-
3
-
-
34250838558
-
A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation
-
Aldinucci A, Gerlini G, Fossati S, Cipriani G, Ballerini C, Biagioli T et al. (2007). A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation. J Immunol 179: 305–312.
-
(2007)
J Immunol
, vol.179
, pp. 305-312
-
-
Aldinucci, A.1
Gerlini, G.2
Fossati, S.3
Cipriani, G.4
Ballerini, C.5
Biagioli, T.6
-
4
-
-
84949844937
-
The Concise Guide to PHARMACOLOGY 2015/16: Enzymes
-
Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE et al. (2015). The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol 172: 6024–6109.
-
(2015)
Br J Pharmacol
, vol.172
, pp. 6024-6109
-
-
Alexander, S.P.H.1
Fabbro, D.2
Kelly, E.3
Marrion, N.4
Peters, J.A.5
Benson, H.E.6
-
5
-
-
83355166912
-
The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice
-
Ali M, Kamjoo M, Thomas HD, Kyle S, Pavlovska I, Babur M et al. (2011). The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice. Mol Cancer Ther 10: 2320–2329.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 2320-2329
-
-
Ali, M.1
Kamjoo, M.2
Thomas, H.D.3
Kyle, S.4
Pavlovska, I.5
Babur, M.6
-
7
-
-
33845301167
-
Poly(ADP-ribose) (PAR) polymer is a death signal
-
Andrabi SA, Kim NS, Yu SW, Wang H, Koh DW, Sasaki M et al. (2006). Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci U S A 103: 18308–18313.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 18308-18313
-
-
Andrabi, S.A.1
Kim, N.S.2
Yu, S.W.3
Wang, H.4
Koh, D.W.5
Sasaki, M.6
-
8
-
-
84901221201
-
Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors
-
Antolín AA, Mestres J (2014). Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors. Oncotarget 5: 3023–3028.
-
(2014)
Oncotarget
, vol.5
, pp. 3023-3028
-
-
Antolín, A.A.1
Mestres, J.2
-
9
-
-
84903604562
-
Aging and risk of severe, disabling, life-threatening, and fatal events in the childhood cancer survivor study
-
Armstrong GT, Kawashima T, Leisenring W (2014). Aging and risk of severe, disabling, life-threatening, and fatal events in the childhood cancer survivor study. J Clin Oncol 32: 1218–1227.
-
(2014)
J Clin Oncol
, vol.32
, pp. 1218-1227
-
-
Armstrong, G.T.1
Kawashima, T.2
Leisenring, W.3
-
10
-
-
79952768723
-
Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases
-
Ba X, Garg NJ (2011). Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases. Am J Pathol 178: 946–955.
-
(2011)
Am J Pathol
, vol.178
, pp. 946-955
-
-
Ba, X.1
Garg, N.J.2
-
11
-
-
84923080018
-
Poly(ADP-ribose) polymerases as modulators of mitochondrial activity
-
Bai P, Nagy L, Fodor T, Liaudet L, Pacher P (2015). Poly(ADP-ribose) polymerases as modulators of mitochondrial activity. Trends Endocrinol Metab 26: 75–83.
-
(2015)
Trends Endocrinol Metab
, vol.26
, pp. 75-83
-
-
Bai, P.1
Nagy, L.2
Fodor, T.3
Liaudet, L.4
Pacher, P.5
-
13
-
-
84928561032
-
Genomic instability in chronic airway inflammatory diseases
-
Bao Z, Xiong J, Li W, Chen Z, Shen H, Ying S (2015). Genomic instability in chronic airway inflammatory diseases. Biomed J 38: 117–124.
-
(2015)
Biomed J
, vol.38
, pp. 117-124
-
-
Bao, Z.1
Xiong, J.2
Li, W.3
Chen, Z.4
Shen, H.5
Ying, S.6
-
14
-
-
84958764117
-
Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: a systematic review and meta-analysis
-
Bao Z, Cao C, Geng X, Tian B, Wu Y, Zhang C et al. (2016). Effectiveness and safety of poly (ADP-ribose) polymerase inhibitors in cancer therapy: a systematic review and meta-analysis. Oncotarget 7: 7629–7639.
-
(2016)
Oncotarget
, vol.7
, pp. 7629-7639
-
-
Bao, Z.1
Cao, C.2
Geng, X.3
Tian, B.4
Wu, Y.5
Zhang, C.6
-
15
-
-
84937578418
-
Structures and mechanisms of enzymes employed in the synthesis and degradation of PARP-dependent protein ADP-ribosylation
-
Barkauskaite E, Jankevicius G, Ahel I (2015). Structures and mechanisms of enzymes employed in the synthesis and degradation of PARP-dependent protein ADP-ribosylation. Mol Cell 58: 935–946.
-
(2015)
Mol Cell
, vol.58
, pp. 935-946
-
-
Barkauskaite, E.1
Jankevicius, G.2
Ahel, I.3
-
16
-
-
67651097788
-
PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats
-
Bartha E, Solti I, Kereskai L, Lantos J, Plozer E, Magyar K et al. (2009). PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats. Cardiovasc Res 83: 501–510.
-
(2009)
Cardiovasc Res
, vol.83
, pp. 501-510
-
-
Bartha, E.1
Solti, I.2
Kereskai, L.3
Lantos, J.4
Plozer, E.5
Magyar, K.6
-
17
-
-
84893812229
-
Mitochondrial dysfunction induced by nuclear poly(ADP-ribose) polymerase-1: a treatable cause of cell death in stroke
-
Baxter P, Chen Y, Xu Y, Swanson RA (2014). Mitochondrial dysfunction induced by nuclear poly(ADP-ribose) polymerase-1: a treatable cause of cell death in stroke. Transl Stroke Res 5: 136–144.
-
(2014)
Transl Stroke Res
, vol.5
, pp. 136-144
-
-
Baxter, P.1
Chen, Y.2
Xu, Y.3
Swanson, R.A.4
-
18
-
-
38049012963
-
Poly(ADP-ribosyl)ation in mammalian ageing
-
Beneke S, Bürkle A (2007). Poly(ADP-ribosyl)ation in mammalian ageing. Nucleic Acids Res 35: 7456–7465.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 7456-7465
-
-
Beneke, S.1
Bürkle, A.2
-
19
-
-
0023606443
-
DNA repair, ADP-ribosylation and pyridine nucleotide metabolism as targets for cancer chemotherapy
-
Berger NA, Berger SJ, Gerson SL (1987). DNA repair, ADP-ribosylation and pyridine nucleotide metabolism as targets for cancer chemotherapy. Anticancer Drug Des 2: 203–209.
-
(1987)
Anticancer Drug Des
, vol.2
, pp. 203-209
-
-
Berger, N.A.1
Berger, S.J.2
Gerson, S.L.3
-
20
-
-
70350136777
-
Drug targets for traumatic brain injury from poly(ADP-ribose)polymerase pathway modulation
-
Besson VC (2009). Drug targets for traumatic brain injury from poly(ADP-ribose)polymerase pathway modulation. Br J Pharmacol 157: 695–704.
-
(2009)
Br J Pharmacol
, vol.157
, pp. 695-704
-
-
Besson, V.C.1
-
21
-
-
0036488604
-
Second cancers in survivors of childhood cancer
-
Bhatia S, Sklar C (2002). Second cancers in survivors of childhood cancer. Nat Rev Cancer 2: 124–132.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 124-132
-
-
Bhatia, S.1
Sklar, C.2
-
22
-
-
84940525090
-
Olaparib in the management of ovarian cancer
-
Bixel K, Hays JL (2015). Olaparib in the management of ovarian cancer. Pharmgenomics Pers Med 8: 127–135.
-
(2015)
Pharmgenomics Pers Med
, vol.8
, pp. 127-135
-
-
Bixel, K.1
Hays, J.L.2
-
23
-
-
84937622587
-
RNA regulation by poly(ADP-ribose) polymerases
-
Bock FJ, Todorova TT, Chang P (2015). RNA regulation by poly(ADP-ribose) polymerases. Mol Cell 58: 959–969.
-
(2015)
Mol Cell
, vol.58
, pp. 959-969
-
-
Bock, F.J.1
Todorova, T.T.2
Chang, P.3
-
24
-
-
84890035030
-
Accelerated aging during chronic oxidative stress: a role for PARP-1
-
Boesten DM, de Vos-Houben JM, Timmermans L, den Hartog GJ, Bast A, Hageman GJ (2013). Accelerated aging during chronic oxidative stress: a role for PARP-1. Oxid Med Cell Longev 2013: 680414.
-
(2013)
Oxid Med Cell Longev
, vol.2013
, pp. 680414
-
-
Boesten, D.M.1
de Vos-Houben, J.M.2
Timmermans, L.3
den Hartog, G.J.4
Bast, A.5
Hageman, G.J.6
-
25
-
-
0021362948
-
Inhibition of malignant transformation in vitro by inhibitors of poly(ADP-ribose) synthesis
-
Borek C, Morgan WF, Ong A, Cleaver JE (1984). Inhibition of malignant transformation in vitro by inhibitors of poly(ADP-ribose) synthesis. Proc Natl Acad Sci U S A 81: 243–247.
-
(1984)
Proc Natl Acad Sci U S A
, vol.81
, pp. 243-247
-
-
Borek, C.1
Morgan, W.F.2
Ong, A.3
Cleaver, J.E.4
-
26
-
-
32444444196
-
Genotoxicity and carcinogenicity studies of antihypertensive agents
-
Brambilla G, Martelli A (2006). Genotoxicity and carcinogenicity studies of antihypertensive agents. Mutat Res 612: 115–149.
-
(2006)
Mutat Res
, vol.612
, pp. 115-149
-
-
Brambilla, G.1
Martelli, A.2
-
27
-
-
59449102286
-
Update on genotoxicity and carcinogenicity testing of 472 marketed pharmaceuticals
-
Brambilla G, Martelli A (2009). Update on genotoxicity and carcinogenicity testing of 472 marketed pharmaceuticals. Mutat Res 681: 209–229.
-
(2009)
Mutat Res
, vol.681
, pp. 209-229
-
-
Brambilla, G.1
Martelli, A.2
-
28
-
-
77954450581
-
Genotoxic and carcinogenic effects of gastrointestinal drugs
-
Brambilla G, Mattioli F, Martelli A (2010). Genotoxic and carcinogenic effects of gastrointestinal drugs. Mutagenesis 25: 315–326.
-
(2010)
Mutagenesis
, vol.25
, pp. 315-326
-
-
Brambilla, G.1
Mattioli, F.2
Martelli, A.3
-
31
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E et al. (2005). Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434: 913–917.
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
Parker, K.M.4
Flower, D.5
Lopez, E.6
-
32
-
-
84955295791
-
Clinical trials of poly(ADP-ribose) polymerase inhibitors for cancer therapy: a review
-
Buege M, Mahajan PB (2015). Clinical trials of poly(ADP-ribose) polymerase inhibitors for cancer therapy: a review. Rev Recent Clin Trials 10: 326–339.
-
(2015)
Rev Recent Clin Trials
, vol.10
, pp. 326-339
-
-
Buege, M.1
Mahajan, P.B.2
-
34
-
-
84886717428
-
Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes
-
Cantó C, Sauve AA, Bai P (2013). Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol Aspects Med 34: 1168–1201.
-
(2013)
Mol Aspects Med
, vol.34
, pp. 1168-1201
-
-
Cantó, C.1
Sauve, A.A.2
Bai, P.3
-
35
-
-
84856651114
-
Targeting poly(ADP-ribose) polymerase-1 as a promising approach for immunomodulation in multiple sclerosis?
-
Cavone L, Chiarugi A (2012). Targeting poly(ADP-ribose) polymerase-1 as a promising approach for immunomodulation in multiple sclerosis? Trends Mol Med 18: 92–100.
-
(2012)
Trends Mol Med
, vol.18
, pp. 92-100
-
-
Cavone, L.1
Chiarugi, A.2
-
36
-
-
0002160618
-
Nicotinamide mononucleotide activation of new DNA-dependent polyadenylic acid synthesizing nuclear enzyme
-
Chambon P, Weill JD, Mandel P (1963). Nicotinamide mononucleotide activation of new DNA-dependent polyadenylic acid synthesizing nuclear enzyme. Biochem Biophys Res Commun 11: 39–43.
-
(1963)
Biochem Biophys Res Commun
, vol.11
, pp. 39-43
-
-
Chambon, P.1
Weill, J.D.2
Mandel, P.3
-
37
-
-
0037337260
-
GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury
-
Chatterjee PK, Patel NS, Sivarajah A, Kvale EO, Dugo L, Cuzzocrea S et al. (2003). GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury. Kidney Int 63: 853–865.
-
(2003)
Kidney Int
, vol.63
, pp. 853-865
-
-
Chatterjee, P.K.1
Patel, N.S.2
Sivarajah, A.3
Kvale, E.O.4
Dugo, L.5
Cuzzocrea, S.6
-
38
-
-
0036499892
-
Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited
-
Chiarugi A (2002). Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited. Trends Pharmacol Sci 23: 122–129.
-
(2002)
Trends Pharmacol Sci
, vol.23
, pp. 122-129
-
-
Chiarugi, A.1
-
39
-
-
56049100464
-
Telomere length regulation by poly(ADP-ribose)polymerase-1
-
Cohausz O, Malanga M, Boukamp P, Althaus FR, Bürkle A (2008). Telomere length regulation by poly(ADP-ribose)polymerase-1. Nucleic Acids Res 36: 6309–6317.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 6309-6317
-
-
Cohausz, O.1
Malanga, M.2
Boukamp, P.3
Althaus, F.R.4
Bürkle, A.5
-
40
-
-
33846362869
-
DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation
-
Cohen-Armon M, Visochek L, Rozensal D, Kalal A, Geistrikh I, Klein R et al. (2007). DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation. Mol Cell 25: 297–308.
-
(2007)
Mol Cell
, vol.25
, pp. 297-308
-
-
Cohen-Armon, M.1
Visochek, L.2
Rozensal, D.3
Kalal, A.4
Geistrikh, I.5
Klein, R.6
-
41
-
-
84908099568
-
Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture
-
Coletta C, Módis K, Oláh G, Brunyánszki A, Herzig DS, Sherwood ER et al. (2014). Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture. Crit Care 18: 511.
-
(2014)
Crit Care
, vol.18
, pp. 511
-
-
Coletta, C.1
Módis, K.2
Oláh, G.3
Brunyánszki, A.4
Herzig, D.S.5
Sherwood, E.R.6
-
42
-
-
84979263828
-
PARP inhibition and gynecologic malignancies: a review of current literature and on-going trials
-
Crafton SM, Bixel K, Hays JL (2016). PARP inhibition and gynecologic malignancies: a review of current literature and on-going trials. Gynecol Oncol 142: 588–596.
-
(2016)
Gynecol Oncol
, vol.142
, pp. 588-596
-
-
Crafton, S.M.1
Bixel, K.2
Hays, J.L.3
-
43
-
-
84886717487
-
Therapeutic applications of PARP inhibitors: anticancer therapy and beyond
-
Curtin NJ, Szabo C (2013). Therapeutic applications of PARP inhibitors: anticancer therapy and beyond. Mol Aspects Med 34: 1217–1256.
-
(2013)
Mol Aspects Med
, vol.34
, pp. 1217-1256
-
-
Curtin, N.J.1
Szabo, C.2
-
44
-
-
84866559001
-
Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib
-
Daemen A, Wolf DM, Korkola JE, Griffith OL, Frankum JR, Brough R et al. (2012). Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib. Breast Cancer Res Treat 135: 505–517.
-
(2012)
Breast Cancer Res Treat
, vol.135
, pp. 505-517
-
-
Daemen, A.1
Wolf, D.M.2
Korkola, J.E.3
Griffith, O.L.4
Frankum, J.R.5
Brough, R.6
-
45
-
-
84861231399
-
The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art
-
De Vos M, Schreiber V, Dantzer F (2012). The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art. Biochem Pharmacol 84: 137–146.
-
(2012)
Biochem Pharmacol
, vol.84
, pp. 137-146
-
-
De Vos, M.1
Schreiber, V.2
Dantzer, F.3
-
46
-
-
84925538968
-
Olaparib: first global approval
-
Deeks ED (2015). Olaparib: first global approval. Drugs 75: 231–240.
-
(2015)
Drugs
, vol.75
, pp. 231-240
-
-
Deeks, E.D.1
-
47
-
-
84929945972
-
Organ-protective effects on the liver and kidney by minocycline in small piglets undergoing cardiopulonary bypass
-
Dhein S, Grassl M, Gerdom M, Vollroth M, Bakhtiary F, von Salisch S et al. (2015). Organ-protective effects on the liver and kidney by minocycline in small piglets undergoing cardiopulonary bypass. Naunyn Schmiedebergs Arch Pharmacol 388: 663–676.
-
(2015)
Naunyn Schmiedebergs Arch Pharmacol
, vol.388
, pp. 663-676
-
-
Dhein, S.1
Grassl, M.2
Gerdom, M.3
Vollroth, M.4
Bakhtiary, F.5
von Salisch, S.6
-
48
-
-
84953204390
-
Efficacy and safety of olaparib monotherapy in germline BRCA1/2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy
-
Domchek SM, Aghajanian C, Shapira-Frommer R, Schmutzler RK, Audeh MW, Friedlander M et al. (2016). Efficacy and safety of olaparib monotherapy in germline BRCA1/2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy. Gynecol Oncol 140: 199–203.
-
(2016)
Gynecol Oncol
, vol.140
, pp. 199-203
-
-
Domchek, S.M.1
Aghajanian, C.2
Shapira-Frommer, R.3
Schmutzler, R.K.4
Audeh, M.W.5
Friedlander, M.6
-
49
-
-
84950159003
-
The development of PARP inhibitors in ovarian cancer: from bench to bedside
-
Drew Y (2015). The development of PARP inhibitors in ovarian cancer: from bench to bedside. Br J Cancer 113: S3–S9.
-
(2015)
Br J Cancer
, vol.113
, pp. S3-S9
-
-
Drew, Y.1
-
50
-
-
79951887369
-
Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2
-
Drew Y, Mulligan EA, Vong WT, Thomas HD, Kahn S, Kyle S et al. (2011). Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2. J Natl Cancer Inst 103: 334–346.
-
(2011)
J Natl Cancer Inst
, vol.103
, pp. 334-346
-
-
Drew, Y.1
Mulligan, E.A.2
Vong, W.T.3
Thomas, H.D.4
Kahn, S.5
Kyle, S.6
-
51
-
-
0026496866
-
Effect of inhibitor of poly (ADP-ribose) polymerase in blood lymphocyte cultures of untreated leprosy patients
-
D'Souza D, Thomas IM, Das BC (1992). Effect of inhibitor of poly (ADP-ribose) polymerase in blood lymphocyte cultures of untreated leprosy patients. Mutat Res 284: 251–255.
-
(1992)
Mutat Res
, vol.284
, pp. 251-255
-
-
D'Souza, D.1
Thomas, I.M.2
Das, B.C.3
-
52
-
-
0038043242
-
Intra-mitochondrial poly-ADP-ribosylation contributes to NAD+ depletion and cell death induced by oxidative stress
-
Du L, Zhang X, Han YY, Burke NA, Kochanek PM, Watkins SC et al. (2003). Intra-mitochondrial poly-ADP-ribosylation contributes to NAD+ depletion and cell death induced by oxidative stress. J Biol Chem 278: 18426–18433.
-
(2003)
J Biol Chem
, vol.278
, pp. 18426-18433
-
-
Du, L.1
Zhang, X.2
Han, Y.Y.3
Burke, N.A.4
Kochanek, P.M.5
Watkins, S.C.6
-
53
-
-
4644305774
-
Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway
-
Du L, Bayir H, Lai Y, Zhang X, Kochanek PM, Watkins SC et al. (2004). Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. J Biol Chem 279: 38563–38570.
-
(2004)
J Biol Chem
, vol.279
, pp. 38563-38570
-
-
Du, L.1
Bayir, H.2
Lai, Y.3
Zhang, X.4
Kochanek, P.M.5
Watkins, S.C.6
-
54
-
-
0018906390
-
(ADP-ribose)n participates in DNA excision repair
-
Durkacz BW, Omidiji O, Gray DA, Shall S (1980). (ADP-ribose)n participates in DNA excision repair. Nature 283: 593–596.
-
(1980)
Nature
, vol.283
, pp. 593-596
-
-
Durkacz, B.W.1
Omidiji, O.2
Gray, D.A.3
Shall, S.4
-
55
-
-
0030842946
-
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
-
Eliasson MJ, Sampei K, Mandir AS, Hurn PD, Traystman RJ, Bao J et al. (1997). Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 3: 1089–1095.
-
(1997)
Nat Med
, vol.3
, pp. 1089-1095
-
-
Eliasson, M.J.1
Sampei, K.2
Mandir, A.S.3
Hurn, P.D.4
Traystman, R.J.5
Bao, J.6
-
56
-
-
79955702894
-
Glutamine contributes to ameliorate inflammation after renal ischemia/reperfusion injury in rats
-
Esposito E, Mondello S, Di Paola R, Mazzon E, Italiano D, Paterniti I et al. (2011). Glutamine contributes to ameliorate inflammation after renal ischemia/reperfusion injury in rats. Naunyn Schmiedebergs Arch Pharmacol 383: 493–508.
-
(2011)
Naunyn Schmiedebergs Arch Pharmacol
, vol.383
, pp. 493-508
-
-
Esposito, E.1
Mondello, S.2
Di Paola, R.3
Mazzon, E.4
Italiano, D.5
Paterniti, I.6
-
57
-
-
21644454451
-
Role of nitrosative stress and activation of poly(ADP-ribose) polymerase-1 in cardiovascular failure associated with septic and hemorrhagic shock
-
Evgenov OV, Liaudet L (2005). Role of nitrosative stress and activation of poly(ADP-ribose) polymerase-1 in cardiovascular failure associated with septic and hemorrhagic shock. Curr Vasc Pharmacol 3: 293–299.
-
(2005)
Curr Vasc Pharmacol
, vol.3
, pp. 293-299
-
-
Evgenov, O.V.1
Liaudet, L.2
-
58
-
-
84918492954
-
A new facet of ADP-ribosylation reactions: SIRTs and PARPs interplay
-
Faraone-Mennella MR (2015). A new facet of ADP-ribosylation reactions: SIRTs and PARPs interplay. Front Biosci (Landmark Ed) 20: 458–473.
-
(2015)
Front Biosci (Landmark Ed)
, vol.20
, pp. 458-473
-
-
Faraone-Mennella, M.R.1
-
59
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB et al. (2005). Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434: 917–921.
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
Tutt, A.N.4
Johnson, D.A.5
Richardson, T.B.6
-
60
-
-
84897442012
-
Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities
-
Fatokun AA, Dawson VL, Dawson TM (2014). Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities. Br J Pharmacol 171: 2000–2016.
-
(2014)
Br J Pharmacol
, vol.171
, pp. 2000-2016
-
-
Fatokun, A.A.1
Dawson, V.L.2
Dawson, T.M.3
-
61
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M et al. (2009). Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 361: 123–134.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
Tutt, A.4
Wu, P.5
Mergui-Roelvink, M.6
-
62
-
-
33644850114
-
The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives
-
Gagné JP, Hendzel MJ, Droit A, Poirier GG (2006). The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives. Curr Opin Cell Biol 18: 145–151.
-
(2006)
Curr Opin Cell Biol
, vol.18
, pp. 145-151
-
-
Gagné, J.P.1
Hendzel, M.J.2
Droit, A.3
Poirier, G.G.4
-
63
-
-
84939863982
-
The role of poly(ADP-ribose) polymerase-1 in rheumatoid arthritis
-
García S, Conde C (2015). The role of poly(ADP-ribose) polymerase-1 in rheumatoid arthritis. Mediators Inflamm 2015: 837250.
-
(2015)
Mediators Inflamm
, vol.2015
, pp. 837250
-
-
García, S.1
Conde, C.2
-
64
-
-
85008145303
-
Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease
-
Gariani K, Ryu D, Menzies KJ, Yi HS, Stein S, Zhang H et al. (2017). Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease. J Hepatol 66: 132–141.
-
(2017)
J Hepatol
, vol.66
, pp. 132-141
-
-
Gariani, K.1
Ryu, D.2
Menzies, K.J.3
Yi, H.S.4
Stein, S.5
Zhang, H.6
-
65
-
-
84930513417
-
Poly(ADP-ribose) polymerase 1 (PARP-1) activation and Ca2+ permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) channels in post-ischemic brain damage: new therapeutic opportunities?
-
Gerace E, Pellegrini-Giampietro DE, Moroni F, Mannaioni G (2015). Poly(ADP-ribose) polymerase 1 (PARP-1) activation and Ca2+ permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) channels in post-ischemic brain damage: new therapeutic opportunities? CNS Neurol Disord Drug Targets 14: 636–646.
-
(2015)
CNS Neurol Disord Drug Targets
, vol.14
, pp. 636-646
-
-
Gerace, E.1
Pellegrini-Giampietro, D.E.2
Moroni, F.3
Mannaioni, G.4
-
66
-
-
84937044948
-
PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function
-
Ghonim MA, Pyakurel K, Ibba SV, Al-Khami AA, Wang J, Rodriguez P et al. (2015a). PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function. J Transl Med 13: 225.
-
(2015)
J Transl Med
, vol.13
, pp. 225
-
-
Ghonim, M.A.1
Pyakurel, K.2
Ibba, S.V.3
Al-Khami, A.A.4
Wang, J.5
Rodriguez, P.6
-
67
-
-
84952012202
-
PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice
-
Ghonim MA, Pyakurel K, Ibba SV, Wang J, Rodriguez P, Al-Khami AA et al. (2015b). PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice. Clin Sci (Lond) 129: 951–962.
-
(2015)
Clin Sci (Lond)
, vol.129
, pp. 951-962
-
-
Ghonim, M.A.1
Pyakurel, K.2
Ibba, S.V.3
Wang, J.4
Rodriguez, P.5
Al-Khami, A.A.6
-
69
-
-
84862758175
-
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
-
Gibson BA, Kraus WL (2012). New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nat Rev Mol Cell Biol 13: 411–424.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 411-424
-
-
Gibson, B.A.1
Kraus, W.L.2
-
70
-
-
84974575150
-
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation
-
Gibson BA, Zhang Y, Jiang H, Hussey KM, Shrimp JH, Lin H et al. (2016). Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science 353: 45–50.
-
(2016)
Science
, vol.353
, pp. 45-50
-
-
Gibson, B.A.1
Zhang, Y.2
Jiang, H.3
Hussey, K.M.4
Shrimp, J.H.5
Lin, H.6
-
71
-
-
0031239152
-
Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts In vitro
-
Gilad E, Zingarelli B, Salzman AL, Szabó C (1997). Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts In vitro. J Mol Cell Cardiol 29: 2585–2597.
-
(1997)
J Mol Cell Cardiol
, vol.29
, pp. 2585-2597
-
-
Gilad, E.1
Zingarelli, B.2
Salzman, A.L.3
Szabó, C.4
-
72
-
-
85012295487
-
A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia
-
Gojo I, Beumer JH, Pratz KW, McDevitt MA, Baer MR, Blackford AL et al. (2017). A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia. Clin Cancer Res 23: 697–706.
-
(2017)
Clin Cancer Res
, vol.23
, pp. 697-706
-
-
Gojo, I.1
Beumer, J.H.2
Pratz, K.W.3
McDevitt, M.A.4
Baer, M.R.5
Blackford, A.L.6
-
73
-
-
0036251182
-
Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis
-
Goldfarb RD, Marton A, Szabó E, Virág L, Salzman AL, Glock D (2002). Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis. Crit Care Med 30: 974–980.
-
(2002)
Crit Care Med
, vol.30
, pp. 974-980
-
-
Goldfarb, R.D.1
Marton, A.2
Szabó, E.3
Virág, L.4
Salzman, A.L.5
Glock, D.6
-
74
-
-
0029080684
-
The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy
-
Griffin RJ, Curtin NJ, Newell DR, Golding BT, Durkacz BW, Calvert AH (1995). The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy. Biochimie 77: 408–422.
-
(1995)
Biochimie
, vol.77
, pp. 408-422
-
-
Griffin, R.J.1
Curtin, N.J.2
Newell, D.R.3
Golding, B.T.4
Durkacz, B.W.5
Calvert, A.H.6
-
75
-
-
84976319225
-
Pharmacologic neuroprotection for functional outcomes after traumatic brain injury: a systematic review of the clinical literature
-
Gruenbaum SE, Zlotnik A, Gruenbaum BF, Hersey D, Bilotta F (2016). Pharmacologic neuroprotection for functional outcomes after traumatic brain injury: a systematic review of the clinical literature. CNS Drugs 30: 791–806.
-
(2016)
CNS Drugs
, vol.30
, pp. 791-806
-
-
Gruenbaum, S.E.1
Zlotnik, A.2
Gruenbaum, B.F.3
Hersey, D.4
Bilotta, F.5
-
76
-
-
84896138015
-
Neurological and histological consequences induced by in vivo cerebral oxidative stress: evidence for beneficial effects of SRT1720, a sirtuin 1 activator, and sirtuin 1-mediated neuroprotective effects of poly(ADP-ribose) polymerase inhibition
-
Gueguen C, Palmier B, Plotkine M, Marchand-Leroux C, Besson VC (2014). Neurological and histological consequences induced by in vivo cerebral oxidative stress: evidence for beneficial effects of SRT1720, a sirtuin 1 activator, and sirtuin 1-mediated neuroprotective effects of poly(ADP-ribose) polymerase inhibition. PLoS One 9: e87367.
-
(2014)
PLoS One
, vol.9
-
-
Gueguen, C.1
Palmier, B.2
Plotkine, M.3
Marchand-Leroux, C.4
Besson, V.C.5
-
77
-
-
34548151570
-
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts
-
Gunji A, Uemura A, Tsutsumi M, Nozaki T, Kusuoka O, Omura K et al. (2006). Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts. Cancer Lett 241: 87–92.
-
(2006)
Cancer Lett
, vol.241
, pp. 87-92
-
-
Gunji, A.1
Uemura, A.2
Tsutsumi, M.3
Nozaki, T.4
Kusuoka, O.5
Omura, K.6
-
78
-
-
0033598713
-
Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
-
Ha HC, Snyder SH (1999). Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci U S A 96: 13978–13982.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 13978-13982
-
-
Ha, H.C.1
Snyder, S.H.2
-
79
-
-
4444383142
-
PARP1 gene disruption in mice preferentially protects males from perinatal brain injury
-
Hagberg H, Wilson MA, Matsushita H, Zhu C, Lange M, Gustavsson M et al. (2004). PARP1 gene disruption in mice preferentially protects males from perinatal brain injury. J Neurochem 90: 1068–1075.
-
(2004)
J Neurochem
, vol.90
, pp. 1068-1075
-
-
Hagberg, H.1
Wilson, M.A.2
Matsushita, H.3
Zhu, C.4
Lange, M.5
Gustavsson, M.6
-
80
-
-
33745616162
-
The parp-1 inhibitor ino-1001 facilitates hemodynamic stabilization without affecting DNA repair in porcine thoracic aortic cross-clamping-induced ischemia/reperfusion
-
Hauser B, Gröger M, Ehrmann U, Albicini M, Brückner UB, Schelzig H et al. (2006). The parp-1 inhibitor ino-1001 facilitates hemodynamic stabilization without affecting DNA repair in porcine thoracic aortic cross-clamping-induced ischemia/reperfusion. Shock 25: 633–640.
-
(2006)
Shock
, vol.25
, pp. 633-640
-
-
Hauser, B.1
Gröger, M.2
Ehrmann, U.3
Albicini, M.4
Brückner, U.B.5
Schelzig, H.6
-
81
-
-
0028500537
-
Analysis of oxygen radical toxicity in pancreatic islets at the single cell level
-
Heller B, Bürkle A, Radons J, Fengler E, Jalowy A, Müller M et al. (1994). Analysis of oxygen radical toxicity in pancreatic islets at the single cell level. Biol Chem Hoppe Seyler 375: 597–602.
-
(1994)
Biol Chem Hoppe Seyler
, vol.375
, pp. 597-602
-
-
Heller, B.1
Bürkle, A.2
Radons, J.3
Fengler, E.4
Jalowy, A.5
Müller, M.6
-
82
-
-
84936806860
-
Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer
-
Henneman L, van Miltenburg MH, Michalak EM, Braumuller TM, Jaspers JE, Drenth AP et al. (2015). Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer. Proc Natl Acad Sci U S A 112: 8409–8414.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 8409-8414
-
-
Henneman, L.1
van Miltenburg, M.H.2
Michalak, E.M.3
Braumuller, T.M.4
Jaspers, J.E.5
Drenth, A.P.6
-
83
-
-
77951023118
-
Toward a unified nomenclature for mammalian ADP-ribosyltransferases
-
Hottiger MO, Hassa PO, Lüscher B, Schüler H, Koch-Nolte F (2010). Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Trends Biochem Sci 35: 208–219.
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 208-219
-
-
Hottiger, M.O.1
Hassa, P.O.2
Lüscher, B.3
Schüler, H.4
Koch-Nolte, F.5
-
84
-
-
84982793319
-
Potential of inducible nitric oxide synthase as a therapeutic target for allergen-induced airway hyperresponsiveness: a critical connection to nitric oxide levels and PARP activity
-
1984703
-
Ibba SV, Ghonim MA, Pyakurel K, Lammi MR, Mishra A, Boulares AH (2016). Potential of inducible nitric oxide synthase as a therapeutic target for allergen-induced airway hyperresponsiveness: a critical connection to nitric oxide levels and PARP activity. Mediators Inflamm 2016: 1984703.
-
(2016)
Mediators Inflamm
, vol.2016
-
-
Ibba, S.V.1
Ghonim, M.A.2
Pyakurel, K.3
Lammi, M.R.4
Mishra, A.5
Boulares, A.H.6
-
85
-
-
84904751060
-
NAD+ and sirtuins in aging and disease
-
Imai S, Guarente L (2014). NAD+ and sirtuins in aging and disease. Trends Cell Biol 24: 464–471.
-
(2014)
Trends Cell Biol
, vol.24
, pp. 464-471
-
-
Imai, S.1
Guarente, L.2
-
86
-
-
84979247551
-
PARP inhibitors in clinical use induce genomic instability in normal human cells
-
Ito S, Murphy CG, Doubrovina E, Jasin M, Moynahan ME (2016). PARP inhibitors in clinical use induce genomic instability in normal human cells. PLoS One 11: e0159341.
-
(2016)
PLoS One
, vol.11
-
-
Ito, S.1
Murphy, C.G.2
Doubrovina, E.3
Jasin, M.4
Moynahan, M.E.5
-
87
-
-
1242303935
-
Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia
-
Iványi Z, Hauser B, Pittner A, Asfar P, Vassilev D, Nalos M et al. (2003). Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia. Shock 19: 415–421.
-
(2003)
Shock
, vol.19
, pp. 415-421
-
-
Iványi, Z.1
Hauser, B.2
Pittner, A.3
Asfar, P.4
Vassilev, D.5
Nalos, M.6
-
88
-
-
18944390248
-
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors
-
Jagtap P, Szabo C (2005). Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov 4: 421–440.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 421-440
-
-
Jagtap, P.1
Szabo, C.2
-
89
-
-
84989915349
-
Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases
-
Jęśko H, Strosznajder RP (2016). Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases. Folia Neuropathol 54: 212–233.
-
(2016)
Folia Neuropathol
, vol.54
, pp. 212-233
-
-
Jęśko, H.1
Strosznajder, R.P.2
-
90
-
-
84881219867
-
Post-transcriptional regulation by poly(ADP-ribosyl)ation of the RNA-binding proteins
-
Ji Y, Tulin AV (2013). Post-transcriptional regulation by poly(ADP-ribosyl)ation of the RNA-binding proteins. Int J Mol Sci 14: 16168–16183.
-
(2013)
Int J Mol Sci
, vol.14
, pp. 16168-16183
-
-
Ji, Y.1
Tulin, A.V.2
-
91
-
-
84882678911
-
Differential regulation of cell death programs in males and females by poly (ADP-ribose) polymerase-1 and 17β estradiol
-
Jog NR, Caricchio R (2013). Differential regulation of cell death programs in males and females by poly (ADP-ribose) polymerase-1 and 17β estradiol. Cell Death Dis 4: e758.
-
(2013)
Cell Death Dis
, vol.4
-
-
Jog, N.R.1
Caricchio, R.2
-
92
-
-
67449152218
-
Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation
-
Jog NR, Dinnall JA, Gallucci S, Madaio MP, Caricchio R (2009). Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation. J Immunol 182: 7297–7306.
-
(2009)
J Immunol
, vol.182
, pp. 7297-7306
-
-
Jog, N.R.1
Dinnall, J.A.2
Gallucci, S.3
Madaio, M.P.4
Caricchio, R.5
-
93
-
-
84995644758
-
Poly ADP-ribose polymerase-1: beyond transcription and towards differentiation
-
Jubin T, Kadam A, Gani AR, Singh M, Dwivedi M, Begum R (2017). Poly ADP-ribose polymerase-1: beyond transcription and towards differentiation. Semin Cell Dev Biol 63: 167–179.
-
(2017)
Semin Cell Dev Biol
, vol.63
, pp. 167-179
-
-
Jubin, T.1
Kadam, A.2
Gani, A.R.3
Singh, M.4
Dwivedi, M.5
Begum, R.6
-
94
-
-
84876728257
-
Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis
-
Kamboj A, Lu P, Cossoy MB, Stobart JL, Dolhun BA, Kauppinen TM et al. (2013). Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis. J Neuroinflammation 10: 49.
-
(2013)
J Neuroinflammation
, vol.10
, pp. 49
-
-
Kamboj, A.1
Lu, P.2
Cossoy, M.B.3
Stobart, J.L.4
Dolhun, B.A.5
Kauppinen, T.M.6
-
95
-
-
84922104385
-
PARP inhibitor, olaparib ameliorates acute lung and kidney injury upon intratracheal administration of LPS in mice
-
Kapoor K, Singla E, Sahu B, Naura AS (2015). PARP inhibitor, olaparib ameliorates acute lung and kidney injury upon intratracheal administration of LPS in mice. Mol Cell Biochem 400: 153–162.
-
(2015)
Mol Cell Biochem
, vol.400
, pp. 153-162
-
-
Kapoor, K.1
Singla, E.2
Sahu, B.3
Naura, A.S.4
-
96
-
-
34247127355
-
The role of poly(ADP-ribose) polymerase-1 in CNS disease
-
Kauppinen TM, Swanson RA (2007). The role of poly(ADP-ribose) polymerase-1 in CNS disease. Neuroscience 145: 1267–1272.
-
(2007)
Neuroscience
, vol.145
, pp. 1267-1272
-
-
Kauppinen, T.M.1
Swanson, R.A.2
-
97
-
-
84863010984
-
Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer
-
Kaye SB, Lubinski J, Matulonis U, Ang JE, Gourley C, Karlan BY et al. (2012). Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer. J Clin Oncol 30: 372–379.
-
(2012)
J Clin Oncol
, vol.30
, pp. 372-379
-
-
Kaye, S.B.1
Lubinski, J.2
Matulonis, U.3
Ang, J.E.4
Gourley, C.5
Karlan, B.Y.6
-
98
-
-
79961146098
-
Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction
-
Kim J, Padanilam BJ (2011). Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction. Am J Physiol Renal Physiol 301: F450–F459.
-
(2011)
Am J Physiol Renal Physiol
, vol.301
, pp. F450-F459
-
-
Kim, J.1
Padanilam, B.J.2
-
99
-
-
0842282466
-
Widespread increased expression of the DNA repair enzyme PARP in brain in ALS
-
Kim SH, Engelhardt JI, Henkel JS, Siklós L, Soós J, Goodman C et al. (2004). Widespread increased expression of the DNA repair enzyme PARP in brain in ALS. Neurology 62: 319–322.
-
(2004)
Neurology
, vol.62
, pp. 319-322
-
-
Kim, S.H.1
Engelhardt, J.I.2
Henkel, J.S.3
Siklós, L.4
Soós, J.5
Goodman, C.6
-
100
-
-
85027933448
-
Proteome-wide profiling of clinical PARP inhibitors reveals compound-specific secondary targets
-
Knezevic CE, Wright G, Remsing Rix LL, Kim W, Kuenzi BM, Luo Y et al. (2016). Proteome-wide profiling of clinical PARP inhibitors reveals compound-specific secondary targets. Cell Chem Biol 23: 1490–1503.
-
(2016)
Cell Chem Biol
, vol.23
, pp. 1490-1503
-
-
Knezevic, C.E.1
Wright, G.2
Remsing Rix, L.L.3
Kim, W.4
Kuenzi, B.M.5
Luo, Y.6
-
101
-
-
84880626754
-
Hereditary breast and ovarian cancer susceptibility genes (review)
-
Kobayashi H, Ohno S, Sasaki Y, Matsuura M (2013). Hereditary breast and ovarian cancer susceptibility genes (review). Oncol Rep 30: 1019–1029.
-
(2013)
Oncol Rep
, vol.30
, pp. 1019-1029
-
-
Kobayashi, H.1
Ohno, S.2
Sasaki, Y.3
Matsuura, M.4
-
102
-
-
29144446064
-
Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia
-
Kofler J, Otsuka T, Zhang Z, Noppens R, Grafe MR, Koh DW et al. (2006). Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia. J Cereb Blood Flow Metab 26: 135–141.
-
(2006)
J Cereb Blood Flow Metab
, vol.26
, pp. 135-141
-
-
Kofler, J.1
Otsuka, T.2
Zhang, Z.3
Noppens, R.4
Grafe, M.R.5
Koh, D.W.6
-
103
-
-
18544382022
-
Poly(ADP-ribosyl)ation regulation of life and death in the nervous system
-
Koh DW, Dawson TM, Dawson VL (2005). Poly(ADP-ribosyl)ation regulation of life and death in the nervous system. Cell Mol Life Sci 62: 760–768.
-
(2005)
Cell Mol Life Sci
, vol.62
, pp. 760-768
-
-
Koh, D.W.1
Dawson, T.M.2
Dawson, V.L.3
-
104
-
-
18044388712
-
Poly (adp-ribose) polymerase inhibitors as potential therapeutic agents in stroke and neurotrauma
-
Komjáti K, Besson VC, Szabó C (2005). Poly (adp-ribose) polymerase inhibitors as potential therapeutic agents in stroke and neurotrauma. Curr Drug Targets CNS Neurol Disord 4: 179–194.
-
(2005)
Curr Drug Targets CNS Neurol Disord
, vol.4
, pp. 179-194
-
-
Komjáti, K.1
Besson, V.C.2
Szabó, C.3
-
105
-
-
84991037085
-
PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions
-
Konecny GE, Kristeleit RS (2016). PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions. Br J Cancer 115: 1157–1173.
-
(2016)
Br J Cancer
, vol.115
, pp. 1157-1173
-
-
Konecny, G.E.1
Kristeleit, R.S.2
-
106
-
-
84937597366
-
PARPs and ADP-Ribosylation: 50 Years … and Counting
-
Kraus WL (2015). PARPs and ADP-Ribosylation: 50 Years … and Counting. Mol Cell 58: 902–910.
-
(2015)
Mol Cell
, vol.58
, pp. 902-910
-
-
Kraus, W.L.1
-
107
-
-
84886719040
-
PARP-1 and gene regulation: progress and puzzles
-
Kraus WL, Hottiger MO (2013). PARP-1 and gene regulation: progress and puzzles. Mol Aspects Med 34: 1109–1123.
-
(2013)
Mol Aspects Med
, vol.34
, pp. 1109-1123
-
-
Kraus, W.L.1
Hottiger, M.O.2
-
108
-
-
84886721124
-
Reprogramming cellular events by poly(ADP-ribose)-binding proteins
-
Krietsch J, Rouleau M, Pic É, Ethier C, Dawson TM, Dawson VL et al. (2013). Reprogramming cellular events by poly(ADP-ribose)-binding proteins. Mol Aspects Med 34: 1066–1087.
-
(2013)
Mol Aspects Med
, vol.34
, pp. 1066-1087
-
-
Krietsch, J.1
Rouleau, M.2
Pic, É.3
Ethier, C.4
Dawson, T.M.5
Dawson, V.L.6
-
109
-
-
39849103134
-
Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury
-
Lai Y, Chen Y, Watkins SC, Nathaniel PD, Guo F, Kochanek PM et al. (2008). Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury. J Neurochem 104: 1700–1711.
-
(2008)
J Neurochem
, vol.104
, pp. 1700-1711
-
-
Lai, Y.1
Chen, Y.2
Watkins, S.C.3
Nathaniel, P.D.4
Guo, F.5
Kochanek, P.M.6
-
111
-
-
85015347376
-
Overall survival in patients with platinum-sensitive recurrent serous ovarian cancer receiving olaparib maintenance monotherapy: an updated analysis from a randomised, placebo-controlled, double-blind, phase 2 trial
-
Ledermann JA, Harter P, Gourley C, Friedlander M, Vergote I, Rustin G et al. (2016). Overall survival in patients with platinum-sensitive recurrent serous ovarian cancer receiving olaparib maintenance monotherapy: an updated analysis from a randomised, placebo-controlled, double-blind, phase 2 trial. Lancet Oncol 17: 1579–1589.
-
(2016)
Lancet Oncol
, vol.17
, pp. 1579-1589
-
-
Ledermann, J.A.1
Harter, P.2
Gourley, C.3
Friedlander, M.4
Vergote, I.5
Rustin, G.6
-
112
-
-
84884902975
-
Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss
-
Lee Y, Karuppagounder SS, Shin JH, Lee YI, Ko HS, Swing D et al. (2013). Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss. Nat Neurosci 16: 1392–1400.
-
(2013)
Nat Neurosci
, vol.16
, pp. 1392-1400
-
-
Lee, Y.1
Karuppagounder, S.S.2
Shin, J.H.3
Lee, Y.I.4
Ko, H.S.5
Swing, D.6
-
113
-
-
84897012760
-
PARP inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies
-
Lee JM, Ledermann JA, Kohn EC (2014). PARP inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. Ann Oncol 25: 32–40.
-
(2014)
Ann Oncol
, vol.25
, pp. 32-40
-
-
Lee, J.M.1
Ledermann, J.A.2
Kohn, E.C.3
-
114
-
-
84960427271
-
Effects of anticancer drugs on chromosome instability and new clinical implications for tumor-suppressing therapies
-
Lee HS, Lee NC, Kouprina N, Kim JH, Kagansky A, Bates S et al. (2016). Effects of anticancer drugs on chromosome instability and new clinical implications for tumor-suppressing therapies. Cancer Res 76: 902–911.
-
(2016)
Cancer Res
, vol.76
, pp. 902-911
-
-
Lee, H.S.1
Lee, N.C.2
Kouprina, N.3
Kim, J.H.4
Kagansky, A.5
Bates, S.6
-
115
-
-
85016132680
-
Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease
-
Lehmann S, Costa AC, Celardo I, Loh SH, Martins LM (2016). Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease. Cell Death Dis 7: e2166.
-
(2016)
Cell Death Dis
, vol.7
-
-
Lehmann, S.1
Costa, A.C.2
Celardo, I.3
Loh, S.H.4
Martins, L.M.5
-
116
-
-
84957588581
-
Phase II study of olaparib (AZD-2281) after standard systemic therapies for disseminated colorectal cancer
-
Leichman L, Groshen S, O'Neil BH, Messersmith W, Berlin J, Chan E et al. (2016). Phase II study of olaparib (AZD-2281) after standard systemic therapies for disseminated colorectal cancer. Oncologist 21: 172–177.
-
(2016)
Oncologist
, vol.21
, pp. 172-177
-
-
Leichman, L.1
Groshen, S.2
O'Neil, B.H.3
Messersmith, W.4
Berlin, J.5
Chan, E.6
-
117
-
-
84901397700
-
ADP-ribosylation: activation, recognition, and removal
-
Li N, Chen J (2014). ADP-ribosylation: activation, recognition, and removal. Mol Cells 37: 9–16.
-
(2014)
Mol Cells
, vol.37
, pp. 9-16
-
-
Li, N.1
Chen, J.2
-
118
-
-
63949083605
-
Sex differences in minocycline-induced neuroprotection after experimental stroke
-
Li J, McCullough LD (2009). Sex differences in minocycline-induced neuroprotection after experimental stroke. J Cereb Blood Flow Metab 29: 670–674.
-
(2009)
J Cereb Blood Flow Metab
, vol.29
, pp. 670-674
-
-
Li, J.1
McCullough, L.D.2
-
119
-
-
77950921560
-
Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia
-
Li X, Klaus JA, Zhang J, Xu Z, Kibler KK, Andrabi SA et al. (2010). Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia. J Neurochem 113: 1012–1022.
-
(2010)
J Neurochem
, vol.113
, pp. 1012-1022
-
-
Li, X.1
Klaus, J.A.2
Zhang, J.3
Xu, Z.4
Kibler, K.K.5
Andrabi, S.A.6
-
120
-
-
84883707984
-
Parp1 deficient mice are protected from streptozotocin-induced diabetes but not caerulein-induced pancreatitis, independent of the induction of Reg family genes
-
Li B, Luo C, Chowdhury S, Gao ZH, Liu JL (2013). Parp1 deficient mice are protected from streptozotocin-induced diabetes but not caerulein-induced pancreatitis, independent of the induction of Reg family genes. Regul Pept 186: 83–91.
-
(2013)
Regul Pept
, vol.186
, pp. 83-91
-
-
Li, B.1
Luo, C.2
Chowdhury, S.3
Gao, Z.H.4
Liu, J.L.5
-
121
-
-
0038408592
-
Oxidative stress and regional ischemia-reperfusion injury: the peroxynitrite-poly(ADP-ribose) polymerase connection
-
Liaudet L, Szabó G, Szabó C (2003). Oxidative stress and regional ischemia-reperfusion injury: the peroxynitrite-poly(ADP-ribose) polymerase connection. Coron Artery Dis 14: 115–122.
-
(2003)
Coron Artery Dis
, vol.14
, pp. 115-122
-
-
Liaudet, L.1
Szabó, G.2
Szabó, C.3
-
123
-
-
85017192994
-
HYDAMTIQ, a selective PARP-1 inhibitor, improves bleomycin-induced lung fibrosis by dampening the TGF-β/SMAD signalling pathway
-
Lucarini L, Durante M, Lanzi C, Pini A, Boccalini G, Calosi L et al. (2016). HYDAMTIQ, a selective PARP-1 inhibitor, improves bleomycin-induced lung fibrosis by dampening the TGF-β/SMAD signalling pathway. J Cell Mol Med 20: 1–12.
-
(2016)
J Cell Mol Med
, vol.20
, pp. 1-12
-
-
Lucarini, L.1
Durante, M.2
Lanzi, C.3
Pini, A.4
Boccalini, G.5
Calosi, L.6
-
124
-
-
84905251990
-
Inhibition of poly(ADP-ribosyl)ation in cancer: old and new paradigms revisited
-
Lupo B, Trusolino L (2014). Inhibition of poly(ADP-ribosyl)ation in cancer: old and new paradigms revisited. Biochim Biophys Acta 1846: 201–215.
-
(2014)
Biochim Biophys Acta
, vol.1846
, pp. 201-215
-
-
Lupo, B.1
Trusolino, L.2
-
125
-
-
27144555760
-
Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation
-
Mabley JG, Horváth EM, Murthy KG, Zsengellér Z, Vaslin A, Benko R et al. (2005). Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation. J Pharmacol Exp Ther 315: 812–820.
-
(2005)
J Pharmacol Exp Ther
, vol.315
, pp. 812-820
-
-
Mabley, J.G.1
Horváth, E.M.2
Murthy, K.G.3
Zsengellér, Z.4
Vaslin, A.5
Benko, R.6
-
126
-
-
34247575344
-
The selective poly(ADP)ribose-polymerase 1 inhibitor INO1001 reduces spinal cord injury during porcine aortic cross-clamping-induced ischemia/reperfusion injury
-
Maier C, Scheuerle A, Hauser B, Schelzig H, Szabó C, Radermacher P et al. (2007). The selective poly(ADP)ribose-polymerase 1 inhibitor INO1001 reduces spinal cord injury during porcine aortic cross-clamping-induced ischemia/reperfusion injury. Intensive Care Med 33: 845–850.
-
(2007)
Intensive Care Med
, vol.33
, pp. 845-850
-
-
Maier, C.1
Scheuerle, A.2
Hauser, B.3
Schelzig, H.4
Szabó, C.5
Radermacher, P.6
-
127
-
-
84867370386
-
Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation
-
Mangerich A, Bürkle A (2012). Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation. Oxid Med Cell Longev 2012: 321653.
-
(2012)
Oxid Med Cell Longev
, vol.2012
, pp. 321653
-
-
Mangerich, A.1
Bürkle, A.2
-
128
-
-
84907961435
-
Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer
-
Martínez-Bosch N, Iglesias M, Munné-Collado J, Martínez-Cáceres C, Moreno M, Guerra C et al. (2014). Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer. J Pathol 234: 214–227.
-
(2014)
J Pathol
, vol.234
, pp. 214-227
-
-
Martínez-Bosch, N.1
Iglesias, M.2
Munné-Collado, J.3
Martínez-Cáceres, C.4
Moreno, M.5
Guerra, C.6
-
130
-
-
3442890964
-
Crosstalk between PARP-1 and NF-nB modulates the promotion of mskin neoplasia
-
Martin-Oliva D, O'Valle F, Munoz-Gamez JA, Valenzuela MT, Nunez MI, Aguilar M et al. (2004). Crosstalk between PARP-1 and NF-nB modulates the promotion of mskin neoplasia. Oncogene 23: 5275–5283.
-
(2004)
Oncogene
, vol.23
, pp. 5275-5283
-
-
Martin-Oliva, D.1
O'Valle, F.2
Munoz-Gamez, J.A.3
Valenzuela, M.T.4
Nunez, M.I.5
Aguilar, M.6
-
131
-
-
33745288540
-
Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis
-
Martin-Oliva D, Aguilar-Quesada R, O'Valle F, Munoz-Gamez JA, Martinez-Romero R, del Moral RG (2006). Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis. Cancer Res 66: 5744–5756.
-
(2006)
Cancer Res
, vol.66
, pp. 5744-5756
-
-
Martin-Oliva, D.1
Aguilar-Quesada, R.2
O'Valle, F.3
Munoz-Gamez, J.A.4
Martinez-Romero, R.5
del Moral, R.G.6
-
132
-
-
84917680186
-
Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases
-
Mashimo M, Kato J, Moss J (2014). Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases. DNA Repair (Amst) 23: 88–94.
-
(2014)
DNA Repair (Amst)
, vol.23
, pp. 88-94
-
-
Mashimo, M.1
Kato, J.2
Moss, J.3
-
133
-
-
84886728595
-
Poly(ADP-ribosyl)ation in carcinogenesis
-
Masutani M, Fujimori H (2013). Poly(ADP-ribosyl)ation in carcinogenesis. Mol Aspects Med 34: 1202–1216.
-
(2013)
Mol Aspects Med
, vol.34
, pp. 1202-1216
-
-
Masutani, M.1
Fujimori, H.2
-
135
-
-
80052034516
-
MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model
-
Matsuura S, Egi Y, Yuki S, Horikawa T, Satoh H, Akira T (2011). MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model. Brain Res 1410: 122–131.
-
(2011)
Brain Res
, vol.1410
, pp. 122-131
-
-
Matsuura, S.1
Egi, Y.2
Yuki, S.3
Horikawa, T.4
Satoh, H.5
Akira, T.6
-
136
-
-
17044430692
-
Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection
-
McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I, Hurn PD (2005). Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection. J Cereb Blood Flow Metab 25: 502–512.
-
(2005)
J Cereb Blood Flow Metab
, vol.25
, pp. 502-512
-
-
McCullough, L.D.1
Zeng, Z.2
Blizzard, K.K.3
Debchoudhury, I.4
Hurn, P.D.5
-
137
-
-
84921272961
-
Neuroprotection for ischaemic stroke: current status and challenges
-
Moretti A, Ferrari F, Villa RF (2015). Neuroprotection for ischaemic stroke: current status and challenges. Pharmacol Ther 146: 23–34.
-
(2015)
Pharmacol Ther
, vol.146
, pp. 23-34
-
-
Moretti, A.1
Ferrari, F.2
Villa, R.F.3
-
138
-
-
38649092421
-
Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage
-
Moroni F (2008). Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage. Curr Opin Pharmacol 8: 96–103.
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 96-103
-
-
Moroni, F.1
-
139
-
-
84863126436
-
Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase
-
Moroni F, Cozzi A, Chiarugi A, Formentini L, Camaioni E, Pellegrini-Giampietro DE et al. (2012). Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase. Br J Pharmacol 165: 1487–1500.
-
(2012)
Br J Pharmacol
, vol.165
, pp. 1487-1500
-
-
Moroni, F.1
Cozzi, A.2
Chiarugi, A.3
Formentini, L.4
Camaioni, E.5
Pellegrini-Giampietro, D.E.6
-
140
-
-
67349272283
-
A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial
-
Morrow DA, Brickman CM, Murphy SA, Baran K, Krakover R, Dauerman H et al. (2009). A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial. J Thromb Thrombolysis 27: 359–364.
-
(2009)
J Thromb Thrombolysis
, vol.27
, pp. 359-364
-
-
Morrow, D.A.1
Brickman, C.M.2
Murphy, S.A.3
Baran, K.4
Krakover, R.5
Dauerman, H.6
-
141
-
-
25144433997
-
Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury
-
Mota RA, Sánchez-Bueno F, Saenz L, Hernández-Espinosa D, Jimeno J, Tornel PL et al. (2005). Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury. Lab Invest 85: 1250–1262.
-
(2005)
Lab Invest
, vol.85
, pp. 1250-1262
-
-
Mota, R.A.1
Sánchez-Bueno, F.2
Saenz, L.3
Hernández-Espinosa, D.4
Jimeno, J.5
Tornel, P.L.6
-
142
-
-
34547567854
-
Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury
-
Mota R, Sánchez-Bueno F, Berenguer-Pina JJ, Hernández-Espinosa D, Parrilla P, Yélamos J (2007). Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury. Br J Pharmacol 151: 998–1005.
-
(2007)
Br J Pharmacol
, vol.151
, pp. 998-1005
-
-
Mota, R.1
Sánchez-Bueno, F.2
Berenguer-Pina, J.J.3
Hernández-Espinosa, D.4
Parrilla, P.5
Yélamos, J.6
-
143
-
-
84880517634
-
The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
-
Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Canto C et al. (2013). The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 154: 430–441.
-
(2013)
Cell
, vol.154
, pp. 430-441
-
-
Mouchiroud, L.1
Houtkooper, R.H.2
Moullan, N.3
Katsyuba, E.4
Ryu, D.5
Canto, C.6
-
144
-
-
80053602773
-
Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury
-
Mukhopadhyay P, Horváth B, Kechrid M, Tanchian G, Rajesh M, Naura AS et al. (2011). Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury. Free Radic Biol Med 51: 1774–1788.
-
(2011)
Free Radic Biol Med
, vol.51
, pp. 1774-1788
-
-
Mukhopadhyay, P.1
Horváth, B.2
Kechrid, M.3
Tanchian, G.4
Rajesh, M.5
Naura, A.S.6
-
145
-
-
84899494248
-
Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis
-
Mukhopadhyay P, Rajesh M, Cao Z, Horváth B, Park O, Wang H et al. (2014). Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis. Hepatology 59: 1998–2009.
-
(2014)
Hepatology
, vol.59
, pp. 1998-2009
-
-
Mukhopadhyay, P.1
Rajesh, M.2
Cao, Z.3
Horváth, B.4
Park, O.5
Wang, H.6
-
146
-
-
85007418088
-
PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis
-
Mukhopadhyay P, Horváth B, Rajesh M, Varga VZ, Gariani K, Ryu D et al. (2017). PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis. J Hepatol 66: 589–600.
-
(2017)
J Hepatol
, vol.66
, pp. 589-600
-
-
Mukhopadhyay, P.1
Horváth, B.2
Rajesh, M.3
Varga, V.Z.4
Gariani, K.5
Ryu, D.6
-
147
-
-
3342896466
-
Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis
-
Murakami K, Enkhbaatar P, Shimoda K, Cox RA, Burke AS, Hawkins HK et al. (2004). Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. Shock 21: 126–133.
-
(2004)
Shock
, vol.21
, pp. 126-133
-
-
Murakami, K.1
Enkhbaatar, P.2
Shimoda, K.3
Cox, R.A.4
Burke, A.S.5
Hawkins, H.K.6
-
149
-
-
84872708384
-
Minocycline blocks asthma-associated inflammation in part by interfering with the T cell receptor-nuclear factor κB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase
-
Naura AS, Kim H, Ju J, Rodriguez PC, Jordan J, Catling AD et al. (2013). Minocycline blocks asthma-associated inflammation in part by interfering with the T cell receptor-nuclear factor κB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase. J Biol Chem 288: 1458–1468.
-
(2013)
J Biol Chem
, vol.288
, pp. 1458-1468
-
-
Naura, A.S.1
Kim, H.2
Ju, J.3
Rodriguez, P.C.4
Jordan, J.5
Catling, A.D.6
-
150
-
-
0038640934
-
Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane
-
Nozaki T, Fujihara H, Watanabe M, Tsutsumi M, Nakamoto K, Kusuoka O et al. (2003). Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. Cancer Sci 94: 497–500.
-
(2003)
Cancer Sci
, vol.94
, pp. 497-500
-
-
Nozaki, T.1
Fujihara, H.2
Watanabe, M.3
Tsutsumi, M.4
Nakamoto, K.5
Kusuoka, O.6
-
151
-
-
33646113598
-
Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice
-
Ogawa K, Masutani M, Kato K, Tang M, Kamada N, Suzuki H et al. (2006). Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice. Cancer Lett 236: 32–38.
-
(2006)
Cancer Lett
, vol.236
, pp. 32-38
-
-
Ogawa, K.1
Masutani, M.2
Kato, K.3
Tang, M.4
Kamada, N.5
Suzuki, H.6
-
152
-
-
84941712094
-
Differentiation-associated downregulation of poly(ADP-ribose) polymerase-1 expression in myoblasts serves to increase their resistance to oxidative stress
-
Oláh G, Szczesny B, Brunyánszki A, López-García IA, Gerö D, Radák Z et al. (2015). Differentiation-associated downregulation of poly(ADP-ribose) polymerase-1 expression in myoblasts serves to increase their resistance to oxidative stress. PLoS One 10: e0134227.
-
(2015)
PLoS One
, vol.10
-
-
Oláh, G.1
Szczesny, B.2
Brunyánszki, A.3
López-García, I.A.4
Gerö, D.5
Radák, Z.6
-
153
-
-
0033054742
-
Clinical trials for severe sepsis. Past failures, and future hopes
-
Opal SM, Cross AS (1999). Clinical trials for severe sepsis. Past failures, and future hopes. Infect Dis Clin North Am 13: 285–297.
-
(1999)
Infect Dis Clin North Am
, vol.13
, pp. 285-297
-
-
Opal, S.M.1
Cross, A.S.2
-
154
-
-
84944057623
-
Delivering on the promise: poly ADP ribose polymerase inhibition as targeted anticancer therapy
-
O'Sullivan Coyne G, Chen A, Kummar S (2015). Delivering on the promise: poly ADP ribose polymerase inhibition as targeted anticancer therapy. Curr Opin Oncol 27: 475–481.
-
(2015)
Curr Opin Oncol
, vol.27
, pp. 475-481
-
-
O'Sullivan Coyne, G.1
Chen, A.2
Kummar, S.3
-
155
-
-
34548725014
-
Poly(ADP-ribose) polymerase expression in kidney transplantation: from alfa (alpha) to omega (omega)
-
O'Valle F, Gomez-Morales M, Del Moral RM, Seron D, Moreso F, Osuna A et al. (2007). Poly(ADP-ribose) polymerase expression in kidney transplantation: from alfa (alpha) to omega (omega). Transplant Proc 39: 2099–2101.
-
(2007)
Transplant Proc
, vol.39
, pp. 2099-2101
-
-
O'Valle, F.1
Gomez-Morales, M.2
Del Moral, R.M.3
Seron, D.4
Moreso, F.5
Osuna, A.6
-
156
-
-
46749118458
-
Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease
-
Pacher P, Szabo C (2008). Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease. Am J Pathol 173: 2–13.
-
(2008)
Am J Pathol
, vol.173
, pp. 2-13
-
-
Pacher, P.1
Szabo, C.2
-
157
-
-
84966447555
-
Clinical application of poly(ADP-ribose) polymerase inhibitors in high-grade serous ovarian cancer
-
Parkes EE, Kennedy RD (2016). Clinical application of poly(ADP-ribose) polymerase inhibitors in high-grade serous ovarian cancer. Oncologist 21: 586–593.
-
(2016)
Oncologist
, vol.21
, pp. 586-593
-
-
Parkes, E.E.1
Kennedy, R.D.2
-
158
-
-
84938198958
-
The rise and fall of poly(ADP-ribose): an enzymatic perspective
-
Pascal JM, Ellenberger T (2015). The rise and fall of poly(ADP-ribose): an enzymatic perspective. DNA Repair (Amst) 32: 10–16.
-
(2015)
DNA Repair (Amst)
, vol.32
, pp. 10-16
-
-
Pascal, J.M.1
Ellenberger, T.2
-
159
-
-
84862952697
-
The role of ADP-ribosylation in regulating DNA double-strand break repair
-
Pears CJ, Couto CA, Wang HY, Borer C, Kiely R, Lakin ND (2012). The role of ADP-ribosylation in regulating DNA double-strand break repair. Cell Cycle 11: 48–56.
-
(2012)
Cell Cycle
, vol.11
, pp. 48-56
-
-
Pears, C.J.1
Couto, C.A.2
Wang, H.Y.3
Borer, C.4
Kiely, R.5
Lakin, N.D.6
-
160
-
-
77956399970
-
Small-molecule PARP modulators – current status and future therapeutic potential
-
Penning TD (2010). Small-molecule PARP modulators – current status and future therapeutic potential. Curr Opin Drug Discov Devel 13: 577–586.
-
(2010)
Curr Opin Drug Discov Devel
, vol.13
, pp. 577-586
-
-
Penning, T.D.1
-
161
-
-
81555212331
-
Mass spectrometry-based functional proteomics of poly(ADP-ribose) polymerase-1
-
Pic E, Gagné JP, Poirier GG (2011). Mass spectrometry-based functional proteomics of poly(ADP-ribose) polymerase-1. Expert Rev Proteomics 8: 759–774.
-
(2011)
Expert Rev Proteomics
, vol.8
, pp. 759-774
-
-
Pic, E.1
Gagné, J.P.2
Poirier, G.G.3
-
162
-
-
0032999788
-
Poly (ADP-ribose) polymerase, nitric oxide and cell death
-
Pieper AA, Verma A, Zhang J, Snyder SH (1999). Poly (ADP-ribose) polymerase, nitric oxide and cell death. Trends Pharmacol Sci 20: 171–181.
-
(1999)
Trends Pharmacol Sci
, vol.20
, pp. 171-181
-
-
Pieper, A.A.1
Verma, A.2
Zhang, J.3
Snyder, S.H.4
-
163
-
-
12344289049
-
Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure
-
Pillai JB, Russell HM, Raman J, Jeevanandam V, Gupta MP (2005). Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure. Am J Physiol Heart Circ Physiol 288: H486–H496.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
, pp. H486-H496
-
-
Pillai, J.B.1
Russell, H.M.2
Raman, J.3
Jeevanandam, V.4
Gupta, M.P.5
-
164
-
-
84902270555
-
Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle
-
Pirinen E, Cantó C, Jo YS, Morato L, Zhang H, Menzies KJ et al. (2014). Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metab 19: 1034–1041.
-
(2014)
Cell Metab
, vol.19
, pp. 1034-1041
-
-
Pirinen, E.1
Cantó, C.2
Jo, Y.S.3
Morato, L.4
Zhang, H.5
Menzies, K.J.6
-
165
-
-
77952573915
-
Deficiency in poly(ADP-ribose) polymerase-1 (PARP-1) accelerates aging and spontaneous carcinogenesis in mice
-
Piskunova TS, Yurova MN, Ovsyannikov AI, Semenchenko AV, Zabezhinski MA, Popovich IG et al. (2008). Deficiency in poly(ADP-ribose) polymerase-1 (PARP-1) accelerates aging and spontaneous carcinogenesis in mice. Curr Gerontol Geriatr Res 2008: 754190.
-
(2008)
Curr Gerontol Geriatr Res
, vol.2008
, pp. 754190
-
-
Piskunova, T.S.1
Yurova, M.N.2
Ovsyannikov, A.I.3
Semenchenko, A.V.4
Zabezhinski, M.A.5
Popovich, I.G.6
-
166
-
-
84994045079
-
Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action
-
Pommier Y, O'Connor MJ, de Bono J (2016). Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action. Sci Transl Med 8: 362ps17.
-
(2016)
Sci Transl Med
, vol.8
, pp. 362ps17
-
-
Pommier, Y.1
O'Connor, M.J.2
de Bono, J.3
-
167
-
-
0036897243
-
Antisense oligonucleotides to poly(ADP-ribose) polymerase-2 ameliorate colitis in interleukin-10-deficient mice
-
Popoff I, Jijon H, Monia B, Tavernini M, Ma M, McKay R et al. (2002). Antisense oligonucleotides to poly(ADP-ribose) polymerase-2 ameliorate colitis in interleukin-10-deficient mice. J Pharmacol Exp Ther 303: 1145–1154.
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 1145-1154
-
-
Popoff, I.1
Jijon, H.2
Monia, B.3
Tavernini, M.4
Ma, M.5
McKay, R.6
-
169
-
-
84865519032
-
Poly (ADP-ribose) polymerase inhibitors: on the horizon of tailored and personalized therapies for epithelial ovarian cancer
-
Ratner ES, Sartorelli AC, Lin ZP (2012). Poly (ADP-ribose) polymerase inhibitors: on the horizon of tailored and personalized therapies for epithelial ovarian cancer. Curr Opin Oncol 24: 564–571.
-
(2012)
Curr Opin Oncol
, vol.24
, pp. 564-571
-
-
Ratner, E.S.1
Sartorelli, A.C.2
Lin, Z.P.3
-
170
-
-
84870855799
-
Tankyrase-targeted therapeutics: expanding opportunities in the PARP family
-
Riffell JL, Lord CJ, Ashworth A (2012). Tankyrase-targeted therapeutics: expanding opportunities in the PARP family. Nat Rev Drug Discov 11: 923–936.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 923-936
-
-
Riffell, J.L.1
Lord, C.J.2
Ashworth, A.3
-
171
-
-
84920692915
-
Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions
-
Rom S, Zuluaga-Ramirez V, Dykstra H, Reichenbach NL, Ramirez SH, Persidsky Y (2015). Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions. J Cereb Blood Flow Metab 35: 28–36.
-
(2015)
J Cereb Blood Flow Metab
, vol.35
, pp. 28-36
-
-
Rom, S.1
Zuluaga-Ramirez, V.2
Dykstra, H.3
Reichenbach, N.L.4
Ramirez, S.H.5
Persidsky, Y.6
-
172
-
-
84988835156
-
PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier
-
Rom S, Zuluaga-Ramirez V, Reichenbach NL, Dykstra H, Gajghate S, Pacher P et al. (2016). PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier. J Neuroinflammation 13: 254.
-
(2016)
J Neuroinflammation
, vol.13
, pp. 254
-
-
Rom, S.1
Zuluaga-Ramirez, V.2
Reichenbach, N.L.3
Dykstra, H.4
Gajghate, S.5
Pacher, P.6
-
173
-
-
84925815358
-
New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases
-
Ryu KW, Kim DS, Kraus WL (2015). New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases. Chem Rev 115: 2453–2481.
-
(2015)
Chem Rev
, vol.115
, pp. 2453-2481
-
-
Ryu, K.W.1
Kim, D.S.2
Kraus, W.L.3
-
174
-
-
84979083733
-
Poly (ADP-ribose) polymerase-1 (PARP-1) -410C/T polymorphism in Sicilian patients with Parkinson's disease
-
Salluzzo MG, Cosentino FI, Romano C, Scillato F, Morale MC, Rando RG et al. (2016). Poly (ADP-ribose) polymerase-1 (PARP-1) -410C/T polymorphism in Sicilian patients with Parkinson's disease. J Neurol Sci 363: 95–96.
-
(2016)
J Neurol Sci
, vol.363
, pp. 95-96
-
-
Salluzzo, M.G.1
Cosentino, F.I.2
Romano, C.3
Scillato, F.4
Morale, M.C.5
Rando, R.G.6
-
175
-
-
84905974297
-
Transcriptional roles of PARP1 in cancer
-
Schiewer MJ, Knudsen KE (2014). Transcriptional roles of PARP1 in cancer. Mol Cancer Res 12: 1069–1078.
-
(2014)
Mol Cancer Res
, vol.12
, pp. 1069-1078
-
-
Schiewer, M.J.1
Knudsen, K.E.2
-
176
-
-
0040976524
-
Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase
-
Schraufstatter IU, Hyslop PA, Hinshaw DB, Spragg RG, Sklar LA, Cochrane CG (1986). Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase. Proc Natl Acad Sci U S A 83: 4908–4912.
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 4908-4912
-
-
Schraufstatter, I.U.1
Hyslop, P.A.2
Hinshaw, D.B.3
Spragg, R.G.4
Sklar, L.A.5
Cochrane, C.G.6
-
178
-
-
0021139816
-
Reduction of sister chromatid exchange frequency with time after mutagen exposure in Chinese hamster ovary cells in the presence of 3-aminobenzamide
-
Schwartz JL, Morgan WF, Wolff S (1984). Reduction of sister chromatid exchange frequency with time after mutagen exposure in Chinese hamster ovary cells in the presence of 3-aminobenzamide. Environ Mutagen 6: 203–210.
-
(1984)
Environ Mutagen
, vol.6
, pp. 203-210
-
-
Schwartz, J.L.1
Morgan, W.F.2
Wolff, S.3
-
179
-
-
0021010206
-
ADP-ribosylation, DNA repair, cell differentiation and cancer
-
Shall S (1983). ADP-ribosylation, DNA repair, cell differentiation and cancer. Princess Takamatsu Symp 13: 3–25.
-
(1983)
Princess Takamatsu Symp
, vol.13
, pp. 3-25
-
-
Shall, S.1
-
180
-
-
0034733928
-
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
-
Shall S, de Murcia G (2000). Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? Mutat Res 460: 1–15.
-
(2000)
Mutat Res
, vol.460
, pp. 1-15
-
-
Shall, S.1
de Murcia, G.2
-
181
-
-
84878251141
-
The protein poly(ADP-ribosyl)ation system: its role in genome stability and lifespan determination
-
Shilovsky GA, Khokhlov AN, Shram SI (2013). The protein poly(ADP-ribosyl)ation system: its role in genome stability and lifespan determination. Biochemistry (Mosc) 78: 433–444.
-
(2013)
Biochemistry (Mosc)
, vol.78
, pp. 433-444
-
-
Shilovsky, G.A.1
Khokhlov, A.N.2
Shram, S.I.3
-
182
-
-
17044456663
-
Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep
-
Shimoda K, Murakami K, Enkhbaatar P, Traber LD, Cox RA, Hawkins HK et al. (2003). Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep. Am J Physiol Lung Cell Mol Physiol 285: L240–L249.
-
(2003)
Am J Physiol Lung Cell Mol Physiol
, vol.285
, pp. L240-L249
-
-
Shimoda, K.1
Murakami, K.2
Enkhbaatar, P.3
Traber, L.D.4
Cox, R.A.5
Hawkins, H.K.6
-
183
-
-
0021023476
-
Effect of poly(ADP-ribose) polymerase inhibitors on the frequency of sister-chromatid exchanges in Bloom syndrome cells
-
Shiraishi Y, Tanaka Y, Kato M, Miwa M, Sugimura T (1983). Effect of poly(ADP-ribose) polymerase inhibitors on the frequency of sister-chromatid exchanges in Bloom syndrome cells. Mutat Res 122: 223–228.
-
(1983)
Mutat Res
, vol.122
, pp. 223-228
-
-
Shiraishi, Y.1
Tanaka, Y.2
Kato, M.3
Miwa, M.4
Sugimura, T.5
-
184
-
-
0035253415
-
Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetrapolidity
-
Simbulan-Rosenthal CM, Rosenthal DS, Luo D, Li JH, Zhang J, Smulsom ME (2001). Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetrapolidity. Nucl Acid Res 29: 841–849.
-
(2001)
Nucl Acid Res
, vol.29
, pp. 841-849
-
-
Simbulan-Rosenthal, C.M.1
Rosenthal, D.S.2
Luo, D.3
Li, J.H.4
Zhang, J.5
Smulsom, M.E.6
-
185
-
-
84908066897
-
Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease
-
Simmons K, Michels AW (2014). Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease. Rheum Dis Clin North Am 40: 797–811.
-
(2014)
Rheum Dis Clin North Am
, vol.40
, pp. 797-811
-
-
Simmons, K.1
Michels, A.W.2
-
186
-
-
0021112635
-
Poly(ADP-ribose) polymerase inhibitors preserve nicotinamide adenine dinucleotide and adenosine 5'-triphosphate pools in DNA-damaged cells: mechanism of stimulation of unscheduled DNA synthesis
-
Sims JL, Berger SJ, Berger NA (1983). Poly(ADP-ribose) polymerase inhibitors preserve nicotinamide adenine dinucleotide and adenosine 5'-triphosphate pools in DNA-damaged cells: mechanism of stimulation of unscheduled DNA synthesis. Biochem 22: 5188–5194.
-
(1983)
Biochem
, vol.22
, pp. 5188-5194
-
-
Sims, J.L.1
Berger, S.J.2
Berger, N.A.3
-
188
-
-
57749178603
-
Update on worldwide efforts to prevent type 1 diabetes
-
Skyler JS, Type 1 Diabetes TrialNet Study Group (2008). Update on worldwide efforts to prevent type 1 diabetes. Ann N Y Acad Sci 1150: 190–196.
-
(2008)
Ann N Y Acad Sci
, vol.1150
, pp. 190-196
-
-
Skyler, J.S.1
-
189
-
-
0035012857
-
A review of the genotoxicity of marketed pharmaceuticals
-
Snyder RD, Green JW (2001). A review of the genotoxicity of marketed pharmaceuticals. Mutat Res 488: 151–169.
-
(2001)
Mutat Res
, vol.488
, pp. 151-169
-
-
Snyder, R.D.1
Green, J.W.2
-
190
-
-
84894906316
-
Comparative cancer risk associated with methotrexate, other non-biologic and biologic disease-modifying anti-rheumatic drugs
-
Solomon DH, Kremer JM, Fisher M, Curtis JR, Furer V, Harrold LR et al. (2014). Comparative cancer risk associated with methotrexate, other non-biologic and biologic disease-modifying anti-rheumatic drugs. Semin Arthritis Rheum 43: 489–497.
-
(2014)
Semin Arthritis Rheum
, vol.43
, pp. 489-497
-
-
Solomon, D.H.1
Kremer, J.M.2
Fisher, M.3
Curtis, J.R.4
Furer, V.5
Harrold, L.R.6
-
192
-
-
0035136240
-
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
-
Soriano FG, Virág L, Jagtap P, Szabó E, Mabley JG, Liaudet L et al. (2001). Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med 7: 108–113.
-
(2001)
Nat Med
, vol.7
, pp. 108-113
-
-
Soriano, F.G.1
Virág, L.2
Jagtap, P.3
Szabó, E.4
Mabley, J.G.5
Liaudet, L.6
-
193
-
-
0036550855
-
Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice
-
Soriano FG, Liaudet L, Szabó E, Virág L, Mabley JG, Pacher P et al. (2002). Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice. Shock 17: 286–292.
-
(2002)
Shock
, vol.17
, pp. 286-292
-
-
Soriano, F.G.1
Liaudet, L.2
Szabó, E.3
Virág, L.4
Mabley, J.G.5
Pacher, P.6
-
194
-
-
84976865494
-
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands
-
Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SP et al. (2016). The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucl Acids Res 44: D1054–D1068.
-
(2016)
Nucl Acids Res
, vol.44
, pp. D1054-D1068
-
-
Southan, C.1
Sharman, J.L.2
Benson, H.E.3
Faccenda, E.4
Pawson, A.J.5
Alexander, S.P.6
-
195
-
-
84905165949
-
Targeting poly(ADP-ribose)polymerase1 in neurological diseases: a promising trove for new pharmacological interventions to enter clinical translation
-
Sriram CS, Jangra A, Kasala ER, Bodduluru LN, Bezbaruah BK (2014). Targeting poly(ADP-ribose)polymerase1 in neurological diseases: a promising trove for new pharmacological interventions to enter clinical translation. Neurochem Int 76: 70–81.
-
(2014)
Neurochem Int
, vol.76
, pp. 70-81
-
-
Sriram, C.S.1
Jangra, A.2
Kasala, E.R.3
Bodduluru, L.N.4
Bezbaruah, B.K.5
-
196
-
-
84952638052
-
Therapeutic targeting of acute lung injury and acute respiratory distress syndrome
-
Standiford TJ, Ward PA (2016). Therapeutic targeting of acute lung injury and acute respiratory distress syndrome. Transl Res 167: 183–191.
-
(2016)
Transl Res
, vol.167
, pp. 183-191
-
-
Standiford, T.J.1
Ward, P.A.2
-
197
-
-
84910682303
-
Sepsis in old age: review of human and animal studies
-
Starr ME, Saito H (2014). Sepsis in old age: review of human and animal studies. Aging Dis 5: 126–136.
-
(2014)
Aging Dis
, vol.5
, pp. 126-136
-
-
Starr, M.E.1
Saito, H.2
-
198
-
-
84897464560
-
PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury
-
Stoica BA, Loane DJ, Zhao Z, Kabadi SV, Hanscom M, Byrnes KR et al. (2014). PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury. J Neurotrauma 31: 758–772.
-
(2014)
J Neurotrauma
, vol.31
, pp. 758-772
-
-
Stoica, B.A.1
Loane, D.J.2
Zhao, Z.3
Kabadi, S.V.4
Hanscom, M.5
Byrnes, K.R.6
-
200
-
-
19444377566
-
Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications
-
Szabó C (2005). Roles of poly(ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and its complications. Pharmacol Res 52: 60–71.
-
(2005)
Pharmacol Res
, vol.52
, pp. 60-71
-
-
Szabó, C.1
-
201
-
-
77955984387
-
Pathophysiological roles of peroxynitrite in circulatory shock
-
Szabó C, Módis K (2010). Pathophysiological roles of peroxynitrite in circulatory shock. Shock 34: S4–14.
-
(2010)
Shock
, vol.34
, pp. S4-14
-
-
Szabó, C.1
Módis, K.2
-
202
-
-
0030000690
-
DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite
-
Szabo C, Zingarelli B, O'Connor M, Salzman AL (1996). DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci U S A 93: 1753–1758.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 1753-1758
-
-
Szabo, C.1
Zingarelli, B.2
O'Connor, M.3
Salzman, A.L.4
-
203
-
-
84897541400
-
Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response
-
Tallis M, Morra R, Barkauskaite E, Ahel I (2014). Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response. Chromosoma 123: 79–90.
-
(2014)
Chromosoma
, vol.123
, pp. 79-90
-
-
Tallis, M.1
Morra, R.2
Barkauskaite, E.3
Ahel, I.4
-
204
-
-
78751643428
-
Minocycline protects cardiac myocytes against simulated ischemia–reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1
-
Tao R, Kim SH, Honbo N, Karliner JS, Alano CC (2010). Minocycline protects cardiac myocytes against simulated ischemia–reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1. J Cardiovasc Pharmacol 56: 659–668.
-
(2010)
J Cardiovasc Pharmacol
, vol.56
, pp. 659-668
-
-
Tao, R.1
Kim, S.H.2
Honbo, N.3
Karliner, J.S.4
Alano, C.C.5
-
205
-
-
84923239468
-
Protective actions of PJ34, a poly(ADP-ribose)polymerase inhibitor, on the blood-brain barrier after traumatic brain injury in mice
-
Tao X, Chen X, Hao S, Hou Z, Lu T, Sun M et al. (2015). Protective actions of PJ34, a poly(ADP-ribose)polymerase inhibitor, on the blood-brain barrier after traumatic brain injury in mice. Neuroscience 291: 26–36.
-
(2015)
Neuroscience
, vol.291
, pp. 26-36
-
-
Tao, X.1
Chen, X.2
Hao, S.3
Hou, Z.4
Lu, T.5
Sun, M.6
-
206
-
-
84957669536
-
Neuroprotective effects of poly(ADP-ribose)polymerase inhibitor olaparib in transient cerebral ischemia
-
Teng F, Zhu L, Su J, Zhang X, Li N, Nie Z et al. (2016). Neuroprotective effects of poly(ADP-ribose)polymerase inhibitor olaparib in transient cerebral ischemia. Neurochem Res 41: 1516–1526.
-
(2016)
Neurochem Res
, vol.41
, pp. 1516-1526
-
-
Teng, F.1
Zhu, L.2
Su, J.3
Zhang, X.4
Li, N.5
Nie, Z.6
-
207
-
-
85014855146
-
Mechanisms of therapy resistance in patient-derived xenograft models of BRCA1-deficient breast cancer
-
Ter Brugge P, Kristel PP, van der Burg E, Boon U, de Maaker M, Lips E et al. (2016). Mechanisms of therapy resistance in patient-derived xenograft models of BRCA1-deficient breast cancer. J Natl Cancer Inst 108: djw148.
-
(2016)
J Natl Cancer Inst
, vol.108
, pp. djw148
-
-
Ter Brugge, P.1
Kristel, P.P.2
van der Burg, E.3
Boon, U.4
de Maaker, M.5
Lips, E.6
-
208
-
-
84886723551
-
Poly-ADP-ribose polymerase: machinery for nuclear processes
-
Thomas C, Tulin AV (2013). Poly-ADP-ribose polymerase: machinery for nuclear processes. Mol Aspects Med 34: 1124–1137.
-
(2013)
Mol Aspects Med
, vol.34
, pp. 1124-1137
-
-
Thomas, C.1
Tulin, A.V.2
-
209
-
-
85013828471
-
Structural basis for potency and promiscuity in poly(ADP-ribose) polymerase (PARP) and tankyrase inhibitors
-
Thorsell AG, Ekblad T, Karlberg T, Löw M, Pinto AF, Trésaugues L et al. (2017). Structural basis for potency and promiscuity in poly(ADP-ribose) polymerase (PARP) and tankyrase inhibitors. J Med Chem 60: 1262–1271.
-
(2017)
J Med Chem
, vol.60
, pp. 1262-1271
-
-
Thorsell, A.G.1
Ekblad, T.2
Karlberg, T.3
Löw, M.4
Pinto, A.F.5
Trésaugues, L.6
-
210
-
-
84904354146
-
The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice
-
To C, Kim E-H, Royce DB, Williams CR, Collins RM, Risingsong R et al. (2014). The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice. Cancer Prev Res 7: 698–707.
-
(2014)
Cancer Prev Res
, vol.7
, pp. 698-707
-
-
To, C.1
Kim, E.-H.2
Royce, D.B.3
Williams, C.R.4
Collins, R.M.5
Risingsong, R.6
-
211
-
-
77955045071
-
Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia
-
Toller IM, Altmeyer M, Kohler E, Hottiger MO, Müller A (2010). Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia. Cancer Res 70: 5912–5922.
-
(2010)
Cancer Res
, vol.70
, pp. 5912-5922
-
-
Toller, I.M.1
Altmeyer, M.2
Kohler, E.3
Hottiger, M.O.4
Müller, A.5
-
212
-
-
0035977206
-
Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis
-
Tong WM, Cortes U, Wang ZQ (2001). Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis. Biochim Biophys Acta 1552: 27–33.
-
(2001)
Biochim Biophys Acta
, vol.1552
, pp. 27-33
-
-
Tong, W.M.1
Cortes, U.2
Wang, Z.Q.3
-
213
-
-
84911090939
-
Brain and cerebrovascular aging – new mechanisms and insights
-
Ungvari Z, Sonntag WE (2014). Brain and cerebrovascular aging – new mechanisms and insights. J Gerontol A Biol Sci Med Sci 69: 1307–1310.
-
(2014)
J Gerontol A Biol Sci Med Sci
, vol.69
, pp. 1307-1310
-
-
Ungvari, Z.1
Sonntag, W.E.2
-
214
-
-
77951925836
-
Poly (ADP-ribose) polymerase-1 initiated neuronal cell death pathway – do androgens matter?
-
Vagnerova K, Liu K, Ardeshiri A, Cheng J, Murphy SJ, Hurn PD et al. (2010). Poly (ADP-ribose) polymerase-1 initiated neuronal cell death pathway – do androgens matter? Neuroscience 166: 476–481.
-
(2010)
Neuroscience
, vol.166
, pp. 476-481
-
-
Vagnerova, K.1
Liu, K.2
Ardeshiri, A.3
Cheng, J.4
Murphy, S.J.5
Hurn, P.D.6
-
215
-
-
84925387313
-
An increased risk of non-melanoma skin cancer during TNF-inhibitor treatment in psoriasis patients compared to rheumatoid arthritis patients probably relates to disease-related factors
-
van Lümig PP, Menting SP, van den Reek JM, Spuls PI, van Riel PL, van de Kerkhof PC et al. (2015). An increased risk of non-melanoma skin cancer during TNF-inhibitor treatment in psoriasis patients compared to rheumatoid arthritis patients probably relates to disease-related factors. J Eur Acad Dermatol Venereol 29: 752–760.
-
(2015)
J Eur Acad Dermatol Venereol
, vol.29
, pp. 752-760
-
-
van Lümig, P.P.1
Menting, S.P.2
van den Reek, J.M.3
Spuls, P.I.4
van Riel, P.L.5
van de Kerkhof, P.C.6
-
216
-
-
0036733355
-
The therapeutic potential of poly(ADP-ribose) polymerase inhibitors
-
Virág L, Szabo C (2002). The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 54: 375–429.
-
(2002)
Pharmacol Rev
, vol.54
, pp. 375-429
-
-
Virág, L.1
Szabo, C.2
-
217
-
-
0032193692
-
Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death
-
Virág L, Salzman AL, Szabó C (1998). Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. J Immunol 161: 3753–3759.
-
(1998)
J Immunol
, vol.161
, pp. 3753-3759
-
-
Virág, L.1
Salzman, A.L.2
Szabó, C.3
-
220
-
-
84857939963
-
Family wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
-
Wahlberg E, Karlberg T, Kouznetsova E, Markova N, Macchiarulo A, Thorsell AG et al. (2012). Family wide chemical profiling and structural analysis of PARP and tankyrase inhibitors. Nat Biotechnol 30: 283–288.
-
(2012)
Nat Biotechnol
, vol.30
, pp. 283-288
-
-
Wahlberg, E.1
Karlberg, T.2
Kouznetsova, E.3
Markova, N.4
Macchiarulo, A.5
Thorsell, A.G.6
-
221
-
-
84924989774
-
PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues – a population pharmacokinetic/pharmacodynamic analysis of rucaparib
-
Wang DD, Li C, Sun W, Zhang S, Shalinsky DR, Kern KA et al. (2015). PARP activity in peripheral blood lymphocytes as a predictive biomarker for PARP inhibition in tumor tissues – a population pharmacokinetic/pharmacodynamic analysis of rucaparib. Clin Pharmacol Drug Dev 4: 89–98.
-
(2015)
Clin Pharmacol Drug Dev
, vol.4
, pp. 89-98
-
-
Wang, D.D.1
Li, C.2
Sun, W.3
Zhang, S.4
Shalinsky, D.R.5
Kern, K.A.6
-
222
-
-
84976337246
-
Pharmacological reconditioning of marginal donor rat lungs using inhibitors of peroxynitrite and poly (ADP-ribose) polymerase during ex vivo lung perfusion
-
Wang X, Wang Y, Parapanov R, Abdelnour E, Gronchi F, Perentes JY et al. (2016). Pharmacological reconditioning of marginal donor rat lungs using inhibitors of peroxynitrite and poly (ADP-ribose) polymerase during ex vivo lung perfusion. Transplant 100: 1465–1473.
-
(2016)
Transplant
, vol.100
, pp. 1465-1473
-
-
Wang, X.1
Wang, Y.2
Parapanov, R.3
Abdelnour, E.4
Gronchi, F.5
Perentes, J.Y.6
-
223
-
-
84973569023
-
Functions of PARylation in DNA damage repair pathways
-
Wei H, Yu X (2016). Functions of PARylation in DNA damage repair pathways. Genom Proteom Bioinform 14: 131–139.
-
(2016)
Genom Proteom Bioinform
, vol.14
, pp. 131-139
-
-
Wei, H.1
Yu, X.2
-
224
-
-
77955657563
-
Ex vivo supplementation with nicotinic acid enhances cellular poly(ADP-ribosyl)ation and improves cell viability in human peripheral blood mononuclear cells
-
Weidele K, Kunzmann A, Schmitz M, Beneke S, Bürkle A (2010). Ex vivo supplementation with nicotinic acid enhances cellular poly(ADP-ribosyl)ation and improves cell viability in human peripheral blood mononuclear cells. Biochem Pharmacol 80: 1103–1112.
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 1103-1112
-
-
Weidele, K.1
Kunzmann, A.2
Schmitz, M.3
Beneke, S.4
Bürkle, A.5
-
225
-
-
84974725107
-
ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling
-
Wright RH, Lioutas A, Le Dily F, Soronellas D, Pohl A, Bonet J et al. (2016). ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling. Science 352: 1221–1225.
-
(2016)
Science
, vol.352
, pp. 1221-1225
-
-
Wright, R.H.1
Lioutas, A.2
Le Dily, F.3
Soronellas, D.4
Pohl, A.5
Bonet, J.6
-
226
-
-
84940547038
-
Minocycline inhibits PARP-1 expression and decreases apoptosis in diabetic retinopathy
-
Wu Y, Chen Y, Wu Q, Jia L, Du X (2015). Minocycline inhibits PARP-1 expression and decreases apoptosis in diabetic retinopathy. Mol Med Rep 12: 4887–4894.
-
(2015)
Mol Med Rep
, vol.12
, pp. 4887-4894
-
-
Wu, Y.1
Chen, Y.2
Wu, Q.3
Jia, L.4
Du, X.5
-
227
-
-
84963623377
-
Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity
-
Xu JC, Fan J, Wang X, Eacker SM, Kam TI, Chen L et al. (2016). Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity. Sci Transl Med 8: 333ra48.
-
(2016)
Sci Transl Med
, vol.8
, pp. 333ra48
-
-
Xu, J.C.1
Fan, J.2
Wang, X.3
Eacker, S.M.4
Kam, T.I.5
Chen, L.6
-
228
-
-
56149089926
-
PARP inhibitor tilts cell death from necrosis to apoptosis in cancer cells
-
Ye K (2008). PARP inhibitor tilts cell death from necrosis to apoptosis in cancer cells. Cancer Biol Ther 7: 942–944.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 942-944
-
-
Ye, K.1
-
229
-
-
84978835906
-
Safety and tolerability of the olaparib tablet formulation in Japanese patients with advanced solid tumours
-
Yonemori K, Tamura K, Kodaira M, Fujikawa K, Sagawa T, Esaki T et al. (2016). Safety and tolerability of the olaparib tablet formulation in Japanese patients with advanced solid tumours. Cancer Chemother Pharmacol 78: 525–531.
-
(2016)
Cancer Chemother Pharmacol
, vol.78
, pp. 525-531
-
-
Yonemori, K.1
Tamura, K.2
Kodaira, M.3
Fujikawa, K.4
Sagawa, T.5
Esaki, T.6
-
230
-
-
84868302068
-
Inhibition of poly(ADP-ribose) polymerase attenuates acute kidney injury in sodium taurocholate-induced acute pancreatitis in rats
-
Yu J, Deng W, Wang W, Ding Y, Jin H, Chen C et al. (2012). Inhibition of poly(ADP-ribose) polymerase attenuates acute kidney injury in sodium taurocholate-induced acute pancreatitis in rats. Pancreas 41: 1299–1305.
-
(2012)
Pancreas
, vol.41
, pp. 1299-1305
-
-
Yu, J.1
Deng, W.2
Wang, W.3
Ding, Y.4
Jin, H.5
Chen, C.6
-
231
-
-
84979642714
-
Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis
-
Yu J, Zuo T, Deng W, Shi Q, Ma P, Chen C et al. (2016). Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis. BMC Gastroenterol 16: 81.
-
(2016)
BMC Gastroenterol
, vol.16
, pp. 81
-
-
Yu, J.1
Zuo, T.2
Deng, W.3
Shi, Q.4
Ma, P.5
Chen, C.6
-
232
-
-
64249104435
-
Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke
-
Yuan M, Siegel C, Zeng Z, Li J, Liu F, McCullough LD (2009). Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke. Exp Neurol 217: 210–218.
-
(2009)
Exp Neurol
, vol.217
, pp. 210-218
-
-
Yuan, M.1
Siegel, C.2
Zeng, Z.3
Li, J.4
Liu, F.5
McCullough, L.D.6
-
233
-
-
78149294004
-
Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1 (PARP1) activity and expression and its implication for PARP inhibitors in clinical trials
-
Zaremba T, Thomas H, Cole M, Plummer ER, Curtin NJ (2010). Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1 (PARP1) activity and expression and its implication for PARP inhibitors in clinical trials. Cancer Chemother Pharmacol 66: 807–812.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, pp. 807-812
-
-
Zaremba, T.1
Thomas, H.2
Cole, M.3
Plummer, E.R.4
Curtin, N.J.5
-
234
-
-
79957726564
-
Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers
-
Zaremba T, Thomas HD, Cole M, Coulthard SA, Plummer ER, Curtin NJ (2011). Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers. Biochem J 436: 671–679.
-
(2011)
Biochem J
, vol.436
, pp. 671-679
-
-
Zaremba, T.1
Thomas, H.D.2
Cole, M.3
Coulthard, S.A.4
Plummer, E.R.5
Curtin, N.J.6
-
235
-
-
0028294246
-
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity
-
Zhang J, Dawson VL, Dawson TM, Snyder SH (1994). Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 263: 687–689.
-
(1994)
Science
, vol.263
, pp. 687-689
-
-
Zhang, J.1
Dawson, V.L.2
Dawson, T.M.3
Snyder, S.H.4
-
236
-
-
84995982172
-
Inhibition of poly(ADP-ribose) polymerase-1 protects chronic alcoholic liver injury
-
Zhang Y, Wang C, Tian Y, Zhang F, Xu W, Li X et al. (2016). Inhibition of poly(ADP-ribose) polymerase-1 protects chronic alcoholic liver injury. Am J Pathol 186: 3117–3130.
-
(2016)
Am J Pathol
, vol.186
, pp. 3117-3130
-
-
Zhang, Y.1
Wang, C.2
Tian, Y.3
Zhang, F.4
Xu, W.5
Li, X.6
-
237
-
-
0030026515
-
Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide
-
Zingarelli B, O'Connor M, Wong H, Salzman AL, Szabó C (1996). Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J Immunol 156: 350–358.
-
(1996)
J Immunol
, vol.156
, pp. 350-358
-
-
Zingarelli, B.1
O'Connor, M.2
Wong, H.3
Salzman, A.L.4
Szabó, C.5
-
238
-
-
0031281259
-
Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase
-
Zingarelli B, Cuzzocrea S, Zsengellér Z, Salzman AL, Szabo C (1997). Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase. Cardiovasc Res 36: 205–215.
-
(1997)
Cardiovasc Res
, vol.36
, pp. 205-215
-
-
Zingarelli, B.1
Cuzzocrea, S.2
Zsengellér, Z.3
Salzman, A.L.4
Szabo, C.5
|