-
1
-
-
0035997249
-
Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins
-
Atwood C.S., Martins R.N., Smith M.A., and Perry G. (2002) Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins. Peptides 23, 1343-1350.
-
(2002)
Peptides
, vol.23
, pp. 1343-1350
-
-
Atwood, C.S.1
Martins, R.N.2
Smith, M.A.3
Perry, G.4
-
2
-
-
12144289492
-
Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: Implications for Alzheimer's disease
-
Planel E., Miyasaka T., Launey T., et al. (2004) Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease. J. Neurosci. 24, 2401-2411.
-
(2004)
J. Neurosci.
, vol.24
, pp. 2401-2411
-
-
Planel, E.1
Miyasaka, T.2
Launey, T.3
-
4
-
-
0027131501
-
Thiamine-dependent enzyme changes in the brains of alcoholics: Relationship to the Wernicke-Korsakoff syndrome
-
Butterworth R.F., Kril J.J., and Harper C.G. (1993) Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome. Alcohol Clin. Exp. Res. 17, 1084-1088.
-
(1993)
Alcohol Clin. Exp. Res.
, vol.17
, pp. 1084-1088
-
-
Butterworth, R.F.1
Kril, J.J.2
Harper, C.G.3
-
5
-
-
1642294173
-
Age and ApoE genotype interaction in Alzheimer's disease: An FDG-PET study
-
Mosconi L., Sorbi S., Nacmias B., et al. (2004) Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study. Psychiatry Res. 130, 141-151.
-
(2004)
Psychiatry Res.
, vol.130
, pp. 141-151
-
-
Mosconi, L.1
Sorbi, S.2
Nacmias, B.3
-
6
-
-
1542407369
-
Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease
-
Mosconi L., Nacmias B., Sorbi S., et al. (2004) Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 75, 370-376.
-
(2004)
J. Neurol. Neurosurg. Psychiatry
, vol.75
, pp. 370-376
-
-
Mosconi, L.1
Nacmias, B.2
Sorbi, S.3
-
7
-
-
0347719366
-
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
-
Reiman E.M., Chen K., Alexander G.E., et al. (2004) Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia. Proc. Natl. Acad. Sci. USA 101, 284-289.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 284-289
-
-
Reiman, E.M.1
Chen, K.2
Alexander, G.E.3
-
8
-
-
0034974107
-
Hippocampal formation glucose metabolism and volume losses in MCI and AD
-
De Santi S., de Leon M.J., Rusinek H., et al. (2001) Hippocampal formation glucose metabolism and volume losses in MCI and AD. Neurobiol. Aging 22, 529-539.
-
(2001)
Neurobiol. Aging
, vol.22
, pp. 529-539
-
-
De Santi, S.1
De Leon, M.J.2
Rusinek, H.3
-
9
-
-
0035953137
-
Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment
-
Arnaiz E., Jelic V., Almkvist O., et al. (2001) Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment. Neuroreport 12, 851-855.
-
(2001)
Neuroreport
, vol.12
, pp. 851-855
-
-
Arnaiz, E.1
Jelic, V.2
Almkvist, O.3
-
10
-
-
0035845499
-
Prediction of cognitive decline in normal elderly subjects with 2- 2-[(18)F]fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET)
-
de Leon M.J., Convit A., Wolf O.T., et al. (2001) Prediction of cognitive decline in normal elderly subjects with 2- 2-[(18)F]fluoro-2-deoxy-D-glucose/ positron-emission tomography (FDG/PET). Proc. Natl. Acad. Sci. USA 98, 10,966-10,971.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10966-10971
-
-
Leon, M.J.1
Convit, A.2
Wolf, O.T.3
-
11
-
-
0036235195
-
Longitudinal PET Evaluation of cerebral metabolic decline in dementia: A potential outcome measure in Alzheimer's disease treatment studies
-
Alexander G.E., Chen K., Pietrini P., Rapoport S.I., and Reiman E.M. (2002) Longitudinal PET Evaluation of cerebral metabolic decline in dementia: a potential outcome measure in Alzheimer's disease treatment studies. Am. J. Psychiatry 159, 738-745.
-
(2002)
Am. J. Psychiatry
, vol.159
, pp. 738-745
-
-
Alexander, G.E.1
Chen, K.2
Pietrini, P.3
Rapoport, S.I.4
Reiman, E.M.5
-
12
-
-
84903202261
-
Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease
-
Shoghi-Jadid K., Small G.W., Agdeppa E.D., et al. (2002) Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am. J. Geriatr. Psychiatry 10, 24-35.
-
(2002)
Am. J. Geriatr. Psychiatry
, vol.10
, pp. 24-35
-
-
Shoghi-Jadid, K.1
Small, G.W.2
Agdeppa, E.D.3
-
13
-
-
0026597107
-
Glucose and memory in mild senile dementia of the Alzheimer type
-
Craft S., Zallen G., and Baker L.D. (1992) Glucose and memory in mild senile dementia of the Alzheimer type. J. Clin. Exp. Neuropsychol. 14, 253-267.
-
(1992)
J. Clin. Exp. Neuropsychol.
, vol.14
, pp. 253-267
-
-
Craft, S.1
Zallen, G.2
Baker, L.D.3
-
14
-
-
0036176504
-
Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein
-
Niwa K., Kazama K., Younkin S.G., Carlson G.A., and Iadecola C. (2002) Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein. Neurobiol Dis. 9, 61-68.
-
(2002)
Neurobiol Dis.
, vol.9
, pp. 61-68
-
-
Niwa, K.1
Kazama, K.2
Younkin, S.G.3
Carlson, G.A.4
Iadecola, C.5
-
15
-
-
0033048258
-
Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia
-
Park L.C., Zhang H., Sheu K.P., et al. (1999) Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia. J. Neurochem. 72, 1948-1958.
-
(1999)
J. Neurochem.
, vol.72
, pp. 1948-1958
-
-
Park, L.C.1
Zhang, H.2
Sheu, K.P.3
-
16
-
-
0032905632
-
Protein-bound acrolein: A novel marker of oxidative stress in Alzheimer's disease
-
Calingasan N.Y., Uchida K., and Gibson G.E. (1999) Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease. J. Neurochem. 72, 751-756.
-
(1999)
J. Neurochem.
, vol.72
, pp. 751-756
-
-
Calingasan, N.Y.1
Uchida, K.2
Gibson, G.E.3
-
17
-
-
0035875690
-
Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis
-
Pratico D., Uryu K., Leight S., Trojanoswki J.Q., and Lee V.M. (2001) Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J. Neurosci. 21, 4183-4187.
-
(2001)
J. Neurosci.
, vol.21
, pp. 4183-4187
-
-
Pratico, D.1
Uryu, K.2
Leight, S.3
Trojanoswki, J.Q.4
Lee, V.M.5
-
18
-
-
0036284936
-
Increase of brain oxidative stress in mild cognitive impairment: A possible predictor of Alzheimer disease
-
Pratico D., Clark C.M., Liun F., Rokach J., Lee V.Y., and Trojanowski J.Q. (2002) Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch. Neurol. 59, 972-976.
-
(2002)
Arch. Neurol.
, vol.59
, pp. 972-976
-
-
Pratico, D.1
Clark, C.M.2
Liun, F.3
Rokach, J.4
Lee, V.Y.5
Trojanowski, J.Q.6
-
19
-
-
0042932786
-
Enhanced brain levels of 8,12-iso-iPF2alpha-VI differentiate AD from frontotemporal dementia
-
Yao Y., Zhukareva V., Sung S., et al. (2003) Enhanced brain levels of 8,12-iso-iPF2alpha-VI differentiate AD from frontotemporal dementia. Neurology 61, 475-478.
-
(2003)
Neurology
, vol.61
, pp. 475-478
-
-
Yao, Y.1
Zhukareva, V.2
Sung, S.3
-
20
-
-
0037660183
-
Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease
-
Fessel J.P., Hulette C., Powell S., Roberts L.J. 2nd, and Zhang J. (2003) Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease. J. Neurochem. 85, 645-650.
-
(2003)
J. Neurochem.
, vol.85
, pp. 645-650
-
-
Fessel, J.P.1
Hulette, C.2
Powell, S.3
Roberts II, L.J.4
Zhang, J.5
-
21
-
-
1542288938
-
Global organization of metabolic fluxes in the bacterium Escherichia coli
-
Almaas E., Kovacs B., Vicsek T., Oltvai Z.N., and Barabasi A.L. (2004) Global organization of metabolic fluxes in the bacterium Escherichia coli. Nature 427, 839-843.
-
(2004)
Nature
, vol.427
, pp. 839-843
-
-
Almaas, E.1
Kovacs, B.2
Vicsek, T.3
Oltvai, Z.N.4
Barabasi, A.L.5
-
22
-
-
0018363365
-
The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex
-
McCormack J.G. and Denton R.M. (1979) The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex. Biochem. J. 180, 533-544.
-
(1979)
Biochem. J.
, vol.180
, pp. 533-544
-
-
McCormack, J.G.1
Denton, R.M.2
-
23
-
-
0025197960
-
Ca2(+)-binding to citrate cycle dehydrogenases
-
Rutter G.A. (1990) Ca2(+)-binding to citrate cycle dehydrogenases. Int. J. Biochem. 22, 1081-1088.
-
(1990)
Int. J. Biochem.
, vol.22
, pp. 1081-1088
-
-
Rutter, G.A.1
-
24
-
-
0842323739
-
Interplay between mitochondria and cellular calcium signalling
-
Jacobson J. and Duchen M.R. (2004) Interplay between mitochondria and cellular calcium signalling. Mol Cell Biochem. 256-257, 209-218.
-
(2004)
Mol Cell Biochem.
, vol.256-257
, pp. 209-218
-
-
Jacobson, J.1
Duchen, M.R.2
-
25
-
-
0034103586
-
Inherent abnormalities in energy metabolism in Alzheimer disease. Interaction with cerebrovascular compromise
-
Blass J.P., Sheu R.K., and Gibson G.E. (2000) Inherent abnormalities in energy metabolism in Alzheimer disease. Interaction with cerebrovascular compromise. Ann. NY Acad. Sci. 903, 204-221.
-
(2000)
Ann. NY Acad. Sci.
, vol.903
, pp. 204-221
-
-
Blass, J.P.1
Sheu, R.K.2
Gibson, G.E.3
-
26
-
-
0033990449
-
The alpha-ketoglutarate dehydrogenase complex in neurodegeneration
-
Gibson G.E., Park L.C., Sheu K.P., Blass J.P., and Calingasan N.Y. (2000) The alpha-ketoglutarate dehydrogenase complex in neurodegeneration. Neurochem. Int. 36, 97-112.
-
(2000)
Neurochem. Int.
, vol.36
, pp. 97-112
-
-
Gibson, G.E.1
Park, L.C.2
Sheu, K.P.3
Blass, J.P.4
Calingasan, N.Y.5
-
27
-
-
0033387202
-
The alpha-ketoglutarate dehydrogenase complex
-
Sheu K.F. and Blass J.P. (1999) The alpha-ketoglutarate dehydrogenase complex. Ann. NY Acad. Sci. 893, 61-78
-
(1999)
Ann. NY Acad. Sci.
, vol.893
, pp. 61-78
-
-
Sheu, K.F.1
Blass, J.P.2
-
28
-
-
0031737226
-
Abnormalities of mitochondrial enzymes in Alzheimer disease
-
Gibson G.E., Sheu K.P., and Blass J.P. (1998) Abnormalities of mitochondrial enzymes in Alzheimer disease. J. Neural Transm. 105, 855-870.
-
(1998)
J. Neural Transm.
, vol.105
, pp. 855-870
-
-
Gibson, G.E.1
Sheu, K.P.2
Blass, J.P.3
-
29
-
-
0012478079
-
Lipoyl dehydrogenase
-
Massy V. Lipoyl dehydrogenase. Enzymes 7, 275-306.
-
Enzymes
, vol.7
, pp. 275-306
-
-
Massy, V.1
-
30
-
-
0019890079
-
Inhibition of bovine kidney alpha-ketoglutarate dehydrogenase complex by reduced nicotinamide adenine dinucleotide in the presence or absence of calcium ion and effect of adenosine 5′-diphosphate on reduced nicotinamide adenine dinucleotide inhibition
-
Lawlis V.B. and Roche T.E. (1981) Inhibition of bovine kidney alpha-ketoglutarate dehydrogenase complex by reduced nicotinamide adenine dinucleotide in the presence or absence of calcium ion and effect of adenosine 5′-diphosphate on reduced nicotinamide adenine dinucleotide inhibition. Biochemistry 20, 2519-2524.
-
(1981)
Biochemistry
, vol.20
, pp. 2519-2524
-
-
Lawlis, V.B.1
Roche, T.E.2
-
31
-
-
0037352050
-
2-Oxo acid dehydrogenase complexes in redox regulation: Role of the lipoate residues and thioredoxin
-
Bunik V.I. (2003) 2-Oxo acid dehydrogenase complexes in redox regulation: role of the lipoate residues and thioredoxin. Eur. J. Biochem. 270, 1036-1042.
-
(2003)
Eur. J. Biochem.
, vol.270
, pp. 1036-1042
-
-
Bunik, V.I.1
-
32
-
-
0024560234
-
Structural and functional peculiarities of alpha-ketoglutarate dehydrogenase with non-interacting active sites
-
Bunik V.I., Buneeva O.A., Lvova N.B., and Gomazkova V.S. (1989) Structural and functional peculiarities of alpha-ketoglutarate dehydrogenase with non-interacting active sites. Biochem. Int. 18, 561-571.
-
(1989)
Biochem. Int.
, vol.18
, pp. 561-571
-
-
Bunik, V.I.1
Buneeva, O.A.2
Lvova, N.B.3
Gomazkova, V.S.4
-
33
-
-
0025024108
-
Change in alpha-ketoglutarate dehydrogenase cooperative properties due to dihydrolipoate and NADH
-
Bunik V.I., Buneeva O.A., and Gomazkova V.S. (1990) Change in alpha-ketoglutarate dehydrogenase cooperative properties due to dihydrolipoate and NADH. FEBS Lett. 269, 252-254.
-
(1990)
FEBS Lett.
, vol.269
, pp. 252-254
-
-
Bunik, V.I.1
Buneeva, O.A.2
Gomazkova, V.S.3
-
34
-
-
0030656589
-
Activation of mitochondrial 2-oxoacid dehydrogenases by thioredoxin
-
Bunik V., Follmann H., and Bisswanger H. (1997) Activation of mitochondrial 2-oxoacid dehydrogenases by thioredoxin. Biol. Chem. 378, 1125-1130.
-
(1997)
Biol. Chem.
, vol.378
, pp. 1125-1130
-
-
Bunik, V.1
Follmann, H.2
Bisswanger, H.3
-
35
-
-
0036408866
-
Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species
-
Bunik V.I. and Sievers C. (2002) Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species. Eur. J. Biochem. 269, 5004-5015.
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 5004-5015
-
-
Bunik, V.I.1
Sievers, C.2
-
36
-
-
0029155520
-
Using lipoate enantiomers and thioredoxin to study the mechanism of the 2-oxoacid-dependent dihydrolipoate production by the 2-oxoacid dehydrogenase complexes
-
Bunik V., Shoubnikova A., Loeffelhardt S., Bisswanger H., Borbe H.O., and Follmann H. (1995) Using lipoate enantiomers and thioredoxin to study the mechanism of the 2-oxoacid-dependent dihydrolipoate production by the 2-oxoacid dehydrogenase complexes. FEBS Lett. 371, 167-170.
-
(1995)
FEBS Lett.
, vol.371
, pp. 167-170
-
-
Bunik, V.1
Shoubnikova, A.2
Loeffelhardt, S.3
Bisswanger, H.4
Borbe, H.O.5
Follmann, H.6
-
37
-
-
0042357517
-
Structure-function analysis of recombinant substrate protein 22 kDa (SP-22). A mitochondrial 2-CYS peroxiredoxin organized as a decameric toroid
-
Gourlay L.J., Bhella D., Kelly S.M., Price N.C., and Lindsay J.G. (2003) Structure-function analysis of recombinant substrate protein 22 kDa (SP-22). A mitochondrial 2-CYS peroxiredoxin organized as a decameric toroid. J. Biol. Chem. 278, 32,631-32,637.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32631-32637
-
-
Gourlay, L.J.1
Bhella, D.2
Kelly, S.M.3
Price, N.C.4
Lindsay, J.G.5
-
38
-
-
0037039818
-
Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein
-
Bryk R., Lima C.D., Erdjument-Bromage H., Tempst P., and Nathan C. (2002) Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 295, 1073-1077.
-
(2002)
Science
, vol.295
, pp. 1073-1077
-
-
Bryk, R.1
Lima, C.D.2
Erdjument-Bromage, H.3
Tempst, P.4
Nathan, C.5
-
39
-
-
0042433242
-
2 production by membrane potential and NAD(P)H redox state
-
2 production by membrane potential and NAD(P)H redox state. J. Neurochem. 86, 1101-1107.
-
(2003)
J. Neurochem.
, vol.86
, pp. 1101-1107
-
-
Starkov, A.A.1
Fiskum, G.2
-
40
-
-
0026445175
-
Reduction of nitrofuran compounds by heart lipoamide dehydrogenase: Role of flavin and the reactive disulfide groups
-
Sreider C.M., Grinblat L., and Stoppani A.O. (1992) Reduction of nitrofuran compounds by heart lipoamide dehydrogenase: role of flavin and the reactive disulfide groups. Biochem. Int. 28, 323-334.
-
(1992)
Biochem. Int.
, vol.28
, pp. 323-334
-
-
Sreider, C.M.1
Grinblat, L.2
Stoppani, A.O.3
-
41
-
-
0037155880
-
Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase
-
Gazaryan I.G., Krasnikov B.F., Ashby G.A., Thorneley R.N., Kristal B.S., and Brown A.M. (2002) Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase. J. Biol. Chem. 277, 10,064-10,072.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 10064-10072
-
-
Gazaryan, I.G.1
Krasnikov, B.F.2
Ashby, G.A.3
Thorneley, R.N.4
Kristal, B.S.5
Brown, A.M.6
-
42
-
-
0018653545
-
Hg2+-stimulated NADH-oxidase activity of Ascaris muscle microsomal lipoamide dehydrogenase
-
Matuda S. and Obo F. (1979) Hg2+-stimulated NADH-oxidase activity of Ascaris muscle microsomal lipoamide dehydrogenase. Biochem. Biophys. Res. Commun. 91, 835-841.
-
(1979)
Biochem. Biophys. Res. Commun.
, vol.91
, pp. 835-841
-
-
Matuda, S.1
Obo, F.2
-
43
-
-
0038714406
-
Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain
-
Kanamori T., Nishimaki K., Asoh S., Ishibashi Y., Takata I., Kuwabara T., Taira K., et al. (2003) Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. EMBO J. 22, 2913-2923.
-
(2003)
EMBO J.
, vol.22
, pp. 2913-2923
-
-
Kanamori, T.1
Nishimaki, K.2
Asoh, S.3
Ishibashi, Y.4
Takata, I.5
Kuwabara, T.6
Taira, K.7
-
44
-
-
9144265671
-
Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology
-
Li K.W., Hornshaw M.P., Van Der Schors R.C., et al. (2004) Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology. J. Biol. Chem. 279, 987-1002.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 987-1002
-
-
Li, K.W.1
Hornshaw, M.P.2
Van Der Schors, R.C.3
-
45
-
-
0031754275
-
Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation
-
Gibson G.E., Zhang H., Sheu K.P., et al. (1998) Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation. Ann. Neurol. 44, 676-681.
-
(1998)
Ann. Neurol.
, vol.44
, pp. 676-681
-
-
Gibson, G.E.1
Zhang, H.2
Sheu, K.P.3
-
46
-
-
0033848159
-
Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype
-
Gibson G.E., Haroutunian V., Zhang H., et al. (2000) Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype. Ann. Neurol. 48, 297-303.
-
(2000)
Ann. Neurol.
, vol.48
, pp. 297-303
-
-
Gibson, G.E.1
Haroutunian, V.2
Zhang, H.3
-
47
-
-
0029884010
-
Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
-
Mastrogiacoma P., Lindsay J.G., Bettendorff L., Rice J., and Kish S.J. (1996) Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. Ann. Neurol. 39, 592-598.
-
(1996)
Ann. Neurol.
, vol.39
, pp. 592-598
-
-
Mastrogiacoma, P.1
Lindsay, J.G.2
Bettendorff, L.3
Rice, J.4
Kish, S.J.5
-
48
-
-
0035950697
-
Association between DLST gene polymorphism and Alzheimer's disease
-
Ma Q., Chan P., and Yang J. (2001) [Association between DLST gene polymorphism and Alzheimer's disease]. Zhonghua Yi Xue Za Zhi 81, 1246-1248.
-
(2001)
Zhonghua Yi Xue Za Zhi
, vol.81
, pp. 1246-1248
-
-
Ma, Q.1
Chan, P.2
Yang, J.3
-
49
-
-
0033594470
-
A DLST genotype associated with reduced risk for Alzheimer's disease
-
Sheu K.P., Brown A.M., Kristal B.S., et al. (1999) A DLST genotype associated with reduced risk for Alzheimer's disease. Neurology 52, 1505-1507.
-
(1999)
Neurology
, vol.52
, pp. 1505-1507
-
-
Sheu, K.P.1
Brown, A.M.2
Kristal, B.S.3
-
50
-
-
0032932396
-
Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population
-
Sheu K.P., Brown A.M., Haroutunian V., et al. (1999) Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population. Ann. Neurol. 45, 48-53.
-
(1999)
Ann. Neurol.
, vol.45
, pp. 48-53
-
-
Sheu, K.P.1
Brown, A.M.2
Haroutunian, V.3
-
51
-
-
1542347864
-
Substantial linkage disequilibrium across the dihydrolipoyl succinyltransferase gene region without Alzheimer's disease association
-
Brown A.M., Gordon D., Lee H., Caudy M., Haroutunian V., and Blass J.P. (2004) Substantial linkage disequilibrium across the dihydrolipoyl succinyltransferase gene region without Alzheimer's disease association. Neurochem. Res. 29, 629-635.
-
(2004)
Neurochem. Res.
, vol.29
, pp. 629-635
-
-
Brown, A.M.1
Gordon, D.2
Lee, H.3
Caudy, M.4
Haroutunian, V.5
Blass, J.P.6
-
52
-
-
0034974005
-
No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome
-
Matsushita S., Arai H., Yuzuriha T., et al. (2001) No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. Neurobiol. Aging 22, 569-574.
-
(2001)
Neurobiol. Aging
, vol.22
, pp. 569-574
-
-
Matsushita, S.1
Arai, H.2
Yuzuriha, T.3
-
53
-
-
7644243802
-
Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish Population
-
Brown A.M., Gordon D., Lee H., et al. (2004) Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish Population. Am. J. Med. Genet., 131, 60-66.
-
(2004)
Am. J. Med. Genet.
, vol.131
, pp. 60-66
-
-
Brown, A.M.1
Gordon, D.2
Lee, H.3
-
55
-
-
0344838535
-
Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson's disease
-
Gibson G.E., Kingsbury A.E., Xu H., et al. (2003) Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson's disease. Neurochem. Int. 43, 129-135.
-
(2003)
Neurochem. Int.
, vol.43
, pp. 129-135
-
-
Gibson, G.E.1
Kingsbury, A.E.2
Xu, H.3
-
56
-
-
12144290495
-
Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity
-
Klivenyi P., Starkov A.A., Calingasan N.Y., et al. (2004) Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. J. Neurochem. 88, 1352-1360.
-
(2004)
J. Neurochem.
, vol.88
, pp. 1352-1360
-
-
Klivenyi, P.1
Starkov, A.A.2
Calingasan, N.Y.3
-
57
-
-
18744435242
-
Frontal lobe dysfunction in progressive supranuclear palsy: Evidence for oxidative stress and mitochondrial impairment
-
Albers D.S., Augood S.J., Park L.C., et al. (2000) Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment. J. Neurochem. 74, 878-881.
-
(2000)
J. Neurochem.
, vol.74
, pp. 878-881
-
-
Albers, D.S.1
Augood, S.J.2
Park, L.C.3
-
58
-
-
0035576822
-
Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy
-
Park L.C., Albers D.S., Xu H., Lindsay J.G., Beal M.F., and Gibson G.E. (2001) Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy. J. Neurosci. Res. 66, 1028-1034.
-
(2001)
J. Neurosci. Res.
, vol.66
, pp. 1028-1034
-
-
Park, L.C.1
Albers, D.S.2
Xu, H.3
Lindsay, J.G.4
Beal, M.F.5
Gibson, G.E.6
-
59
-
-
24644523846
-
Mitochondrial enzymes in schizophrenia
-
Bubber P., Tang J., Haroutunian V., et al. (2004) Mitochondrial enzymes in schizophrenia. Mol. Neurosci. 24, 231-237.
-
(2004)
Mol. Neurosci.
, vol.24
, pp. 231-237
-
-
Bubber, P.1
Tang, J.2
Haroutunian, V.3
-
60
-
-
0033535948
-
Declines in mitochondrial respiration during cardiac reperfusion: Age-dependent inactivation of alpha-ketoglutarate dehydrogenase
-
Lucas D.T. and Sweda L.I. (1999) Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase. Proc. Natl. Acad. Sci. USA 96, 6689-6693.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 6689-6693
-
-
Lucas, D.T.1
Sweda, L.I.2
-
61
-
-
0032512411
-
Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal
-
Humphries K.M., Yoo Y., and Szweda L.I. (1998) Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal. Biochemistry 37, 552-557.
-
(1998)
Biochemistry
, vol.37
, pp. 552-557
-
-
Humphries, K.M.1
Yoo, Y.2
Szweda, L.I.3
-
62
-
-
0009426712
-
α-Ketoglutarate dehydrogenase and oxidative stress
-
International Society for Neurochemistry.
-
Xu H., Jeitner T., Zhang H., and Gibson G.E. (2001) α-Ketoglutarate dehydrogenase and oxidative stress. International Society for Neurochemistry. J. Neurochem. 78S, 132.
-
(2001)
J. Neurochem.
, vol.78 S
, pp. 132
-
-
Xu, H.1
Jeitner, T.2
Zhang, H.3
Gibson, G.E.4
-
63
-
-
0033000269
-
Depolarization of in situ mitochondria due to hydrogen peroxide-induced oxidative stress in nerve terminals: Inhibition of alpha-ketoglutarate dehydrogenase
-
Chinopoulos C., Tretter L., and Adam-Vizi V. (1999) Depolarization of in situ mitochondria due to hydrogen peroxide-induced oxidative stress in nerve terminals: inhibition of alpha-ketoglutarate dehydrogenase. J. Neurochem. 73, 220-228.
-
(1999)
J. Neurochem.
, vol.73
, pp. 220-228
-
-
Chinopoulos, C.1
Tretter, L.2
Adam-Vizi, V.3
-
64
-
-
0034670134
-
Differential alterations in antioxidant capacity in cells from Alzheimer patients
-
Gibson G.E., Zhang H., Sheu K.R., and Park L.C. (2000) Differential alterations in antioxidant capacity in cells from Alzheimer patients. Biochim. Biophys. Acta 1502, 319-329.
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, pp. 319-329
-
-
Gibson, G.E.1
Zhang, H.2
Sheu, K.R.3
Park, L.C.4
-
65
-
-
0345146921
-
Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status
-
Nulton-Persson A.C., Starke D.W., Mieyal J.J., and Szweda L.I. (2003) Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status. Biochemistry 42, 4235-4242.
-
(2003)
Biochemistry
, vol.42
, pp. 4235-4242
-
-
Nulton-Persson, A.C.1
Starke, D.W.2
Mieyal, J.J.3
Szweda, L.I.4
-
66
-
-
0023116918
-
Inactivation of 2-oxoglutarate dehydrogenase in rat liver mitochondria by its substrate and t-butyl hydroperoxide
-
Rokutan K., Kawai K., and Asada K. (1987) Inactivation of 2-oxoglutarate dehydrogenase in rat liver mitochondria by its substrate and t-butyl hydroperoxide. J. Biochem. (Tokyo) 101, 415-422.
-
(1987)
J. Biochem. (Tokyo)
, vol.101
, pp. 415-422
-
-
Rokutan, K.1
Kawai, K.2
Asada, K.3
-
67
-
-
0034282468
-
Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae
-
Cabiscol E., Piulats E., Echave P., Herrero E., and Ros J. (2000) Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae. J. Biol. Chem. 275, 27,393-27,398.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27393-27398
-
-
Cabiscol, E.1
Piulats, E.2
Echave, P.3
Herrero, E.4
Ros, J.5
-
68
-
-
0029995035
-
Catecholamines enhance dihydrolipoamide dehydrogenase inactivation by the copper Fenton system. Enzyme protection by copper chelators
-
Correa J.G. and Stoppani A.O. (1996) Catecholamines enhance dihydrolipoamide dehydrogenase inactivation by the copper Fenton system. Enzyme protection by copper chelators. Free Radical Res 24, 311-322.
-
(1996)
Free Radical Res
, vol.24
, pp. 311-322
-
-
Correa, J.G.1
Stoppani, A.O.2
-
69
-
-
1342306400
-
Acrolein inhibits NADH-linked mitochondrial enzyme activity: Implications for Alzheimer's disease
-
Pocernich C.B. and Butterfield D.A. (2003) Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease. Neurotox. Res. 5, 515-520.
-
(2003)
Neurotox. Res.
, vol.5
, pp. 515-520
-
-
Pocernich, C.B.1
Butterfield, D.A.2
-
70
-
-
0142213541
-
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity
-
Moreau R., Heath S.H., Doneanu C.E., Lindsay J.G., and Hagen T.M. (2003) Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity. Antioxid. Redox Signal. 5, 517-527.
-
(2003)
Antioxid. Redox Signal.
, vol.5
, pp. 517-527
-
-
Moreau, R.1
Heath, S.H.2
Doneanu, C.E.3
Lindsay, J.G.4
Hagen, T.M.5
-
71
-
-
0027059235
-
Inactivation of mitochondrial metabolism by hyperoxia-induced oxidative stress
-
Pruijn F.B., Schoonen W.G., and Joenje H. (1992) Inactivation of mitochondrial metabolism by hyperoxia-induced oxidative stress. Ann. NY Acad. Sci. 663, 453-455.
-
(1992)
Ann. NY Acad. Sci.
, vol.663
, pp. 453-455
-
-
Pruijn, F.B.1
Schoonen, W.G.2
Joenje, H.3
-
72
-
-
0025375669
-
Respiratory failure and stimulation of glycolysis in Chinese hamster ovary cells exposed to normobaric hyperoxia
-
Schoonen W.G., Wanamarta A.H., van der Klei-van Moorsei J.M., Jakobs C., and Joenje H. (1990) Respiratory failure and stimulation of glycolysis in Chinese hamster ovary cells exposed to normobaric hyperoxia. J. Biol. Chem. 265, 1118-1124.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 1118-1124
-
-
Schoonen, W.G.1
Wanamarta, A.H.2
Van Der Klei-van Moorsei, J.M.3
Jakobs, C.4
Joenje, H.5
-
73
-
-
0344443765
-
Oxidative alpha-ketoglutarate dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: Implications for Parkinson's disease
-
Kumar M.J., Nicholls D.G., and Andersen J.K. (2003) Oxidative alpha-ketoglutarate dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: implications for Parkinson's disease. J. Biol. Chem. 278, 46,432-46,439.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 46432-46439
-
-
Kumar, M.J.1
Nicholls, D.G.2
Andersen, J.K.3
-
74
-
-
0942298545
-
Endogenous mitochondrial oxidative stress: Neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice
-
Hinerfeld D., Traini M.D., Weinberger R.P., Cochran B., Doctrow S.R., Harry J., et al. (2004) Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice. J. Neurochem. 88, 657-667.
-
(2004)
J. Neurochem.
, vol.88
, pp. 657-667
-
-
Hinerfeld, D.1
Traini, M.D.2
Weinberger, R.P.3
Cochran, B.4
Doctrow, S.R.5
Harry, J.6
-
75
-
-
0037117306
-
Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme
-
Gibson G.E., Zhang H., Xu H., Park L.C., and Jeitner T.M. (2002) Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme. Biochim. Biophys. Acta 1586, 177-189.
-
(2002)
Biochim. Biophys. Acta
, vol.1586
, pp. 177-189
-
-
Gibson, G.E.1
Zhang, H.2
Xu, H.3
Park, L.C.4
Jeitner, T.M.5
-
76
-
-
0031693023
-
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease
-
McNaught K.S., Carrupt P.A., Altomare C., et al. (1998) Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease. Biochem. Pharmacol. 56, 921-933.
-
(1998)
Biochem. Pharmacol.
, vol.56
, pp. 921-933
-
-
McNaught, K.S.1
Carrupt, P.A.2
Altomare, C.3
-
77
-
-
0028989810
-
Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
-
McNaught K.S., Altomare C., Cellamare S., et al. (1995) Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neuroreport 6, 1105-1108.
-
(1995)
Neuroreport
, vol.6
, pp. 1105-1108
-
-
McNaught, K.S.1
Altomare, C.2
Cellamare, S.3
-
78
-
-
0035659572
-
Oxidative metabolites of 5-S-cysteinyldopamine inhibit the pyruvate dehydrogenase complex
-
Li H. and Dryhurst G. (2001) Oxidative metabolites of 5-S-cysteinyldopamine inhibit the pyruvate dehydrogenase complex. J. Neural Transm. 108, 1363-1374.
-
(2001)
J. Neural Transm.
, vol.108
, pp. 1363-1374
-
-
Li, H.1
Dryhurst, G.2
-
79
-
-
0036801419
-
Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione
-
Jiang X.R. and Dryhurst G. (2002) Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione. Chem. Res. Toxicol. 15, 1242-1247.
-
(2002)
Chem. Res. Toxicol.
, vol.15
, pp. 1242-1247
-
-
Jiang, X.R.1
Dryhurst, G.2
-
80
-
-
0032879644
-
Inhibition of select mitochondrial enzymes in PC12 cells exposed to S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
-
Park L.C., Gibson G.E., Bunik V., and Cooper A.J. (1999) Inhibition of select mitochondrial enzymes in PC12 cells exposed to S-(1,1,2,2- tetrafluoroethyl)-L-cysteine. Biochem. Pharmacol. 58, 1557-1565.
-
(1999)
Biochem. Pharmacol.
, vol.58
, pp. 1557-1565
-
-
Park, L.C.1
Gibson, G.E.2
Bunik, V.3
Cooper, A.J.4
-
81
-
-
0030812593
-
Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length
-
Cooper A.J., Sheu K.R., Burke J.R., et al. (1997) Transglutaminase- catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length. Proc. Natl. Acad. Sci. USA 94, 12,604-12,609.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 12604-12609
-
-
Cooper, A.J.1
Sheu, K.R.2
Burke, J.R.3
-
82
-
-
0034054745
-
Specific phosphorylation of Torpedo 43K rapsyn by endogenous kinase(s) with thiamine triphosphate as the phosphate donor
-
Nghiem H.O., Bettendorff L., and Changeux J.P. (2000) Specific phosphorylation of Torpedo 43K rapsyn by endogenous kinase(s) with thiamine triphosphate as the phosphate donor. FASEB J. 14, 543-554.
-
(2000)
FASEB J.
, vol.14
, pp. 543-554
-
-
Nghiem, H.O.1
Bettendorff, L.2
Changeux, J.P.3
-
83
-
-
0041867626
-
Modulation of acethylcholine synthesis in rat brain synaptosomes by thiamine and its relation to the regulation of the pyruvate dehydrogenase complex activity
-
Proceedings of the International Meeting on the Function of Thiamine Diphosphate enzymes, Bisswanger H. and Ullrich J., eds., VCH, Weinheim
-
Parkhomenko Yu. M., Protasova Z.S., Chernysh I.Yu., and Pkhakadze E.G. (1991) Modulation of acethylcholine synthesis in rat brain synaptosomes by thiamine and its relation to the regulation of the pyruvate dehydrogenase complex activity, in Biochemistry and Physiology of Thiamine Diphosphate Enzymes. Proceedings of the International Meeting on the Function of Thiamine Diphosphate enzymes, Bisswanger H. and Ullrich J., eds., VCH, Weinheim.
-
(1991)
Biochemistry and Physiology of Thiamine Diphosphate Enzymes
-
-
Parkhomenko, Yu.M.1
Protasova, Z.S.2
Chernysh, I.Yu.3
Pkhakadze, E.G.4
-
84
-
-
2442433959
-
Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism
-
Ke Z. and Gibson G.E. (2004) Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism. Neurochem. Int., 45, 361-369.
-
(2004)
Neurochem. Int.
, vol.45
, pp. 361-369
-
-
Ke, Z.1
Gibson, G.E.2
-
85
-
-
0031891606
-
Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain
-
Sheu K.P., Calingasan N.Y., Lindsay J.G., and Gibson G.E. (1998) Immunochemical characterization of the deficiency of the alpha-ketoglutarate dehydrogenase complex in thiamine-deficient rat brain. J. Neurochem. 70, 1143-1150.
-
(1998)
J. Neurochem.
, vol.70
, pp. 1143-1150
-
-
Sheu, K.P.1
Calingasan, N.Y.2
Lindsay, J.G.3
Gibson, G.E.4
-
86
-
-
0033985184
-
Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture
-
Park L.C., Calingasan N.Y., Uchida K., Zhang H., and Gibson G.E. (2000) Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture. J. Neurochem. 74, 114-124.
-
(2000)
J. Neurochem.
, vol.74
, pp. 114-124
-
-
Park, L.C.1
Calingasan, N.Y.2
Uchida, K.3
Zhang, H.4
Gibson, G.E.5
-
87
-
-
0017122070
-
Inhibition of acetylcholine synthesis and of carbohydrate utilization by maple-syrup-urine disease metabolites
-
Gibson G.E. and Blass J.P. (1976) Inhibition of acetylcholine synthesis and of carbohydrate utilization by maple-syrup-urine disease metabolites. J. Neurochem. 26, 1073-1078.
-
(1976)
J. Neurochem.
, vol.26
, pp. 1073-1078
-
-
Gibson, G.E.1
Blass, J.P.2
-
88
-
-
0037454668
-
Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation
-
Huang H.M., Zhang H., Xu H., and Gibson G.E. (2003) Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation. Biochim. Biophys. Acta 1637, 119-126.
-
(2003)
Biochim. Biophys. Acta
, vol.1637
, pp. 119-126
-
-
Huang, H.M.1
Zhang, H.2
Xu, H.3
Gibson, G.E.4
-
89
-
-
0141481850
-
Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death
-
Huang H.M., Ou H.C., Xu H., Chen H.L., Fowler C., and Gibson G.E. (2003) Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death. J. Neurosci. Res. 74, 309-317.
-
(2003)
J. Neurosci. Res.
, vol.74
, pp. 309-317
-
-
Huang, H.M.1
Ou, H.C.2
Xu, H.3
Chen, H.L.4
Fowler, C.5
Gibson, G.E.6
-
90
-
-
0034671429
-
Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of α-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress
-
Tretter L. and Adam-Vizi V. (2000) Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of α-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress. J. Neurosci. 20, 8972-8979.
-
(2000)
J. Neurosci.
, vol.20
, pp. 8972-8979
-
-
Tretter, L.1
Adam-Vizi, V.2
-
92
-
-
0031042999
-
Enzymological and physiological consequences of restructuring the lipoyl domain content of the pyruvate dehydrogenase complex of Escherichia coli
-
Guest J.R., Attwood M.M., Machado R.S., Matqi K.Y., Shaw J.E., and Turner S.L. (1997) Enzymological and physiological consequences of restructuring the lipoyl domain content of the pyruvate dehydrogenase complex of Escherichia coli. Microbiology 143(Pt. 2), 457-466.
-
(1997)
Microbiology
, vol.143
, Issue.2 PART
, pp. 457-466
-
-
Guest, J.R.1
Attwood, M.M.2
Machado, R.S.3
Matqi, K.Y.4
Shaw, J.E.5
Turner, S.L.6
-
93
-
-
0029159818
-
Metabolic engineering in Escherichia coli: Lowering the lipoyl domain content of the pyruvate dehydrogenase complex adversely affects the growth rate and yield
-
Dave E., Guest J.R., and Attwood M.M. (1995) Metabolic engineering in Escherichia coli: lowering the lipoyl domain content of the pyruvate dehydrogenase complex adversely affects the growth rate and yield. Microbiology 141(Pt. 8), 1839-1849.
-
(1995)
Microbiology
, vol.141
, Issue.8 PART
, pp. 1839-1849
-
-
Dave, E.1
Guest, J.R.2
Attwood, M.M.3
-
94
-
-
0002457965
-
Site directed mutatagenesis of dihydrolipoaminde acetyltransferase and post translational modification of it in lipoyl domains
-
(Bisswanger, H. and Shellenberger, A., eds.), Chemie, Weinheim
-
Guest J.R., Ali S.T., Artymu P., Ford G., Green J., and Russsel G.C. (1990) Site directed mutatagenesis of dihydrolipoaminde acetyltransferase and post translational modification of it in lipoyl domains, in Biochemistry and Physiology of Thiamin Diphosphate Enzymes, (Bisswanger, H. and Shellenberger, A., eds.), Chemie, Weinheim, pp. 176-193.
-
(1990)
Biochemistry and Physiology of Thiamin Diphosphate Enzymes
, pp. 176-193
-
-
Guest, J.R.1
Ali, S.T.2
Artymu, P.3
Ford, G.4
Green, J.5
Russsel, G.C.6
-
95
-
-
0034728670
-
Beta-amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation
-
Ekinci F.J., Linsley M.D., and Shea T.B. (2000) Beta-amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation. Brain Res. Mol. Brain Res. 76, 389-395.
-
(2000)
Brain Res. Mol. Brain Res.
, vol.76
, pp. 389-395
-
-
Ekinci, F.J.1
Linsley, M.D.2
Shea, T.B.3
-
96
-
-
0037474263
-
Apoptotic neuronal cell death induced by the non-fibrillar amyloid-beta peptide proceeds through an early reactive oxygen species-dependent cytoskeleton perturbation
-
Sponne I., Fifre A., Drouet B., Klein C., et al. (2003) Apoptotic neuronal cell death induced by the non-fibrillar amyloid-beta peptide proceeds through an early reactive oxygen species-dependent cytoskeleton perturbation. J. Biol. Chem. 278, 3437-3445.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 3437-3445
-
-
Sponne, I.1
Fifre, A.2
Drouet, B.3
Klein, C.4
-
97
-
-
0037098866
-
Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach
-
Behl C. and Moosmann B. (2002) Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach. Free Radical Biol. Med. 33, 182-191.
-
(2002)
Free Radical Biol. Med.
, vol.33
, pp. 182-191
-
-
Behl, C.1
Moosmann, B.2
-
98
-
-
0028233494
-
Hydrogen peroxide mediates amyloid beta protein toxicity
-
Behl C., Davis J.B., Lesley R., and Schubert D. (1994) Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77, 817-827.
-
(1994)
Cell
, vol.77
, pp. 817-827
-
-
Behl, C.1
Davis, J.B.2
Lesley, R.3
Schubert, D.4
-
99
-
-
0034801348
-
Different mechanisms of oxidative stress and neurotoxicity for alzheimer's abeta(1-42) and abeta(25-35)
-
Varadarajan S., Kanski J., Aksenova M., Lauderback C., and Butterfield D.A. (2001) Different mechanisms of oxidative stress and neurotoxicity for alzheimer's abeta(1-42) and abeta(25-35). J. Am. Chem. Soc. 123, 5625-5631.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 5625-5631
-
-
Varadarajan, S.1
Kanski, J.2
Aksenova, M.3
Lauderback, C.4
Butterfield, D.A.5
-
100
-
-
0033860372
-
Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity
-
Varadarajan S., Yatin S., Aksenova M., and Butterfield D.A. (2000) Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J. Struct. Biol. 130, 184-208.
-
(2000)
J. Struct. Biol.
, vol.130
, pp. 184-208
-
-
Varadarajan, S.1
Yatin, S.2
Aksenova, M.3
Butterfield, D.A.4
-
101
-
-
0035168757
-
N-Acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: Effects on beta-amyloid secretion and tau phosphorylation
-
Olivieri G., Baysang G., Meier F., et al. (2001) N-Acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation. J. Neurochem. 76, 224-233.
-
(2001)
J. Neurochem.
, vol.76
, pp. 224-233
-
-
Olivieri, G.1
Baysang, G.2
Meier, F.3
-
102
-
-
18344414746
-
The a beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
-
Huang X., Atwood C.S., Hartshorn M.A., et al. (1999) The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry 38, 7609-7616.
-
(1999)
Biochemistry
, vol.38
, pp. 7609-7616
-
-
Huang, X.1
Atwood, C.S.2
Hartshorn, M.A.3
-
103
-
-
0033022771
-
Involvement of oxidative stress on the impairment of energy metabolism induced by a beta peptides on PC12 cells: Protection by antioxidants
-
Pereira C., Santos M.S., and Oliveira C. (1999) Involvement of oxidative stress on the impairment of energy metabolism induced by A beta peptides on PC12 cells: protection by antioxidants. Neurobiol. Dis. 6, 209-219.
-
(1999)
Neurobiol. Dis.
, vol.6
, pp. 209-219
-
-
Pereira, C.1
Santos, M.S.2
Oliveira, C.3
-
104
-
-
0028118846
-
Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death
-
Shearman M.S., Ragan C.I., and Iversen L.L. (1994) Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death. Proc. Natl. Acad. Sci. USA 91, 1470-1474.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 1470-1474
-
-
Shearman, M.S.1
Ragan, C.I.2
Iversen, L.L.3
-
105
-
-
4243233629
-
β-Amyloid inhibits mitohondrial cytochrome oxidase and exacerbates nitric oxide toxicity: Implications for Alzheimer's disease
-
Sharpe M.A., Canevari L., Clark J.B., and Casley C. (2001) β-Amyloid inhibits mitohondrial cytochrome oxidase and exacerbates nitric oxide toxicity: implications for Alzheimer's disease. J. Neurochem. 78S, 91.
-
(2001)
J. Neurochem.
, vol.78 S
, pp. 91
-
-
Sharpe, M.A.1
Canevari, L.2
Clark, J.B.3
Casley, C.4
-
106
-
-
0036272650
-
Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
-
Casley C.S., Canevari L., Land J.M., Clark J.B., and Sharpe M.A. (2002) Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J. Neurochem. 80, 91-100.
-
(2002)
J. Neurochem.
, vol.80
, pp. 91-100
-
-
Casley, C.S.1
Canevari, L.2
Land, J.M.3
Clark, J.B.4
Sharpe, M.A.5
-
107
-
-
11144353586
-
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
-
Lustbader J.W., Cirilli M., Lin C., et al. (2004) ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 304, 448-452.
-
(2004)
Science
, vol.304
, pp. 448-452
-
-
Lustbader, J.W.1
Cirilli, M.2
Lin, C.3
-
108
-
-
9444264677
-
Alzheimer-type pathology in a patient with mitochondrial myopathy, encephalopathy lactic acidosis and stroke-like episodes (MELAS)
-
Kaido M., Fujimura H., Soga F., et al. (1996) Alzheimer-type pathology in a patient with mitochondrial myopathy, encephalopathy lactic acidosis and stroke-like episodes (MELAS). Acta Neuropathol. (Berl.) 92, 312-318.
-
(1996)
Acta Neuropathol. (Berl.)
, vol.92
, pp. 312-318
-
-
Kaido, M.1
Fujimura, H.2
Soga, F.3
-
109
-
-
1442323991
-
Intraneuronal amyloid-beta1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death
-
Pierrot N., Ghisdal P., Caumont A.S., and Octave J.N. (2004) Intraneuronal amyloid-beta1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death. J. Neurochem. 88, 1140-1150.
-
(2004)
J. Neurochem.
, vol.88
, pp. 1140-1150
-
-
Pierrot, N.1
Ghisdal, P.2
Caumont, A.S.3
Octave, J.N.4
-
110
-
-
10144231437
-
Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency
-
Calingasan N.Y., Gandy S.E., Baker H., et al. (1996) Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. Am. J. Pathol. 149, 1063-1071.
-
(1996)
Am. J. Pathol.
, vol.149
, pp. 1063-1071
-
-
Calingasan, N.Y.1
Gandy, S.E.2
Baker, H.3
-
111
-
-
0029985732
-
Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells
-
Frederikse P.H., Garland D., Zigler J.S. Jr., and Piatigorsky J. (1996) Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells. J. Biol. Chem. 271, 10,169-10,174.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 10169-10174
-
-
Frederikse, P.H.1
Garland, D.2
Zigler Jr., J.S.3
Piatigorsky, J.4
-
112
-
-
0034643895
-
Oxidative stress induces intracellular accumulation of amyloid beta- Protein (Abeta) in human neuroblastoma cells
-
Misonou H., Morishima-Kawashima M., and Ihara Y. (2000) Oxidative stress induces intracellular accumulation of amyloid beta- protein (Abeta) in human neuroblastoma cells. Biochemistry 39, 6951-6959.
-
(2000)
Biochemistry
, vol.39
, pp. 6951-6959
-
-
Misonou, H.1
Morishima-Kawashima, M.2
Ihara, Y.3
-
113
-
-
0033957486
-
Mercury induces cell cytotoxicity and oxidative stress and increases beta-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells
-
Olivieri G., Brack C., Muller-Spahn F., et al. (2000) Mercury induces cell cytotoxicity and oxidative stress and increases beta-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells. J. Neurochem. 74, 231-236.
-
(2000)
J. Neurochem.
, vol.74
, pp. 231-236
-
-
Olivieri, G.1
Brack, C.2
Muller-Spahn, F.3
-
114
-
-
0028200649
-
Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative
-
Gabuzda D., Busciglio J., Chen L.B., Matsudaira P., and Yankner B.A. (1994) Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J. Biol. Chem. 269, 13,623-13,628.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 13623-13628
-
-
Gabuzda, D.1
Busciglio, J.2
Chen, L.B.3
Matsudaira, P.4
Yankner, B.A.5
-
115
-
-
0031767946
-
The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells
-
Webster M.T., Pearce B.R., Bowen D.M., and Francis P.T. (1998) The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells. J. Neural Transm 105, 839-853.
-
(1998)
J. Neural. Transm.
, vol.105
, pp. 839-853
-
-
Webster, M.T.1
Pearce, B.R.2
Bowen, D.M.3
Francis, P.T.4
-
116
-
-
0029094305
-
Neurofibrillary tangles in chronic alcoholics
-
Cullen K.M. and Halliday G.M. (1995) Neurofibrillary tangles in chronic alcoholics. Neuropathol Appl. Neurobiol. 21(4), 312-318.
-
(1995)
Neuropathol. Appl. Neurobiol.
, vol.21
, Issue.4
, pp. 312-318
-
-
Cullen, K.M.1
Halliday, G.M.2
-
117
-
-
0026659777
-
Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF
-
Cheng B. and Mattson M.P. (1992) Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: prevention by NGF and bFGF. Exp. Neurol. 117, 114-123.
-
(1992)
Exp. Neurol.
, vol.117
, pp. 114-123
-
-
Cheng, B.1
Mattson, M.P.2
-
118
-
-
0025183062
-
Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation
-
Blass J.P., Baker A.C., Ko L.W., and Black R.S. (1990) Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation. Arch. Neurol. 47, 864-869.
-
(1990)
Arch. Neurol.
, vol.47
, pp. 864-869
-
-
Blass, J.P.1
Baker, A.C.2
Ko, L.W.3
Black, R.S.4
-
119
-
-
0008817624
-
Effects of ginkgo biloba (EGb761) on metabolism of reactive oxygen species in fibroblasts from Alzheimer's disease patients and controls
-
Christen Y., ed. IPSEN Foundation Salal Editeur, Marseille, France
-
Gibson G.E. and Zhang H. (2000) Effects of ginkgo biloba (EGb761) on metabolism of reactive oxygen species in fibroblasts from Alzheimer's disease patients and controls, in Advances in Ginkgo biloba Extract Research, vol 8, Ginkgo Biloba Extract (EGB 761) as a Neuroprotective Agent: From Basic Studies to Clinical Trials, Christen Y., ed. IPSEN Foundation Salal Editeur, Marseille, France.
-
(2000)
Advances in Ginkgo Biloba Extract Research, Vol 8, Ginkgo Biloba Extract (EGB 761) As a Neuroprotective Agent: from Basic Studies to Clinical Trials
, vol.8
-
-
Gibson, G.E.1
Zhang, H.2
-
120
-
-
12144289492
-
Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: Implications for Alzheimer's disease
-
Planel E., Miyasaka T., Launey T., et al. (2004) Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease. J. Neurosci. 24, 2401-2411.
-
(2004)
J. Neurosci.
, vol.24
, pp. 2401-2411
-
-
Planel, E.1
Miyasaka, T.2
Launey, T.3
-
121
-
-
0035675703
-
Frontotemporal dementia: Clinical, neuroimaging, and molecular biological findings in 6 patients
-
Jauss M., Herholz K., Kracht L., et al. (2001) Frontotemporal dementia: clinical, neuroimaging, and molecular biological findings in 6 patients. Eur. Arch. Psychiatry Clin. Neurosci. 251, 225-231.
-
(2001)
Eur. Arch. Psychiatry Clin. Neurosci.
, vol.251
, pp. 225-231
-
-
Jauss, M.1
Herholz, K.2
Kracht, L.3
-
122
-
-
0034575582
-
Dietary restriction attenuates the neuronal loss, induction of heme oxygenase-1 and blood-brain barrier breakdown induced by impaired oxidative metabolism
-
Calingasan N.Y. and Gibson G.E. (2000) Dietary restriction attenuates the neuronal loss, induction of heme oxygenase-1 and blood-brain barrier breakdown induced by impaired oxidative metabolism. Brain Res. 885, 62-69.
-
(2000)
Brain Res.
, vol.885
, pp. 62-69
-
-
Calingasan, N.Y.1
Gibson, G.E.2
-
123
-
-
0034058593
-
Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism
-
Calingasan N.Y., Huang P.L., Chun H.S., Fabian A., and Gibson G.E. (2000) Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism. J. Neuropathol Exp. Neurol. 59, 207-217.
-
(2000)
J. Neuropathol. Exp. Neurol.
, vol.59
, pp. 207-217
-
-
Calingasan, N.Y.1
Huang, P.L.2
Chun, H.S.3
Fabian, A.4
Gibson, G.E.5
-
125
-
-
1542723493
-
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
-
Suh J.H., Shenvi S.V., Dixon B.M., Liu H., Jaiswal A.K., Liu R.M., et al. (2004) Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc. Natl. Acad. Sci. USA 101, 3381-3386.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 3381-3386
-
-
Suh, J.H.1
Shenvi, S.V.2
Dixon, B.M.3
Liu, H.4
Jaiswal, A.K.5
Liu, R.M.6
-
126
-
-
0029873732
-
The isomers of thioctic acid alter C-deoxyglucose incorporation in rat basal ganglia
-
Seaton T.A., Jenner P., and Marsden C.D. (1996) The isomers of thioctic acid alter C-deoxyglucose incorporation in rat basal ganglia. Biochem. Pharmacol. 51, 983-986.
-
(1996)
Biochem. Pharmacol.
, vol.51
, pp. 983-986
-
-
Seaton, T.A.1
Jenner, P.2
Marsden, C.D.3
-
127
-
-
0034986275
-
Alpha-lipoic acid as a new treatment option for Azheimer type dementia
-
Hager K., Marahrens A., Kenklies M., Riederer P., and Munch G. (2001) Alpha-lipoic acid as a new treatment option for Azheimer type dementia. Arch. Gerontol Geriatr. 32, 275-282.
-
(2001)
Arch. Gerontol Geriatr.
, vol.32
, pp. 275-282
-
-
Hager, K.1
Marahrens, A.2
Kenklies, M.3
Riederer, P.4
Munch, G.5
-
128
-
-
0035341962
-
Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal
-
Korotchkina L.G., Yang H., Tirosh O., Packer L., and Patel M.S. (2001) Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal. Free Radical Biol. Med. 30, 992-999.
-
(2001)
Free Radical Biol. Med.
, vol.30
, pp. 992-999
-
-
Korotchkina, L.G.1
Yang, H.2
Tirosh, O.3
Packer, L.4
Patel, M.S.5
-
129
-
-
0034955984
-
Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease
-
Andreassen O.A., Ferrante R.J., Huang H.M., et al. (2001) Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease. Ann. Neurol. 50, 112-117.
-
(2001)
Ann. Neurol.
, vol.50
, pp. 112-117
-
-
Andreassen, O.A.1
Ferrante, R.J.2
Huang, H.M.3
-
130
-
-
0033016722
-
Dietary thiamin level influences levels of its diphosphate form and thiamin-dependent enzymic activities of rat liver
-
Blair P.V., Kobayashi R., Edwards H.M., 3rd, Shay N.F., Baker D.H., and Harris R.A. (1999) Dietary thiamin level influences levels of its diphosphate form and thiamin-dependent enzymic activities of rat liver. J. Nutr. 129, 641-648.
-
(1999)
J. Nutr.
, vol.129
, pp. 641-648
-
-
Blair, P.V.1
Kobayashi, R.2
Edwards III, H.M.3
Shay, N.F.4
Baker, D.H.5
Harris, R.A.6
-
132
-
-
0026035893
-
A trial of thiamine in Alzheimer's disease
-
Nolan K.A., Black R.S., Sheu K.P., Langberg J., and Blass J.P. (1991) A trial of thiamine in Alzheimer's disease. Arch. Neurol. 48, 81-83.
-
(1991)
Arch. Neurol.
, vol.48
, pp. 81-83
-
-
Nolan, K.A.1
Black, R.S.2
Sheu, K.P.3
Langberg, J.4
Blass, J.P.5
-
133
-
-
0005257682
-
Metabolic enhancement in the treatment of Alzheiemer Disease
-
Vellas B, Fitten L.J., Winblad B., Feldman H., Grundman M., and Giacobini E., eds., Springer-Verlag, New York
-
Blass J.P. (2002) Metabolic enhancement in the treatment of Alzheiemer Disease, in Research and Practice in Alzheimer's Disease, Vellas B, Fitten L.J., Winblad B., Feldman H., Grundman M., and Giacobini E., eds., Springer-Verlag, New York, pp. 282-287.
-
(2002)
Research and Practice in Alzheimer's Disease
, pp. 282-287
-
-
Blass, J.P.1
|