PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

Cell Reports

Volumn 13, Issue 2, 2015, Pages 376-386

  Kostic, Marko ^a   Ludtmann, Marthe H R ^b   Bading, Hilmar ^c   Hershfinkel, Michal ^a   Steer, Erin ^d   Chu, Charleen T ^d   Abramov, Andrey Y ^b   Sekler, Israel ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE; PROTEIN SERINE THREONINE KINASE; PTEN INDUCED PUTATIVE KINASE 1; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG; CALCIUM; PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE; SLC8B1PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL SURVIVAL; CONTROLLED STUDY; DEPOLARIZATION; DOPAMINERGIC NERVE CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MITOCHONDRION; PHOSPHORYLATION; TUMOR CELL LINE;

ANIMALS; CALCIUM; CELL LINE, TUMOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOPAMINERGIC NEURONS; HEK293 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; PHOSPHORYLATION; PROTEIN KINASES; SODIUM-CALCIUM EXCHANGER;

EID: 84944076528     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.08.079     Document Type: Article

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