Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity

Molecular Cell

Volumn 65, Issue 6, 2017, Pages 1014-1028.e7

  Dong, Zhiwei ^a,e   Shanmughapriya, Santhanam ^a   Tomar, Dhanendra ^a   Siddiqui, Naveed ^b   Lynch, Solomon ^c   Nemani, Neeharika ^a   Breves, Sarah L ^a   Zhang, Xueqian ^a   Tripathi, Aparna ^a   Palaniappan, Palaniappan ^a   Riitano, Massimo F ^a   Worth, Alison M ^a   Seelam, Ajay ^a   Carvalho, Edmund ^a   Subbiah, Ramasamy ^a   Jaña, Fabián ^a   Soboloff, Jonathan ^a   Peng, Yizhi ^e   Cheung, Joseph Y ^a   Joseph, Suresh K ^d   Caplan, Jeffrey ^c   Rajan, Sudarsan ^a   Stathopulos, Peter B ^b   Madesh, Muniswamy ^a   more..

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF DELAWARE   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

bioenergetics; calcium; EMRE; gluathionylation; MCU; MCUR1; MICU1; MICU2; mitochondria; reactive oxygen species

Indexed keywords

CALCIUM; CYSTEINE; MITOCHONDRIAL CALCIUM UNIPORTER; OLIGOMER; UNCLASSIFIED DRUG; CALCIUM CHANNEL; GLUTATHIONE; LIPOPOLYSACCHARIDE; REACTIVE OXYGEN METABOLITE; THROMBIN;

ARTICLE; BIOENERGY; CALCIUM TRANSPORT; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; OXIDATION; OXIDATIVE STRESS; PROTEIN PROTEIN INTERACTION; ANIMAL; C57BL MOUSE; CALCIUM SIGNALING; CELL HYPOXIA; CHANNEL GATING; CHEMISTRY; CHLOROCEBUS AETHIOPS; CV-1 CELL LINE; DRUG EFFECTS; ENDOTHELIUM CELL; ENERGY METABOLISM; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; MOUSE; MUTATION; OXIDATION REDUCTION REACTION; PATHOLOGY; PROTEIN MULTIMERIZATION; PROTEIN PROCESSING; PROTEIN QUATERNARY STRUCTURE; STRUCTURE ACTIVITY RELATION; TIME FACTOR;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; CELL DEATH; CELL HYPOXIA; CERCOPITHECUS AETHIOPS; COS CELLS; CYSTEINE; ENDOTHELIAL CELLS; ENERGY METABOLISM; GLUTATHIONE; HEK293 CELLS; HELA CELLS; HUMANS; ION CHANNEL GATING; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MUTATION; OXIDATION-REDUCTION; PROTEIN MULTIMERIZATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, QUATERNARY; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; TIME FACTORS; TRANSFECTION;

EID: 85014115995     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2017.01.032     Document Type: Article

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