012
, pp. 428010
-
-
Gandhi, S.1
Abramov, A.Y.2
-
2
-
-
0034740585
-
DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria
-
Votyakova TV and Reynolds IJ (2001) DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria. J Neurochem 79, 266–277.
-
(2001)
J Neurochem
, vol.79
, pp. 266-277
-
-
Votyakova, T.V.1
Reynolds, I.J.2
-
3
-
-
84969902407
-
Oxidation of NADH and ROS production by respiratory complex I
-
Vinogradov AD and Grivennikova VG (2016) Oxidation of NADH and ROS production by respiratory complex I. Biochim Biophys Acta 1857, 863–871.
-
(2016)
Biochim Biophys Acta
, vol.1857
, pp. 863-871
-
-
Vinogradov, A.D.1
Grivennikova, V.G.2
-
4
-
-
84921814081
-
Nrf2 regulates ROS production by mitochondria and NADPH oxidase
-
Kovac S, Angelova PR, Holmstrom KM, Zhang Y, Dinkova-Kostova AT and Abramov AY (2015) Nrf2 regulates ROS production by mitochondria and NADPH oxidase. Biochim Biophys Acta 1850, 794–801.
-
(2015)
Biochim Biophys Acta
, vol.1850
, pp. 794-801
-
-
Kovac, S.1
Angelova, P.R.2
Holmstrom, K.M.3
Zhang, Y.4
Dinkova-Kostova, A.T.5
Abramov, A.Y.6
-
5
-
-
0000466588
-
Respiratory chain linked H(2)O(2) production in pigeon heart mitochondria
-
Loschen G, Flohe L and Chance B (1971) Respiratory chain linked H(2)O(2) production in pigeon heart mitochondria. FEBS Lett 18, 261–264.
-
(1971)
FEBS Lett
, vol.18
, pp. 261-264
-
-
Loschen, G.1
Flohe, L.2
Chance, B.3
-
6
-
-
0015363173
-
The cellular production of hydrogen peroxide
-
Boveris A, Oshino N and Chance B (1972) The cellular production of hydrogen peroxide. Biochem J 128, 617–630.
-
(1972)
Biochem J
, vol.128
, pp. 617-630
-
-
Boveris, A.1
Oshino, N.2
Chance, B.3
-
7
-
-
0016148483
-
Superoxide radicals as precursors of mitochondrial hydrogen peroxide
-
Loschen G, Azzi A, Richter C and Flohe L (1974) Superoxide radicals as precursors of mitochondrial hydrogen peroxide. FEBS Lett 42, 68–72.
-
(1974)
FEBS Lett
, vol.42
, pp. 68-72
-
-
Loschen, G.1
Azzi, A.2
Richter, C.3
Flohe, L.4
-
8
-
-
23244435445
-
The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration
-
Gibson GE, Blass JP, Beal MF and Bunik V (2005) The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration. Mol Neurobiol 31, 43–63.
-
(2005)
Mol Neurobiol
, vol.31
, pp. 43-63
-
-
Gibson, G.E.1
Blass, J.P.2
Beal, M.F.3
Bunik, V.4
-
9
-
-
4544359913
-
Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species
-
Starkov AA, Fiskum G, Chinopoulos C, Lorenzo BJ, Browne SE, Patel MS and Beal MF (2004) Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J Neurosci 24, 7779–7788.
-
(2004)
J Neurosci
, vol.24
, pp. 7779-7788
-
-
Starkov, A.A.1
Fiskum, G.2
Chinopoulos, C.3
Lorenzo, B.J.4
Browne, S.E.5
Patel, M.S.6
Beal, M.F.7
-
10
-
-
75749136883
-
Signaling functions of reactive oxygen species
-
Forman HJ, Maiorino M and Ursini F (2010) Signaling functions of reactive oxygen species. Biochemistry 49, 835–842.
-
(2010)
Biochemistry
, vol.49
, pp. 835-842
-
-
Forman, H.J.1
Maiorino, M.2
Ursini, F.3
-
11
-
-
0019948668
-
Similar activities of nerve growth factor and its homologue proinsulin in intracellular hydrogen peroxide production and metabolism in adipocytes. Transmembrane signalling relative to insulin-mimicking cellular effects
-
Mukherjee SP and Mukherjee C (1982) Similar activities of nerve growth factor and its homologue proinsulin in intracellular hydrogen peroxide production and metabolism in adipocytes. Transmembrane signalling relative to insulin-mimicking cellular effects. Biochem Pharmacol 31, 3163–3172.
-
(1982)
Biochem Pharmacol
, vol.31
, pp. 3163-3172
-
-
Mukherjee, S.P.1
Mukherjee, C.2
-
12
-
-
0030008268
-
Fenton chemistry: an introduction
-
Wardman P and Candeias LP (1996) Fenton chemistry: an introduction. Radiat Res 145, 523–531.
-
(1996)
Radiat Res
, vol.145
, pp. 523-531
-
-
Wardman, P.1
Candeias, L.P.2
-
13
-
-
77955283617
-
Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase
-
Vaarmann A, Gandhi S and Abramov AY (2010) Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase. J Biol Chem 285, 25018–25023.
-
(2010)
J Biol Chem
, vol.285
, pp. 25018-25023
-
-
Vaarmann, A.1
Gandhi, S.2
Abramov, A.Y.3
-
14
-
-
84891374075
-
Lipid peroxidation is essential for phospholipase C activity and the inositol-trisphosphate-related Ca(2)(+) signal
-
Domijan AM, Kovac S and Abramov AY (2014) Lipid peroxidation is essential for phospholipase C activity and the inositol-trisphosphate-related Ca(2)(+) signal. J Cell Sci 127, 21–26.
-
(2014)
J Cell Sci
, vol.127
, pp. 21-26
-
-
Domijan, A.M.1
Kovac, S.2
Abramov, A.Y.3
-
15
-
-
84992650853
-
Functional role of mitochondrial reactive oxygen species in physiology
-
Angelova PR and Abramov AY (2016) Functional role of mitochondrial reactive oxygen species in physiology. Free Radic Biol Med 100, 81–85.
-
(2016)
Free Radic Biol Med
, vol.100
, pp. 81-85
-
-
Angelova, P.R.1
Abramov, A.Y.2
-
16
-
-
33846818524
-
Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation
-
Abramov AY, Scorziello A and Duchen MR (2007) Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J Neurosci 27, 1129–1138.
-
(2007)
J Neurosci
, vol.27
, pp. 1129-1138
-
-
Abramov, A.Y.1
Scorziello, A.2
Duchen, M.R.3
-
17
-
-
84937700323
-
Functional Oxygen Sensitivity of Astrocytes
-
Angelova PR, Kasymov V, Christie I, Sheikhbahaei S, Turovsky E, Marina N, Korsak A, Zwicker J, Teschemacher AG, Ackland GL et al. (2015) Functional Oxygen Sensitivity of Astrocytes. J Neurosci 35, 10460–10473.
-
(2015)
J Neurosci
, vol.35
, pp. 10460-10473
-
-
Angelova, P.R.1
Kasymov, V.2
Christie, I.3
Sheikhbahaei, S.4
Turovsky, E.5
Marina, N.6
Korsak, A.7
Zwicker, J.8
Teschemacher, A.G.9
Ackland, G.L.10
-
18
-
-
85014115995
-
Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity
-
Dong Z, Shanmughapriya S, Tomar D, Siddiqui N, Lynch S, Nemani N, Breves SL, Zhang X, Tripathi A, Palaniappan P et al. (2017) Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity. Mol Cell 65, 1014–1028.
-
(2017)
Mol Cell
, vol.65
, pp. 1014-1028
-
-
Dong, Z.1
Shanmughapriya, S.2
Tomar, D.3
Siddiqui, N.4
Lynch, S.5
Nemani, N.6
Breves, S.L.7
Zhang, X.8
Tripathi, A.9
Palaniappan, P.10
-
19
-
-
84966589393
-
Mitochondrial ROS regulation of proliferating cells
-
Diebold L and Chandel NS (2016) Mitochondrial ROS regulation of proliferating cells. Free Radic Biol Med 100, 86–93.
-
(2016)
Free Radic Biol Med
, vol.100
, pp. 86-93
-
-
Diebold, L.1
Chandel, N.S.2
-
20
-
-
55949119836
-
Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease
-
Bras J, Singleton A, Cookson MR and Hardy J (2008) Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease. FEBS J 275, 5767–5773.
-
(2008)
FEBS J
, vol.275
, pp. 5767-5773
-
-
Bras, J.1
Singleton, A.2
Cookson, M.R.3
Hardy, J.4
-
21
-
-
85016814394
-
The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis
-
Hardy J (2017) The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”. FEBS J 284, 1040–1044.
-
(2017)
FEBS J
, vol.284
, pp. 1040-1044
-
-
Hardy, J.1
-
22
-
-
58349116718
-
Parkinson's disease and nursing home placement: the economic impact of the need for care
-
Vossius C, Nilsen OB and Larsen JP (2009) Parkinson's disease and nursing home placement: the economic impact of the need for care. Eur J Neurol 16, 194–200.
-
(2009)
Eur J Neurol
, vol.16
, pp. 194-200
-
-
Vossius, C.1
Nilsen, O.B.2
Larsen, J.P.3
-
23
-
-
84979780748
-
Alpha-synuclein and beta-amyloid - different targets, same players: calcium, free radicals and mitochondria in the mechanism of neurodegeneration
-
Angelova PR and Abramov AY (2017) Alpha-synuclein and beta-amyloid - different targets, same players: calcium, free radicals and mitochondria in the mechanism of neurodegeneration. Biochem Biophys Res Commun 483, 1110–1115.
-
(2017)
Biochem Biophys Res Commun
, vol.483
, pp. 1110-1115
-
-
Angelova, P.R.1
Abramov, A.Y.2
-
25
-
-
0030923869
-
Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease
-
Sheehan JP, Swerdlow RH, Miller SW, Davis RE, Parks JK, Parker WD and Tuttle JB (1997) Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease. J Neurosci 17, 4612–4622.
-
(1997)
J Neurosci
, vol.17
, pp. 4612-4622
-
-
Sheehan, J.P.1
Swerdlow, R.H.2
Miller, S.W.3
Davis, R.E.4
Parks, J.K.5
Parker, W.D.6
Tuttle, J.B.7
-
26
-
-
78649815388
-
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
-
Du H, Guo L, Yan S, Sosunov AA, McKhann GM and Yan SS (2010) Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc Natl Acad Sci USA 107, 18670–18675.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 18670-18675
-
-
Du, H.1
Guo, L.2
Yan, S.3
Sosunov, A.A.4
McKhann, G.M.5
Yan, S.S.6
-
27
-
-
28744449206
-
Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
-
Caspersen C, Wang N, Yao J, Sosunov A, Chen X, Lustbader JW, Xu HW, Stern D, McKhann G and Yan SD (2005) Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease. FASEB J 19, 2040–2041.
-
(2005)
FASEB J
, vol.19
, pp. 2040-2041
-
-
Caspersen, C.1
Wang, N.2
Yao, J.3
Sosunov, A.4
Chen, X.5
Lustbader, J.W.6
Xu, H.W.7
Stern, D.8
McKhann, G.9
Yan, S.D.10
-
28
-
-
0036272650
-
Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
-
Casley CS, Canevari L, Land JM, Clark JB and Sharpe MA (2002) Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem 80, 91–100.
-
(2002)
J Neurochem
, vol.80
, pp. 91-100
-
-
Casley, C.S.1
Canevari, L.2
Land, J.M.3
Clark, J.B.4
Sharpe, M.A.5
-
29
-
-
0032810909
-
beta-Amyloid fragment 25–35 selectively decreases complex IV activity in isolated mitochondria
-
Canevari L, Clark JB and Bates TE (1999) beta-Amyloid fragment 25–35 selectively decreases complex IV activity in isolated mitochondria. FEBS Lett 457, 131–134.
-
(1999)
FEBS Lett
, vol.457
, pp. 131-134
-
-
Canevari, L.1
Clark, J.B.2
Bates, T.E.3
-
30
-
-
84934278495
-
Cu(II) enhances the effect of Alzheimer's amyloid-beta peptide on microglial activation
-
Yu F, Gong P, Hu Z, Qiu Y, Cui Y, Gao X, Chen H and Li J (2015) Cu(II) enhances the effect of Alzheimer's amyloid-beta peptide on microglial activation. J Neuroinflammation 12, 122.
-
(2015)
J Neuroinflammation
, vol.12
, pp. 122
-
-
Yu, F.1
Gong, P.2
Hu, Z.3
Qiu, Y.4
Cui, Y.5
Gao, X.6
Chen, H.7
Li, J.8
-
32
-
-
79955764600
-
Amyloid beta-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide
-
Ma T, Hoeffer CA, Wong H, Massaad CA, Zhou P, Iadecola C, Murphy MP, Pautler RG and Klann E (2011) Amyloid beta-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide. J Neurosci 31, 5589–5595.
-
(2011)
J Neurosci
, vol.31
, pp. 5589-5595
-
-
Ma, T.1
Hoeffer, C.A.2
Wong, H.3
Massaad, C.A.4
Zhou, P.5
Iadecola, C.6
Murphy, M.P.7
Pautler, R.G.8
Klann, E.9
-
33
-
-
80155148269
-
The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease
-
McManus MJ, Murphy MP and Franklin JL (2011) The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease. J Neurosci 31, 15703–15715.
-
(2011)
J Neurosci
, vol.31
, pp. 15703-15715
-
-
McManus, M.J.1
Murphy, M.P.2
Franklin, J.L.3
-
34
-
-
84899869133
-
The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease
-
Ng LF, Gruber J, Cheah IK, Goo CK, Cheong WF, Shui G, Sit KP, Wenk MR and Halliwell B (2014) The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease. Free Radic Biol Med 71, 390–401.
-
(2014)
Free Radic Biol Med
, vol.71
, pp. 390-401
-
-
Ng, L.F.1
Gruber, J.2
Cheah, I.K.3
Goo, C.K.4
Cheong, W.F.5
Shui, G.6
Sit, K.P.7
Wenk, M.R.8
Halliwell, B.9
-
35
-
-
85037067562
-
Deuterium-reinforced polyunsaturated fatty acids improve cognition in a mouse model of sporadic Alzheimer's disease
-
Elharram A, Czegledy NM, Golod M, Milne GL, Pollock E, Bennett BM and Shchepinov MS (2017) Deuterium-reinforced polyunsaturated fatty acids improve cognition in a mouse model of sporadic Alzheimer's disease. FEBS J 284, 4083–4095.
-
(2017)
FEBS J
, vol.284
, pp. 4083-4095
-
-
Elharram, A.1
Czegledy, N.M.2
Golod, M.3
Milne, G.L.4
Pollock, E.5
Bennett, B.M.6
Shchepinov, M.S.7
-
36
-
-
84975782094
-
Mitochondrial Dysfunction in Neocortex and Hippocampus of Olfactory Bulbectomized Mice, a Model of Alzheimer's Disease
-
Avetisyan AV, Samokhin AN, Alexandrova IY, Zinovkin RA, Simonyan RA and Bobkova NV (2016) Mitochondrial Dysfunction in Neocortex and Hippocampus of Olfactory Bulbectomized Mice, a Model of Alzheimer's Disease. Biochemistry (Mosc) 81, 615–623.
-
(2016)
Biochemistry (Mosc)
, vol.81
, pp. 615-623
-
-
Avetisyan, A.V.1
Samokhin, A.N.2
Alexandrova, I.Y.3
Zinovkin, R.A.4
Simonyan, R.A.5
Bobkova, N.V.6
-
37
-
-
0345055313
-
Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production
-
Keller JN, Guo Q, Holtsberg FW, Bruce-Keller AJ and Mattson MP (1998) Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production. J Neurosci 18, 4439–4450.
-
(1998)
J Neurosci
, vol.18
, pp. 4439-4450
-
-
Keller, J.N.1
Guo, Q.2
Holtsberg, F.W.3
Bruce-Keller, A.J.4
Mattson, M.P.5
-
38
-
-
33646380409
-
The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides. Philos
-
Abramov AY and Duchen MR (2005) The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides. Philos. Trans R Soc Lond B Biol Sci 360, 2309–2314.
-
(2005)
Trans R Soc Lond B Biol Sci
, vol.360
, pp. 2309-2314
-
-
Abramov, A.Y.1
Duchen, M.R.2
-
39
-
-
3342993135
-
Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD
-
Hashimoto Y, Kaneko Y, Tsukamoto E, Frankowski H, Kouyama K, Kita Y, Niikura T, Aiso S, Bredesen DE, Matsuoka M et al. (2004) Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD. J Neurochem 90, 549–558.
-
(2004)
J Neurochem
, vol.90
, pp. 549-558
-
-
Hashimoto, Y.1
Kaneko, Y.2
Tsukamoto, E.3
Frankowski, H.4
Kouyama, K.5
Kita, Y.6
Niikura, T.7
Aiso, S.8
Bredesen, D.E.9
Matsuoka, M.10
-
40
-
-
1642499152
-
Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase
-
Abramov AY, Canevari L and Duchen MR (2004) Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci 24, 565–575.
-
(2004)
J Neurosci
, vol.24
, pp. 565-575
-
-
Abramov, A.Y.1
Canevari, L.2
Duchen, M.R.3
-
41
-
-
79957871035
-
Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death
-
Abeti R, Abramov AY and Duchen MR (2011) Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. Brain 134, 1658–1672.
-
(2011)
Brain
, vol.134
, pp. 1658-1672
-
-
Abeti, R.1
Abramov, A.Y.2
Duchen, M.R.3
-
42
-
-
84899410193
-
Rare individual amyloid-beta oligomers act on astrocytes to initiate neuronal damage
-
Narayan P, Holmstrom KM, Kim DH, Whitcomb DJ, Wilson MR, St George-Hyslop P, Wood NW, Dobson CM, Cho K, Abramov AY et al. (2014) Rare individual amyloid-beta oligomers act on astrocytes to initiate neuronal damage. Biochemistry 53, 2442–2453.
-
(2014)
Biochemistry
, vol.53
, pp. 2442-2453
-
-
Narayan, P.1
Holmstrom, K.M.2
Kim, D.H.3
Whitcomb, D.J.4
Wilson, M.R.5
St George-Hyslop, P.6
Wood, N.W.7
Dobson, C.M.8
Cho, K.9
Abramov, A.Y.10
-
43
-
-
10044244916
-
Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture
-
Abramov AY, Canevari L and Duchen MR (2004) Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture. Biochim Biophys Acta 1742, 81–87.
-
(2004)
Biochim Biophys Acta
, vol.1742
, pp. 81-87
-
-
Abramov, A.Y.1
Canevari, L.2
Duchen, M.R.3
-
44
-
-
85029634459
-
Mitochondrial Permeability Transition Pore as a Suitable Targ e t for Neuroprotective Agents Against Alzheimer's Disease
-
Shevtsova EF, Vinogradova DV, Neganova ME, Avila-Rodriguez M, Ashraf GM, Barreto GE, Bachurin SO and Aliev G (2017) Mitochondrial Permeability Transition Pore as a Suitable Targ e t for Neuroprotective Agents Against Alzheimer's Disease. CNS Neurol Disord Drug Targets 16, 677–685.
-
(2017)
CNS Neurol Disord Drug Targets
, vol.16
, pp. 677-685
-
-
Shevtsova, E.F.1
Vinogradova, D.V.2
Neganova, M.E.3
Avila-Rodriguez, M.4
Ashraf, G.M.5
Barreto, G.E.6
Bachurin, S.O.7
Aliev, G.8
-
45
-
-
53549129483
-
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
-
Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM, Yan Y, Wang C, Zhang H, Molkentin JD et al. (2008) Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med 14, 1097–1105.
-
(2008)
Nat Med
, vol.14
, pp. 1097-1105
-
-
Du, H.1
Guo, L.2
Fang, F.3
Chen, D.4
Sosunov, A.A.5
McKhann, G.M.6
Yan, Y.7
Wang, C.8
Zhang, H.9
Molkentin, J.D.10
-
46
-
-
85015423137
-
Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration
-
Esteras N, Rohrer JD, Hardy J, Wray S and Abramov AY (2017) Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration. Redox Biol 12, 410–422.
-
(2017)
Redox Biol
, vol.12
, pp. 410-422
-
-
Esteras, N.1
Rohrer, J.D.2
Hardy, J.3
Wray, S.4
Abramov, A.Y.5
-
47
-
-
84864958466
-
Cerebral hypoperfusion and cognitive impairment: the pathogenic role of vascular oxidative stress
-
Liu H and Zhang J (2012) Cerebral hypoperfusion and cognitive impairment: the pathogenic role of vascular oxidative stress. Int J Neurosci 122, 494–499.
-
(2012)
Int J Neurosci
, vol.122
, pp. 494-499
-
-
Liu, H.1
Zhang, J.2
-
48
-
-
85028316451
-
Resveratrol loaded solid lipid nanoparticles attenuate mitochondrial oxidative stress in vascular dementia by activating Nrf2/HO-1 pathway
-
Yadav A, Sunkaria A, Singhal N and Sandhir R (2018) Resveratrol loaded solid lipid nanoparticles attenuate mitochondrial oxidative stress in vascular dementia by activating Nrf2/HO-1 pathway. Neurochem Int 112, 239–254.
-
(2018)
Neurochem Int
, vol.112
, pp. 239-254
-
-
Yadav, A.1
Sunkaria, A.2
Singhal, N.3
Sandhir, R.4
-
49
-
-
26444613280
-
Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain
-
Zhang N, Komine-Kobayashi M, Tanaka R, Liu M, Mizuno Y and Urabe T (2005) Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. Stroke 36, 2220–2225.
-
(2005)
Stroke
, vol.36
, pp. 2220-2225
-
-
Zhang, N.1
Komine-Kobayashi, M.2
Tanaka, R.3
Liu, M.4
Mizuno, Y.5
Urabe, T.6
-
50
-
-
0036570159
-
Oxidatively modified proteins in aging and disease
-
Beal MF (2002) Oxidatively modified proteins in aging and disease. Free Radic Biol Med 32, 797–803.
-
(2002)
Free Radic Biol Med
, vol.32
, pp. 797-803
-
-
Beal, M.F.1
-
51
-
-
33646375711
-
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
-
Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T et al. (2006) High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 38, 515–517.
-
(2006)
Nat Genet
, vol.38
, pp. 515-517
-
-
Bender, A.1
Krishnan, K.J.2
Morris, C.M.3
Taylor, G.A.4
Reeve, A.K.5
Perry, R.H.6
Jaros, E.7
Hersheson, J.S.8
Betts, J.9
Klopstock, T.10
-
52
-
-
2942519840
-
Protection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants
-
Gonzalez-Polo RA, Soler G, Rodriguezmartin A, Moran JM and Fuentes JM (2004) Protection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants. Cell Biol Int 28, 373–380.
-
(2004)
Cell Biol Int
, vol.28
, pp. 373-380
-
-
Gonzalez-Polo, R.A.1
Soler, G.2
Rodriguezmartin, A.3
Moran, J.M.4
Fuentes, J.M.5
-
53
-
-
77950221314
-
Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations
-
Abramov AY, Smulders-Srinivasan TK, Kirby DM, Acin-Perez R, Enriquez JA, Lightowlers RN, Duchen MR and Turnbull DM (2010) Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations. Brain 133, 797–807.
-
(2010)
Brain
, vol.133
, pp. 797-807
-
-
Abramov, A.Y.1
Smulders-Srinivasan, T.K.2
Kirby, D.M.3
Acin-Perez, R.4
Enriquez, J.A.5
Lightowlers, R.N.6
Duchen, M.R.7
Turnbull, D.M.8
-
54
-
-
12144284373
-
Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease
-
Andrews ZB, Horvath B, Barnstable CJ, Elsworth J, Yang L, Beal MF, Roth RH, Matthews RT and Horvath TL (2005) Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. J Neurosci 25, 184–191.
-
(2005)
J Neurosci
, vol.25
, pp. 184-191
-
-
Andrews, Z.B.1
Horvath, B.2
Barnstable, C.J.3
Elsworth, J.4
Yang, L.5
Beal, M.F.6
Roth, R.H.7
Matthews, R.T.8
Horvath, T.L.9
-
55
-
-
69249214308
-
DJ-1 changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALS
-
Lev N, Ickowicz D, Barhum Y, Melamed E and Offen D (2009) DJ-1 changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALS. J Mol Neurosci 38, 94–102.
-
(2009)
J Mol Neurosci
, vol.38
, pp. 94-102
-
-
Lev, N.1
Ickowicz, D.2
Barhum, Y.3
Melamed, E.4
Offen, D.5
-
56
-
-
25444514752
-
Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress
-
Li HM, Niki T, Taira T, Iguchi-Ariga SM and Ariga H (2005) Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress. Free Radic Res 39, 1091–1099.
-
(2005)
Free Radic Res
, vol.39
, pp. 1091-1099
-
-
Li, H.M.1
Niki, T.2
Taira, T.3
Iguchi-Ariga, S.M.4
Ariga, H.5
-
57
-
-
78649866553
-
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
-
Guzman JN, Sanchez-Padilla J, Wokosin D, Kondapalli J, Ilijic E, Schumacker PT and Surmeier DJ (2010) Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468, 696–700.
-
(2010)
Nature
, vol.468
, pp. 696-700
-
-
Guzman, J.N.1
Sanchez-Padilla, J.2
Wokosin, D.3
Kondapalli, J.4
Ilijic, E.5
Schumacker, P.T.6
Surmeier, D.J.7
-
58
-
-
61649088435
-
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death
-
Gandhi S, Wood-Kaczmar A, Yao Z, Plun-Favreau H, Deas E, Klupsch K, Downward J, Latchman DS, Tabrizi SJ, Wood NW et al. (2009) PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell 33, 627–638.
-
(2009)
Mol Cell
, vol.33
, pp. 627-638
-
-
Gandhi, S.1
Wood-Kaczmar, A.2
Yao, Z.3
Plun-Favreau, H.4
Deas, E.5
Klupsch, K.6
Downward, J.7
Latchman, D.S.8
Tabrizi, S.J.9
Wood, N.W.10
-
59
-
-
56349137588
-
Mitochondrial respiratory dysfunction in familiar parkinsonism associated with PINK1 mutation
-
Piccoli C, Sardanelli A, Scrima R, Ripoli M, Quarato G, D'Aprile A, Bellomo F, Scacco S, De MG, Filla A et al. (2008) Mitochondrial respiratory dysfunction in familiar parkinsonism associated with PINK1 mutation. Neurochem Res 33, 2565–2574.
-
(2008)
Neurochem Res
, vol.33
, pp. 2565-2574
-
-
Piccoli, C.1
Sardanelli, A.2
Scrima, R.3
Ripoli, M.4
Quarato, G.5
D'Aprile, A.6
Bellomo, F.7
Scacco, S.8
De, M.G.9
Filla, A.10
-
60
-
-
80054765940
-
Bioenergetic consequences of PINK1 mutations in Parkinson disease
-
Abramov AY, Gegg M, Grunewald A, Wood NW, Klein C and Schapira AH (2011) Bioenergetic consequences of PINK1 mutations in Parkinson disease. PLoS One 6, e25622.
-
(2011)
PLoS One
, vol.6
-
-
Abramov, A.Y.1
Gegg, M.2
Grunewald, A.3
Wood, N.W.4
Klein, C.5
Schapira, A.H.6
-
61
-
-
33846288002
-
Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6
-
Hoepken HH, Gispert S, Morales B, Wingerter O, Del TD, Mulsch A, Nussbaum RL, Muller K, Drose S, Brandt U et al. (2007) Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol Dis 25, 401–411.
-
(2007)
Neurobiol Dis
, vol.25
, pp. 401-411
-
-
Hoepken, H.H.1
Gispert, S.2
Morales, B.3
Wingerter, O.4
Del, T.D.5
Mulsch, A.6
Nussbaum, R.L.7
Muller, K.8
Drose, S.9
Brandt, U.10
-
62
-
-
84944076528
-
PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons
-
Kostic M, Ludtmann MH, Bading H, Hershfinkel M, Steer E, Chu CT, Abramov AY and Sekler I (2015) PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons. Cell Rep 13, 376–386.
-
(2015)
Cell Rep
, vol.13
, pp. 376-386
-
-
Kostic, M.1
Ludtmann, M.H.2
Bading, H.3
Hershfinkel, M.4
Steer, E.5
Chu, C.T.6
Abramov, A.Y.7
Sekler, I.8
-
63
-
-
84900993015
-
PINK1 deficiency in beta-cells increases basal insulin secretion and improves glucose tolerance in mice
-
Deas E, Piipari K, Machhada A, Li A, Gutierrez-del-Arroyo A, Withers DJ, Wood NW and Abramov AY (2014) PINK1 deficiency in beta-cells increases basal insulin secretion and improves glucose tolerance in mice. Open Biol 4, 140051.
-
(2014)
Open Biol
, vol.4
, pp. 140051
-
-
Deas, E.1
Piipari, K.2
Machhada, A.3
Li, A.4
Gutierrez-del-Arroyo, A.5
Withers, D.J.6
Wood, N.W.7
Abramov, A.Y.8
-
64
-
-
84938775013
-
The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics
-
Dinkova-Kostova AT, Baird L, Holmstrom KM, Meyer CJ and Abramov AY (2015) The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics. Biochem Soc Trans 43, 602–610.
-
(2015)
Biochem Soc Trans
, vol.43
, pp. 602-610
-
-
Dinkova-Kostova, A.T.1
Baird, L.2
Holmstrom, K.M.3
Meyer, C.J.4
Abramov, A.Y.5
-
65
-
-
84861476741
-
Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease
-
Gandhi S, Vaarmann A, Yao Z, Duchen MR, Wood NW and Abramov AY (2012) Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease. PLoS One 7, e37564.
-
(2012)
PLoS One
, vol.7
-
-
Gandhi, S.1
Vaarmann, A.2
Yao, Z.3
Duchen, M.R.4
Wood, N.W.5
Abramov, A.Y.6
-
66
-
-
85030765773
-
Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin
-
Xiao B, Goh JY, Xiao L, Xian H, Lim KL and Liou YC (2017) Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. J Biol Chem 292, 16697–16708.
-
(2017)
J Biol Chem
, vol.292
, pp. 16697-16708
-
-
Xiao, B.1
Goh, J.Y.2
Xiao, L.3
Xian, H.4
Lim, K.L.5
Liou, Y.C.6
-
67
-
-
85016419081
-
Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases
-
Berger NA, Besson VC, Boulares AH, Burkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL et al. (2018) Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases. Br J Pharmacol 175, 192–222.
-
(2018)
Br J Pharmacol
, vol.175
, pp. 192-222
-
-
Berger, N.A.1
Besson, V.C.2
Boulares, A.H.3
Burkle, A.4
Chiarugi, A.5
Clark, R.S.6
Curtin, N.J.7
Cuzzocrea, S.8
Dawson, T.M.9
Dawson, V.L.10
-
68
-
-
84989266728
-
Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation
-
Delgado-Camprubi M, Esteras N, Soutar MP, Plun-Favreau H and Abramov AY (2017) Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation. Cell Death Differ 24, 120–131.
-
(2017)
Cell Death Differ
, vol.24
, pp. 120-131
-
-
Delgado-Camprubi, M.1
Esteras, N.2
Soutar, M.P.3
Plun-Favreau, H.4
Abramov, A.Y.5
-
69
-
-
84991490229
-
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase
-
Ludtmann MH, Angelova PR, Ninkina NN, Gandhi S, Buchman VL and Abramov AY (2016) Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase. J Neurosci 36, 10510–10521.
-
(2016)
J Neurosci
, vol.36
, pp. 10510-10521
-
-
Ludtmann, M.H.1
Angelova, P.R.2
Ninkina, N.N.3
Gandhi, S.4
Buchman, V.L.5
Abramov, A.Y.6
-
70
-
-
84878994255
-
Properties of native brain alpha-synuclein
-
Burre J, Vivona S, Diao J, Sharma M, Brunger AT and Sudhof TC (2013) Properties of native brain alpha-synuclein. Nature 498, E4–E6.
-
(2013)
Nature
, vol.498
, pp. E4-E6
-
-
Burre, J.1
Vivona, S.2
Diao, J.3
Sharma, M.4
Brunger, A.T.5
Sudhof, T.C.6
-
71
-
-
58149379599
-
Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria
-
Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M and Edwards RH (2008) Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria. J Neurosci 28, 12305–12317.
-
(2008)
J Neurosci
, vol.28
, pp. 12305-12317
-
-
Nakamura, K.1
Nemani, V.M.2
Wallender, E.K.3
Kaehlcke, K.4
Ott, M.5
Edwards, R.H.6
-
72
-
-
84954311788
-
Aggregated alpha-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
-
Reeve AK, Ludtmann MH, Angelova PR, Simcox EM, Horrocks MH, Klenerman D, Gandhi S, Turnbull DM and Abramov AY (2015) Aggregated alpha-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons. Cell Death Dis 6, e1820.
-
(2015)
Cell Death Dis
, vol.6
-
-
Reeve, A.K.1
Ludtmann, M.H.2
Angelova, P.R.3
Simcox, E.M.4
Horrocks, M.H.5
Klenerman, D.6
Gandhi, S.7
Turnbull, D.M.8
Abramov, A.Y.9
-
73
-
-
84905372211
-
Soluble, prefibrillar alpha-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction
-
Luth ES, Stavrovskaya IG, Bartels T, Kristal BS and Selkoe DJ (2014) Soluble, prefibrillar alpha-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction. J Biol Chem 289, 21490–21507.
-
(2014)
J Biol Chem
, vol.289
, pp. 21490-21507
-
-
Luth, E.S.1
Stavrovskaya, I.G.2
Bartels, T.3
Kristal, B.S.4
Selkoe, D.J.5
-
74
-
-
58849086657
-
Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson's disease cybrids
-
Esteves AR, Arduino DM, Swerdlow RH, Oliveira CR and Cardoso SM (2009) Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson's disease cybrids. Antioxid Redox Signal 11, 439–448.
-
(2009)
Antioxid Redox Signal
, vol.11
, pp. 439-448
-
-
Esteves, A.R.1
Arduino, D.M.2
Swerdlow, R.H.3
Oliveira, C.R.4
Cardoso, S.M.5
-
75
-
-
84959254675
-
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
-
Deas E, Cremades N, Angelova PR, Ludtmann MH, Yao Z, Chen S, Horrocks MH, Banushi B, Little D, Devine MJ et al. (2016) Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease. Antioxid Redox Signal 24, 376–391.
-
(2016)
Antioxid Redox Signal
, vol.24
, pp. 376-391
-
-
Deas, E.1
Cremades, N.2
Angelova, P.R.3
Ludtmann, M.H.4
Yao, Z.5
Chen, S.6
Horrocks, M.H.7
Banushi, B.8
Little, D.9
Devine, M.J.10
-
76
-
-
84927599056
-
Lipid peroxidation is essential for alpha-synuclein-induced cell death
-
Angelova PR, Horrocks MH, Klenerman D, Gandhi S, Abramov AY and Shchepinov MS (2015) Lipid peroxidation is essential for alpha-synuclein-induced cell death. J Neurochem 133, 582–589.
-
(2015)
J Neurochem
, vol.133
, pp. 582-589
-
-
Angelova, P.R.1
Horrocks, M.H.2
Klenerman, D.3
Gandhi, S.4
Abramov, A.Y.5
Shchepinov, M.S.6
-
77
-
-
0031056409
-
Which clinical features differentiate progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) from related disorders? A clinicopathological study
-
Litvan I, Campbell G, Mangone CA, Verny M, McKee A, Chaudhuri KR, Jellinger K, Pearce RK and D'Olhaberriague L (1997) Which clinical features differentiate progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) from related disorders? A clinicopathological study Brain 120 (Pt 1), 65–74.
-
(1997)
Brain
, vol.120
, pp. 65-74
-
-
Litvan, I.1
Campbell, G.2
Mangone, C.A.3
Verny, M.4
McKee, A.5
Chaudhuri, K.R.6
Jellinger, K.7
Pearce, R.K.8
D'Olhaberriague, L.9
-
78
-
-
85032264354
-
Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation
-
Angelova PR, Barilani M, Lovejoy C, Dossena M, Vigano M, Seresini A, Piga D, Gandhi S, Pezzoli G, Abramov AY et al. (2018) Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation. Redox Biol 14, 474–484.
-
(2018)
Redox Biol
, vol.14
, pp. 474-484
-
-
Angelova, P.R.1
Barilani, M.2
Lovejoy, C.3
Dossena, M.4
Vigano, M.5
Seresini, A.6
Piga, D.7
Gandhi, S.8
Pezzoli, G.9
Abramov, A.Y.10
-
79
-
-
84865654196
-
Amyotrophic lateral sclerosis: new insights into underlying molecular mechanisms and opportunities for therapeutic intervention
-
Cozzolino M, Pesaresi MG, Gerbino V, Grosskreutz J and Carri MT (2012) Amyotrophic lateral sclerosis: new insights into underlying molecular mechanisms and opportunities for therapeutic intervention. Antioxid Redox Signal 17, 1277–1330.
-
(2012)
Antioxid Redox Signal
, vol.17
, pp. 1277-1330
-
-
Cozzolino, M.1
Pesaresi, M.G.2
Gerbino, V.3
Grosskreutz, J.4
Carri, M.T.5
-
80
-
-
84860650335
-
Mitochondrial dysfunction in ALS
-
Cozzolino M and Carri MT (2012) Mitochondrial dysfunction in ALS. Prog Neurobiol 97, 54–66.
-
(2012)
Prog Neurobiol
, vol.97
, pp. 54-66
-
-
Cozzolino, M.1
Carri, M.T.2
-
81
-
-
0029587548
-
Studies on cellular free radical protection mechanisms in the anterior horn from patients with amyotrophic lateral sclerosis
-
Shaw IC, Fitzmaurice PS, Mitchell JD and Lynch PG (1995) Studies on cellular free radical protection mechanisms in the anterior horn from patients with amyotrophic lateral sclerosis. Neurodegeneration 4, 391–396.
-
(1995)
Neurodegeneration
, vol.4
, pp. 391-396
-
-
Shaw, I.C.1
Fitzmaurice, P.S.2
Mitchell, J.D.3
Lynch, P.G.4
-
82
-
-
0035955478
-
Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients
-
Shibata N, Nagai R, Uchida K, Horiuchi S, Yamada S, Hirano A, Kawaguchi M, Yamamoto T, Sasaki S and Kobayashi M (2001) Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients. Brain Res 917, 97–104.
-
(2001)
Brain Res
, vol.917
, pp. 97-104
-
-
Shibata, N.1
Nagai, R.2
Uchida, K.3
Horiuchi, S.4
Yamada, S.5
Hirano, A.6
Kawaguchi, M.7
Yamamoto, T.8
Sasaki, S.9
Kobayashi, M.10
-
83
-
-
0035070937
-
Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation
-
Shibata N (2001) Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation. Neuropathology 21, 82–92.
-
(2001)
Neuropathology
, vol.21
, pp. 82-92
-
-
Shibata, N.1
-
84
-
-
84887340065
-
UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis
-
Peixoto PM, Kim HJ, Sider B, Starkov A, Horvath TL and Manfredi G (2013) UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis. Mol Cell Neurosci 57, 104–110.
-
(2013)
Mol Cell Neurosci
, vol.57
, pp. 104-110
-
-
Peixoto, P.M.1
Kim, H.J.2
Sider, B.3
Starkov, A.4
Horvath, T.L.5
Manfredi, G.6
-
85
-
-
84991320347
-
Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts
-
Onesto E, Colombrita C, Gumina V, Borghi MO, Dusi S, Doretti A, Fagiolari G, Invernizzi F, Moggio M, Tiranti V et al. (2016) Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts. Acta Neuropathol Commun 4, 47.
-
(2016)
Acta Neuropathol Commun
, vol.4
, pp. 47
-
-
Onesto, E.1
Colombrita, C.2
Gumina, V.3
Borghi, M.O.4
Dusi, S.5
Doretti, A.6
Fagiolari, G.7
Invernizzi, F.8
Moggio, M.9
Tiranti, V.10
-
86
-
-
85019197514
-
Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates
-
Bartolome F, Esteras N, Martin-Requero A, Boutoleau-Bretonniere C, Vercelletto M, Gabelle A, Le Ber I, Honda T, Dinkova-Kostova AT, Hardy J et al. (2017) Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates. Sci Rep, 7, 1666.
-
(2017)
Sci Rep
, vol.7
, pp. 1666
-
-
Bartolome, F.1
Esteras, N.2
Martin-Requero, A.3
Boutoleau-Bretonniere, C.4
Vercelletto, M.5
Gabelle, A.6
Le, B.I.7
Honda, T.8
Dinkova-Kostova, A.T.9
Hardy, J.10
-
87
-
-
84870387253
-
Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model
-
Brunetti D, Dusi S, Morbin M, Uggetti A, Moda F, D'Amato I, Giordano C, d'Amati G, Cozzi A, Levi S et al. (2012) Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model. Hum Mol Genet 21, 5294–5305.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 5294-5305
-
-
Brunetti, D.1
Dusi, S.2
Morbin, M.3
Uggetti, A.4
Moda, F.5
D'Amato, I.6
Giordano, C.7
d'Amati, G.8
Cozzi, A.9
Levi, S.10
-
88
-
-
84989938145
-
Coenzyme A corrects pathological defects in human neurons of PANK2-associated neurodegeneration
-
Orellana DI, Santambrogio P, Rubio A, Yekhlef L, Cancellieri C, Dusi S, Giannelli SG, Venco P, Mazzara PG, Cozzi A et al. (2016) Coenzyme A corrects pathological defects in human neurons of PANK2-associated neurodegeneration. EMBO Mol Med 8, 1197–1211.
-
(2016)
EMBO Mol Med
, vol.8
, pp. 1197-1211
-
-
Orellana, D.I.1
Santambrogio, P.2
Rubio, A.3
Yekhlef, L.4
Cancellieri, C.5
Dusi, S.6
Giannelli, S.G.7
Venco, P.8
Mazzara, P.G.9
Cozzi, A.10
-
89
-
-
85029849263
-
iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease
-
Arber C, Angelova PR, Wiethoff S, Tsuchiya Y, Mazzacuva F, Preza E, Bhatia KP, Mills K, Gout I, Abramov AY et al. (2017) iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease. PLoS One 12, e0184104.
-
(2017)
PLoS One
, vol.12
-
-
Arber, C.1
Angelova, P.R.2
Wiethoff, S.3
Tsuchiya, Y.4
Mazzacuva, F.5
Preza, E.6
Bhatia, K.P.7
Mills, K.8
Gout, I.9
Abramov, A.Y.10
-
90
-
-
85037081102
-
Neurodegeneration with brain iron accumulation
-
Wiethoff S and Houlden H (2017) Neurodegeneration with brain iron accumulation. Handb Clin Neurol 145, 157–166.
-
(2017)
Handb Clin Neurol
, vol.145
, pp. 157-166
-
-
Wiethoff, S.1
Houlden, H.2
-
91
-
-
33745553895
-
PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron
-
Morgan NV, Westaway SK, Morton JE, Gregory A, Gissen P, Sonek S, Cangul H, Coryell J, Canham N, Nardocci N et al. (2006) PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron. Nat Genet 38, 752–754.
-
(2006)
Nat Genet
, vol.38
, pp. 752-754
-
-
Morgan, N.V.1
Westaway, S.K.2
Morton, J.E.3
Gregory, A.4
Gissen, P.5
Sonek, S.6
Cangul, H.7
Coryell, J.8
Canham, N.9
Nardocci, N.10
-
92
-
-
85002770488
-
PLA2G6 mutations related to distinct phenotypes: a new case with early-onset parkinsonism
-
Giri A, Guven G, Hanagasi H, Hauser AK, Erginul-Unaltuna N, Bilgic B, Gurvit H, Heutink P, Gasser T, Lohmann E et al. (2016) PLA2G6 mutations related to distinct phenotypes: a new case with early-onset parkinsonism. Tremor Other Hyperkinet Mov (NY) 6, 363.
-
(2016)
Tremor Other Hyperkinet Mov (NY)
, vol.6
, pp. 363
-
-
Giri, A.1
Guven, G.2
Hanagasi, H.3
Hauser, A.K.4
Erginul-Unaltuna, N.5
Bilgic, B.6
Gurvit, H.7
Heutink, P.8
Gasser, T.9
Lohmann, E.10
-
93
-
-
84936791921
-
Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction
-
Kinghorn KJ, Castillo-Quan JI, Bartolome F, Angelova PR, Li L, Pope S, Cocheme HM, Khan S, Asghari S, Bhatia KP et al. (2015) Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction. Brain 138, 1801–1816.
-
(2015)
Brain
, vol.138
, pp. 1801-1816
-
-
Kinghorn, K.J.1
Castillo-Quan, J.I.2
Bartolome, F.3
Angelova, P.R.4
Li, L.5
Pope, S.6
Cocheme, H.M.7
Khan, S.8
Asghari, S.9
Bhatia, K.P.10
-
94
-
-
85017618880
-
Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich's ataxia
-
Abeti R, Parkinson MH, Hargreaves IP, Angelova PR, Sandi C, Pook MA, Giunti P and Abramov AY (2016) Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich's ataxia. Cell Death Dis 7, e2237.
-
(2016)
Cell Death Dis
, vol.7
-
-
Abeti, R.1
Parkinson, M.H.2
Hargreaves, I.P.3
Angelova, P.R.4
Sandi, C.5
Pook, M.A.6
Giunti, P.7
Abramov, A.Y.8
-
95
-
-
84938099619
-
Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia
-
Abeti R, Uzun E, Renganathan I, Honda T, Pook MA and Giunti P (2015) Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia. Pharmacol Res 99, 344–350.
-
(2015)
Pharmacol Res
, vol.99
, pp. 344-350
-
-
Abeti, R.1
Uzun, E.2
Renganathan, I.3
Honda, T.4
Pook, M.A.5
Giunti, P.6
-
96
-
-
85020286880
-
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients
-
Quinti L, Dayalan NS, Trager U, Chen X, Kegel-Gleason K, Lleres D, Connolly C, Chopra V, Low C, Moniot S et al. (2017) KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients. Proc Natl Acad Sci USA 114, E4676–E4685.
-
(2017)
Proc Natl Acad Sci USA
, vol.114
, pp. E4676-E4685
-
-
Quinti, L.1
Dayalan, N.S.2
Trager, U.3
Chen, X.4
Kegel-Gleason, K.5
Lleres, D.6
Connolly, C.7
Chopra, V.8
Low, C.9
Moniot, S.10
-
97
-
-
84978757596
-
SIRT2- and NRF2-targeting thiazole-containing compound with therapeutic activity in Huntington's disease models
-
Quinti L, Casale M, Moniot S, Pais TF, Van Kanegan MJ, Kaltenbach LS, Pallos J, Lim RG, Naidu SD, Runne H et al. (2016) SIRT2- and NRF2-targeting thiazole-containing compound with therapeutic activity in Huntington's disease models. Cell Chem Biol 23, 849–861.
-
(2016)
Cell Chem Biol
, vol.23
, pp. 849-861
-
-
Quinti, L.1
Casale, M.2
Moniot, S.3
Pais, T.F.4
Van Kanegan, M.J.5
Kaltenbach, L.S.6
Pallos, J.7
Lim, R.G.8
Naidu, S.D.9
Runne, H.10
|