β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

Brain

Volumn 134, Issue 6, 2011, Pages 1658-1672

  Abeti, Rosella ^a   Abramov, Andrey Y ^b   Duchen, Michael R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

amyloid; mitochondria; NADPH oxidise; PARP; reactive oxygen production

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM ION; CYCLOPHILIN D; DIPHENYLIODONIUM SALT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FLUORESCENCE; GLUCOSE TRANSPORT; HIPPOCAMPUS; IN VITRO STUDY; KNOCKOUT MOUSE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT;

4-CHLORO-7-NITROBENZOFURAZAN; AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CALCIUM; CELL DEATH; COCULTURE TECHNIQUES; DEOXYGLUCOSE; DISEASE MODELS, ANIMAL; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOSE; HIPPOCAMPUS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, TRANSGENIC; NAD; NADPH OXIDASE; NEURONS; OXYGEN CONSUMPTION; PEPTIDE FRAGMENTS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; TETRADECANOYLPHORBOL ACETATE;

EID: 79957871035     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awr104     Document Type: Article

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