UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis

Molecular and Cellular Neuroscience

Volumn 57, Issue , 2013, Pages 104-110

  Peixoto, Pablo M ^a,b   Kim, Hyun Jeong ^a   Sider, Brittany ^a   Starkov, Anatoly ^a   Horvath, Tamas L ^c   Manfredi, Giovanni ^a  

^a FEIL FAMILY BRAIN AND MIND RESEARCH INSTITUTE   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ALS; Mitochondria; SOD1; UCP2

Indexed keywords

ANTIMYCIN A1; CALCIUM ION; REACTIVE OXYGEN METABOLITE; ROTENONE; UNCOUPLING PROTEIN 2;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN MITOCHONDRION; CALCIUM TRANSPORT; CELL ENERGY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DISEASE COURSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; GENE OVEREXPRESSION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALS; AMYOTROPHIC LATERAL SCLEROSIS; CENTRAL NERVOUS SYSTEM; CNS; HUCP2; HUMAN UNCOUPLING PROTEIN 2; MITOCHONDRIA; NON-TRANSGENIC; NTG; REACTIVE OXYGEN SPECIES; RESPIRATORY QUOTIENT; ROS; RQ; SOD1; SUPEROXIDE DISMUTASE 1; UCP2;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTIMYCIN A; CALCIUM; DISEASE PROGRESSION; HUMANS; ION CHANNELS; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUTATION; REACTIVE OXYGEN SPECIES; ROTENONE; SUPEROXIDE DISMUTASE; UNCOUPLING AGENTS;

EID: 84887340065     PISSN: 10447431     EISSN: 10959327     Source Type: Journal    
DOI: 10.1016/j.mcn.2013.10.002     Document Type: Article

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