Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction

Journal of Biological Chemistry

Volumn 289, Issue 31, 2014, Pages 21490-21507

  Luth, Eric S ^a   Stavrovskaya, Irina G ^b   Bartels, Tim ^a   Kristal, Bruce S ^b   Selkoe, Dennis J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; OLIGOMERS;

AGGREGATION STATE; MEMBRANE POTENTIALS; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL FUNCTION; MITOCHONDRIAL SWELLING; NEURONAL POPULATIONS; PARKINSON DISEASE; PERMEABILITY TRANSITION PORES;

MITOCHONDRIA;

ALPHA SYNUCLEIN; CALCIUM ION; CYTOCHROME C; HYDROGEN PEROXIDE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; OLIGOMER; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOFLAVINE; BIOPOLYMER; CALCIUM; THIAZOLE DERIVATIVE;

ARTICLE; BETA SHEET; CALCIUM HOMEOSTASIS; CELL ISOLATION; CELL MEMBRANE DEPOLARIZATION; CELL STRESS; CONTROLLED STUDY; CYTOSOL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; ENZYME ACTIVITY; FLUOROMETRY; HUMAN; HYDROPHILICITY; IMMUNOREACTIVITY; LIGHT SCATTERING; MITOCHONDRION; MITOCHONDRION SWELLING; NONHUMAN; OSCILLATION; PARKINSON DISEASE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PURIFICATION; PROTEIN SECRETION; WESTERN BLOTTING; ANIMAL; CHEMISTRY; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; PHYSIOLOGY;

ALPHA-SYNUCLEIN; ANIMALS; BIOPOLYMERS; CALCIUM; ELECTRON TRANSPORT COMPLEX I; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; THIAZOLES;

EID: 84905372211     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.545749     Document Type: Article

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