Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage

Biochemistry

Volumn 53, Issue 15, 2014, Pages 2442-2453

  Narayan, Priyanka ^a,h   Holmström, Kira M ^b,i   Kim, Dong Hyun ^c   Whitcomb, Daniel J ^c   Wilson, Mark R ^d   St George Hyslop, Peter ^e,f   Wood, Nicholas W ^b   Dobson, Christopher M ^a   Cho, Kwangwook ^c,g   Abramov, Andrey Y ^b   Klenerman, David ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF WOLLONGONG   (Australia)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF TORONTO   (Canada)

^g UNIVERSITY OF BRISTOL   (United Kingdom)

^h WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

ⁱ NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; NEURODEGENERATIVE DISEASES; NEURONS;

ALZHEIMER'S DISEASE; CASPASE-3 ACTIVATION; INTRACELLULAR CALCIUM; LONG-TERM POTENTIATIONS; PHYSIOLOGICAL DAMAGES; QUANTITATIVE APPROACH; SINGLE-MOLECULE TECHNIQUE; SPECIFIC INTERACTION;

OLIGOMERS;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; CALCIUM; CASPASE 3; CHAPERONE; CLUSTERIN; OLIGOMER; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DAMAGE; ENZYME ACTIVATION; FLUORESCENCE; HIPPOCAMPUS; LONG TERM POTENTIATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SYNAPSE;

AMYLOID BETA-PEPTIDES; ANIMALS; ASTROCYTES; BIOPOLYMERS; CALCIUM; CASPASE 3; ENZYME ACTIVATION; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84899410193     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401606f     Document Type: Article

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