The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease

Free Radical Biology and Medicine

Volumn 71, Issue , 2014, Pages 390-401

  Ng, Li Fang ^a   Gruber, Jan ^a,b   Cheah, Irwin K ^a   Goo, Chong Kit ^a   Cheong, Wei Fun ^a   Shui, Guanghou ^c   Sit, Kim Ping ^a   Wenk, Markus R ^a   Halliwell, Barry ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b YALE NUS COLLEGE   (Singapore)

^c INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

Author keywords

Alzheimer disease; Caenorhabditis elegans; Cardiolipin; Complex IV; Cytochrome c oxidase; Electron transport chain; Free radicals; Healthspan; Lifespan; Mitochondria targeted antioxidants; MitoQ; Oxidative stress; Amyloid peptides

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; ANTIOXIDANT; CARDIOLIPIN; MITOCHONDRIAL DNA; MITOQ; UNCLASSIFIED DRUG; 10-(6'-UBIQUINONYL)DECYLTRIPHENYLPHOSPHONIUM BROMIDE; MULTIENZYME COMPLEX; ORGANOPHOSPHORUS COMPOUND; REACTIVE OXYGEN METABOLITE; UBIQUINONE;

ADULT; ALZHEIMER DISEASE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; IN VIVO STUDY; LIFESPAN; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PARALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY CHAIN; TARGET CELL; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION; GENETICS; HUMAN; LONGEVITY; METABOLISM; PATHOLOGY; PROTEIN CARBONYLATION; TRANSGENE;

ADENOSINE TRIPHOSPHATE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; CAENORHABDITIS ELEGANS; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; GENE EXPRESSION; HUMANS; LONGEVITY; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; ORGANOPHOSPHORUS COMPOUNDS; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTEIN CARBONYLATION; REACTIVE OXYGEN SPECIES; TRANSGENES; UBIQUINONE;

EID: 84899869133     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.03.003     Document Type: Article

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